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Development and Demonstration of Australian First Working Sodium Guide Star Laser

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Optics and Photonics Journal 2022年第4期12卷 88-100页

作者： Yue Gao Yanjie Wang amy chan Ben Greene EOS Defence Systems Pty Ltd. Canberra Australia

The Australian first working sodium guide star laser system has been designed and developed for various astronomical and space-related applications. A completely diode-pumped pulsed system was developed initially followed by a largely fiber-based continuous wave (CW) system operating at 589 nm achieved through a unique wavelength conversion scheme by combining 1342 and 1050 nm through a sum frequency generation process. For the CW system, single-mode laser beams at both 1342 and 1050 nm are achieved from fiber-based seed oscillators and fiber amplifiers. The output power of ~25 W at 1342 nm is achieved from a single frequency fiber Raman amplifier. Output power up to 70 W at 1050 nm is achieved from a Yb-doped fiber pre-amplifier followed by a Yb-doped fiber power amplifier. For the sum frequency generation process, optimum focusing parameters are evaluated and determined. The CW system has generated more than 20 W output power at 589 nm, a circularly polarised beam with a good beam quality, spectral linewidth ≤ 2 MHz, and the laser output locked on the sodium D2 line at 589.159 nm. The system has been successfully demonstrated at EOS Space Research Centre, Mt Stromlo, Canberra, and become the Australian first working sodium guide star laser system.

关键词： Fiber Laser Continuous Wave Laser Pulsed Laser Diode Pump Solid State Sum Frequency Generation Adaptive Optics Sodium Laser Guide Star

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生态女性主义与观世音

江苏大学学报（社会科学版） 2009年第2期11卷 46-51页

作者：陈洁诗香港树仁大学英国语言及文学系

生态女性主义一词由法国学者迪邦娜（Franqoised’Eaubonne）在1974年所创，它结合了女性主义与生态运动的反思。生态女性主义虽然在西方已流行了30年，但是在华文世界中仍缺乏专著和较深入的讨论。电子女性主义（cyberfeminism）者哈... 详细信息

生态女性主义一词由法国学者迪邦娜（Franqoised’Eaubonne）在1974年所创，它结合了女性主义与生态运动的反思。生态女性主义虽然在西方已流行了30年，但是在华文世界中仍缺乏专著和较深入的讨论。电子女性主义（cyberfeminism）者哈乐葳（DonnaHaraway）提出以有机机械人（cyborg）作为未来女性主义的象征，女性主义者若需要启发的话，应该向前看，从科技和有机机械人的形象寻找启示，而非回到古老的属灵生态女性主义（SpiritualEcofeminism）。虽然两种女性主义看似大相径庭，但电子女性主义可以帮助生态女性主义走出自然／文化、人类／动物，甚至是男性／女性的二元思想。较哈乐葳的有机机械人和西方神话的女神，中国化的观世音更加适合作为生态女性主义的象征。从观世音出发可以发现，法国哲学家德勒兹（Gilles Deleuze）的转化生成与生态伦理具有密切关系。

关键词：生态女性主义观世音德勒兹转化生成

香港个人资料私隐专员公署:社交媒体与个人资料私隐保障

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全球传媒学刊 2017年第2期4卷 80-86页

作者：陈美仪黎智敏袁烨香港个人资料私隐专员公署投诉及查询部香港个人资料私隐专员公署合规部清华大学新闻与传播学院

在社交媒体时代,保障数据安全越来越凸显其重要性。作为独立的法定监管机构,香港个人资料私隐专员公署从建立之日起,就致力于保障香港市民的隐私数据安全。1996年,公署出台的个人资料隐私保护条例正式生效,成为亚洲第一份完整的个人资... 详细信息

在社交媒体时代,保障数据安全越来越凸显其重要性。作为独立的法定监管机构,香港个人资料私隐专员公署从建立之日起,就致力于保障香港市民的隐私数据安全。1996年,公署出台的个人资料隐私保护条例正式生效,成为亚洲第一份完整的个人资料保障法。条例确定了六项数据保障原则,并规定了公署的监管范围。本文介绍了公署的工作内容和程序,并借助案例阐述了社交媒体对公署日常业务的影响,包括对监管合规、投诉、查询以及公共关系和教育等的作用。

关键词：香港私隐专员公署个人数据保障个人隐私保障法社交媒体

Risk factors and natural history of breast cancer in younger Chinese women

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World Journal of Clinical Oncology 2014年第5期5卷 1097-1106页

作者： Winnie Yeo Hang-Mei Lee amy chan Emily YY chan Miranda CM chan Keeng-Wai chan Sharon WW chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee Department of Clinical Oncology Chinese University of Hong Kong Prince of Wales Hospital Hong Kong Breast Cancer Foundation Jockey Club School of Public Health and Primary Care Chinese University of Hong Kong Department of Surgery Kwong Wah Hospital Diagnostix Pathology Laboratories Ltd Canossa Hospital Kowloon East Cluster Breast Centre Department of Surgery United Christian Hospital Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Private Clinical Oncologist Radiotherapy and Oncology Centre Hong Kong Baptist Hospital Comprehensive Oncology Centre Hong Kong Sanatorium and Hospital Hong Kong Adventist Oncology Center Hong Kong Adventist Hospital Department of Clinical Oncology University of Hong Kong Department of Clinical Oncology Tuen Mun Hospital Private Surgeon Department of Clinical Oncology Princess Margaret Hospital

AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent ***: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older ***

关键词： Hong Kong Breast Cancer Registry Breast cancer Younger Chinese women Sociodemographic characteristics Risk factors Clinicopathological characteristics Breast cancer treatment

Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans

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Neural Regeneration Research 2015年第11期10卷 1717-1719页

作者： amy C.Nau Matthew C.Murphy Kevin C.chan UPMC Eye Center Ophthalmology and Visual Science Research Center Department of Ophthalmology School of Medicine University of Pittsburgh Mc Gowan Institute for Regenerative Medicine University of Pittsburgh Louis J.Fox Center for Vision Restoration University of Pittsburgh Department of Bioengineering Swanson School of Engineering University of Pittsburgh McGowan Institute for Regenerative Medicine University of Pittsburgh Center for the Neural Basis of Cognition University of Pittsburgh Carnegie Mellon University

Blindness provides an unparalleled opportunity to study plasticity of the nervous system in *** work in this area examined the often dramatic modifications to the visual cortex that result when visual input is completely absent from birth or very early in life（Kupers and Ptito,2014）.More recent studies explored what happens to the visual pathways in the context of acquired *** is particularly relevant as the majority of diseases that cause vision loss occur in the elderly.

关键词： Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans BOLD

Storylines of family medicine Ⅳ:perspectives on practice—lenses of appreciation

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Family Medicine and Community Health 2024年第S3期12卷 33-42页

作者： William B Ventres Leslie A Stone Radeeb Akhtar Jeffrey M Ring Lucy M Candib Erick Messias Ronald M Epstein Marc Tunzi amy L Lee Christopher P Morley Carina M Brown David Slawson Jill Konkin David G Campbell Ian Couper Susan Williams Robert Brooks Lucie Walters Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine and Community Health Icahn School of Medicine at Mount SinaiNew YorkNew YorkUSA Independent Health Psychologist Los AngelesCaliforniaUSA Family Medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA Psychiatry and Behavioral Neurosciences Saint Louis University School of MedicineSaint LouisMissouriUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family Medicine Residency Program Natividad Medical CenterSalinasCaliforniaUSA Family Medicine Tufts University School of MedicineBostonMassachusettsUSA Public Health and Preventive Medicine SUNY Upstate Medical UniversitySyracuseNew YorkUSA Cone Health Family Medicine Residency The University of North Carolina School of MedicineGreensboroNorth CarolinaUSA Family Medicine Atrium HealthCharlotteNorth CarolinaUSA Family Medicine University of Alberta Faculty of Medicine&DentistryEdmontonAlbertaCanada Cunninghame Arm Medical Centre Australian College of Rural and Remote MedicineLakes EntranceQueenslandAustralia Ukwanda Centre for Rural Health Stellenbosch University Faculty of Medicine and Health SciencesCape TownWestern CapeSouth Africa Adelaide Rural Clinical School The University of AdelaideAdelaideSouth AustraliaAustralia Department of Rural Health Broken Hill UniversityBroken HillNew South WalesAustralia Adelaide Rural Clinical School The University of Adelaide Faculty of Health and Medical SciencesMount GambierSouth AustraliaAustralia

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅳ:perspectives on practice—lenses of appreciation’,authors address the following themes:‘Relational connections in the doctor–patient partnership’,‘Feminism and family medicine’,‘Positive family medicine’,‘Mindful practice’,‘The new,old ethics of family medicine’,‘Public health,prevention and populations’,‘Information mastery in family medicine’and‘Clinical courage.’May readers nurture their curiosity through these essays.

关键词： thematic illustration doctor

Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity

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Genes & Diseases 2022年第4期9卷 1049-1061页

作者： Yi-Lin Chiu Yi-Ying Wu Robert B.Barndt Yu-Wen Lin Hou-Ping Sytwo amy Cheng Kacy Yang Khee-Siang chan Jehng-Kang Wang Michael D.Johnson Chen-Yong Lin Lombardi Comprehensive Cancer Center Department of Oncology Georgetown UniversityWashingtonDC 20057USA Department of Biochemistry National Defense Medical CenterTapei 114Chinese Taipei Division of Hematology/Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTapei 114Chinese Taipei School of Medicine National Defense Medical CenterTapei 114Chinese Taipei Department of Intensive Care Medicine Chi Mei Medical CenterTainan 710Chinese Taipei

The integral membrane,Kunitz-type serine protease inhibitors HAI-1 and HAI-2,can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and *** levels of extracellular matriptase proteolytic activity have,however,been observed in some neoplastic B-cells with high levels of endogenous HAI-2,indicating that HAI-2 may be an ineffective matriptase inhibitor at the cellular *** different effectiveness of the HAIs in the control of extracellular matriptase proteolytic activity is examined *** inducing matriptase zymogen activation in the HAI Teton Daudi Burkitt lymphoma cells,which naturally express matriptase with very low levels of HAI-2 and no HAI-1,nascent active matriptase was rapidly inhibited or shed as an enzymatically active *** increasing HAI-1 expression,cellular matriptase-HAI-1 complex increased,and extracellular active matriptase decreased *** HAI-2 expression,however,resulted in cellular matriptase-HAI-2 complex levels reaching a plateau,while extracellular active matriptase remained *** contrast to this differential effect,both HAI-1 and HAI-2,even at very low levels,were shown to promote the expression and cell-surface translocation of endogenous *** difference in the suppression of extracellular active matriptase by the two closely related serine protease inhibitors could result from the primarily cell surface expression of HAI-1 compared to the mainly intracellular localization of *** HAIs,therefore,resemble one another with respect to promoting matriptase expression and surface translocation but differ in their effectiveness in the control of extracellular matriptase enzymatic activity.

关键词： HAI-1 HAI-2 Matriptase Neoplastic B-cells Proteolytic activity

Modelling for optimal control of SLS process

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Modelling for optimal control of SLS process

Important role of cardiac spect imaging in patients undergoing percutaneous transluminal coronary angioplasty

第十九届中国控制会议

作者： S．H．Choi S．Samavedam amy M．M．chan Department of Industrial and Manufacturing Systems Engineering The University of Hong Kong Hong Kong Department of Industrial and Manufacturing Systems Engineering The University of Hong Kong Hong Kong Department of Industrial and Manufacturing Systems Engineering The University of Hong Kong Hong Kong

＜正＞The paper proposes a virtual reality system for modelling and optimal control of the Selective Laser Sintering （SLS） process. The system helps minimise manufacturing risks of prototypes early in the product development cycle, and hence shortens the costly Design-Build-Test cycle. It models and simulates the SLS process to tune up the process parameters for optimal fabrication control of prototypes. The system also simulates the layer building process of a prototype to estimate its surface accuracy and build-time.

关键词： SLS virtual prototyping modelling, process optimization

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Chinese Medical Journal 1999年第3期 64-67页

作者： Babington Chun kuen Yung, Wai Kwong chan, Chiu Sun Yue, Wai Chau Fan, Kwok Fai Leung amy Siu ling Fung and James Chi sang chan Department of Radiology and Organ Imaging (Yung CK, Fan WC, chan CS) & Department of Medicine and Geriatrics (

Objective To examine the utilization and contribution of cardiac perfusion scans to patients undergoing percutaneous transluminal coronary angioplasty. Methods From July 1996 to January 1998, 34 patients underwent percutaneous transluminal coronary angioplasty and cardiac SPECT imaging was studied. Twenty five patients had pre procedure SPECT scans. The agreement between angioplasty strategies and SPECT findings of ischemia and hypokinesia was *** When radionuclide imaging was performed before revascularization procedures, 84% of the patients had intervention strategies guided by scan findings. Perfusion scan findings including extent and severity of ischemia, degree of hypokinesia directed the selection of target vessel for angioplasty in the patient subgroup with multi vessel disease. Post angioplasty radionuclide cardiac scans were performed only on symptomatic patients, demonstrating ischemia and hypokinesia in most of them, conceivably reflected the selection *** We recommend routine pre and post angioplasty radionuclide imaging with multigated scans for wall motion assessment for all patients receiving coronary intervention.

关键词： multigated SPECT angioplasty ischemia hypokinesia