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Body Talk

明日风尚 2009年第3期 140-145页

作者： Adele leung Taylor U n Workshop Vin C tsang Adele leung Taylor U n Workshop Vin C tsang

our body speaks,when we are willing to

关键词： listen willing body

Predicting eczema severity beyond ch.ldhood

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World Journal of Pediatrics 2016年第1期12卷 44-48页

作者： Kam Lun Hon Yin-ch.ng K.tsang Terence ch.en W.Poon nga Hin Pong Matthew Kwan Shirley lau Yuen-ch.n ch.u Hin-Hei Wong Ting-Fan leung Department of Pediatrics The Chinese University of Hong KongPrince of Wales HospitalHong KongChina Faculty of Medicine The Chinese University of Hong KongChina

Background:We evaluated factors associated with eczema severity in ***:nottingham Eczema Severity Score(nESS),family and personal history of atopy,skin prick test for common food and aeroallergens,highest serum IgE level and eosinophil count were *** with paired nESSs(ch.ldhood-nESS is nESS performed atnce-nESS is nESS performed at age>10 years)were further ***:Adolescence-nESS(n=383 patients)was associated with eczema onset in infancy,dust mite and food allergen sensitization,dietary avoidance,use of wet wrap,traditional ch.nese medicine,immunomodulant(azathioprine or cyclosporine),high IgE level,eosinophil count,but not with family/personal history of ***-two patients had both ch.ldhood-nESS and adolescence-nESS(mean follow-up of 6.8 years)showing that adolescence-nESS was associated with ch.ldhood-nESS severity grades(P=0.034).Of these patients,48%remained in the same severity grades,whereas 39%improved,and 13%deteriorated from ch.ldhood to ***:It is not possible to assure parents that their ch.ld can outgrow *** eczema prognosis research.long-term follow-up is warranted.

关键词： atopic dermatitis atopy eczema nottingham Eczema Severity Score prognosis

Immunoregulatory and Anti-cancer Activities of Combination Treatment of novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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ch.nese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben ch.ng-Lap ch.n Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUAnG Dan-qi Miranda Sin-Man tsang Clara Bik-San lau Ping-ch.ng leung ch.n-Kwok Wong Institute of ch.nese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research.on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of ch.mical Pathology The Chinese University of Hong KongHong Kong SARChina ch.na-Australia International Research.Centre for ch.nese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio ch.n R&D Centre for ch.nese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mech.nisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TnBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench.:naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each.mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pnd overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and ch.mokines such.as C-C motif ch.mokine 2 and interleukin-10 of tumors were significantly downregulated(Pn combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines ch.nese medicine tumor microenvironment

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.ch.ng Carolyn A.Cohen Daniel leung Xiwei Wang Xiaofeng Mu Yuet ch.ng Tsun Ming lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.tsang Sara ch.othai Tsz ch.n Kwan John K.C.Li Karl C.K.ch.n Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man ch.n Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina Sch.ol of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research.Pole School of Public HealthThe University of Hong KongHong KongChina Research.Institute for Bioresources and Biotech.ology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(nCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SnM[sum of individual(S),nucleocapsid protein(n),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SnM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),n-specific IL-2^(+)CD4^(+),n-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRnT90),PRnT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research.to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BnT162b2 in adolescents

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Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen Daniel leung Jaime S.Rosa Duque Samuel M.S.ch.ng Yuet ch.ng Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man ch.n Leo C.H.tsang Karl C.K.ch.n John K.C.Li Leo L.H.Luk Sara ch.othai Kelvin K.H.Kwan nym Coco ch. Masashi Mori Trushar Jeevan Ahmed Kandeil Rich.rd JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research.Pole School of Public HealthThe University of Hong KongHong KongChina Sch.ol of Public Health The University of Hong KongHong KongChina Research.Institute for Bioresources and Biotech.ology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BnT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(nCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BnT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFn-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFn-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BnT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

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Evolution

明日风尚 2009年第4期 135-140页

作者： Adele leung Taylor U n Workshop Winky tsang(i face)

~~（共6页)

关键词： shoes clothing Label

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Beauty Unplugged

明日风尚 2009年第2期 144-149页

作者： Adele leung Taylor U n Workshop Winky tsang(i face)

~~（共6页)

关键词：屯户 laura

Subtle side ch.in modification of triphenylamine‐based polymer hole‐transport layer materials produces efficient and stable inverted perovskite solar cells

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Interdisciplinary Materials 2022年第2期1卷 281-293页

作者： Yue-Min Xie Qin Yao Qifan Xue Zixin Zeng Tianqi niu yingzhi Zhou Ming-Peng Zhuo Sai-Wing tsang Hin-Lap Yip Yong Cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouP.R.China Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates(South ch.na University of Tech.ology) GuangzhouP.R.China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina Sch.ol of Energy and Environmental Science City University of Hong KongKowloonHong KongChina

Polymer hole-transport layers(HTLs)are critical components of inverted perovskite solar cells(IPVSCs).Triphenylamine derivatives PTAA(poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine])and Poly-TPD(poly[n,n′-bis(4-butylphenyl)-n,n′-bis(phenyl)benzidine])have been widely adopted as hole-transport materials due to their perovskite passivation effects and suitable energy ***,the passivation mech.nism(i.e.,the functional group responsible for perovskite passivation)of triphenylamine derivative polymers remains unclear,hindering the development and application of this polymer ***,we develop a novel Poly-TPD derivative,S-Poly-TPD,by replacing the n-butyl functional group of Poly-TPD with an isobutyl group to explore the influence of alkyl groups on HTL performance and top-deposited perovskite *** with Poly-TPD,the increased ch.(3)-terminal unit density and the decreased spatial distance between the-ch.ch.(3) and-ch.(2)-ch.(3) units and the benzene ring in S-Poly-TPD not only enhanced the hole-transport ability but also improved the perovskite passivation effect,revealing for the first time the role of the alkyl groups in perovskite *** a result,the S-Poly-TPD-based IPVSCs demonstrated high power-conversion efficiencies of 15.1% and 21.3% in wide-bandgap[MAPbI_(2)Br(SCn)0.12]and normal-bandgap[(FAPbI_(3))0.92(MAPbBr_(3))0.08]devices,respectively.

关键词： alkyl group inverted perovskite solar cells(IPVSCs) perovskite passivation polymer hole transport layers(HTLs) Poly-TPD,PTAA

BAHA在鼻咽癌放疗术后伴中耳流脓患者中的应用

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BAHA在鼻咽癌放疗术后伴中耳流脓患者中的应用