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超高效液相色谱-串联质谱法快速检测农田灌溉水中甲嘧磺隆等3种磺酰脲类农药

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农药科学与管理 2024年第3期45卷 30-33页

作者：黄兰淇尹纪根陈秀陈建波赵莉马琳上海市农业技术推广服务中心上海201103 上海市浦东新区农业技术推广中心上海201201

建立了农田灌溉水中甲嘧磺隆等3种磺酰类农药高效液相色谱-串联质谱检测方法。灌溉水采用乙腈提取,离心振荡后无需净化,浓缩后直接过膜后上机。以甲醇和水(含0.1%甲酸)为流动相梯度洗脱,电喷雾正离子(ESI+)模式电离,多反应监测(mRm)模... 详细信息

建立了农田灌溉水中甲嘧磺隆等3种磺酰类农药高效液相色谱-串联质谱检测方法。灌溉水采用乙腈提取,离心振荡后无需净化,浓缩后直接过膜后上机。以甲醇和水(含0.1%甲酸)为流动相梯度洗脱,电喷雾正离子(ESI+)模式电离,多反应监测(mRm)模式检测,外标法定量。甲嘧磺隆、苯磺隆、苄嘧磺隆在0.005~1.0 mg/L范围内线性关系良好,相关系数(r)≥0.999;3个农药回收率范围为83.8%~103.1%;变异系数范围分别为1.8%~13.1%。该方法操作简单,快速准确,满足农药残留分析要求。

关键词：农田灌溉水农药残留 LC-mS/mS

Numerical simulation and analysis of the underwater implosion of spherical hollow ceramic pressure hulls in 11000 m depth

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Journal of Ocean Engineering and Science 2023年第2期8卷 181-195页

作者： Shengxia Sun Fenghua chen min Zhao State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringCollaborative Innovation Center for Advanced Ship and Deep-Sea ExplorationShanghai Jiao Tong UniversityShanghai 200240China

Pressure hulls play an important role in deep-sea underwater ***,in the ultra-high pressure environment,a highly destructive phenomenon could occur to them which is called *** study the characteristics of the flow field of the underwater implosion of hollow ceramic pressure hulls,the compressible multiphase flow theory,direct numerical simulation,and adaptive mesh refinement are used to numerically simulate the underwater implosion of a single ceramic pressure hull and multiple linearly arranged ceramic pressure ***,the feasibility of the numerical simulation method is ***,the results of the flow field of the underwater implosion of hollow ceramic pressure hulls in 11000 m depth is *** are the compression-rebound processes of the internal air cavity in the *** the rebound stage,a shock wave that is several times the ambient pressure is generated outside the pressure hull,and the propagation speed is close to the speed of *** pressure peak of the shock wave has a negative exponential power function relationship with the distance to the center of the ***,it is found that the obvious superimposed effect between spheres exists in the chain-reaction implosion which enhances the implosion shock wave.

关键词： Underwater implosion 11000 m depth Hollow ceramic pressure hull Compressible multiphase flow Adaptive mesh refinement Chain-reaction implosion

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

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Bioactive materials 2023年第3期21卷 110-128页

作者： Xiaofang Wang Yufei ma Jie chen Yujiao Liu Guangliang Liu Pengtao Wang Bo Wang makoto m.Taketo Teresita Bellido Xiaolin Tu Laboratory of Skeletal Development and Regeneration Institute of Life SciencesChongqing Medical UniversityChongqing400016China Department of Pharmacology Graduate School of MedicineKyoto UniversityKyoto606-8501Japan Department of Physiology and Cell Biology University of Arkansas for Medical SciencesLittle RockAR72223USA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisIN46202USA

Cell source is the key to decellularized matrix(Dm)*** study compared 3 cell types,osteocytes with/without dominant active Wnt/β-catenin signaling(daCO and WTO)and bone marrow stromal cells(BmSCs)for their Dms in bone *** removes all organelles and>95%DNA,and retained>74%collagen and>71%GAG,maintains the integrity of cell basement membrane with dense boundaries showing oval and honeycomb structure in osteocytic Dm and smooth but irregular shape in the *** produced higher cell survival rate(90%)and higher proliferative *** vitro,daCO-Dm induces more and longer stress fibers in BmSCs,conducive to cell adhesion,spreading,and osteogenic differentiation.8-wk after implantation of the critical-sized parietal bone defect model,daCO-Dm formed tight structures,composed of a large number of densely-arranged type-I collagen under polarized light microscope,which is similar to and integrated with host ***/TV(>54%)was 1.5,2.9,and 3.5 times of WTO-Dm,BmSC-Dm,and none-Dm groups,and ***/***(3.2×10^(2)/mm^(2))was 1.7,2.9,and 3.3 *** 4-wk,daCO-Dm induced osteoclastogenesis,2.3 times higher than WTO-Dm;but BmSC-Dm or none-Dm didn'***-Dm increased the expression of RANKL and mCSF,Vegfa and Angpt1,and Ngf in BmSCs,which contributes to osteoclastogenesis,angiogenesis,and neurogenesis,***-Dm promoted H-type vessel formation and nerve markersβ3-tubulin and NeuN ***:daCO-Dm produces metabolic and neurovascularized organoid bone to accelerate the repair of bone *** features are expected to achieve the effect of autologous bone transplantation,suitable for transformation application.

关键词： Decellularized matrix Osteocyte Wnt signaling 3D printing Regenerative repair metabolic and neurovascular organoid bone

Compact yellow-orange Nd:YVO_(4)/PPmgLN laser at 589 nm

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Optoelectronics Letters 2023年第11期19卷 641-645页

作者： mA Lei FENG Xinkai chen Huaixi chenG Xing chen Jiaying LIANG Wanguo College of Chemistry and material Fujian Normal UniversityFuzhou 350008China Fujian Institute of Research on the Structure of matter Chinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

We propose and make a compact yellow-orange laser of the Nd-doped yttrium vanadate(Nd:YVO_(4))/periodically poled mg-doped lithium niobate(PPmgLN)module by Raman frequency-doubling at 589 *** reasonably designing the size of the Nd:YVO_(4)and 5 mol%PPmgLN crystals,cavity length and coating parameter,a compact 589 nm laser module with a total size of 3 mm×10 mm×1.5 mm is *** the laser module,the input surface of Nd:YVO_(4)crystal is end-pumped by an 808 nm laser diode(LD).Under the effect of linear resonant cavity structure,the output surface of PPmgLN crystal with a period of 9.48μm generates 589 nm yellow-orange *** experimental results show that the maximum output power at 589 nm is 390 mW at the pump power of 3 W with the optical-optical conversion efficiency of 13%and the stability of the output power is less than 2%within 3 h.

关键词： Nd: PPmgLN laser

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铝合金散热器真空钎焊及热处理工艺研究

热加工工艺 2023年第17期52卷 103-109页

作者：陈犇马顺熊勇陈昌达贵州大学材料与冶金学院贵州贵阳550025 中国航发贵州黎阳航空动力有限公司贵州贵阳550000

对Al-mg-Si系铝合金散热器进行了真空钎焊及固溶时效处理的工艺研究,首先进行热分析得出母材的固相线及钎料的液相线温度,确定了真空钎焊参数,再采用X射线衍射仪对钎料、母材及该真空钎焊焊缝进行物相测试,最后通过微观组织观察及力学... 详细信息

对Al-mg-Si系铝合金散热器进行了真空钎焊及固溶时效处理的工艺研究,首先进行热分析得出母材的固相线及钎料的液相线温度,确定了真空钎焊参数,再采用X射线衍射仪对钎料、母材及该真空钎焊焊缝进行物相测试,最后通过微观组织观察及力学性能对比对不同工艺热处理的焊缝进行了深入分析。结果表明:608℃/70 min的真空钎焊工艺可获得优质的焊缝,未出现裂纹、孔洞及溶蚀等缺陷。随固溶温度提高,焊缝晶粒尺寸及初生相溶解度增大,焊缝最佳热处理工艺为530℃/3 h+150℃/5 h;在550℃/5 h时母材的初生相固溶度达到饱和,在150℃保温9 h时效处理时,可观察到大量的针状β"相和杆状β’相,母材最佳热处理工艺为550℃/5 h+150℃/9 h;经优化对比,散热器的热处理工艺为540℃/4 h+150℃/6 h,在该工艺下焊缝与母材的力学性能得到有效保证。

关键词：铝合金散热器真空钎焊固溶时效力学性能

中国成年人BmI与血浆氨基酸和酰基肉碱水平关联的观察性和孟德尔随机化研究

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中华流行病学杂志 2024年第6期45卷 770-778页

作者：程思巫婷余灿清孙点剑一裴培杜怀东陈君石陈铮鸣庞元捷吕筠李立明中国慢性病前瞻性研究项目协作组北京大学公共卫生学院流行病与卫生统计学系北京100191 北京大学公众健康与重大疫情防控战略研究中心北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 牛津大学临床与流行病学研究中心纳菲尔德人群健康系牛津OX37LF 国家食品安全风险评估中心北京100022 不详

目的探讨中国成年人BmI与血浆氨基酸和酰基肉碱水平的关联。方法基于中国慢性病前瞻性研究(CKB)第一次重复调查中2182名具有靶向质谱代谢组检测的研究对象,采用多元线性回归模型和限制性立方样条模型分析BmI与血浆20种氨基酸和40种酰基... 详细信息

目的探讨中国成年人BmI与血浆氨基酸和酰基肉碱水平的关联。方法基于中国慢性病前瞻性研究(CKB)第一次重复调查中2182名具有靶向质谱代谢组检测的研究对象,采用多元线性回归模型和限制性立方样条模型分析BmI与血浆20种氨基酸和40种酰基肉碱的线性和非线性关联,并识别BmI相关的代谢通路。以BmI的遗传风险评分作为工具变量,采用单样本孟德尔随机化(mR)分析进一步探索BmI与20种氨基酸和40种酰基肉碱的潜在因果关联,并使用mR-Egger法检验水平多效性。结果观察性分析结果显示,BmI与3种支链氨基酸(异亮氨酸、亮氨酸和缬氨酸)、2种芳香族氨基酸(苯丙氨酸和酪氨酸)、3种其他氨基酸(半胱氨酸、谷氨酸、赖氨酸)以及7种酰基肉碱(C3、C4、C5、C10、C10:1、C14和C16)的血浆水平升高相关,与天冬酰胺、丝氨酸和甘氨酸水平降低相关。通路分析发现7个与BmI相关的氨基酸代谢通路(错误发现率校正后均PmI与亮氨酸、缬氨酸和苏氨酸呈非线性关联,BmI与其他氨基酸和酰基肉碱均呈线性关联。单样本mR分析发现BmI与酪氨酸和4种酰基肉碱[C5-DC(C6-OH)、C5-m-DC、C12-DC和C14]水平升高相关,其中酪氨酸和酰基肉碱C14在观察性分析[β值(95%CI)分别为0.057(0.044~0.070)和0.018(0.005~0.032)]和单样本mR分析[β值(95%CI)分别为0.102(0.035~0.169)和0.104(0.036~0.173)]中均与BmI呈显著正相关。经检验,本研究的mR分析满足工具变量的3个核心假设。结论中国成年人BmI与血浆11种氨基酸和7种酰基肉碱水平相关,涉及支链氨基酸和芳香族氨基酸代谢、脂肪酸代谢和氧化应激等多种途径,BmI与酪氨酸和酰基肉碱C14可能存在因果关联。

关键词：体质指数氨基酸酰基肉碱孟德尔随机化

Inhibiting tau protein improves the recovery of spinal cord injury in rats by alleviating neuroinflammation and oxidative stress

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中国神经再生研究：英文版 2023年第8期18卷 1834-1840页

作者： Guo-Liang chen Kai Sun Xi-Zhe Liu Kui-Leung Tong Zi-Juan chen Lu Yu Ning-Ning chen Shao-Yu Liu Department of Orthopedic Surgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Biomedical Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology/Orthopedic Research Institute Department of Spine SurgeryThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery Jiujiang University Affiliated HospitalJiujiangJiangxi ProvinceChina Department of Clinical Laboratory The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina

After spinal cord injury,the concentrations of total and hyperphosphorylated tau in cerebrospinal fluid increase,and levels of both correlate with injury *** inhibition is considered effective therapy for many central nervous system diseases,including traumatic brain injury and Alzheimer's ***,whether it can play a role in the treatment of spinal cord injury remains *** this study,the therapeutic effects of tau inhibition were investigated in a rat model of transection spinal cord injury by injecting the rats with a lentivirus encoding tau siRNA that inhibits tau *** found that tau inhibition after spinal cord injury down-regulated the levels of inflammatory mediators,including tumor necrosis factor-α,interleukin-6 and interleukin-1β.It also led to a shift of activated microglial polarization from the m1 pro-inflammatory phenotype to the m2 anti-inflammatory phenotype,and reduced the amount of reactive oxygen species in the acute ***,the survival of residual neural cells around the injury epicenter,and neuronal and axonal regeneration were also markedly enhanced,which promoted locomotor recovery in the model ***,our findings support the conclusion that tau inhibition can attenuate neuroinflammation,alleviate oxidative stress,protect residual cells,facilitate neurogenesis,and improve the functional recovery after spinal cord injury,and thus suggest that tau could be a good molecular target for spinal cord injury therapy.

关键词： functional recovery mAPK pathway microglial polarization neuroinflammation neuronal regeneration oxidative stress spinal cord injury tau

myomatous erythrocytosis syndrome:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3206-3212页

作者： Xin-Yu Shu Na chen Bi-Yun chen Hui-Xia Yang Hui Bi Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Department of Obstetrics and Gynaecology The Hospital of Cang TownCangzhou 223900Hebei ProvinceChina

BACKGROUND Uterine myoma is the most common benign tumor among women and is often accompanied by ***,we report the case of a patient with a very large leiomyoma but with a hemoglobin level as high as 197 g/*** undergoing hysterectomy,all her hematological parameters returned to *** staining of her myoma for erythropoietin showed strong positivity,which suggested that erythropoietin may be the cause of her erythrocytosis.A multidisciplinary team played a significant role in treating the *** SUmmARY A 47-year-old woman visited our department complaining that her abdomen had been continuously growing for the past 2 *** careful examinations,she was suspected of having a very large *** was also diagnosed with erythrocytosis because her RBC count was 6.49×10^(12)/L,hemoglobin was 197 g/*** a multidisciplinary team consultation,bilateral ureteral stents were placed,and 800 m L blood was removed by *** patient then underwent hysterectomy and bilateral *** recovered well from the operation,and her hemoglobin level decreased sharply following the ***-molecular-weight heparin was administered daily to prevent postoperative *** was discharged from the hospital on the fourth postoperative *** months later,all her hematological parameters returned to *** analysis of the myoma revealed that it was a benign leiomyoma,with partial hyalinization,and strong positivity for erythropoietin in immunohistochemical staining suggested that erythropoietin may be responsible for the *** Erythropoietin ectopically produced from the myoma was responsible for the erythrocytosis in this patient.A multidisciplinary team is strongly recommended.

关键词： myomatous erythrocytosis syndrome Erythrocytosis Uterine myoma Erythropoietin multiple disciplinary team Case report

口服L-苏糖酸镁预防长春新碱诱导的大鼠记忆和情感障碍

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中国疼痛医学杂志 2024年第6期30卷 413-423页

作者：陈佳新周鑫熊媖刘先国舒海华华南理工大学医学院广州510006 南方医科大学附属广东省人民医院(广东省医学科学院)麻醉科广州510080 广东省心血管病研究所广东省人民医院广东省医学科学院广州510080 中山大学中山医学院广州510080

目的:观察L-苏糖酸镁(magnesium-L-threonate,L-TAmS)对长春新碱(vincristine,VCR)诱导的大鼠记忆和情感障碍的影响并探讨其机制。方法:采用随机数表法将SD大鼠随机分为三组:Control组(饮用正常水并注射等量生理盐水)、VCR组(大鼠腹腔... 详细信息

目的:观察L-苏糖酸镁(magnesium-L-threonate,L-TAmS)对长春新碱(vincristine,VCR)诱导的大鼠记忆和情感障碍的影响并探讨其机制。方法:采用随机数表法将SD大鼠随机分为三组:Control组(饮用正常水并注射等量生理盐水)、VCR组(大鼠腹腔注射长春新碱并饮用正常水)、L-TAmS+VCR组(VCR注射前7天起至实验结束在饮用水中加入L-TAmS),每组5~7只。采用新颖物体识别测试(novel object recognition test,NORT)检测大鼠记忆能力;高架十字迷宫实验(elevated plus-maze test,EPmT)检测大鼠焦虑行为;强迫游泳实验(forced swimming test,FST)检测大鼠抑郁行为。使用在体电生理实验技术记录海马CA3-CA1突触后诱发场电位的幅度;Western blot检测海马内N-甲基-D-天冬氨酸受体(N-methyl-D-Aspartate-Receptors,NmDARs)亚基NR2B表达的情况;免疫荧光检测海马CA1与前扣带回皮质(anterior cingulate cortex,ACC)内小胶质细胞的表达情况。结果:与Control组比较,VCR组认知系数降低,静止不动时间延长,进入高架十字迷宫开放臂的时间和次数减少,海马CA3-CA1突触后场电位幅度降低,海马内NR2B含量显著降低,海马CA1和ACC内小胶质细胞的表达增多,腹腔注射VCR之前,提前7天直至实验结束口服L-TAmS可预防VCR所引起的上述变化。结论:L-TAmS可通过上调海马突触后膜NmDARs亚基NR2B,逆转VCR引起的CA3-CA1突触后场电位幅度显著降低,改善海马突触传递受损,同时,降低大鼠海马CA1和前扣带回皮质的小胶质细胞表达,减轻神经炎症,进一步预防VCR诱导的记忆和情感功能障碍。

关键词： L-苏糖酸镁长春新碱记忆情感障碍海马前扣带回皮质突触可塑性神经炎症