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Enhanced Strength-Ductility Synergy in Submerged Friction Stir Processing ER2319 Alloy Manufactured by Wire-Arc Additive Manufacturing via Creating Ultrafine Microstructure

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 793-807页

作者： Jinpeng hu Tao Sun Fujun Cao Yifu Shen Zhiyuan Yang chan Guo College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics(NUAA)Nanjing 210016China

Submerged friction stir processing(SFSP)with flowing water was employed to alleviate the porosities and coarse-grained structure introduced by wire-arc *** a result,uniform and ultrafine grained(UFG)structure with average grain size of 0.83μm was achieved with the help of sharply reduced heat input and holding time at elevated *** optimized UFG structure enabled a superior combination of strength and ductility with high ultimate tensile strength and elongation of 273.17 MPa and 15.39%.Specifically,grain refinement strengthening and decentralized θ(Al_(2)Cu)phase in the sample subjected to SFSP made great contributions to the enhanced *** addition,the decrease in residual stresses and removal of pores substantially enhance the *** rates of cooling and low temperature cycling,which are facilitated by the water-cooling environment throughout the machining process,are vital in obtaining superior *** work provides a new method for developing a uniform and UFG structure with excellent mechanical properties.

关键词： Submerged friction stir processing Wire-arc additive manufacturing Al-Cu alloy Residual stress Strengthening and toughening mechanism Ultrafine grained microstructure

Association of Genetic Polymorphisms with Age at Onset in Han Chinese Patients with Bipolar Disorder

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Neuroscience Bulletin 2019年第4期35卷 591-594页

作者： Shao-hua hu Yu-Qing Han Ting-Ting Mou Man-Li huang Jian-Bo Lai Chee H Ng Jing Lu Qiao-Qiao Lu Qiu-Yan Lin Yu-Zhi Zhang Jian-Bo hu Ning Wei Wei-Juan Xu Wei-hua Zhou Jing-Kai Chen chan-chan hu Xiao-Yi Zhou Shao-Jia Lu Yi Xu Department of Psychiatry the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China The Key Laboratory of Mental Disorder Management in Zhejiang Province Hangzhou 310003 China Brain Research Institute of Zhejiang University Hangzhou 310003 China Mental Health Center Zhejiang Xiaoshan Hospital Hangzhou 311200 China Department of Psychiatry University of Melbourne Melbourne Victoria 3010 Australia

Dear Editor,Bipolar disorder (BD) is a chronic and disabling disorder characterized by manic, hypomanic, or depressive episodes, with an estimated lifetime prevalence ranging from 1% to 5%. Globally, it is a leading c... 详细信息

关键词： Association Genetic Polymorphisms Bipolar Disorder

Antimony oxides-protected ultrathin Ir-Sb nanowires as bifunctional hydrogen electrocatalysts

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Nano Research 2024年第3期17卷 1042-1049页

作者： Bingyan Xu Xuan huang Shangheng Liu Zhiwei hu Cheng-Wei Kao Ting-Shan chan Hongbo Geng Ying Zhang Xiaoqing huang Country State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Max Planck Institute for Chemical Physics of Solids Dresden 01187Germany “National Synchrotron Radiation Research Center” Hsinchu 30076TaiwanChina School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Developing electrocatalysts with fast kinetics and long-term stability for alkaline hydrogen oxidation reaction(HOR)and hydrogen evolution reaction(HER)is of considerable importance for the industrial production of green and sustainable ***,an ultrathin Ir-Sb nanowires(Ir-Sb NWs)protected by antimony oxides(SbO_(x))was synthesized as an efficient bifunctional catalyst for both HOR and HER under alkaline *** from the much higher mass activities of Ir-Sb nanowires than those of Ir nanowires(Ir NWs)and commercial Pt/C,the SbO_(x) protective layer also contributes to the maintenance of morphology and anti-CO poisoning ability,leading to the long-term cycling performance in the presence of ***,the Ir-Sb NW/SbO_(x) exhibits the highest catalytic activities,which are about 3.5 and 4.8 times to those of Ir NW/C and commercial Pt/C toward HOR,*** work provides that the ultrathin morphology and H_(2)O-occupied Sb sites can exert the intrinsic high activity of Ir and effectively optimize the absorption of OH*both in alkaline HER/HOR electrolysis.

关键词： Ir nanowire amorphous antimony oxides bifunctional mechanism hydrogen evolution reaction hydrogen oxidation reaction

Dialectical behavior therapy-based psychological intervention for woman in late pregnancy and early postpartum suffering from COVID-19:a case report

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第5期21卷 394-399页

作者： Jin-wen huANG Xiao-yi ZHOU Shao-jia LU Yi XU Jian-bo hu Man-li huANG hua-fen WANG chan-chan hu Shu-guang LI Jing-kai CHEN Zhong WANG Shao-hua hu Ning WEI Department of Psychiatry the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China The Key Laboratory of Mental Disorder Management in Zhejiang Province Hangzhou 310003China Zhejiang Engineering Center for Mathematical Mental Health Hangzhou 310003China Department of Nursing the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

目的:孕产妇的心理健康风险较为突出,但尚未有文献说明何种心理干预方式对患有新冠肺炎的围产期孕妇有效。本文报告了一例确诊新冠肺炎的35周2天孕妇在入住隔离病房后,使用辩证行为治疗(DBT)相关技术对其存在的抑郁和焦虑症状在围产期... 详细信息

目的:孕产妇的心理健康风险较为突出,但尚未有文献说明何种心理干预方式对患有新冠肺炎的围产期孕妇有效。本文报告了一例确诊新冠肺炎的35周2天孕妇在入住隔离病房后,使用辩证行为治疗(DBT)相关技术对其存在的抑郁和焦虑症状在围产期进行持续心理干预的案例,旨在探究以DBT为基础的短程心理治疗对围产期新冠肺炎患者的抑郁和焦虑症状的改善作用。创新点:首例对确诊新冠肺炎的孕产妇进行产前及产后心理评估及干预的案例。也是首次报道在公共卫生危机事件的个体干预中使用了DBT相关技术。方法:患者,女,30岁,孕35周+2天,干咳两天就诊,在当地医院进行新型冠状病毒核酸测验提示阳性后转入浙江大学医学院附属第一医院住院治疗。2020年2月8日行剖腹产,产后继续在隔离病房治疗。入院后精神科访谈及心理测量均提示存在抑郁和焦虑症状,于2月7日、10日、16日进行三次心理干预,主要使用DBT相关干预技术,包括放松训练、正念练习、情绪控制技巧训练、人际支持等。期间根据患者的需要及时调整干预策略。通过三次心理干预,患者的抑郁、焦虑症状得到改善,抑郁和焦虑量表评分与基线比显著下降。结论:本报告显示了对确诊新冠肺炎的隔离病房患者及时进行心理干预的必要性。心理干预能有效改善患者的抑郁、焦虑症状,减少或避免了精神类药物的使用,为新冠肺炎的临床治疗提供了支持。此报告也为以DBT为基础的心理治疗在危机干预中的应用提供了临床证据。

关键词：新冠肺炎孕期产后心理干预辨证行为治疗

Efficacy of internet-based integrated intervention on depression and anxiety symptoms in patients with COVID-19

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第5期21卷 400-404页

作者： Ning WEI Bo-chao huANG Shao-jia LU Jian-bo hu Xiao-yi ZHOU chan-chan hu Jing-kai CHEN Jin-wen huANG Shu-guang LI Zheng WANG Dan-dan WANG Yi XU Shao-hua hu Department of Psychiatry the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China The Key Laboratory of Mental Disorder's Management of Zhejiang Province Hangzhou 310003China Zhejiang Engineering Center for Mathematical Mental Health Hangzhou 310003China

目的:探讨基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的有效性。创新点:针对大规模公共卫生事件的患者,首次采用基于网络的整合心理干预技术开展抑郁焦虑症状的治疗。这不仅能够让隔离患者更便捷地获得心理干预,而且减少了心理... 详细信息

目的:探讨基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的有效性。创新点:针对大规模公共卫生事件的患者,首次采用基于网络的整合心理干预技术开展抑郁焦虑症状的治疗。这不仅能够让隔离患者更便捷地获得心理干预,而且减少了心理医生的感染暴露机会。方法:纳入26例伴有抑郁焦虑症状的新冠肺炎患者,随机分为干预组和对照组。干预组给予基于网络的整合心理干预,患者在医生指导下,通过智能手机聆听音频材料,并接受整合心理干预,包括放松训练、正念治疗、"安全地"技术和蝴蝶拥抱法;对照组则给予支持性心理治疗。通过HAMD-17与HAMA量表评估患者的抑郁焦虑水平。我们发现在1周末及2周末干预组患者HAMD-17与HAMA减分均明显优于对照组。结论:基于网络的整合心理干预可有效改善伴有抑郁焦虑症状的新冠肺炎患者的情绪症状,且对隔离患者来说更便捷,也减少了心理医生的感染暴露机会。

关键词：新冠肺炎基于网络的整合心理干预抑郁焦虑

Opening of mitochondrial calcium activated potassium channel participates in the cardioprotective effect of puerarin

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Opening of mitochondrial calcium activated potassium channel...

Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma

浙江省生理科学会2006年学术年会

作者： chan-chan hu, Na Li, Qin Gao, Qiang Xia Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China

The aim of the present study was to determine whether the clinically effective cardioprotection conferred by puerarin (Pue) against ischemia and reperfusion is mediated by mitochondrial calcium activated

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 852-860页

作者： Hai-Jian hu Ping Li Bin Tong Yu-Lian Pang Hong-Dou Luo Fei-Fei Wang chan Xiong Yu-Lin Yu Hai He Xu Zhang Affiliated Eye Hospital of Nanchang University Jiangxi Research Institute of Ophthalmology and Visual ScienceJiangxi Clinical Research Center for Ophthalmic DiseaseJiangxi Branch of National Clinical Research Center for Ocular DiseasesNanchang 330006Jiangxi ProvinceChina Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430015Hubei ProvinceChina

AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced ***:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were *** relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were *** with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were ***:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without *** area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal ***:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.

关键词： 10-2 visual field ganglion cell-inner plexiform layer retinal nerve fiber layer thickness glaucoma

Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming Wang Hong-Wei Tao Feng-chan Wang Ping Han Na Liu Guo-Jing Zhao Hai-Bo hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFJT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFJT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFJT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFJT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFJT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Results showed significant therapeutic effects of MFJT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation results that MFJT treatment induced apoptosis(downregulated Bcl-2 levels and upregulated Bax levels in lung tissue),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and superoxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERK1/2 phosphorylation,increased GSK3βlevels).Conclusion:Our study revealed MFJT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

Two-photon polymerization lithography for imaging optics

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International Journal of Extreme Manufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-Feng Pan Chi Li Kishan S Menghrajani Markus A Schmidt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi Nair Suseela Nair John You En chan Tomohiro Mori Yueqiang hu Guangwei hu Stefan A Maier Haoran Ren huigao Duan Joel K W Yang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronomy Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of Material Research FSU Jena07745 JenaGermany Institute of Materials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayama Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore Department of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical imaging systems have greatly extended human visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum of wavelengths from x-ray to radio frequencies and impact research activities and our daily *** glass lenses are fabricated through a series of complex processes,while polymers offer versatility and ease of ***,modern applications often require complex lens assemblies,driving the need for miniaturization and advanced designs with micro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dimensional(3D)printing,or additive manufacturing,presents a solution to these challenges with benefits of rapid prototyping,customized geometries,and efficient production,particularly suited for miniaturized optical imaging *** 3D printing methods have demonstrated advantages over traditional counterparts,yet challenges remain in achieving nanoscale ***-photon polymerization lithography(TPL),a nanoscale 3D printing technique,enables the fabrication of intricate structures beyond the optical diffraction limit via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,micro-and nanoscale capabilities,and rapid prototyping of almost arbitrary complex 3D *** this review,we emphasize the importance of the criteria for optical performance evaluation of imaging devices,discuss material properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoramic review on this topic,it will equip researchers with foundational knowledge and recent advancements of TPL for imaging optics,promoting a deeper understanding of the *** leveraging on its high-resolution capability,extensive material range,and true 3D processing,alongside advances in materials,fabrication,and design,we en

关键词： two-photon polymerization lithography 3D printing additive manufacturing imaging optics and nanophotonics