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chinese Science Bulletin 2011年第32期56卷 3409-3415页

作者： chan raymond c k Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or IcD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in china's Mainland. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in china's Mainland. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium.

关键词：精神障碍中国大陆神经茅根信息人力多维表达式 IcD

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?

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chinese Science Bulletin 2011年第32期56卷 3372-3375页

作者： DAZZAN Paola chan raymond c k Department of Psychosis Studies Institute of Psychiatry King's College London UK Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

Approximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cognitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis.

关键词：精神病患者神经系统心理障碍异常脑功能障碍基板共享运动性能

Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes

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chinese Science Bulletin 2011年第32期56卷 3376-3381页

作者： McALONAN Grainne M YU kevin k chan raymond c k cHUA Siew E cHEUNG charlton Department of Psychiatry the University of Hong Kong State key Laboratory for Brain and cognitive Sciences the University of Hong Kong Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.

关键词：神经疾病似然估计审查工作解剖精神分裂症稳定质数进修

A family study of endophenotypes for psychosis within an early intervention programme in Hong kong: Rationale and preliminary findings

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chinese Science Bulletin 2011年第32期56卷 3394-3397页

作者： LUI Simon S Y SHAM Pak chan raymond c k cHEUNG Eric F c Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Graduate University of chinese Academy of Sciences castle Peak Hospital Department of Psychiatry the University of Hong Kong

The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in china as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in china. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.

关键词：精神病患者稳定家庭早期原理预计香港面部表情识别

Relationship between prospective memory and vigilance: Evidence from ERP

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chinese Science Bulletin 2012年第31期57卷 4057-4063页

作者： WANG Ya LI XueBing HUANG Jia cAO XiaoYan cUI JiFang ZHAO Qing WANG YuNa SHUM David H k chan raymond c k Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Graduate University of chinese Academy of Sciences Beijing 100049China Nattonal Instttute of Educatton Sczences Beijing 100088China Behavioural Basis of Health Program Griffith Health Institute and School of Applied PsychologyGriffith UniversityBrisbane 4122Australia

Event-related potentials (ERPs) were used in this study to investigate the neural correlates of prospective memory (PM) and vigilance. Twenty college or graduate students participated in this study. They were administered a PM and a vigilance task and physiological data were collected at the same time. Behavioral results showed that the RT associated with PM cues was longer than those associated with vigilance targets. ERP results showed that PM cues and vigilance targets did not show significant difference in the N2 but PM cues evoked greater N300 than vigilance targets, and vigilance targets evoked greater parietal positivity/P3 than PM cues, suggesting vigilance and PM have similar but also distinctive neural basis.

关键词： ERP 记忆证据事件相关电位生理数据 PM 研究生神经

First episode psychosis with extrapyramidal signs prior to antipsychotic drug treatment

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chinese Science Bulletin 2011年第32期56卷 3361-3371页

作者： HONER William G LANG Donna J kOPALA Lili c MAcEWAN G William SMITH Geoffrey N cHEN Eric Y H chan raymond c k Department of Psychiatry University of British Columbia Vancouver BC Canada Department of Radiology University of British Columbia Vancouver BC Canada Department of Psychiatry Dalhousie University Halifax NS Canada Department of Psychiatry University of Hong Kong key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Extrapyramidal movement disorders are common in chronic schizophrenia, and may be an intrinsic feature of the illness as well as related to antipsychotic drug treatment. Similar dysfunctions at illness onset may have implications for outcome, and for under- standing the mechanisms of illness. The objectives were to examine the clinical correlates of pre-treatment movement disorders at first episode of psychosis, and determine associations with neuropsychological function and striatal structure. Never medicated subjects were recruited from consecutive admissions to Early Psychosis Programs with defined catchment areas in Hong kong, china, and Halifax, canada. Standardized clinical, neuropsychological and brain imaging assessments were carried out at baseline and following acute and long term treatment with typical or atypical antipsychotic drugs. At the Hong kong site, we studied 84 subjects with first episode psychosis (n = 10 with EPS). At the Halifax site, we studied 40 subjects with first episode psychosis (n = 17 with EPS), and 23 healthy comparison subjects. Subjects with movement disorders prior to treatment (EPS+) had higher total PANSS scores at baseline (mean elevation 19.9% Hong kong, P = 0.016; 14.7% Halifax, P = 0.049). In subjects treated with atypical antipsychotics (all Halifax), EPS+ status at baseline predicted more movement disorders at long term follow up (P = 0.0005). In both cohorts, EPS+ subjects had poorer acute symptomatic treatment response assessed with the PANSS (Hong kong P = 0.005; Halifax P = 0.017). Neuropsychological impairment related to executive dysfunction appeared greater in a small sam- ple of EPS+ subjects (Hong kong, effect size 0.26-0.27, P caudate volumes were 4.5% larger in EPS+ compared with EPS-subjects (Halifax P = 0.042), and correlations between striatal volumes and age were different in the EPS+ group. In conclu- sion, pre-treatment EPS is present in a substantial minority of subjects with first episode psych

关键词：药物治疗精神病体外症状运动障碍每股收益神经功能精神分裂症

行为表现与言语报告:3～5岁儿童的一级观点采择(英文)

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心理学报 2010年第7期42卷 754-767页

作者：赵婧王璐苏彦捷陈楚侨北京大学心理学系北京100871 中国科学院心理研究所神经心理学与应用认知神经科学实验室北京1001001 中国科学院心理研究所心理健康重点实验室北京100101

为考察3-5岁儿童一级观点采择的行为表现与言语报告之间的潜在差异,本研究采用＂单面镜＂范式设计了两个实验。实验1中,54名儿童成对与实验者一起完成观点采择游戏,逻辑回归分析结果表明3-5岁儿童的行为表现不存在显著差异（B=？0.225,W... 详细信息

为考察3-5岁儿童一级观点采择的行为表现与言语报告之间的潜在差异,本研究采用＂单面镜＂范式设计了两个实验。实验1中,54名儿童成对与实验者一起完成观点采择游戏,逻辑回归分析结果表明3-5岁儿童的行为表现不存在显著差异（B=？0.225,Wald=0.38,p=0.541）。方差分析也没有发现儿童的行为表现和言语报告存在差异。由于实验1中的编码系统存在一些局限,并且缺少对儿童偏好的控制,因此在实验2中进行了改进。实验2选择了另外60名3-5岁儿童完成藏玩具游戏。方差分析发现了实验范式类型（行为表现或言语报告）、年龄和性别的三因素交互作用（F（2,48）=3.55,p=0.037,η2=0.13）。结果表明随着年龄增加,男孩与女孩一级观点采择的行为表现都显著提高,而男孩言语报告的提高程度显著低于女孩。总体而言,考察儿童一级观点采择时,行为表现可能比言语报告提供更多信息。

关键词：观点采择策略使用行为表现言语报告

首发精神分裂症患者的运动协调功能与前额叶白质及皮质脊髓束完整性

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中国心理卫生杂志 2012年第8期26卷 561-565页

作者：程章韩雪杨磊王煦陈楚侨于欣洪楠原岩波北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学)北京100191 北京大学人民医院放射科北京100035 中国科学院心理研究所心理健康重点实验室北京100101

目的:应用弥散张量成像(DTI)探讨首发精神分裂症患者神经系统软体征中的运动协调功能与前额叶白质及皮质脊髓束各向异性比值(FA)的关系。方法:纳入42例符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的首发精神分裂症患者和46例... 详细信息

目的:应用弥散张量成像(DTI)探讨首发精神分裂症患者神经系统软体征中的运动协调功能与前额叶白质及皮质脊髓束各向异性比值(FA)的关系。方法:纳入42例符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的首发精神分裂症患者和46例年龄、性别及受教育年限相匹配的健康对照。两组研究对象均用剑桥神经科检查(cNI)评定神经系统软体征,并接受头颅磁共振成像检查。用阳性与阴性症状量表(PANSS)评估患者组基线和半年后的临床症状。用感兴趣区测定的方法,分析患者组和对照组神经系统软体征中的运动协调领域分与前额叶白质及皮质脊髓束各层面(内囊、大脑脚、小脑中脚水平)FA值间的关系。结果:神经系统软体征中的运动协调领域分在患者组中与前额叶白质FA值呈正相关(r=0.35,P<0.05),在健康对照中则与小脑中脚水平皮质脊髓束FA值呈正相关(r=0.34,P<0.05)。将患者按半年后阴性症状分为高分组和低分组,高分组运动协调领域分与前额叶白质(r=0.68,P<0.05)呈正相关,与小脑中脚水平皮质脊髓束(r=-0.67,P<0.05)FA值呈负相关;低分组则与内囊FA值呈正相关(r=0.60,P<0.05)。结论:本研究提示首发精神分裂症患者半年后阴性症状高分组、低分组及正常人群中,运动协调功能相关的脑区分别为前额叶、内囊和小脑中脚层面的皮质脊髓束,提示有必要进一步研究运动协调功能相关的脑区不同对患者预后的预测意义。

关键词：精神分裂症弥散张量成像神经系统软体征运动协调

精神病临床高危人群的症状和功能改变:一项系统综述和三水平元分析

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心理科学进展 2025年第1期33卷 42-61页

作者：赵子卿余锦婷陈嘉彦王芸茹黄佳陈楚侨中国人民大学心理学系北京100872 北京体育大学心理学院北京100091 中国科学院心理研究所心理健康重点实验室神经心理学与应用认知神经科学实验室北京100101 中国科学院大学心理学系北京100101

精神病临床高危(clinical high-risk for psychosis,cHR-P)人群的症状和功能发展存在异质性,澄清这个群体症状和功能的改变及联系,有利于精神病早期预防。元分析纳入54篇文献,探究cHR-P人群各维度临床症状和功能的纵向改变、基线症状对... 详细信息

精神病临床高危(clinical high-risk for psychosis,cHR-P)人群的症状和功能发展存在异质性,澄清这个群体症状和功能的改变及联系,有利于精神病早期预防。元分析纳入54篇文献,探究cHR-P人群各维度临床症状和功能的纵向改变、基线症状对随访功能的预测作用、调节效应。结果发现,cHR-P人群轻微阳性症状、阴性症状、瓦解症状、情感症状、一般精神病理症状、整体功能和角色功能随时间显著改善,社会功能没有显著改善;基线阴性症状显著负向预测随访的整体功能、社会功能、角色功能,基线的瓦解症状、情感症状、一般精神病理症状与随访的整体功能显著负相关;受教育程度显著调节轻微阳性症状和阴性症状的纵向变化,年龄、轻微阳性症状亚组比例和短暂间歇性精神病性症状亚组比例显著调节情感症状的纵向变化。这揭示阴性症状改善少和社会功能损害是cHR-P人群的核心特征,提示未来可针对阴性症状研发干预措施,进而改善社会功能。

关键词：精神病临床高危人群纵向改变三水平元分析阴性症状社会功能

维普期刊数据库博看期刊

Truncated Fractional-Order Total Variation Model for Image Restoration

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Journal of the Operations Research Society of china 2019年第4期7卷 561-578页

作者： raymond Honfu chan Hai-Xia Liang college of Science City University of Hong KongHong KongChina Department of Mathematical Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Fractional-order derivative is attracting more and more interest from researchers working on image processing because it helps to preserve more texture than total variation when noise is *** the existing works,the Grunwald–Letnikov fractional-order derivative is usually used,where the Dirichlet homogeneous boundary condition can only be considered and therefore the full lower triangular Toeplitz matrix is generated as the discrete partial fractional-order derivative *** this paper,a modified truncation is considered in generating the discrete fractional-order partial derivative operator and a truncated fractional-order total variation(tFoTV)model is proposed for image ***,first any boundary condition can be used in the numerical ***,the accuracy of the reconstructed images by the tFoTV model can be *** alternating directional method of multiplier is applied to solve the tFoTV *** convergence is also analyzed *** the numerical experiments,we apply the tFoTV model to recover images that are corrupted by blur and *** numerical results show that the tFoTV model provides better reconstruction in peak signal-to-noise ratio(PSNR)than the full fractional-order variation and total variation *** the numerical results,we can also see that the tFoTV model is comparable with the total generalized variation(TGV)model in *** addition,we can roughly fix a fractional order according to the structure of the image,and therefore,there is only one parameter left to determine in the tFoTV model,while there are always two parameters to be fixed in TGV model.

关键词： Image restoration Fractional-order derivative Truncated fractional-order total variation model Total variation Total generalized variation Alternating directional method of multiplier