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Impact of single chamber and dual chamber permanent pacemaker implantation on left ventricular function:An observational study

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World Journal of Cardiology 2024年第11期16卷 644-650页

作者： Merajul Haque Monika Bhandari Akshyaya Pradhan Pravesh Vishwakarma Abhishek Singh Ayush Shukla Akhil sharma Gaurav Chaudhary Rishi Sethi Sharad chandra Arvind Jaiswal Sudhanshu Kumar Dwivedi Department of Cardiology BRD Medical CollegeGorakhpur 273013Uttar PradeshIndia Department of Cardiology King George’s Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND Permanent pacemaker implantation has the potential to impact left ventricular(LV)function and hence quality of life(QoL)in the long *** To assess the effect of single-and dual-chamber pacing on LV function and *** This study included 56 patients who underwent permanent pacing:Dual pacing,dual sensing,dual responsive and rate responsive(DDDR)for the initial 3 months,ventricular sensing,inhibited response and rate responsive(VVIR)for the next 3 months,and DDDR mode for the last 3 *** the study period,various echocardiographic parameters,functional status,and QoL were measured to assess the impact of pacing on LV function compared with baseline and at every 3 months *** A significant change appeared in cardiac function after VVIR pacing which was in diastolic properties of LV as shown by increase in isovolumic relaxation time from(85.28±9.54 ms)to(89.53±9.65 ms).At the 3-,6-,and 9-month follow-up,reduction in LV ejection fraction was observed to be 62.71±4.66%,61.07±4.41%,and 58.48±3.89%,*** increase in the QoL scores was noted at every follow-up *** An apparent depressant effect on LV function due to right ventricular pacing,with a higher incidence of adverse outcomes in the VVIR *** addition,an upsurge in QoL scores for the study population was noted,which indicates improvement in the QoL of patients post-pacing,irrespective of the ***,the DDDR mode is a highly preferable pacing mode.

关键词： Artificial pacemaker Echocardiography Left ventricular function Quality of life

A 10 Years Comparative Study to Assess Trends in Seroprevalence of Transfusion Transmitted Infections among Blood Donors at Gwalior, India

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Open Journal of Blood Diseases 2014年第2期4卷 24-32页

作者： Dharmesh chandra sharma Sunita Rai Savita Bharat Sudha Iyenger Shruti Gupta Bharat Jain Department of Microbiology Gajra Raja Medical College Gwalior India Department of Pathology Blood Bank Gajra Raja Medical College Gwalior India

Introduction: Transfusion Transmitted Infections (TTIs) threaten safety of the recipients and the community as a whole and are the subject of real concern worldwide. Aims and Objectives: To know the prevalence of transfusion transmitted infections amongst the blood donors, to evaluate the changing trends of TTIs and to compare these observations within the study as well as with the other relevant studies. Place and Duration of Study: This study was carried out at Blood Bank, Department of Pathology, Gajra Raja Medical College, Gwalior, India, from January 2004 to December 2013 (ten years). Materials and Methods: In this study 122,006 voluntary and replacement donations were screened for TTIs;HIV, HBV, HCV, Syphilis, Malaria and their seroprevalence was calculated. Further study was divided in Group “A” (from 2004 to 2008) and Group “B” (from 2009 to 2013) to compare the results. Results: Out of total 122,006 blood units collected, 79,750 (65.3%) were voluntary and 42,256 (34.7%) were replacement donors. The seropositivity of TTIs in the entire study, in group “A” and in Group “B” was 3.26% (3985/122,006) (p = 0.000005), 2.25% (1238/54,874) (p = 0.000005) and 4.09% (2747/67,123) (p = 0.000005) respectively. In Group “A” and “B” seroprevalence of HIV, HBV, HCV, Syphilis and Malaria was 0.29%, 1.16%, 0.61%, 0.06%, 0.11% and 0.13%, 3.15%, 0.24%, 0.17%, 0.03% respectively. Conclusion: Our study concluded that there was significant increase in seroprevalence of HBV and syphilis whereas decreasing pattern in HIV, HCV and Malaria was observed in last five years as compared to previous five years among the blood donors.

关键词： Transfusion Transmitted Infections (TTIs) Blood Donor (BD) Human Immunodeficiency Virus (HIV) Hepatitis B Virus (HBV) Hepatitis C Virus (HCV) Syphilis and Malaria

A Biphenotypic (Mixed Phenotypic) Acute Leukemia: Report of Two Cases with Immunophenotypic Study

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Open Journal of Blood Diseases 2013年第2期3卷 65-68页

作者： Anupam Sarma Jagannath Dev sharma Chidananda Bhuyan Munlima Hazarika Amal chandra Kataki Department of Gynecologic Oncology Dr. B. Borooah Cancer Institute Guwahati India Department of Medical Oncology Dr. B. Borooah Cancer Institute Guwahati India Department of Pathology Dr. B. Borooah Cancer Institute Guwahati India

Biphenotypic acute leukemia (BAL) is an uncommon clinical entity. It is a type of acute leukemia with features characteristic of both the myeloid and lymphoid lineages and for this reason is designated as mixed-lineage, hybrid or biphenotypic acute leukemia. As strict diagnostic criteria have only recently been established, the precise incidence among acute leukemia is uncertain, although it is likely to account for approximately less then 5% of all acute leukemia. BAL is now collectively considered as “mixed phenotype acute leukemia” (MPAL). We hereby report two cases of a rare disease, BAL from our institution in the light of morphology, cytochemistry, flow cytometry and review of literature regarding these cases are described.

关键词： Biphenotypic Acute Leukaemia (BAL) Mixed Phenotype Acute Leukemia (MPAL) Flow Cytometry Cytochemistry

Synthesis of Fluorite-Type Nanopowders by Citrate-Nitrate Auto-Combustion Process: A Systematic Approach

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Materials Sciences and Applications 2012年第2期3卷 110-115页

作者： Mridula Biswas Prasanta Kumar Ojha Chadalapaka Durga Prasad Nitin Madhusudan Gokhale Suresh chandra sharma 不详

Citrate-nitrate autocombustion process is a promising synthesis route in the field of nanomaterials. This route involves many controlling parameters which ultimately affect properties of the products. In the present research work, the effect of concentration of fuel to that of metal nitrates has been studied in a systematic manner. The nature of exothermic reaction was analyzed with DSC-TGA and the powder properties were characterized by XRD, TEM and BET measurement. The properties of the powders have been explained with respect to fuel content, vigorousness of the exothermic reaction, combustion temperature and duration. The most vigorous reaction was found to occur for the composition with FER of 0.50 with the production of the smallest crystallite size of 9 nm.

关键词： Combustion Synthesis DSC-TGA XRD TEM

Study of anisotropic variation of cosmic rays intensity with solar activity

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Natural Science 2011年第2期3卷 101-103页

作者： chandra Mani Tiwari Devendra sharma Lalji Tiwari Ajay Kumar Saxena Dadan Prasad Tiwari 不详

The annual average values of amplitudes and phases of first two harmonics of cosmic ray anisotropy have been derived by using the harmonic analysis technique for the period 1989 to 2004, which covers mostly the major period of solar cycles 22 and 23. In this paper we have taken the pressure corrected hourly data for Kiel neutron monitor station (cut off rigidity ≈ 2.29 GV) to derive the harmonic component of cosmic ray daily variation and compared with the data of Halekala neutron monitor (cut off rigidity ≈ 13.2 GV) for the period 1991 to 2004. From the analysis it has been concluded that the diurnal amplitude and phase of daily variation of cosmic rays have been found to be correlated with solar activity. However, the semi-diurnal amplitude and phase are inversely correlated with solar activity for both the stations.

关键词： Cosmic Ray Anisotropic Variation Solar Parameter

Omics Studies and Systems Biology Perspective towards Abiotic Stress Response in Plants

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American Journal of Plant Sciences 2020年第12期11卷 2172-2194页

作者： Jyoti Prakash Sahoo Laxmipreeya Behera Siddhartha Shankar sharma Jannila Praveena Suman Kumari Nayak Kailash chandra Samal Department of Agricultural Biotechnology Odisha University of Agriculture and Technology Bhubaneswar India Department of Genetics and Plant Breeding Uttar Banga Krishi Viswavidyalaya Cooch Behar India Department of Fruit Science and Horticulture Technology Odisha University of Agriculture and Technology Bhubaneswar India Department of Plant Physiology Odisha University of Agriculture and Technology Bhubaneswar India

Plant abiotic stress responses are vital yield-restricting aspect in agriculture. Recent technology in plant biology allows research of such stress responses at a molecular scale in plants. Network analysis provides in-depth knowledge regarding omics information visualisation as it reduces the intrinsic intricacy of such data. The use of integrated functional genomics helps to understand the relationship between the genomic profile and the phenotypic profile in different environmental conditions of an organism. Plants’ responses to abiotic stress are often considered as a complex process. Systems biology approaches allow visualising and understanding how plant life works to overcome abiotic stress. The combination of integrated functional genomics along with bioinformatics will put a hand in additional in-depth research knowledge on stress tolerance to plants by exploiting available genetic information and continuously improving techniques and strategies. Most of the omics technologies are high throughput with very rapid data generation rates and humongous outputs. These technologies have made noticeable contributions to the modern-day improvements in our knowledge of plant biology. So, in this review, omics studies and the system biology approach towards abiotic stress tolerance in plants are highlighted.

关键词： Genomics Proteomics Transcriptomics System Biology Abiotic Stress Plants

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开展机构协作发展远程教育

中国远程教育 2004年第04S期 29-32页

作者： chandra B.sharma Sohanvir S.Chaudhary 肖俊洪汕头广播电视大学

本文原文发表于“学习联邦”(CommonwealthofLearning)网站《知识系列》(KnowledgeSeries)栏目(2003年)。学习联邦是英联邦各成员国的政府首脑倡议成立的政府间组织,其宗旨是鼓励开发和共享开放学习和远程教育的知识、资源和技术。目前... 详细信息

本文原文发表于“学习联邦”(CommonwealthofLearning)网站《知识系列》(KnowledgeSeries)栏目(2003年)。学习联邦是英联邦各成员国的政府首脑倡议成立的政府间组织,其宗旨是鼓励开发和共享开放学习和远程教育的知识、资源和技术。目前我国远程教育机构也正在开展各种形式的协作,既有电大之间的协作,也有电大与其他教育机构的协作,还有国际间的协作,但毕竟一切刚刚起步许多地方有待于进一步完善。因此,我们认为这篇经验之谈的文章所提出的一些原则、建议、指南等对我们有一定指导意义和借鉴价值。现将其译成中文,以飨读者,并向印度甘地国立开放大学sharma高级讲师和Chaudhary教授以及学习联邦组织致谢!

关键词：机构协作远程教育资源共享教育政策评估标准

Efficacy of Whole Blood Reconstituted (WBR) in Exchange Transfusion (ET) in Hemolytic Disease of New Born (HDN) —A Study of 110 Cases

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Open Journal of Blood Diseases 2013年第1期3卷 15-20页

作者： Dharmesh chandra sharma Sunita Rai Sudha Iyengar Bharat Jain Satya Sao Ajay Gaur Rahul Sapra Department of Pathology Gajra Raja Medical College Gwalior India Emergency Blood Bank Gwalior India Kilkari Nursing Home Gwalior India

Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of IgG antibodies in maternal circulation, which causes hemolysis in the fetus by crossing the placenta and sensitizing red cells for destruction by macrophages in the fetal spleen with consequent hyperbilirubinemia. Exchange transfusion with or without phototherapy is the method of choice for treating the newborn with on going hemolysis Methods/Materials: Sample size consisted of 110 neonates in whom 119 exchange transfusions were carried out with WBR. WBR was prepared by suspending O Rhesus-D (RhD) positive/negative cells (compatible with neonate’s/ mother’s serum) in AB plasma. Double volume exchange transfusion(s) were carried out through umbilical vein by push-pull technique. Results: Out of 110 cases, 61 (55.5%) were of RhD HDN whereas ABO and other group HDN cases were 30 (27.3%) and 19 (17.3%) respectively. An average post-ET fall in indirect serum bilirubin by 54.6% and correction of anemia by3.7 gm/dl were reported in the study. Conclusion: An average post-ET fall in indirect serum bilirubin and correction of anemia was found to be more significant when compared to other studies. Hence we recommend exchange transfusion in HDN with WBR to obtain reasonable fall in indirect serum bilirubin and high average rate of correction of anemia.

关键词： Whole Blood Reconstituted (WBR) Hemolytic Disease of Newborn (HDN) Exchange Transfusion (ET) Hyperbilirubinemia Anemia Correction

mLBOA:A Modified Butterfly Optimization Algorithm with Lagrange Interpolation for Global Optimization

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Journal of Bionic Engineering 2022年第4期19卷 1161-1176页

作者： Sushmita sharma Sanjoy Chakraborty Apu Kumar Saha Sukanta Nama Saroj Kumar Sahoo Department of Mathematics National Institute of Technology AgartalaAgartalaTripura 799046India Department of Computer Science and Engineering Iswar Chandra Vidyasagar CollegeBeloniaTripura 799155India Department of Computer Science and Engineering National Institute of Technology AgartalaAgartalaTripura 799046India Department of Applied Mathematics Maharaja Bir Bikram UniversityAgartalaTripura 799004India

Though the Butterfly Bptimization Algorithm(BOA)has already proved its effectiveness as a robust optimization algorithm,it has certain ***,a new variant of BOA,namely mLBOA,is proposed here to improve its *** proposed algorithm employs a self-adaptive parameter setting,Lagrange interpolation formula,and a new local search strategy embedded with Levy flight search to enhance its searching ability to make a better trade-off between exploration and ***,the fragrance generation scheme of BOA is modified,which leads for exploring the domain effectively for better *** evaluate the performance,it has been applied to solve the IEEE CEC 2017 benchmark *** results have been compared to that of six state-of-the-art algorithms and five BOA ***,various statistical tests,such as the Friedman rank test,Wilcoxon rank test,convergence analysis,and complexity analysis,have been conducted to justify the rank,significance,and complexity of the proposed ***,the mLBOA has been applied to solve three real-world engineering design *** all the analyses,it has been found that the proposed mLBOA is a competitive algorithm compared to other popular state-of-the-art algorithms and BOA variants.

关键词： Butterfly optimization algorithm Lagrange interpolation Levy flight search IEEE CEC 2017 functions Engineering design problems