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S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

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Bone Research 2019年第4期7卷 424-436页

作者： Haemin kim Bongjun kim Sang Il kim hyung Joon kim Brian YRyu Junho Chung Zang Hee Lee Hong-Hee kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

Super-resolving material microstructure image via deep learning for microstructure characterization and mechanical behavior analysis

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npj Computational Materials 2021年第1期7卷 867-877页

作者： Jaimyun Jung Juwon Na hyung Keun Park Jeong Min Park Gyuwon kim Seungchul Lee Hyoung Seop kim Department of Materials AI&Big-Data Korea Institute of Materials Science(KIMS)Changwon-siRepublic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Department of Materials Science and Engineering Pohrepresent the average grainang University of Science and Technology(POSTECH)PohangRepublic of Korea Graduate School of Artificial Intelligence Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Graduate Institute of Ferrous Technology Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea

The digitized format of microstructures,or digital microstructures,plays a crucial role in modern-day materials ***,the acquisition of digital microstructures through experimental means can be unsuccessful in delivering sufficient resolution that is necessary to capture all relevant geometric features of the *** resolution-sensitive microstructural features overlooked due to insufficient resolution may limit one’s ability to conduct a thorough microstructure characterization and material behavior analysis such as mechanical analysis based on numerical ***,a highly efficient super-resolution imaging based on deep learning is developed using a deep super-resolution residual network to super-resolved low-resolution(LR)microstructure data for microstructure characterization and finite element(FE)mechanical *** characterization and FE model based mechanical analysis using the super-resolved microstructure data not only proved to be as accurate as those based on high-resolution(HR)data but also provided insights on local microstructural features such as grain boundary normal and local stress distribution,which can be only partially considered or entirely disregarded in LR data-based analysis.

关键词： microstructure Microstructure analysis

Anticoagulation and delayed bowel resection in the management of mesenteric venous thrombosis

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World Journal of Gastroenterology 2013年第30期19卷 5025-5028页

作者： hyung-Kee kim Jae Min Chun Seung Huh Division of Transplantation and Vascular Surgery Department of SurgeryKyungpook National University School of Medicine

Acute mesenteric venous thrombosis is potentially lethal because it can result in mesenteric ischemia and,ultimately,bowel infarction requiring surgical *** anticoagulation for the prevention of thrombus propagation is a well-recognized treatment modality and the current mainstay therapy for patients with acute mesenteric venous ***,the decision between prompt surgical exploration vs conservative treatment with anticoagulation is somewhat difficult in patients with suspected bowel *** we describe a patient with acute mesenteric venous thrombosis who presented with bowel ischemia and was treated with anticoagulation and delayed short-segment bowel resection.

关键词： Thrombosis Mesenteric vein Anticoagulation Small intestine Resection

Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： Mi-Young kim Jun-hyung Cho Joo Young Cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

Technical advances in external radiotherapy for hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第32期22卷 7311-7321页

作者： Shin-hyung Park Jae-Chul kim Min Kyu Kang Department of Radiation Oncology Kyungpook National University Hospital Department of Radiation Oncology Kyungpook National University School of Medicine

Radiotherapy techniques have substantially improved in the last two decades. After the introduction of 3-dimensional conformal radiotherapy, radiotherapy has been increasingly used for the treatment of hepatocellular carcinoma(HCC). Currently, more advanced techniques, including intensity-modulated radiotherapy(IMRT), stereotactic ablative body radiotherapy(SABR), and charged particle therapy, are used for the treatment of HCC. IMRT can escalate the tumor dose while sparing the normal tissue even though the tumor is large or located near critical organs. SABR can deliver a very high radiation dose to small HCCs in a few fractions, leading to high local control rates of 84%-100%. Various advanced imaging modalities are used for radiotherapy planning and delivery to improve the precision of radiotherapy. These advanced techniques enable the delivery of high dose radiotherapy for early to advanced HCCs without increasing the radiation-induced toxicities. However, as there have been no effective tools for the prediction of the response to radiotherapy or recurrences within or outside the radiation field, future studies should focus on selecting the patients who will benefit from radiotherapy.

关键词： Hepatocellular carcinoma Radiotherapy 3D-conformal Radiotherapy Intensity-modulated Radiotherapy stereotactic ablative body Radiotherapy Charged particle therapy Image-guided Radiotherapy

Investigation on the effectiveness of pretreatment in stormwater management technologies

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Journal of Environmental Sciences 2014年第9期26卷 1824-1830页

作者： Marla C.Maniquiz-Redillas Franz Kevin F.Geronimo Lee-hyung kim Dept.of Civil and Environmental Engineering Kongju National UniversityCheonanChungnamdoSouth Korea

The effectiveness of presettling basins as component of stormwater best management practice （BMP） technologies was investigated. Storm event monitoring and sediment collection were conducted from May 2009 to November 2012 on the presettling basins of the three BMP technologies designed to capture and treat stormwater runoff from highly impervious roads and parking lots. Data on captured runoff and sediment, total suspended solids （TSS） loadings, rainfall and runoff rate, sediment accumulation rate, as well as particle distribution and pollutant concentrations of sediment were gathered and analyzed along with the physical design characteristics of the presettling basins such as surface area and storage volume. Regression models were generated to determine significant relationships between design parameters. Results revealed that the storage volume ratio （ratio of storage volume of presettling basin to BMP） was an important parameter in designing the presettling basin of the BMP. For practicality, optimizing the design of the presetfling basin means that the storage volume ratio should be determined based on the desired captured amount of runoff and sediment from runoff to limit the frequency of maintenance caused by the accumulation of sediment. It was recommended that pretreatment of runoff should be employed when the site in which the BMP is to be sited has high TSS loading and runoff rate, and is subjected to high intensity rainfall.

关键词： Best management practicePresettling basinPretreatmentSedimentStormwater runoff

Challenges for clinicians treating autoimmune pancreatitis:Current perspectives

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World Journal of Clinical Cases 2023年第1期11卷 30-46页

作者： Seong-Hun kim Yun Chae Lee hyung Ku Chon Division of Gastroenterology Department of Internal MedicineJeonbuk National University Medical SchoolJeonju 54907South Korea Department of Internal Medicine Institution of Wonkwang Medical ScienceWonkwang University School of Medicine and HospitalIksan 54538South Korea

Autoimmune pancreatitis(AIP)is a rare disease clinically characterized by obstructive jaundice,unintentional weight loss,acute pancreatitis,focal pancreatic mass,and *** is classified into two subtypes-type 1 and type 2-according to pathological findings,clinical features,and serology test results,but some cases may be defined as type not otherwise in the absence of pathological findings and inflammatory bowel *** address the differences in diagnostic criteria by country,standard diagnostic criteria for AIP were proposed in 2011 by an international consensus of expert *** diagnosis of AIP from pancreatic ductal adenocarcinoma is important but remains challenging for ***,all subtypes of AIP show dramatic response to steroid *** review discusses the current perspectives on the diagnosis and management of AIP in clinical practice.

关键词： Autoimmune pancreatitis Pancreatic cancer International consensus diagnostic criteria Steroid

Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

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Bioactive Materials 2022年第2期7卷 35-48页

作者： hyung Shik kim Seung Jae Lee Dong Yun Lee Department of Bioengineering College of Engineeringand BK FOUR Biopharmaceutical Innovation Leader for Education and Research GroupHanyang UniversitySeoul04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul04763Republic of Korea

Orally absorbable gold nanoparticles(AuNP)having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme(GBM)for patients with its highest incidence ***,we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin(Lf)and lactoferrin receptor(LfR)that is highly expressed in the intestine,blood-brain barrier and *** stability and long circulation of AuNP,glutathione and polyethylene glycol(PEG)is introduced,which is called to *** Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice,11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain,respectively,compared with ***,orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor ***,we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption,and that its efficient photothermal therapy is possible.

关键词： intestine absorption gastrointestinal

Preserving finger length in a patient with symmetric digital gangrene under local anesthesia:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6640-6645页

作者： Keun hyung kim In chang Ko Hoon kim Soo Yeon Lim Department of Plastic and Reconstructive Surgery Konyang University Medical CenterKonyang University of College of MedicineDaejeon 35365South Korea Department of Plastic and Reconstructive Surgery Konyang University HospitalKonyang University of College of MedicineMyunggok Medical Research CenterDaejeon 35365South Korea

BACKGROUND Case reports of symmetric digital gangrene resulting from high-dose vasopressors use in patients with alcoholic ketoacidosis,leading to cardiac arrest,are *** date,no specific treatment method for autolysis or surgical amputation or guidelines for determining the level of amputation have been *** SUMMARY In this case report,we describe a treatment method that effectively preserved the function of fingers by surgical treatment under local anesthesia with a minimum operative time,while also preserving finger length to the maximum possible *** Our approach may contribute to improved postoperative quality of life by preserving finger length.

关键词： Acidosis Disseminated intravascular coagulation Ketosis Purpura fulminans Surgical amputation Case report