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结合色彩补偿与双背景光融合的水下图像复原

光学精密工程 2024年第7期32卷 1059-1074页

作者：林森查子月沈阳理工大学自动化与电气工程学院辽宁沈阳110159

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,... 详细信息

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,降低水体背景颜色影响;根据背景光强度和颜色分布特性,提出双候选背景光融合方法,准确估计全局背景光;不依赖任何水体环境参数,根据背景颜色与散射系数的内在关系,采用引导-高通滤波,优化并增强各通道透射率;最后,逆求解成像模型复原水下图像。实验结果表明,在4个不同的水下数据集上与经典及新颖方法对比,所提方法恢复的图像颜色更自然,纹理细节更丰富清晰;色差值改善幅度达5.4%,UCIQE及FDUM指标提升幅度分别达8.3%和4.5%。所提方法在定性和定量实验中更具优势,能够显著提高水下图像质量。

关键词：水下图像复原色彩补偿背景光融合透射率估计

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金属矿区周边农田土壤与农作物重金属健康风险评估

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环境科学 2024年第4期45卷 2461-2472页

作者：魏洪斌罗明向垒查理思安徽省高潜水位矿区水土资源综合利用与生态保护工程实验室淮南232001 自然资源部国土整治中心(自然资源部土地科技创新中心)/自然资源部土地整治重点实验室北京100035 自然资源部南方石山地区矿山地质环境修复工程技术创新中心南宁530028 暨南大学生命科学技术学院广州510632 广东财经大学公共管理学院广州510320

为探明金属矿区周边农田土壤与农作物重金属污染特征与人体健康风险,通过对矿区周边农田土壤和农作物进行样品采集并分析测定其Cd、Pb和As等重金属含量,采用地累积指数法、富集系数法和综合潜在生态风险指数法,研究土壤和农作物重金属... 详细信息

为探明金属矿区周边农田土壤与农作物重金属污染特征与人体健康风险,通过对矿区周边农田土壤和农作物进行样品采集并分析测定其Cd、Pb和As等重金属含量,采用地累积指数法、富集系数法和综合潜在生态风险指数法,研究土壤和农作物重金属的污染特征与综合潜在生态风险,采用蒙特卡罗模拟法进行土壤和农作物重金属的健康风险评估.结果表明,凉桥村土壤重金属污染主要是Cd、As和Pb,分别有100%、100%和75%以上土壤样品超过农田土壤筛选值(gB 15618-2018),农作物中Cd、Pb、As、Cr和ni这5种重金属的含量,均超标《食品安全国家标准食品中污染物限量》(gB 2762-2017)严重;地累积指数和富集系数表明Cd和As污染严重,综合潜在生态风险指数(RI)普遍高于600,具有极高生态风险,其中Cd、As和Pb贡献最大,贡献率分别为77.8%、14.4%和3.1%.健康风险评估表明,凉桥村居民通过摄入农作物以及误食土壤造成较高的致癌风险(致癌风险>10-6)以及非致癌健康风险(危害商值>1);蒙特卡罗模拟人群健康风险分析显示,凉桥村土壤重金属污染暴露途径下具有较高致癌与非致癌风险的人群为儿童和成人女性,摄入农作物的风险概率远大于土壤暴露途径.该区域应采取风险管控和治理修复措施,减缓农田土壤与农作物重金属的致癌风险,成人和儿童应预防吸入土壤颗粒物和经口摄入土壤,儿童还应重点预防皮肤接触土壤的暴露途径.

关键词：金属矿区土壤与作物重金属污染健康风险评价蒙特卡罗模拟

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无菌性骨折不愈合的治疗

中华骨科杂志 2024年第9期44卷 644-650页

作者：查晔军蒋协远首都医科大学附属北京积水潭医院创伤骨科、骨科冲击波诊疗中心北京100035

骨折不愈合指骨折在预期时间内未能愈合,且无新的干预下不可能愈合的情况。骨折不愈合可根据有无感染和骨折部位的生物活性进行分类。无菌性骨折不愈合主要分为萎缩性、营养不良性、肥大性骨折不愈合以及假性关节和骨缺损,不同类型的骨... 详细信息

骨折不愈合指骨折在预期时间内未能愈合,且无新的干预下不可能愈合的情况。骨折不愈合可根据有无感染和骨折部位的生物活性进行分类。无菌性骨折不愈合主要分为萎缩性、营养不良性、肥大性骨折不愈合以及假性关节和骨缺损,不同类型的骨折不愈合采用不同的治疗策略。治疗骨折不愈合的关键在于准确诊断、控制感染、矫正畸形,并根据患者的具体情况选择合适的治疗方法。软组织管理在骨折不愈合的治疗中也起着重要作用,有时需要进行软组织修复以提供良好的愈合环境。骨折不愈合的治疗方法分为非手术和手术治疗。非手术治疗的优势在于避免可能的手术并发症,可分为直接干预和间接干预。间接干预方式包括:戒烟、优化营养、纠正内分泌和代谢紊乱、消除或减少某些药物;直接干预措施包括:负重、外固定、电磁刺激、超声波刺激、冲击波治疗、甲状旁腺激素。在手术干预之前应先尝试保守治疗,保守治疗无效或需行积极干预时再考虑行手术治疗。手术治疗方案包括更换髓内钉、髓内钉动力化、钢板固定、环形外固定架、关节置换等,需根据软组织的完整性、骨质缺损程度和合并疾病进行选择。自体骨移植是治疗骨折不愈合的金标准,另外同种异体骨移植和其他骨移植替代品也是治疗不愈合的选择。最理想的治疗方法需同时考虑外科医生的经验和技能、治疗方法的相对风险和益处以及患者的耐受性。

关键词：骨折,不愈合体外冲击波疗法骨折固定术骨移植

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长株潭城市群人居环境质量评价及空间分异研究

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水土保持研究 2024年第5期31卷 365-375页

作者：钟洋查海焱吴智朋湖南师范大学地理科学学院湖南师范大学城乡转型过程与效应校级重点实验室

[目的]分析长株潭城市群内各市县之间人居环境质量的时空演变差异，探究其空间分异格局的成因，为未来长株潭城市群缩小人居环境差距，构建良好人居环境提供科学支撑。[方法]选取长株潭城市群2013年、2015年、2017年、2019年、2021年相... 详细信息

[目的]分析长株潭城市群内各市县之间人居环境质量的时空演变差异，探究其空间分异格局的成因，为未来长株潭城市群缩小人居环境差距，构建良好人居环境提供科学支撑。[方法]选取长株潭城市群2013年、2015年、2017年、2019年、2021年相关人居环境指标，运用熵值法、耦合协调度和地理探测器模型等研究方法，对长株潭城市群包括23个区市县人居环境质量及其分异机理展开探究。[结果](1)总体上研究区内人居环境质量都得到不同程度的改善，但有差距扩大的趋势；(2)空间分布呈“中心高、周边低”向“均衡”的格局发展；(3)城市群各市县人居环境耦合度高但协调度较低；(4)从自然生态环境、经济发展环境、社会保障环境和个人居住环境等方面进行影响因素分析发现：自然生态环境对人居环境的改善起着底托作用；经济发展环境是人居环境改善的关键；社会保障环境是人居环境的后盾；个人居住环境是人居环境质量高低的直接体现。[结论]长株潭城市群内各市县间的人居环境在时空发展过程中没有达到一个较好的协调发展阶段，人居环境的质量是一个多因素综合作用的结果，长株潭城市群各地区要自觉承担“三高四新”和强省会战略的历史使命，依托各自的优势实现经济错位发展和高质量发展；进一步完善各地区的基础设施和城市更新行动，加强生态环境建设，实现资源的均等性；党和政府工作重心下沉，关注基层群众的基本民生问题，从而建成高质量的人居环境。

关键词：人居环境耦合协调度空间分异地理探测器模型长株潭城市群

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Ternary niCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy

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Fundamental Research 2024年第4期4卷 926-933页

作者： Tingting Hu zhan Zhou Jiajia zha.gareth RWilliams Zhikang Wu Wei zhao Weich.ng Shen Hai Li Xisheng Weng Ruizheng Liang chaoliang Tan State Key Laboratory of chemical Resource Engineering Bejing Advanced Innovation Center for Soft Matter Science and EngineeringBejing University of Chemical TechnologyBeijing100029China College of chemistry and chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China Department of Electrical Engineering City University of Hong KongHong Kong SAR 999077China UCL School of Pharmacy University College LondonLondon WCIN 1AXUnited Kingdom Institute of Advanced Materials(IAM)and Key Laboratory of Flexible Electronics(KLoFE) Nanjing Tech University(NanjingTech)Nanjing 211816China Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong SAR 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China

Combining photodynamic therapy(PDT)with chemodynamic therapy(CDT)has been proven to be a promising strategy to improve the treatment efficiency of cancer,because of the synergistic therapeutic effect arising between the two ***,we report an inorganic nanoagent based on ternary niCoTi-layered double hydroxide(niCoTi-LDH)nanosheets to realize highly efficient photodynamic/chemodynamic synergistic *** niCoTi-LDH nanosheets exhibit oxygen vacancy-promoted electron-hole separation and photogenerated holeinduced O_(2)-independent reactive oxygen species(ROS)generation under acidic circumstances,realizing in situ pH-responsive ***,due to the effective conversion between Co^(3+)and Co^(2+)caused by photogenerated electrons,the niCoTi-LDH nanosheets catalyze the release of hydroxyl radicals(-OH)from H_(2)O_(2)through Fenton reactions,resulting in *** irradiation enhances the catalyzed ability of the niCoTi-LDH nanosheets to promote the ROS generation,resulting in a better performance than TiO_(2)nanoparticles at pH *** vitro and in vivo experimental results show conclusively that niCoTi-LDH nanosheets plus irradiation lead to efficient cell apoptosis and significant inhibition of tumor *** study reports a new pH-responsive inorganic nanoagent with oxygen vacancy-promoted photodynamic/chemodynamic synergistic performance,offering a potentially appealing clinical strategy for selective tumor elimination.

关键词： Layereddouble hydroxides Photodynamic therapy pH-responsive chemodynamic therapy Oxygen vacancy

Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： Wei-Long Xu Pei-Pei Zhou Xu Yu Ting Tian Jin-Jing Bao ch.ng-Rong ni Min zha Xiao Wu Jiang-Yi Yu Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKgROUnD Development of end-stage renal disease is predominantly attributed to diabetic nephropathy(Dn).Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mech.nism through which myricetin influences the progression of Dn remains *** To investigate the effects of myricetin on Dn and explore its potential therapeutic *** Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of myricetin led to a mitigating effect on Dn-induced renal dysfunction and ***,we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory cytokine-related ***,myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by high glucose in RAW 264.7 ***,myricetin modulated the M1-type polarization of the RAW 264.7 *** docking and bioinformatic analyses revealed Akt as the target of *** protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： Myricetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization

Simulation Study of Solid Rocket Motor C/C Throat Liner Ablation Based on Two Regions

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Journal of Power and Energy Engineering 2024年第4期12卷 1-19页

作者： guanneng ch.n Yihua Xu Xiaojiang zha Hemeng Shi Bing Liu School of Aircraft Engineering Nanchang Hangkong University Nanchang China

Based on the ablation micro-morphological characteristics, thermo-chemical ablation mech.nism, and mech.nical stripping mech.nism, a dual-region solid rocket motor C/C throat liner ablation model and physical model are established. The ablation program was written and the experimental data of 70 lb BATES engine platform was used for model validation. The relative errors between the simulation calculation results and the experimental results were −6.83% - 10.20%. The ablation program was applied to study the effects of combustion chamber temperature, pressure, oxidation component concentration, throat particle concentration and particle scouring angle on the nozzle throat liner, which provides a reference for the design of the nozzle throat liner and the estimation of solid rocket motor ablation.

关键词： Dual-Area Ablation Model C/C Throat Liner Ablation Environment Ablation Program

传统布艺在区域文旅产业中应用的优化设计——以万载夏布为例

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西部皮革 2024年第10期46卷 127-129页

作者：查文心武汉工程大学

为了保护和传承非物质文化遗产，通过综合运用文献分析、实地调研及案例分析等多种方法，文章探究了万载夏布在区域文旅产业中应用的主要问题，并将分析出的不足经验总结为万载夏布在文旅产业中发展的应用策略。研究认为，把传统的万载... 详细信息

为了保护和传承非物质文化遗产，通过综合运用文献分析、实地调研及案例分析等多种方法，文章探究了万载夏布在区域文旅产业中应用的主要问题，并将分析出的不足经验总结为万载夏布在文旅产业中发展的应用策略。研究认为，把传统的万载夏布与现代的文旅产业相结合，在产品种类、应用途径、宣传方法等方面进行创新设计，为促进万载夏布产业的稳定、可持续性发展提供借鉴和启示。

关键词：传统布艺万载夏布区域文旅产业

novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHOng Yue-long JIAng Li-ying FEng Jie zha Jing-wei YAO Yin LI Xian-ming DEng Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,genome-wide RnA-sequencing studies were conducted to elucidate the mech.nisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and nF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor nF-kB c-Myc PI3K/AKT p53