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Organic X-Ray Image Sensors Using a Medium Bandgap Polymer Donor with Low Dark Current

ENERGY & ENVIRONMENTAL MATERIALS 2024年第6期7卷 230-237页

作者： Ha, Jong-Woon Eom, Seung Hun cha, bo kyung Song, Seyeong Eun, Hyeong Ju Kim, Jong H. Park, Jong Mok Kim, bongsoo Park, Byoungwook Ko, Seo-Jin Yoon, Sung Cheol Lee, changjin Jung, In Hwan Hwang, Do-Hoon Pusan Natl Univ Chem Inst Funct Mat Dept Chem Busan 46241 South Korea Korea Res Inst Chem Technol KRICT Div Adv Energy Mat Res Ctr Daejeon 34114 South Korea Korea Electrotechnol Res Inst KERI Electromed Device Res Ctr Ansan 15588 South Korea Ulsan Natl Inst Sci & Technol UNIST Grad Sch Carbon Neutral Sch Energy & Chem Engn Ulsan 44919 South Korea Ajou Univ Dept Mol Sci & Technol Suwon 16449 South Korea Korea Res Inst Chem Technol Res Ctr Adv Specialty Chem Ulsan 44412 South Korea Ulsan Natl Inst Sci & Technol UNIST Dept Chem Ulsan 44919 South Korea Hanyang Univ Dept Organ & Nano Engn Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency situations. However, this is quite challenging because of the heavy weight of the scintillator and silicon photodetectors. The weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic photodetectors. This study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer (similar to 700 nm), owing to the symmetric backbone and highly soluble molecular structure of bithienopyrroledione. The ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density (J(d) similar to 10(-10) A cm(-2)) at a negative bias (-2.0 V) while maintaining high responsivity (R = 0.29 A W-1) even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D-sh* = 2.18 x 10(13) Jones in the organic photodetectors. Printed organic photodetectors are developed by slot-die coating for use in X-ray detectors, which exhibit D-sh* = 2.73 x 10(12) Jones with clear rising (0.26 s) and falling (0.29 s) response times upon X-ray irradiation. Detection reliability is also proven by linear response of the X-ray detector, and the X-ray detection limit is 3 mA.

关键词： low dark current low detection limit organic photodetector printable X-ray DETECTORS PHOTOCONDUCTORS SENSITIVITY

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Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： Young-Joon Park bo Eun Nam Chung-Mo Park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

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Diagnostic value of maximal-outer-diameter and maximal-mural-thickness in use of ultrasound for acute appendicitis in children

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World Journal of Gastroenterology 2009年第23期15卷 2900-2903页

作者： bo-kyung Je Sung-Bum Kim Seung Hwa Lee Ki Yeol Lee Sang Hoon cha Department of Radiology College of Medicine Korea University #516 Gojan1-Dong Danwon-Gu Ansan-City Gyeonggi-Do 425-707 South Korea Department of Internal Medicine Dongshin Hospital #430 Hongeundong Seodaemungu Seoul 120-100 South Korea

MM： To evaluate the maximal-outer-diameter （MOD） and the maximal-mural-thickness （MMT） of the appendix in children with acute appendicitis and to determine their optimal cut-off values to diagnose acute appendicitis.METHODS： In total, 164 appendixes from 160 children between 1 and 17 years old （84 males, 76 females; mean age, 7.38 years） were examined by high-resolution abdominal ultrasound for acute abdominal pain and the suspicion of acute appendicitis. We measured the MOD and the MMT at the thickest point of the appendix. Patients were categorized into two groups according to their medical records： patients who had surgery （surgical appendix group） and patients who did not have surgery （non-surgical appendix group）. Data were analyzed by MedCalc v.9.3. The rank sum test （Mann-Whitney test） was used to evaluate the difference in the MOD and the MMT between the two groups. ROC curve analysis was used to determine the optimal cut-off value of the MOD and the MMT on diagnosis of acute appendicitis.RESULTS： There were 121 appendixes （73.8%） in the non-surgical appendix group and 43 appendixes （26.2%） in the surgical appendix group. The median MOD differed significantly between the two groups （0.37 cm vs 0.76 cm, P〈 0.0001）, and the median MMT also differed （0.15 cm vs 0.33 cm, P 〈 0.0001）. The optimal cut-off value of the MOD and the MMT for diagnosis of acute appendicitis in children was 〉 0.57 cm （sensitivity 95.4%, specificity 93.4%） and 〉 0.22 cm （sensitivity 90.7%, specificity 79.3%）, respectively.CONCLUSION： The MOD and the MMT are reliable criteria to diagnose acute appendicitis in children. An MOD 〉 0.57 cm and an MMT 〉 0.22 cm are the optimal criteria.

关键词： Appendicitis Ultrasonography Pediatrics Diagnosis ROC curve

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Proteasomal adaptations to FDA-approved proteasome inhibitors:a potential mechanism for drug resistance?

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Cancer Drug Resistance 2021年第3期4卷 634-645页

作者： kyung bo Kim Department of Pharmaceutics College of PharmacyUniversity of KentuckyLexingtonKY 40536-0596USA

With proteasome inhibitors(PIs)becoming clinically available since 2003,outcomes for patients with multiple myeloma(MM)have dramatically changed,improving quality of life and *** the impressive treatment success,however,almost all MM patients who initially respond to these PIs eventually develop ***,a portion of MM patients is inherently unresponsive to the *** mechanistic investigations identified several non-proteasomal signaling pathways suspected to be linked to the PI resistance,for which several excellent reviews are currently *** the other hand,it is still unclear how cancer cells under high PI environments adapt to spare proteasome activity essential for survival and proliferation regardless of cancer evolution *** review outlines current progress towards understanding the proteasomal adaptations of cells in response to PI treatment to maintain necessary proteasome activity.A better understanding of cellular proteasomal changes in response to the PIs could provide a rationale to develop new therapeutics that could be used to overcome resistance to existing PI drugs.

关键词： Constitutive proteasome immunoproteasome carfilzomib bortezomib drug resistance

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Comparative outcomes of the pathogen in cultured Jones tubes used in lacrimal bypass surgery according to follow up periods

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国际眼科杂志:英文版 2023年第10期16卷 1623-1629页

作者： bo Hyun Park Hui kyung Kim Yeon Ji Jo Jong Soo Lee Department of Ophthalmology Pusan National University School of Medicine&Medical Research Institute of Pusan National University HospitalPusan 49241Republic of Korea

AIM:To evaluate the pathogens in cultured Jones tubes used in lacrimal bypass surgery according to the postoperative periods and to obtain data for the prevention of infection of functional lacrimal stent ***:Totally 71 patients(81 eyes)who underwent the removal of Jones tubes were enrolled in *** the removed Jones tubes were cultured for bacterial and fungal identification and tested for bacterial antibiotic *** results were analyzed according to the duration of the inserted Jones tube after lacrimal bypass ***:Of the 81 eyes,bacteria were isolated from 69 eyes(85.2%)and fungi from 6 eyes(7.4%).Among 69 eyes,40.6% showed Staphylococcus aureus(***),11.6% were Pseudomonas aeruginosa(***).Gram-positive bacteria were isolated more than Gramnegative bacteria,but Gram-negative bacteria showed a higher incidence in the Jones tube implanted for over 10y(P=0.035).The antibiotic sensitivity test showed that 46.4% of *** were resistant to *** terms of antibiotics commonly used in ocular clinical practice,vancomycin was sensitive to *** and Streptococcus pneumoniae(***),amikacin responded to *** and Proteus mirabilis(***).Trimethoprim/sulfamethoxazole(TMP/SMX)was all sensitive to ***,*** and *** except ***:*** is the most commonly found organism in the Jones tube after lacrimal bypass surgery,and 46.4% of them are methicillin-resistant ***(MRSA),sensitive to ***,*** responded with amikacin is dominantly detected in the Jones tubes implanted for more than 10y.

关键词： Jones tube lacrimal bypass surgery Pseudomonas aeruginosa Proteus mirabilis Staphylococcus aureus

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Radiologic factors related to double-bar insertion in minimal invasive repair of pectus excavatum

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World Journal of Pediatrics 2015年第2期11卷 148-153页

作者： Ki Hwan Kim Ki Yeol Lee Jung bok Lee kyung-Sook Yang Jinwook Hwang bo kyung Je Hyung Joo Park Department of Radiology Korea University College of MedicineAnsanKorea1 Department of Clinical Epidemiology and Biostatics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Biostatistics Korea University College of MedicineSeoulKorea Departmentof Thoracic Surgery Korea University College of MedicineAnsanKorea Department of Thoracic and Cardiovascular Surgery Seoul St.Mary's Hospitalthe Catholic University of KoreaSeoulKorea

Background:Pectus excavatum is the most common congenital chest wall deformity,with a high incidence in live *** study aimed to evaluate the measured factors on CT images related to the number of pectus bars for surgical ***:A total of 497 patients who had undergone minimally invasive repair between April 2007 and July 2011 were classified into single-bar(n=358)and doublebar(n=139)insertion *** measured eight distinct distances and one angle on CT scans to reflect quantitative *** analysis and multivariate logistic regression analysis were performed to detect statistically significant association between radiologic measurements and the pectus bars ***:After adjusting for age and gender,the transverse distance(T),the transverse distance of the depression area(A),the inclined distance of the depression area(B),the AP distance of the depression area(C),the depression angle(G),and the eccentric distance of deformity(E)were significantly correlated with double-bar *** regression model showed that age(,P<0.0001),gender(P<0.0001),depression angle(G)(P<0.0001),direction of the depression(DD)(P<***1)and depression depth(D)(P<0.0001)were significantly associated with doublebar ***:CT scan provides useful factors which can be of assistance in predicting the number of pectus bars for the surgical correction of pectus excavatum.

关键词： computed tomography Nuss procedure pectus excavatum

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Biliary reflux detection in anomalous union of the pancreaticobiliary duct patients

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World Journal of Gastroenterology 2012年第9期18卷 952-959页

作者： Suk Keu Yeom Seung Wha Lee Sang Hoon cha Hwan Hoon Chung bo kyung Je Baek Hyun Kim Jong Jin Hyun Department of Radiology Korea University Ansan Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalGyeonggi-do 425-707South Korea

AIM： To demonstrate the imaging findings of biliopan creatic and pancreatico-biliary reflux in patients with anomalous union of the pancreatico biliary duct （AUPBD） on gadoxetic acidenhanced functional magnetic res... 详细信息

关键词： Bile reflux Choledochal cyst Encoscopicretrograde cholangio-pancreatography Gadolinium-eth-oxybenzyl-diethylenetriamine penta-acetic acid Magneticresonance imaging

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Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum

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Asian Journal of Andrology 2013年第1期15卷 134-137页

作者： Kai Sun Chen Zhao Xiang-Feng Chen Hye-kyung Kim bo-Ram Choi Yi-Ran Huang Jong-Kwan Park Department of Urology Renji Hospital Shanghai Jiao Tong University School of Medicine and Shanghai Institute of Andrology Shanghai 200127 China Department of Urology Chonbuk National University and Research Institute of Clinical Medicine and Clinical Trial Center of Medical Device of Chonbuk National University Hospital Jeonju 561-712 South Korea

The effect of Cuscuta chinensis extract on the rabbit penile corpus cavernosum （PCC） was evaluated in the present study. Penises obtained from healthy male New Zealand white rabbits （2.5-3.0 kg） were precontracted with phenylephrine （Phe, 10 pmol I^-1） and then treated with various concentrations of Cuscuta chinensis extract （1, 2, 3, 4 and 5 mg ml^-1）. The change in penile tension was recorded, and cyclic nucleotides in the PCC were measured by radioimmunoassay （RIA）. The interaction between Cuscuta chinensis and sildenafil was also evaluated. The result indicated that the PCC relaxation induced by Cuscuta chinensis extract was concentration-dependent. Pre-treatment with an nitric oxide synthase （NOS） inhibitor （No〉 nitro-L-arginine-methyl ester, L-NAME）, a guanylyl cyclase inhibitor （1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-l-one, ODQ）, or a protein kinase A inhibitor （KT 5720） did not completely inhibit the relaxation. Incubation of penile cavernous tissue with the Cuscuta chinensis extract significantly increased cyclic guanosine monophosphate （cGMP） and cyclic adenosine monophosphate （cAMP） in the PCC. Moreover, the Cuscuta chinensis extract significantly enhanced sildenafil-induced PCC relaxation. In conclusion, the Cuscuta chinensis extract exerts a relaxing effect on penile cavernous tissue in part by activating the NO-cGMP pathway, and it may improve erectile dysfunction （ED）, which does not completely respond to sildenafil citrate.

关键词： Cuscuta chinensis erectile dysfunction (ED) NO-cGMP pathway penile corpus cavernosum (PCC) sildenafil

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Interstitial tissue-specific gene expression in mouse testis by intra-tunica albuguineal injection of recombinant baculovirus

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Asian Journal of Andrology 2009年第3期11卷 342-350页

作者： Hyun Jung Park Won Young Lee Jin Hoi Kim Jae Hwan Kim Hun Jong Jung Nam Hyung Kim bo kyung Kim Hyuk Song Department of Animal Science College of Natural Science Konkuk University Chung-ju 380-701 Korea cha Stem Cell Institute Graduate School of Life Science and Biotechnology Pochon CHA University Seoul 135-907 Korea Department of Animal Biotechnology College of Animal Biotechnology Konkuk University Seoul 143-701 Korea Occupation and Environment Department Medical School Konkuk University Chung-ju 380-704 Korea Department of Animal Science College of Agriculture Chungbuk National University Choung-ju Chung-buk 361-763 Korea Department of Physiology Medical School Konkuk University Chung-ju 380-701 Korea

The purpose of this study is to establish a gene delivery system for interstitial tissue-specific protein expression in mice testes using modified recombinant baculovirus. Green fluorescent protein （GFP）-expressing recombinant baculovirus （GFP-baculovirus）, in which the insect cell-specific polyhedron promoter was replaced by the cytomegalovirus （CMV）-IE promoter, was used to transfect testicular cells in vitro, and for intra-tunica albuguineal injection of the interstitial tissue of the testis. GFP expression was monitored in frozen testes sections by fluorescence microscopy. Expression of GFP in testicular tissues was also assessed by reverse transcription polymerase chain reaction （RT-PCR）, and protein expression was assessed by Western blot. Testicular cells in vitro were infected efficiently by modified recombinant GFP-baculovirus. lntra-tunica albuguineal injection of GFP- baculovirus into the mouse testis resulted in a high level of GFP expression in the interstitial tissues. RT-PCR analysis clearly showed GFP gene expression in the testis, particularly interstitial tissues. Intra-tunica albuguineal injection of a modified baculovirus that encoded recombinant rat insulin-like growth factor binding protein （IGFBP）-5 resulted in an increase in IGFBP-5 in testis and semen. In conclusion, we have developed an efficient delivery system for gene expression in vivo in testicular cells, particularly cells of the interstitial tissue using intratunica albuguineal injection of a modified recombinant baculovirus. This method will be particularly relevant for application that requires gene delivery and protein expression in the testicular cells of the outer seminiferous tubule of the testis.

关键词： intra-tunica albuguineal injection recombinant baculovirus testis gene delivery

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PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer： a retrospective study

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Asian Journal of Andrology 2017年第4期19卷 458-462页

作者： Sung Han Kim Weon Seo Park bo Ram Park Jungnam Joo Jae Young Joung Ho kyung Seo Jinsoo Chung Kang Hyun Lee Department of Urology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Pathology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Statistics Biometric Research Branch Clinical Research Coordination Center Research Institute and Hospital of National Cancer Center Goyang Korea.

Prostate cancer is the second most common male cancer, with half of all patients going on to develop metastases. To better identify patients at high risk for prostate cancer progression and reduce prostate cancer-related mortality, improved prognostic factors are required. In this study, we used immunohistochemistry （IHC） to determine the prognostic values of multiple tissue biomarkers in hormone-na＇l＇ve prostatectomy specimens of prostate cancer. Using 510 prostatectomy specimens collected between 2002 and 2012, IHC analysis was performed for Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2, and Ki-67 on formalin-fixed paraffin-embedded sections. The Cox proportional hazard model was used to determine the predictive risk factors for biochemical recurrence （BCR） of prostate cancer. During a median 44-month follow-up, 128 （25.1%） patients developed BCR. A multivariate regression analysis revealed that Ki-67 （hazard ratio [HR]. 1.60, P = 0.033）, PSCA （HR： 0.42, P 〈 0.001）, and Cox-2 （HR： 2.05, P = 0.003） were the only significant prognostic tissue markers of BCR. Resection margin status （HR： 1.67, P = 0.010）, pathologic pTO/l/2 stage （vs pT3/4; HR： 0.20, P = 0.002）, preoperative PSA levels （HR.. 1.03, P 〈 0.001）, biopsied （HR： 1.30, P = 0.022） and pathologic （HR： 1.42, P = 0.005） Gleason scores, and prostate size （HR： 0.97, P = 0.003） were significant clinicopathologic factors. The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for BCR in patients with clinically localized prostate cancer following radical prostatectomy.

关键词： biomarker immunohistochemistry prostatectomy recurrence tissue microarray

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