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Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2296-2307页

作者： Shan-Shan Xie Yong Zhi chang-ming Shao Bin-Fang Zeng Department of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017Xinjiang Uygur Autonomous RegionChina

BACKGROUND The Chinese medicine Yangyin Huowei mixture(YYHWM)exhibits good clinical efficacy in the treatment of chronic atrophic gastritis(CAG),but the mechanisms underlying its activity remain *** To investigate the therapeutic effects of YYHWM and its underlying mechanisms in a CAG rat *** Sprague-Dawley rats were allocated into control,model,vitacoenzyme,and low,medium,and high-dose YYHWM *** was induced in rats using Nmethyl-N′-nitro-N-nitrosoguanidine,ranitidine hydrochloride,hunger and satiety perturbation,and ethanol *** an 8-wk intervention period,stomach samples were taken,stained,and examined for histopathological *** was utilized to quantify serum levels of PG-I,PG-II,G-17,IL-1β,IL-6,and TNF-α.Western blot analysis was performed to evaluate protein expression of IL-10,JAK1,and *** The model group showed gastric mucosal layer disruption and inflammatory cell *** with the blank control group,serum levels of PGI,PGII,and G-17 in the model group were significantly reduced(82.41±3.53 vs 38.52±1.71,23.06±0.96 vs 11.06±0.70,and 493.09±12.17 vs 225.52±17.44,P<0.01 for all),whereas those of IL-1β,IL-6,and TNF-αwere significantly increased(30.15±3.07 vs 80.98±4.47,69.05±12.72 vs 110.85±6.68,and 209.24±11.62 vs 313.37±36.77,P<0.01 for all),and the protein levels of IL-10,JAK1,and STAT3 were higher in gastric mucosal tissues(0.47±0.10 vs 1.11±0.09,0.49±0.05 vs 0.99±0.07,and 0.24±0.05 vs 1.04±0.14,P<0.01 for all).Compared with the model group,high-dose YYHWM treatment significantly improved the gastric mucosal tissue damage,increased the levels of PGI,PGII,and G-17(38.52±1.71 vs 50.41±3.53,11.06±0.70 vs 15.33±1.24,and 225.52±17.44 vs 329.22±29.11,P<0.01 for all),decreased the levels of IL-1β,IL-6,and TNF-α(80.98±4.47 vs 61.56±4.02,110.85±6.68 vs 89.20±8.48,and 313.37±36.77 vs 267.30±9.31,P<0.01 for all),and evidently decreased the protein levels of IL-10 and STAT3 in gastric mucosal tissues(1

关键词： Yangyin Huowei mixture IL-10/JAK1/STAT3 pathway Chronic atrophic gastritis Inflammatory factor Gastric secretory function

Nanodiamond/Ti_(3)C_(2) MXene-coated quartz crystal microbalance humidity sensor with high sensitivity and high quality factor

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Rare Metals 2024年第6期43卷 2719-2729页

作者： Yao Yao Qiao Chen Yan-Qi Li Xian-He Huang Wei-Wei Ling Zhe-MiaoXie Jia-QiWang chang-ming Chen College of Communication Engineering Chengdu University of Information TechnologyChengdu 610225China School of Automation Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Advanced Micro-/Nano-Devices Lab Department of Systems Design EngineeringUniversity of WaterlooWaterlooON N2L 3GlCanada

To address the challenge of achieving both high sensitivity and a high quality factor in quartz crystal microbalance(QCM)humidity sensors,a nanodiamond(ND)/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor was *** material characteristics of ND,Ti_(3)C_(2)MXene,and ND/Ti_(3)C_(2)MXene composite were analyzed by transmission electron microscopy(TEM)and Fourier transform infrared(FTIR)*** experimental results demonstrated that the hydrophilic ND nanoparticles coated on Ti_(3)C_(2) MXene nanosheet prevented the self-stacking of Ti_(3)C_(2)MXene and enhanced the sensitivity of Ti_(3)C_(2) MXene-based QCM humidity ***,the high mechanical modulus of Ti_(3)C_(2) MXene material helped ND/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor to achieve a high quality factor(>20,000).ND/Ti_(3)C_(2)MXene compositecoated QCM humidity sensor exhibited a sensitivity of 82.45 Hz/%RH,a humidity hysteresis of 1.1%RH,fast response/recovery times,acceptable repeatability,and good stability from 11.3%RH to 97.3%*** response mechanism of ND/Ti_(3)C_(2) MXene composite-coated QCM humidity sensor was analyzed in combination with a bi-exponential kinetic adsorption ***,the potential application of ND/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor was demonstrated through its frequency response to wooden blocks with different moisture contents.

关键词： Humidity sensor Quartz crystal microbalance Nanodiamond Ti_(3)C_(2)MXene High quality factor

A Sender-Initiated Fuzzy Logic Contrnol Method for Network Load Balancing

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Journal of Computer and Communications 2024年第8期12卷 110-122页

作者： ming-chang Huang Department of Business Information System/Management Operations University of North Carolina Charlotte USA

In this paper, a sender-initiated protocol is applied which uses fuzzy logic control method to improve computer networks performance by balancing loads among computers. This new model devises sender-initiated protocol for load transfer for load balancing. Groups are formed and every group has a node called a designated representative (DR). During load transferring processes, loads are transferred using the DR in each group to achieve load balancing purposes. The simulation results show that the performance of the protocol proposed is better than the compared conventional method. This protocol is more stable than the method without using the fuzzy logic control.

关键词： Load Balancing Fuzzy Logic Control Sender-Initiated

Recent advances of high performance SiO_(x)(0

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Materials Reports(Energy) 2024年第2期4卷 23-33页

作者： Wenwen Deng Ying Zhou Naiqi Hu Shaocong Ni Weihang Zhang chang ming Li School of Material Science and Engineering Suzhou University of Science and TechnologySuzhou215009PR China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071PR China State Key Laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic ChemistryMOE Key Laboratory of High Performance Polymer Materials and TechnologyJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry&Chemical EngineeringNanjing UniversityNanjing210023PR China

SiOx is attractive as an anode material for lithium-ion batteries(LIBs)due to its high capacity,low cost,and relatively higher cyclic stability than Si ***,the intrinsic low electronic conductivity,low initial coulombic efficiency(ICE),and volume expansion during cycles hinder its *** this review,we summarize advances in high performance SiOx anodes,mainly from two aspects:active material and *** future perspective is investigated at the end of this *** review provides strategical guidance for developing high performance SiOx anodes.

关键词： SiOx Anode High-performance Active material Binders

Developing a diagnostic model for predicting prostate cancer: a retrospective study based on Chinese multicenter clinical data

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Asian Journal of Andrology 2024年第1期26卷 34-40页

作者： chang-ming Wang Lei Yuan Xue-Han Liu Shu-Qiu Chen Hai-Feng Wang Qi-Fei Dong Bin Zhang ming-Shuo Huang Zhi-Yong Zhang Jun Xiao Tao Tao Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Medical Sciences The First Affiliated Hospital of USTcDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Urology Affiliated Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Urology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200000China Department of Urology Affiliated Anhui Provincial Hospital of Anhui Medical UniversityHefei 230001China

The overdiagnosis of prostate cancer(PCa)caused by nonspecific elevation serum prostate-specific antigen(PSA)and the overtreatment of indolent PCa have become a global problem that needs to be solved *** aimed to construct a prediction model and provide a risk stratification system to reduce unnecessary *** this retrospective study,clinical data of 1807 patients from three Chinese hospitals were *** final model was built using stepwise logistic regression *** apparent performance of the model was assessed by receiver operating characteristic curves,calibration plots,and decision curve ***,a risk stratification system of clinically significant prostate cancer(csPCa)was created,and diagnosis-free survival analyses were *** multivariable screening and evaluation of the diagnostic performances,a final diagnostic model comprised of the PSA density and Prostate Imaging-Reporting and Data System(PI-RADS)score was *** validation in the development cohort and two external cohorts showed excellent discrimination and ***,we created a risk stratification system using risk thresholds of 0.05 and 0.60 as the cut-off *** follow-up results indicated that the diagnosis-free survival rate for csPCa at 12 months and 24 months postoperatively was 99.7%and 99.4%,respectively,for patients with a risk threshold below O.05 after the initial negative prostate biopsy,which was significantly better than patients with higher *** diagnostic model and risk stratification system can achieve a personalized risk calculation of *** provides a standardized tool for Chinese patients and physicians when considering thenecessity of prostatebiopsy.

关键词： nomogram prostate biopsy prostate cancer Prostate Imaging-Reporting and Data System prostate-specific antigen density

基于代价参考粒子滤波器组的多目标检测前跟踪算法

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自动化学报 2024年第4期50卷 851-861页

作者：卢锦马令坤吕春玲章为川 Sun chang-ming 陕西科技大学电子信息与人工智能学院西安710021 施耐德(西安)创新技术有限公司西安710121 格里菲斯大学集成与智能系统研究所澳大利亚布里斯班4111 联邦科学与工业研究组织Data61中心澳大利亚悉尼1710

针对图像序列中多目标检测和跟踪算法结构复杂、计算量大、性能降低等问题,提出一种基于代价参考粒子滤波器组的多目标检测前跟踪(Cost-reference particle filter bank based multi-target track-before-detect, CRPFB-MTBD)算法,将多... 详细信息

针对图像序列中多目标检测和跟踪算法结构复杂、计算量大、性能降低等问题,提出一种基于代价参考粒子滤波器组的多目标检测前跟踪(Cost-reference particle filter bank based multi-target track-before-detect, CRPFB-MTBD)算法,将多目标跟踪问题转换为序贯地检测和跟踪多个单目标的问题.首先,采用代价参考粒子滤波器组序贯地估计所有可能单目标状态序列;其次,基于所有可能单目标状态序列的欧氏距离和累积代价确定目标数量;最后,根据累积代价判断每个目标出现和消失的具体时刻.仿真实验验证了CRPFB-MTBD的优良性能,与基于传统粒子滤波的多目标检测前跟踪算法(Particle filter based multi-target track-before-detect, PF-MTBD)、基于概率假设密度的检测前跟踪算法(Probability hypothesis density based track-before-detect, PHD-TBD)和基于伯努利滤波的检测前跟踪算法(Bernoulli based track-before-detect, Bernoulli-TBD)相比, CRPFB-MTBD的目标状态序列和数量估计结果最佳,且平均单次运行时间极短.

关键词：多目标跟踪检测前跟踪粒子滤波代价参考粒子滤波器组滤波器组

Assessment of ECMWF’s Precipitation Forecasting Performance for China from 2017 to 2022

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Journal of Tropical Meteorology 2024年第3期30卷 257-274页

作者： PAN Liu-jie ZHANG Hong-fang LIANG Mian LIU Jia-huimin DAI chang-ming Shaanxi Meteorological Observatory Xi’an 710014 China Key Laboratory of Eco-Environment and Meteorology for the Qinling Mountains and Loess Plateau Xi’an 710014 China Shaanxi Meteorological Service Centre Xi’an 710014 China

This study used the China Meteorological Administration(CMA)three-source fusion gridded precipitation analysis data as a reference to evaluate the precipitation forecast performance of the European Centre for Medium-Range Weather Forecasts(ECMWF)model for China from 2017 to *** main conclusions are as *** precipitation forecast capability of the ECMWF model for China has gradually improved from 2017 to *** scores such as bias,equitable threat score(ETS),and Fractions Skill Score(FSS)showed improvements for different categories of *** bias of light rain forecasts overall adjusted towards smaller values,and the increase in forecast scores was greater in the warm season than in the cold *** ETS for torrential rain more intense categories significantly increased,although there were large fluctuations in bias across different *** model exhibited higher precipitation bias in most areas of North China,indicating overprediction,while it showed lower bias in South China,indicating *** ETSs indicate that the model performed better in forecasting precipitation in the northeastern part of China without the influence of climatic background *** of the differences between the first period and the second period of the forecast shows that the precipitation amplitude in the ECMWF forecast shifted from slight underestimation to overestimation compared to that of CMPAS05,reducing the likelihood of missing extreme precipitation *** improvement in ETS is mainly due to the reduction in bias and false alarm rates and,more importantly,an increase in the hit *** 2017 to 2022,the area coverage error of model precipitation forecast relative to observations showed a decreasing trend at different scales,while the FSS showed an increasing trend,with the highest FSS observed in *** ETS followed a parabolic trend with increasing neighborhood radius,with the better ETS neighborhood radius generally

关键词： ECMWF forecasting verification neighborhood verification FSS

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幼儿园生活化课程的建构与实施

学前教育研究 2024年第4期 83-86页

作者：常明洛阳市实验幼儿园洛阳471000

生活化是幼儿园课程的根本特征,幼儿园课程需要走向生活化。幼儿园生活化课程基于生活又高于生活,其实践目的在于引导幼儿更好地体验生活和感知生命的意义,通过生活化的课程内容和实施方式来拓展幼儿的经验范畴,全面发展幼儿的能力。幼... 详细信息

生活化是幼儿园课程的根本特征,幼儿园课程需要走向生活化。幼儿园生活化课程基于生活又高于生活,其实践目的在于引导幼儿更好地体验生活和感知生命的意义,通过生活化的课程内容和实施方式来拓展幼儿的经验范畴,全面发展幼儿的能力。幼儿园生活化课程的建构与实施在目标上应为了幼儿的生活,在内容上应来源于幼儿的生活,在方式上应基于幼儿的日常生活,在评价上也应体现生活化的特征。

关键词：日常生活生活化课程园本课程

CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma ming-chang Miao Ping-An Ding Bi-Bo Tan Wen-Bo Liu Shuo Guo Li-Mian Er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics