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Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives

World Journal of Gastroenterology 2010年第45期16卷 5732-5738页

作者： Huseyin Demirsoy Kamil Ozdil Ozdal Ersoy Besir Kesici cetin karaca Canan Alkim Nihat Akbayir Levent Kamil Erdem Mehmet Derya Onuk Hulya Tugrul Beyzadeoglu Department of Gastroenterology Sisli Etfal Training and Research Hospital34377 IstanbulTurkey Hulya Tugrul Beyzadeoglu Institute of Hygiene34020 IstanbulTurkey

AIM: To identify the role of anti-pancreatic antibody (PAB) in the diagnosis of inflammatory bowel diseases (IBD) among Turkish patients, and its frequency in firstdegree ***: PAB and anti-Saccharomyces cerevisiae (ASCA) were examined in serum samples of 214 subjects including patients with Crohn's disease (CD, n = 64), ulcerative colitis (UC, n = 63), first-degree relatives of patients with CD (n = 25), first-degree relatives of patients with UC (n = 28),and a control group with gastrointestinal symptoms other than (IBD) (n = 34) by indirect immunofluorescence Positivity of PAB and ASCA was compared in terms of Vienna classification, disease activity and medications ***: In terms of PAB positivity, no difference was found between patients with CD (14.1%) and UC (7.9%) however, significant difference was observed between patients with CD and subjects in the control group (P 150 (P < 0.05).CONCLUSION: PAB is valuable in the diagnosis of IBD rather than CD, but cannot be used alone for diagnostic purposes. PAB is not superior to ASCA in CD diagnosis and in detecting CD among relatives of patients with CD.

关键词： Anti-pancreatic antibody Anti-Saccharomyces cerevisiae antibody Crohn’s disease Ulcerative colitis Inflammatory bowel disease

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Terry's nail: an overlooked physical finding incirrhosis

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 109-109页

作者： Bulent Baran Ozlem Mutluay Soyer cetin karaca Department of Gastroenterohepatology Istanbul Faculty of MedicineIstanbul University

The Editor welcomes submissions for possible publication in the Letters to the Editor *** commenting on an article published in the Journal or other interesting pieces will be considered if they are received within 6 ... 详细信息

关键词： an overlooked physical finding incirrhosis Terry’s nail

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Current state and clinical outcome in Turkish patients with hepatocellular carcinoma

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World Journal of Hepatology 2018年第1期10卷 51-61页

作者： Omer Ekinci Bulent Baran Asli Cifcibasi Ormeci Ozlem Mutluay Soyer Suut Gokturk Sami Evirgen Arzu Poyanli Mine Gulluoglu Filiz Akyuz cetin karaca Kadir Demir Fatih Besisik Sabahattin Kaymakoglu Department of Gastroenterohepatology Istanbul Faculty of Medicine Istanbul University Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Department of Gastroenterology Ko? University Hospital Department of Radiology Istanbul Faculty of Medicine Istanbul University Department of Pathology Istanbul Faculty of Medicine Istanbul University

AIM To investigate clinical, etiological, and prognostic features in patients with hepatocellular *** Patients with hepatocellular carcinoma who were followed-up from 2001 to 2011 were included in the study. The diagnosis was established by histopathological and/or radiological criteria. We retrospectively reviewed clinical and laboratory data, etiology of primary liver disease, imaging characteristics and treatments. ChildPugh and Barcelona Clinic Liver Cancer stage was determined at initial diagnosis. Kaplan-Meier survival analysis was done to find out treatment effect on survival. Risk factors for vascular invasion and overall survival were investigated by multivariate Cox regression analyses. RESULTS Five hundred and forty-five patients with hepatocellular carcinoma were included in the study. Viral hepatitis was prevalent and 68 patients either had normal liver or were non-cirrhotic. Overall median survival was 16(13-19) mo. Presence of extrahepatic metastasis was associated with larger tumor size(OR = 3.19, 95%CI: 1.14-10.6). Independent predictor variables of vascular invasion were AFP(OR = 2.95, 95%CI: 1.38-6.31), total tumor diameter(OR = 3.14, 95%CI: 1.01-9.77), and hepatitis B infection( OR = 5.37, 95 % CI : 1.23-23.39). Liver functional reserve, tumor size/extension, AFP level and primary treatment modality were independent predictors of overall survival. Transarterial chemoembolization(HR = 0.38, 95%CI: 0.28-0.51) and radioembolization(HR = 0.36, 95%CI: 0.18-0.74) provided a comparable survival benefit in the real life setting. Surgical treatments as resection and transplantation were found to be associated with the best survival compared with loco-regional treatments(log-rank, P < 0.001).CONCLUSION Baseline liver function, oncologic features including AFP level and primary treatment modality determines overall survival in patients with hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Cirrhosis Alfafetoprotein Prognosis Treatment Survival

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What is the impact of capsule endoscopy in the long term period?

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World Journal of Gastrointestinal Endoscopy 2016年第7期8卷 344-348页

作者： Asli Ormeci Filiz Akyuz Bulent Baran Suut Gokturk Tugrul Ormeci Binnur Pinarbasi Ozlem Mutluay Soyer Sami Evirgen Umit Akyuz cetin karaca Kadir Demir Sabahattin Kaymakoglu Fatih Besisik Division of Gastroenterohepatology Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Department of Radiology Medipol University Department of Gastroenterology Yeditepe Univer-sity

AIM: To assess the clinical impact of capsule endoscopy(CE) in the long-term follow-up period in patients with obscure gastrointestinal bleeding(OGIB). METHODS: One hundred and forty-one patients who applied CE for OGIB between 2009 and 2012 were retrospectively analyzed, and this cohort was then questioned prospectively. Demographic data of the patients were determined via the presence of comorbid diseases, use of non-steroidal anti-inflammatory drugs anticoagulant-antiaggregant agents, previous diagnostic tests for bleeding episodes, CE findings, laboratory tests and ***: CE was performed on 141 patients becauseof OGIB. The capsule was retained in the upper gastrointestinal(GI) system in two of the patients, thus video monitoring was not achieved. There were 139 patients [62% male, median age: 72 years(range: 13-93 years) and a median follow-up duration: 32 mo(range: 6-82 mo)]. The overall diagnostic yield of CE was 84.9%. Rebleeding was determined in 40.3%(56/139) of the patients. The rebleeding rates of patients with positive and negative capsule results at the end of the follow-up were 46.6%(55/118) and 4.8%(1/21), respectively. In the multivariate analysis, usage of NSAIDs, anticoagulant-antiaggregant therapies(OR = 5.8; 95%CI: 1.86-18.27) and vascular ectasia(OR = 6.02; 95%CI: 2.568-14.146) in CE were detected as independent predictors of rebleeding. In the univariate analysis, advanced age, comorbidity, and overt bleeding were detected as predictors of ***: CE is a reliable method in the diagnosis of obscure GI bleeding. Negative CE correlated with a significantly lower rebleeding risk in the long-term follow-up period.

关键词： Capsule endoscopy Small bowel Obscure gastrointestinal bleeding Rebleeding

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Coincidence of three solid tumors in a patient with multiple myeloma

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Chinese Medical Journal 2013年第6期126卷 1186-1187页

作者： Muzaffer Keklik Serdar Sivgin Kemal Deniz Halit karaca Olgun Kontas Suleyman Balkanli Celalettin Eroglu Ummuhan Abdulrezzak Gulfugan Kuzu Leylagul Kaynar Mustafa cetin Ali Unal Bulent Eser Department of Hematology Faculty of Medicine Erciyes University Kavseri Turkey Department of Pathology Faculty of Medicine Erciyes University Kavseri Turkey Department of Medical Oncology Faculty of Medicine Erciyes University Kavseri Turkey Department of Radiation Oncology Faculty of Medicine Erciyes University Kavseri Turkey Department of Nuclear Medicine Faculty of Medicine Erciyes University Kavseri Turkey Department of Internal Medicine Faculty of Medicine Erciyes University Kavseri Turkey

Multiple primary cancers （MPC） are specific .malignant tumors type, manifesting as more than one primary tumor diagnosed in the same patient, either simultaneously or sequentially. The diagnostic criteria include： the cancer must be clearly malignant as determined by histological evaluation; each cancer must be geographically separate and distinct;

关键词： colon cancer lung cancer multiple myeloma multiple primary cancer

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