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Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation

Molecular Plant 2021年第8期14卷 1312-1327页

作者： ho Byoung Chae Min Gab Kim chang ho kang Joung Hun Park Eun Seon Lee Sang-Uk Lee Yong Hun Chi Seol Ki Paeng Su Bin Bae Seong Dong Wi Byung-Wook Yun Woe-Yeon Kim Dae-Jin Yun David Mackey Sang Yeol Lee Division of Applied Life Sciences(BK21)and PMBBRC Gyeongsang National UniversityJinju 52828Korea College of Pharmacy Research Institute of Pharmaceutical ScienceGyeongsang National UniversityJinju 52828Korea School of Applied Biosciences College of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Korea Department of horticulture and Crop Science Department of Molecular Geneticsand Center for Applied Plant SciencesThe Ohio State UniversityColumbusOH 43210USA College of Life Sciences Qingdao Agricultural UniversityQingdao 266109P.R.China Plant Propagation Team Plant Production DivisionSejong National ArboretumSejong 30106Korea

Reactive oxygen signaling regulates numerous biological processes,including stress responses in *** sensors transduce reactive oxygen signals into cellular ***,we present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog(QSOX1)is a redox sensor that negatively regulates plant immunity against a bacterial *** expression level of QSOX1 is inversely correlated with pathogen-induced reactive oxygen species(ROS)***,QSOX1 both senses and regulates ROS levels by interactingn with and mediating redox regulation of S-nitrosoglutathione reductase,which,consistent with previous findings,influences reactive nitrogen-mediated regulation of ROS ***,our data indicate that QSOX1 is a redox sensorthat negatively regulates plant immunity by linking reactive oxygen and reactive nitrogen signaling to limit ROS production.

关键词： redox sensor plant immu nity QSOX1 GSNOR reactive oxygen species(ROS) reactive nitrogen species(RNS)

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Thioredoxin Reductase Type C （NTRC） Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent holdase Chaperone Function

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Molecular Plant 2013年第2期6卷 323-336页

作者： ho Byoung Chae Jeong Chan Moon Mi Rim Shin Yong Hun Chi Young Jun Jung Sun Yong Lee Ganesh M. Nawkar Hyun Suk Jung Jae Kyung Hyun Woe Yeon Kim chang ho kang Dae-Jin Yun Kyun Oh Lee Sang Yeol Lee Division of Applied Life Science (BK21 Program) and PMBBRC Gyeongsang National University 501 Jinju-daero Jinju 660-701 Korea Division of Electron Microscopic Research Korea Basic Science Institute 113 Gwahangno Yuse0ng-guDaejeon 303-333 Korea

Genevestigator analysis has indicated heat shock induction of transcripts for NADPH-thioredoxin reduc-tase, type C （NTRC） in the light. Here we show overexpression of NTRC in Arabidopsis （NTRC°E） resulting in enhanced tolerance to heat shock, whereas NTRC knockout mutant plants （ntrcl） exhibit a temperature sensitive phenotype. To investigate the underlying mechanism of this phenotype, we analyzed the protein＇s biochemical properties and protein structure. NTRC assembles into homopolymeric structures of varying complexity with functions as a disulfide reductase, a foldase chaperone, and as a holdase chaperone. The multiple functions of NTRC are closely correlated with protein structure.. Complexes of higher molecular weight （HMW） showed stronger activity as a holdase chaperone, while low molecular weight （LMW） species exhibited weaker holdase chaperone activity but stronger disulfide reductase and fol-dase chaperone activities. Heat shock converted LMW proteins into HMW complexes. Mutations of the two active site Cys residues of NTRC into Ser （C217/454S-NTRC） led to a complete inactivation of its disulfide reductase and foldase chaperone functions, but conferred only a slight decrease in its holdase chaperone function. The overexpression of the mutated C217/454S-NTRC provided Arabidopsis with a similar degree of thermotolerance compared with that of NTRC°E plants. however, after prolonged incubation under heat shock, NTRC°E plants tolerated the stress to a higher degree than C217/454S-NTRC°E plants. The results suggest that the heat shock-mediated holdase chaperone function of NTRC is responsible for the increased thermotolerance of Arabidopsis and the activity is significantly supported by NADPH.

关键词： NADPH-thioredoxin reductase type C (NTRC) oligomeric complexes disulfide reductase foldase and holdasechaperone functions redox thermotolerance.

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Report of Precision Agriculture in Korea

Report of Precision Agriculture in Korea

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国际农业工程大会

作者： Soon cheul Kim Yoeung Kil Cho chang ho kang Woo Pung Park Choung Keun Lee Yeongnam Agricultural Research Institute 1085 Neai-dong Milyang-city Gyeongnam 627-803 Korea National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA National Institute of Agricultural Engineering 249 Seodun-dong Gwonson-gu Suwon-city Gyeonggi-do 441-100 KOREA

＜正＞ Precision agriculture is the first stage in Korea. however, the research of that has been carrying since 1998 with centering around the Rural Development Administration. Besides, It has been actively working on...

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Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-Yuan kang Yi-Ting chang Sheng-Yang Huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

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聚己内醯胺的分子量分布测定

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化学学报 1955年第1期 63-68页

作者：张德龢陈康钱人元中国科学院有机化学研究所

(1)用1％聚已內醯胺在85％甲酸溶液裏加水分級沉澱的方法,测定了兩個聚己內醯胺試樣的分子量分佈曲線。結果都顯示有一極爲狹窄的高峯,和一羣分佈極寬的分子量較低的部分。所以單就試樣的數均分子量,是不足以了解聚合物的聚合情况的。 ... 详细信息

(1)用1％聚已內醯胺在85％甲酸溶液裏加水分級沉澱的方法,测定了兩個聚己內醯胺試樣的分子量分佈曲線。結果都顯示有一極爲狹窄的高峯,和一羣分佈極寬的分子量較低的部分。所以單就試樣的數均分子量,是不足以了解聚合物的聚合情况的。 (2)介紹了聚己內醯胺的羧基滴定的方法。 (3)為了更好地了解己內醯胺的聚合機構,聚合條件和加熱時間對聚合物分子量分佈的影響,值得作進一步的研究。

关键词：数均分子量 KOH 苯甲醇所得苄醇局部麻醉药数均聚合度滴定

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-hong Wu Dan-Dan Xu kang He chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Pathophysiology after pancreaticoduodenectomy

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World Journal of Gastroenterology 2015年第19期21卷 5794-5804页

作者： chang Moo kang Jin ho Lee chang Moo kang Jin Ho Lee Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Seoul 120-752 South Korea.

Pancreaticoduodenectomy （PD） will result in removalof important multiorgans in upper intestinal tract andsubsequently secondary physiologic change. In thepast, surgeons just focused on the safety of surgicalprocedure; however, PD is regarded as safe and widelyapplied to treatment of periampullary lesions. Practicalissues after PD, such as, effect of duodenectomy,metabolic surgery-like effect, alignment effect ofgastrointestinal continuity, and non-alcoholic fatty liverdisease were summarized and discussed.

关键词： Pancreaticoduodenectomy Delayed gastricemptying Metabolic surgery Exocrine insufficiency Fatty liver Postoperative pancreatic fistula

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Optical diffraction gratings embedded in BK-7 glass by low-density plasma formation using femtosecond laser

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 165-169页

作者： Jung-Kyu PARK Sung-Hak Cho Kwang-ho KIM Myung-chang kang Nano Machining Laboratory Korea Institute of Machinery and Material Daejeon 305-343 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

The optical embedded diffraction gratings with the internal refractive index modification in BK-7 glass plates were demonstrated using low-density plasma formation excited by a high-intensity femtosecond （130 fs） Ti： sapphire laser （λp=790 rim）. The refractive index modifications with diameters ranging from 400 nm to 4 gm were photoinduced after plasma formation occurred upon irradiation with peak intensities of more than 1 ×10^13 W/cm2. The graded refractive index profile was fabricated to be a symmetric around the center of the point at which low-density plasma occurred. The maximum refractive index change （An） was estimated to be 1.5x10 2. Several optical embedded gratings in BK-7 glass plate were demonstrated with refractive index modification induced by the scanning of low-density plasma formation.

关键词： BK-7 glass plate diffraction grating refractive index modification plasma formation femtosecond laser

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Controlled mutual quantum entity authentication using entanglement swapping

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Chinese Physics B 2015年第9期24卷 116-124页

作者： Min-Sung kang chang-ho hong Jino Heo Jong-In Lim Hyung-Jin Yang Center for Information Security Technologies (CIST) Korea University Graduate School of Information Security Korea University Department of Physics Korea University

In this paper, we suggest a controlled mutual quantum entity authentication protocol by which two users mutually certify each other on a quantum network using a sequence of Greenberger–horne–Zeilinger（GHZ）-like states. Unlike existing unidirectional quantum entity authentication, our protocol enables mutual quantum entity authentication utilizing entanglement swapping; moreover, it allows the managing trusted center（TC） or trusted third party（TTP） to effectively control the certification of two users using the nature of the GHZ-like state. We will also analyze the security of the protocol and quantum channel.

关键词： quantum authentication quantum cryptography quantum communication GHZ-like state

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Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia

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Asian Journal of Andrology 2010年第5期12卷 690-696页

作者： Koo Han Yoo Su kang Kim Joo-ho Chung Sung-Goo chang Department of Urology School of Medicine Kyung Hee University Seou1130-702 Korea Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul 130-702 Korea

The precise aetiology of benign prostatic hyperplasia （BPH） remains unclear; however, it is known that immunological inflammatory processes have a role in the pathogenesis of BPH initiation and progression. Nitric oxide synthase 2 （NOS2） inducible expression is closely correlated with prostatic disease, including prostate cancer and BPH. The aim of this study was to investigate the relationship between NOS2 polymorphisms and BPH. With a cohort of 205 controls and 229 BPH subjects, we genotyped three single nucleotide polymorphisms （SNPs） in the NOS2 gene, including rs2779248 （promoter, -278 T/C）, rs 10459953 （5＇-untranslated region） and rs2297518 （exon 16, missense, Ser608Leu）, using direct sequencing and restriction fragment length polymorphism. The genotypic and allelic frequencies between control and BPH subjects were compared, and the associations among the BPH subjects were analyzed. SNPStats, SNPAnalyzer and HelixTree programmes were used to analyze SNPs. There was no association on SNPs between control and BPH subjects. When BPH subjects were analyzed, there was no association on SNPs between the low and high prostate-specific antigen groups. however, one SNP （rs 10459953, odds ratio [OR] = 0.44, 95% confidence interval [CI] = 0.29-0.65, P 〈 0.0001, in codominant model; OR = 0.23, 95% CI = 0.12-0.46, P 〈 0.0001, in dominant model; and OR = 0.46, 95% CI = 0.24-0.86, P = 0.015, in recessive model） was associated with prostatic volume in BPH. We detected a strong association in genotype frequencies of NOS2 SNP （rs10459953） between subjects with small and large prostatic volume in BPH. The result suggests that NOS2 may be associated with prostatic volume in BPH.

关键词： benign prostatic hyperplasia nitric oxide synthase 2 single nucleotide polymorphism

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