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Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier

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Neural Regeneration Research 2020年第12期15卷 2344-2352页

作者： Xue-Song Mi Qian Feng Amy Cheuk yin Lo Raymond Chuen-chung chang Sookja Kim chung Kwok-Fai So Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina changsha Academician Expert Workstation Aier Eye Hospital GroupChangshaHunan ProvinceChina State Key Laboratory of Brain and Cognitive Sciences Hong Kong Special Administrative RegionChina Department of Ophthalmology The University of Hong KongHong Kong Special Administrative RegionChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administrative RegionChina School of Biomedical Science LKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Our previous study verified the protective effects of Lycium barbarum polysaccharides(LBP)on retinal neurons and blood vessels in acute ocular hypertension(AOH)*** investigate the effect of LBP on the reactivity of retinal glial cells,an AOH mouse model was established in one eye by maintaining ocular hypertension of 90 mm Hg for 60 *** LBP solution(1 mg/kg)or phosphate-buffered saline was administrated to the mice by gavage daily,starting 7 days before the AOH insult and continuing until the mice were sacrificed for specimen collection on day 4 *** AOH insult,increased numbers of astrocytes and microglia were observed,together with decreased expression of the following glial cell biomarkers in the retinal ganglion cells of AOH mice:glial fibrillary acidic protein,glutamine synthetase,aquaporin-4,S-100 proteins,ionized calcium-binding adaptor molecule 1,amyloid precursor protein and receptor of advanced glycosylation *** intervention with LBP,the above changes were significantly ***,morphological remodeling of blood vessel-associated retinal astrocytes,marked by glial fibrillary acidic protein,was also *** results,taken together,suggest that LBP regulated the production of amyloid-βand expression of receptor of advanced glycosylation end-products,as well as mediating the activity of retinal glial cells,which may lead to the promotion of better maintenance of the blood-retinal barrier and improved neuronal survival in AOH *** study was approved by the Committee for the Use of Live Animals in Teaching and Research(approval ***-#1664-08).

关键词： astrocyte blood-retinal barrier glial cell Lycium barbarum microglia model plasticity remodel retina

Stearoyl-CoA desaturase 1 inhibitor supplemented with gemcitabine treatment reduces the viability and fatty acid content of pancreatic cancer cells in vitro

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Journal of Pancreatology 2021年第4期4卷 170-177页

作者： Amon B.Hackney Wen y.chung John Isherwood Ashley R.Dennison Naomi Martin Faculty of Health and Life Sciences De Montfort University Department of Hepatobiliary and Pancreatic Surgery Leicester General Hospital Department of Respiratory Sciences University of LeicesterLeicesterUK

Objective:Pancreatic cancer(PC)is an aggressive cancer with ineffective *** of stearoyl-CoA desaturase 1(SCD1)suppresses cancer proliferation and might act as a novel chemotherapy supplement,but this has not been investigated in ***,the effects of SCD1 inhibitor CAy10566 supplemented with gemcitabine treatment(gemcitabine+CAy10566)on PC cell viability,apoptosis,phenotype,fatty acid content,platelet-derived growth factor release,and cell size were ***:Human PC cell line(PANC-1)was treated with SCD1 inhibitor CAy10566 with or without *** viability was assayed using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide and apoptosis and phenotype were determined using flow *** acid content and platelet-derived growth factor release were measured by enzyme-linked immunosorbent *** size was determined using scanning electron ***:Half-maximal inhibitory concentration of gemcitabine or CAy10566 significantly reduced PANC-1 viability compared to gemcitabine alone(Pype of phosphatidylserine,tissue factor or basigin expression were detected at therapeutic doses(P>0.05).Apoptosis was significantly increased following incubation with CAy10566(Py acid content of cells was significantly higher following gemcitabine treatment compared to CAy10566 alone or gemcitabine+CAy10566(Py gemcitabine-treated cells was significantly increased compared to 142 nM CAy10566 alone or gemcitabine+CAy10566(Py10566 did not affect the size of isolated tumor cells but gemcitabine+CAy10566 significantly increased the size compared to the control(Py decreased significantly after the treatment with gemcitabine+CAy10566 compared with CAy10566 alone(Pycles of chemotherapy were mimicked and treatment was removed,the number of cell v

关键词： Gemcitabine Metabolomics Pancreatic cancer SCD1 inhibitor Viability

Traditional Chinese medicine for gait disturbance in adrenoleukodystrophy:A case report and review of literature

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World Journal of Clinical Cases 2021年第31期9卷 9691-9698页

作者： Hyungsuk Kim Taeoh Kim Whisung Cho Hokyung chang Won-Seok chung Department of Korean Medicine Rehabilitation Kyung Hee UniversitySeoul 02447South Korea

BACKGROUND Adrenoleukodystrophy(ALD)is caused by a deficit in the ABCD1 gene,which leads to demyelination of neurons and dysfunction of the adrenal cortices and *** the three known phenotypes,30%-50%of male ALD patients present with the adrenomyeloneuropathy phenotype,characterized by gait disturbance as the initial *** SUMMARy A 46-year-old man with a prior diagnosis of ALD was admitted to a Korean medicine hospital for the treatment of gait *** ability to walk was severely impaired at admission,significantly affecting the patient’s quality of *** was treated with acupuncture,pharmacopuncture,electroacupuncture,and herbal medicine for 23 *** 25-Foot Walk test(25FW),timed up and go(TUG),comfortable gait speed(CGS),numeric rating scale(NRS),Berg Balance Scale(BBS),Tinetti test,manual muscle test(MMT),and 3-level version of EuroQol-5 dimension(EQ-5D-3L)were used to evaluate the *** outcomes of the 25FW,TUG,and CGS improved during *** the time of admission to discharge we observed:A decrease in NRS scores in the lower extremities and the lower back;an increase of 3 points in the BBS;a 1-point increase in the balancing part of the Tinetti Test;MMT and EQ-5D-3L performances remained *** Traditional Chinese medicine treatments could be a therapeutic option to alleviate issues related to gait disturbance in ALD.

关键词： Traditional Chinese medicine Herbal medicine Gait disturbance Adrenoleukodystrophy Adenosine triphosphate Case report

Realization of orientation interpolation of 6-axis articulated robot using quaternion

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Journal of Central South University 2012年第12期19卷 3407-3414页

作者： AHN Jin-su chung Won-jee JUNG chang-doo School of Mechatronics Changwon National UniversityChangwon 641-773Korea

In general, the orientation interpolation of industrial robots has been done based on Euler angle system which can result in singular point （so-called Gimbal Lock）. However, quaternion interpolation has the advantage of natural （specifically smooth） orientation interpolation without Gimbal Lock. This work presents the application of quatemion interpolation, specifically Spherical Linear IntERPolation （SLERP）, to the orientation control of the 6-axis articulated robot （RS2） using LabVIEW and RecurDyn. For the comparison of SLERP with linear Euler interpolation in the view of smooth movement （profile） of joint angles （torques）, the two methods are dynamically simulated on RS2 by using both LabVIEW and RecurDyn. Finally, our original work, specifically the implementation of SLERP and linear Euler interpolation on the actual robot, i.e. RS2, is done using LabVIEW motion control tool kit. The SLERP orientation control is shown to be effective in terms of smooth joint motion and torque when compared to a conventional （linear） Euler interpolation.

关键词： quaternion spherical linear interpolation (SLERP) Euler angle linear Euler interpolation 6-axis articulated robot

New approaches to water purification for resource- constrained settings： Production of activated biochar by chemical activation with diammonium hydrogenphosphate

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 194-208页

作者： Mohit Nahata chang y. Seo Pradeep Krishnakumar Johannes Schwank Department of Chemical Engineering University of Michigan-Ann Arbor Ann Arbor MI 48109 USA

A significant portion of the world＇s population does not have access to safe drinking water. This problem is most acute in remote, resource-constrained rural settings in developing countries. Water filtration using activated carbon is one of the important steps in treating con- taminated water. Lignocellulosic biomass is generally available in abundance in such locations, such as the African rain forests. Our work is focused on developing a simple method to synthesize activated biochar from locally available materials. The preparation of activated biochar with diammonium hydrogenphosphate （DAP） as the activating agent is explored under N2 flow and air. The study, carried out with cellulose as a model biomass, provides some insight into the interaction between DAP and biomass, as well as the char forming mechanism. Various characterization techniques such as N2 physisorption, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy and Raman spectroscopy are utilized to compare the properties between biochar formed under nitrogen and partial oxidative conditions. At a temperature of 450 ℃, the loading of DAP over cellulose is systematically varied, and its effect on activation is examined. The activated biochar samples are predominantly microporous in the range of concentrations studied. The interaction of DAP with cellulose is investigated and the nature of bonding of the heteroatoms to the carbonaceous matrix is elucidated. The results indicate that the quality of biochar prepared under partial oxidation condition is comparable to that ofbiochar prepared under nitrogen, leading to the possibility of an activated biochar production scheme on a small scale in resource-constrained settings.

关键词： cellulose DAP activation heteroatom,microporous

Microstructural Evolution of Infrared Brazed CP-Ti Using Ti-Cu-Ni Brazes

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Journal of Materials Science & Technology 2011年第2期27卷 131-138页

作者： C.T.chang T.y.yeh R.K.Shiue C.S.chang Department of Mechanical Engineering National Hualien Industrial Vocational Senior High SchoolHualien 970TaiwanChina Department of Materials Science and Engineering National Taiwan UniversityTaipei 106TaiwanChina Engineered Materials Solutions 39 Perry AvenueMS 4-1AttleboroMA 02703-2410USA

Microstructural evolution of infrared vacuum brazed CP-Ti using two Ti-based braze alloys,Ti-15Cu-15Ni and Ti-15Cu-25Ni,has been *** infrared brazed joint consisted of eutectic Ti 2 Cu/Ti 2 Ni intermetallic compounds and Ti-rich *** eutectic Ti 2 Cu/Ti 2 Ni intermetallic compounds disappeared from the joint after being annealed at 900 C for 1 *** contrast,the depletion rate of both Cu and Ni from the braze alloy into CP-Ti substrate at 750 C annealing was greatly decreased as compared with that annealed at 900 *** Ti 2 Cu/Ti 2 Ni phases were observed even if the specimen was annealed at 750 C for 15 *** the Ni content of the Ti-15Cu-25Ni braze alloy is much higher than that of the Ti-15Cu-15Ni alloy,the amount of eutectic Ti 2 Cu/Ti 2 Ni phases in Ti-15Cu-25Ni brazed joint is more than that in Ti-15Ci-15Ni brazed ***,similar microstructural evolution can be obtained from the infrared brazed joint annealed at various temperatures and/or time for both filler metals.

关键词： Infrared Brazing CP-Ti Ti-Cu-Ni fillers Microstructure

Manipulating metal-oxygen local atomic structures in singlejunctional p-Si/WO_(3) photocathodes for efficient solar hydrogen generation

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Nano Research 2021年第7期14卷 2285-2293页

作者： Wu Zhou chung-Li Dong yiqing Wang yu-Cheng Huang Lingyun He Han-Wei chang Shaohua Shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityShaanxi 710049China Department of Physics Tamkang UniversityTamsui 25137TaiwanChina

Self-passivation in aqueous solution and sluggish surface reaction kinetics significantly limit the photoelectrochemical(PEC)performances of silicon-based ***,a WO_(3) thin layer is deposited on the p-Si substrate by pulsed laser deposition(PLD),acting as a photocathode for PEC hydrogen *** to bare p-Si,the single-junctional p-Si/WO_(3) photoelectrodes exhibit excellent and stable PEC performances with significantly increased cathodic photocurrent density and exceptional anodic shift in onset potential for water *** is revealed that the WO_(3) layer could reduce the charge transfer resistance across the electrode/electrolyte interface by eliminating the effect of Fermi level pinning on the surface of *** importantly,by varying the oxygen pressures during PLD,the collaborative modulation of W–O bond covalency and WO6 octahedral structure symmetry contributes to the promoted charge carrier transport and ***,a large band bending at the p-Si/WO_(3) junction,induced by the optimized O vacancy contents in WO_(3),could provide a photovoltage as high as~500 mV to efficiently drive charge transfer to overcome the water reduction ***,by manipulating W–O local atomic structures in the deposited WO_(3) layer,a great improvement in PEC performance could be achieved over the singlejunctional p-Si/WO_(3) photocathodes for solar hydrogen generation.

关键词： silicon local atomic structure water splitting photocathodes hydrogen generation

Challenges and opportunities for battery health estimation:Bridging laboratory research and real-world applications

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Journal of Energy Chemistry 2024年第2期89卷 434-436,I0011页

作者： Te Han Jinpeng Tian C.y.chung yi-Ming Wei Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Department of Electrical and Electronic Engineering and Research Centre for Grid Modernization The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina

Addressing climate change demands a significant shift away from fossil fuels,with sectors like electricity and transportation relying heavily on renewable *** to this transition are energy storage systems,notably lithium-ion *** time,these batteries degrade,affecting their efficiency and posing safety *** and predicting battery aging is essential,especially estimating its state of health(SOH).Various SOH estimation methods exist,from traditional model-based approaches to machine learning approaches.

关键词： Energy storage systems State of health Multi-source data Scientific AI Data-sharing mechanism

Clinical values of Barcelona Clinic Liver Cancer subgroup and up-to-7 criteria in intermediate stage hepatocellular carcinoma with transcatheter arterial chemoembolization

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World Journal of Clinical Cases 2022年第21期10卷 7275-7284页

作者： Shou-Wu Lee yen-Chun Peng Han-chung Lien chung-Wang Ko Chun-Fang Tung Chi-Sen chang Division of Gastroenterology and Hepatology Department of Internal MedicineTaichung Veterans General HospitalTaichung 40705Taiwan Department of Internal Medicine Yang Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichung 40227Taiwan Department of Internal Medicine Chung Shan Medical UniversityTaichung 40201Taiwan

BACKGROUND Transarterial chemoembolization(TACE)is a recommended treatment for patients with intermediate stage hepatocellular carcinoma(HCC)but with variable treatment *** To determine factors for predicting outcomes of TACE in patients with intermediate stage B *** Patients with Barcelona Clinic Liver Cancer(BCLC)stage B HCC who underwent TACE as the primary treatment were enrolled at Taichung Veterans General Hospital from January 2005 to December *** were assigned to either the objective responder(OR)group or the non-OR group according to mRECIST *** and radiological characteristics were compared between the 2 *** overall survival of enrolled subjects was *** In 128 enrolled patients,66(51.6%)were in the OR group and 62(48.4%)in the non-OR *** with the non-OR group,the OR group had a significantly smaller HCC size(6.55 cm vs 9.50 cm,P=0.001)and was within the up-to-7 criteria(50%vs 26.7%,P=0.001).After multivariable analyses,these significant associations still *** survival rate of all the subjects averaged 20.65±13.26 *** survival rate at 1-year was 64.8%,2-year was 46.9%,and 3-year was 31.2%.For those patients with OR to TACE,smaller tumor size and within up-to-7 criteria were associated with significantly better overall *** patients with subgroup B1 had the highest OR ratio(75%)and better overall survival(26.70±12.07 mo)after *** BCLC stage B HCC patients with smaller tumor size or within up-to-7 criteria had better survival outcomes to *** stage B subgroup is useful to predict refractoriness to TACE.

关键词： Hepatocellular carcinoma Objective response Overall survival Transcatheter arterial chemoembolization Barcelona Clinic Liver Cancer