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Management of nephropathy in patients with type 2 diabetes

Chinese Medical Journal 2002年第1期115卷 129-135页

作者： Critchley JA Zhao HL Tomlinson B Leung W Thomas GN chan jc Cockram CS Chinese Univ Hong Kong Prince Wales Hosp Dept Med & Therapeut Div Clin Pharmacol Shatin Hong Kong Peoples R China

Purpose To review evidence-based management of nephropathy in patients with type 2 *** sources A literature search (MEDLINE 1966 to 2000) was performed using the key word 'diabetic nephropathy'. Relevant book chapters were also *** selection Well-controlled, prospective landmark studies and expert review articles on diabetic nephropathy were *** extraction Data and conclusions from the selected articles that provide solid evidence to the optimal management of diabetic nephropathy were extracted and interpreted in light of our clinical research experience with many thousands of Hong Kong Chinese *** Hypertension, long diabetes duration, poor glycaemic control and central obesity are the most important risk factors. Microalbuminuria is a practical marker to predict overt nephropathy in type 2 diabetic patients. Risk factor modification, renal function monitoring and combined therapies are the current integrated approaches to manage patients with diabetic kidney disease. Optimal glycaemic control is the mainstay of treatment but effective antihypertensive therapy is also key to delaying the progression of diabetic nephropathy. Angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor antagonists have important renoprotective actions independent of their blood pressure lowering actions. Conclusions Diabetic nephropathy is the leading cause of end-stage renal disease worldwide. Monitoring renal function and screening for microalbuminuria will allow the identification of patients with nephropathy at a very early stage for intervention. Tight glycaemic control and aggressive antihypertensive treatment as well as the use of renin-angiotensin system inhibitors should substantially delay the progression of nephropathy.

关键词： type 2 diabetes · nephropathy · albuminuria · hypertension · renin-angiotensin system

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用双指O环试验确定不适于针剌治疗的疼痛性疾病

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国外医学（中医中药分册） 1989年第4期11卷 40-41页

作者： chan.,jc 崔蒙

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监测轴承磨损可减少被迫停机

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吉林电力技术 1993年第5期6卷 64-66页

作者： chan.,jc 赵淑群

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MATRIX ANALYSIS TO ADDITIVE SCHWARZ METHODS

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Journal of Computational Mathematics 1995年第4期13卷 325-336页

作者： Sun, jc chan, TF ACAD SINICA CTR COMPBEIJING 100080PEOPLES R CHINA UNIV CALIF LOS ANGELES LOS ANGELESCA

Matrix analysis on additive Schwarz methods as preconditioners is given in this paper. Both cases of with and without coarse mesh are considered. It is pointed out that an advantage of matrix analysis is to obtain mor... 详细信息

关键词： TA MATRIX ANALYSIS TO ADDITIVE SCHWARZ METHODS BA

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Peptide synthesis using pentafluorophenyl diphenylphosphate (FDP) as coupling reagent

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Chinese Journal of Chemistry 1995年第2期13卷 175-189页

作者： CHEN, SQ XU, jc CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Comparison of the reaction speed and yield with its analogues and some conventional peptide coupling reagents, pentafluorophenyl diphenylphosphate (FDP) was shown to be a more preferable ''active ester'' type reagent for the peptide synthesis. The synthesis of oligopeptides using FDP was achieved with high yields. The influences of several reaction parameters such as solvent, base, additive and temperature on the coupling reaction were studied using HPLC method. The degree of racemization with FDP determined by HPLC or Young test was shown to be lower than that of DCCI. Octapeptide Gly-Cys(Bzl)-Ser-Gly-Lys-Leu-Ile-Cys(Bzl)-OH, corresponding to the amino acid sequence of gp41 of HIV-1, was successfully synthesized by 5+3 approach using FDP with high yield.

关键词： PEPTIDE SYNTHESIS COUPLING REAGENT PENTAFLUOROPHENYL DIPHENYL PHOSPHATE

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A CRACK CLOSURE MODEL FOR BRITTLE ROCK SUBJECTED TO COMPRESSIVE-SHEAR LOADING

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中国有色金属学会会刊：英文版 1999年第2期9卷 223-228页

作者： Chen, F Sun, ZQ Xu, jc Cent S Univ Technol Opening Lab Mech Changsha 410083 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＣｏｍｐｒｅｓｓｉｏｎｓｈｅａｒｆｒａｃｔｕｒｅｏｆｒｏｃｋｗａｓｉｎｖｅｓｔｉｇａｔｅｄｂｙｍａｎｙｒｅｓｅａｒｃｈｅｒｓ，Ｒａｏｅｔａｌ［１］ｓｔｕｄｉｅｄｔｈｉｓｆａｉｌｕｒｅｍｏ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＣｏｍｐｒｅｓｓｉｏｎｓｈｅａｒｆｒａｃｔｕｒｅｏｆｒｏｃｋｗａｓｉｎｖｅｓｔｉｇａｔｅｄｂｙｍａｎｙｒｅｓｅａｒｃｈｅｒｓ，Ｒａｏｅｔａｌ［１］ｓｔｕｄｉｅｄｔｈｉｓｆａｉｌｕｒｅｍｏｄｅｕｓｉｎｇｆｏｕｒｐｏｉｎｔｂ...

关键词： crack closurecompressiveshear loadingstress intensity factor

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A Novel Sieving Medium for Separation of DNA Fragments-Poly(acrylamide-dimethylacrylamide)

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Chinese Chemical Letters 2000年第11期11卷 1015-1018页

作者： Ren, jc Fang, ZF Hunan Normal Univ Coll Chem & Chem Engn Dept Chem Changsha 410081 Peoples R China

A short chain poly (acrylamide-dimethylacrylamide) was synthesized in water phase using isopropanol as a chain transfer agent. This copolymer can form a stable dynamic coating on the inner surface of the capillary, thereby suppressing the electroosmotic flow and DNA-capillary wall interaction. The high efficient separation of DNA fragments and SSCP analysis were obtained in bare capillaries using this copolymer as a sieving medium.

关键词： poly (acrylamide-dimethylacrylamide) DNA capillary electrophoresis

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Total Synthesis of Saprorthoquinone

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Chinese Chemical Letters 1997年第8期8卷 695-696页

作者： Duan, WH Cai, jc CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

Saprorthoquinone (1), isolated from the roots of salvia prionitis Hance, was synthesized starting from p-methoxyphenylacetic acid.

关键词： Total Synthesis of Saprorthoquinone

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Synthesis of F-alkylated MDP Analogs

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Chinese Chemical Letters 1996年第11期7卷 993-994页

作者： Zhang, MZ Xu, jc GUANGXI NORMAL UNIV DEPT CHEMGUILIN 541004GUANGXIPEOPLES R CHINA ACAD SINICA SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Four F-alkylated muramyl dipeptides were synthesized by an efficient coupling reagent, Benzotriazol-1-yloxy-bis(pyrrolidino)carbo hexafluoro-phosphate(BBC)([1]).

关键词： MDP Synthesis of F-alkylated MDP Analogs

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RUPTURE OF THIN METAL TUBES BY NORMAL AND OBLIQUE IMPACT OF BLUNT CONICALNOSED MISSILES:EXPERIMENTS

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Acta Mechanica Solida Sinica 2000年第1期13卷 67-74页

作者： Mu, jc Zhang, TG Taiyuan Univ Technol Inst Appl Mech Shanxi 030024 Peoples R China

Impact tests at both normal and oblique angles of incidence were conducted on thin mild tubes using a moderate size of 90 degrees conical-nosed missiles. The minimum impact speed that generated cracks through the thickness of the wall, termed the speed for rupture, was measured, and various modes of rupture were identified. For a thin tube hit by a missile at a normal angle of obliquity at the speed for rupture, the contact region spreads across the nose of the missile, and the transverse shear deformation is predominant in the final failure process. If the angle of obliquity is 30 degrees, the missile pierces a hole through the wall of the tube. At the speed for rupture, the kinetic energy of the missile for oblique angle 30 degrees is only about 45% that required for plugging at a normal angle of obliquity.

关键词： thin tube conical-nosed missile the speed for rupture rupture mode

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