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Exploring the reproductive ecology of the tropical semifossorial snake Ninia atrata

Zoological Research 2020年第2期41卷 157-171页

作者： Teddy Angarita-Sierra cesar Alejandro Lopez-Hurtado Tropical Organism Biology Research Group Universidad Nacional de ColombiaBogota111321Colombia Yoluka ONG Fundacion de Investigacion en Biodiversidad y ConservacionBogota110931Colombia Vicerrectoria de Investigacion Universidad Manuela BeltranBogota110231Colombia

Based on histological analyses and field studies,this research describes the reproductive ecology of a population of Ninia atrata snakes inhabiting an oil palm ***,through a multivariate approach,we explored the main drivers of reproductive output in *** showed that prey abundance and food intake were crucial variables contributing to reproductive *** linear regression models showed that neonates had high sensitivity(R2=55.29%)to extreme changes in climate,which was strongly related to slug and snail abundance variability and microhabitat *** cycles were markedly different between the sexes,being continuous in males and cyclical in *** this variation,reproductive cycles at the population level were seasonal *** recruitment of neonates all year,multiple clutches,high mating frequency,and continuous sperm production characterized the reproductive phenology of *** addition,a significant number of previtellogenic females presented oviductal sperm as well as uterine scars,suggesting a high precocity in the *** main drivers of reproductive output also differed between the *** females,clutch size and secondary follicle variability were highly related to stomach bolus volume,fat body area,and body *** males,height of piles of palm leaves and body mass,rather than intrinsic reproductive traits,were the main drivers of sperm ***,in both cases,the relationship between body mass,prey abundance,and food intake suggests that *** follows the income breeding strategy to compensate for reproductive costs and to maximize fitness.

关键词： Continuous male reproduction Clutch mass Income breeding Iteroparity Spermatogenesis Oogenesis Reproductive effort El Nino-Southern Oscillation(ENSO)

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Regulation of multidrug resistance by microRNAs in anti-cancer therapy

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Acta Pharmaceutica Sinica B 2017年第1期7卷 38-51页

作者： Xin An cesar Sarmiento Tao Tan Hua Zhu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Surgery Davis Heart and Lung Research InstituteThe Ohio State University Wexner Medical Center

Multidrug resistance(MDR) remains a major clinical obstacle to successful cancer *** diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly *** RNAs(mi RNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins *** evidence shows that mi RNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of mi RNAs in regulating MDR in cancer treatment.

关键词： Multidrug resistance miRNA Cancer Therapy Autophagy Redox Homeostasis

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Analysis of three-dimensional vortexes below the free surface in a continuous casting mold

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 397-406页

作者： cesar A.Real-Ramirez Jesus I.Gonzalez-Trejo Universidad Autonoma Metropolitana-Azcapotzalco.San Pablo 180 02200Mexico CityMexico

To study fluctuations of the free surface of liquid steel in the mold,two different models with the same casting conditions but different thicknesses were employed to analyze the hydrodynamic behavior at the top of the *** first model was a standard thickness slab,and the second had a thickness three times *** is found with the second model that above the plane formed by the steel jets,it is possible to observe four three-dimensional vortexes that interact with the submerged entry nozzle（SEN）and mold *** using a biphasic model to simulate the interface between the liquid and air inside the mold,the flow asymmetry and the fluctuations of the free surface can be clearly observed.

关键词： continuous casting molds flow patterns three dimensional vortes mathematical models computer simulation

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Fuzzy C-means Rule Generation for Fuzzy Entry Temperature Prediction in a Hot Strip Mill

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Journal of Iron and Steel Research International 2016年第2期23卷 116-123页

作者： Jose Angel BARRIOS cesar VILLANUEVA Alberto CAVAZOS Rafael COLAS Mechanical and Electrical Engineering Faculty Autonomous University of Nuevo LeonSan Nicolas de los Garza 66451Nuevo LeonMexico Hot Rolling Department Ternium ChurubuscoMonterrey 64000Nuevo LeonMexico

Variable estimation for finishing mill set-up in hot rolling is greatly affected by measurement uncertainties, variations in the incoming bar conditions and product changes. The fuzzy C-means algorithm was evaluated for rule base generation for fuzzy and fuzzy grey-box temperature estimation. Experimental data were collected from a real- life mill and three different sets were randomly drawn. The first set was used for rule-generation, the second set was used for training those systems with learning capabilities, while the third one was used for validation. The perform- ance of the developed systems was evaluated by five performance measures applied over the prediction error with the validation set and was compared with that of the empirical rule-base fuzzy systems and the physical model used in plant. The results show that the fuzzy C-means generated rule-bases improve temperature estimation; however, the best results are obtained when fuzzy C-means algorithm, grey-box modeling and learning functions are combined. Application of fuzzy C-means rule generation brings improvement on performance of up to 72%.

关键词： gray-box modeling ANFIS hot rolling temperature estimation fuzzy C-means rule base generation

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Neurovascular unit permeability in neuroinflammatory diseases:a common pathologic and therapeutic target?

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Neural Regeneration Research 2023年第8期18卷 1715-1716页

作者： Molly Monsour cesar V.Borlongan University of South Florida Morsani College of Medicine TampaFLUSA Department of Neurosurgery and Brain Repair University of South FloridaMorsani College of MedicineTampaFLUSA

Deleterious inflammatory cell invasion has been implicated in neurological diseases,partly manifesting as a leaky blood-central nervous system ba rrier(BCNSB)(Huang et al.,2021).Uncovering the perturbations of the neurovascular unit(NVU)may reveal the role of detrimental proinflammatory cells and signaling molecules in disrupting the central nervous system immuneprivileged environment.

关键词： invasion inflammatory diseases

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Modern data sources and techniques for analysis and forecast of road accidents:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第4期7卷 432-446页

作者： Camilo Gutierrez-Osorio cesar Pedraza Departamento de Ingeniena de Sistemas e Industrial Universidad Nacional de ColombiaBogotaColombia

Road accidents are one of the most relevant causes of injuries and death worldwide,and therefore,they constitute a significant field of research on the use of advanced algorithms and techniques to analyze and predict traffic accidents and determine the most relevant elements that contribute to road *** research of road accident prediction aims to respond to the challenge of offer tools to generate a more secure mobility environment,and ultimately,save *** paper aims to provide an overview of the state of the art in the prediction of road accidents through machine learning algorithms and advanced techniques for analyzing information,such as convolutional neural networks and long short-term memory networks,among other deep learning ***,in this article,a compendium and study of the most used data sources for the road accident forecast is *** a classification is proposed according to its origin and characteristics,such as open data,measurement technologies,onboard equipment and social media *** the analysis of the information,the different algorithms employed to make predictions about road accidents are listed and compared,as well as their applicability depending on the types of data being analyzed,along with the results obtained and their ease of interpretation and *** best results reported by the authors are obtained when two or more analytic techniques are combined,in such a way that analysis of the obtained results is *** the future challenges in road traffic forecasting lies the enhancement of the scope of the proposed models and predictions by the incorporation of heterogeneous data sources,that include geo spatial data,information from traffic volume,traffic statistics,video,sound,text and sentiment from social media,that many authors concur that can improve the precision and accuracy of the analysis and predictions.

关键词： Traffic engineering Data analysis Machine learning Road accident forecasting Traffic accident prediction

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Using risk-benefit analysis to control Salmonella in chicken meat

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Food Quality and Safety 2021年第4期5卷 375-387页

作者： Eduardo cesar Tondo Claudia Titze Hessel Gonçalves Department of Food Science Institute of Food Science and Technology of the Federal University of Rio Grande do Sul-ICTA/UFRGSPorto AlegreRSBrazil

We have created a risk-benefit analysis(RBA)model to assist in food safety decision-making by analyzing Salmonella control in Brazilian chicken ***,we described the issues in a risk profile and used a 5x5 matrix to rank the risks associated with *** then classified the magnitude of benefits and costs of control measures using another ***,we verified the beneficial effects of recommended control measures using Quantitative Microbiological Risk Assessment(QMRA).The RBA classified Salmonella contamination as risk 6,indicating that control measures should be taken in the short and medium *** also recommended the adoption of biosecurity measures on farms to reduce the prevalence of Salmonella in birds,better control of carcass washings and chiller tank management,and information placement on packages and campaigns to raise the awareness of the population about the need to control Salmonella contamination before *** the other hand,it did not recommend better controls at scalding and *** confirmed the beneficial effects of the recommended control *** example,as Salmonella prevalence in poultry increased from 4.04 per cent to 50 per cent,the risk of infection per serving also increased from 0.0080 to *** better controls in washings and chiller tank management did not affect the risk of infection,it reduced Salmonella counts on *** assume that the presence of Salmonella on carcasses was due to improper thermal processing or cross-contamination,which increased the risk from 0.0080 to *** RBA demonstrated the logic involved in the adoption of control measures,and this can be helpful in the risk management of food safety issues.

关键词： Risk management risk perception food safety

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Solution to the quadratic assignment problem usingsemi-Lagrangian relaxation

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Journal of Systems Engineering and Electronics 2016年第5期27卷 1063-1072页

作者： huizhen zhang cesar beltran-royo bo wang liang ma ziying zhang school of management university of shanghai for science and technologyShanghai 200093China department of statistics and operations research rey juan carlos universityMostoles(Madrid)28933Spain school of materials engineering shanghai university of engineering scienceShanghai 201620China

The semi-Lagrangian relaxation （SLR）, a new exactmethod for combinatorial optimization problems with equality constraints,is applied to the quadratic assignment problem （QAP）.A dual ascent algorithm with finite convergence is developed forsolving the semi-Lagrangian dual problem associated to the *** perform computational experiments on 30 moderately difficultQAP instances by using the mixed integer programming solvers,Cplex, and SLR＋Cplex, respectively. The numerical results notonly further illustrate that the SLR and the developed dual ascentalgorithm can be used to solve the QAP reasonably, but also disclosean interesting fact： comparing with solving the unreducedproblem, the reduced oracle problem cannot be always effectivelysolved by using Cplex in terms of the CPU time.

关键词： quadratic assignment problem (QAP) semi-Lagrangian relaxation (SLR) Lagrangian relaxation dual ascentalgorithm.

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Installing a prototype wind turbine to produce energy in Antarctica to allow a permanent Colombian scientific base to be established

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Advances in Polar Science 2020年第4期31卷 258-273页

作者： cesar Lozano JIMENEZ Conceptual Design of a UAV type VTOL(FAC-USB) Department of AeronauticsGraduate Program in Aeronautical EngineeringSan Buenaventura University(USB)Cr 8H#172-20BtáD.CCund6671090Colombia Administration of Aeronautical Maintenance Personal(FAC-EPFAC)/Department of Aeronautical Logistics Graduate Program in Specialist Aeronautical logisticsPostgraduate School of Colombian Air Force University(EPFAC)Cr11102-50 P 34 Ed EsdegueBtá6206518Colombia

This study was performed to support an expeditionary team of Colombian scientists seeking to promote and undertake research in various scientific fields in *** work was part of the Colombian Antarctic Program,which comprises various projects intended to lead to a permanent Colombian scientific base being established in the *** first step involved installing a Colombian-made wind turbine to produce electricity at a permanent *** aeolian turbine was designed to provide sufficient electricity to illuminate and heat a small *** turbine was constructed using readily accessible materials but taking the Madrid Protocol environmental regulations into *** project was performed at the Argentinian Antarctic Marambio Station on Seymour Island,off the Antarctic *** initial field study performed in 2015 was the first of three phases of the *** the initial phase,local meteorological data were gathered to support development of a prototype turbine and to allow a design to be selected that was robust enough for the extreme environmental *** wind turbine was then constructed in *** second phase involved transporting the turbine to Antarctica and installing it at the Marambio Station in ***,the physical conditions of structural and electronic components of the turbine were carefully inspected at the beginning of 2020(after the turbine had operated continually for^2 years)to allow repairs to be made and any necessary re-engineering to be performed.

关键词： wind energy renewable energy Marambio Station Seymour Island Colombia Antarctic Program

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Modal energy transfer by thermally induced refractive index gratings in Yb-doped fibers

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Light(Science & Applications) 2018年第1期7卷 483-494页

作者： Christoph Stihler cesar Jauregui Andreas Tünnermann Jens Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universität JenaAlbert-Einstein-Str.1507745 JenaGermany Helmholtz-Institute Jena Fröbelstieg 307743 JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering Albert-Einstein-Str.707745 JenaGermany

Thermally induced refractive index gratings in Yb-doped fibers lead to transverse mode instability(TMI)above an average power threshold,which represents a severe problem for many *** obtain a deeper understanding of TMI,the evolution of the strength of the thermally induced refractive index grating with the average output power in a fiber amplifier is experimentally investigated for the first *** investigation is performed by introducing a phase shift between the refractive index grating and modal interference pattern,which is obtained by applying a pump power variation to the fiber *** is demonstrated that the refractive index grating is sufficiently strong to enable modal energy coupling at powers that are significantly below the TMI threshold if the induced phase shift is sufficiently *** experiments indicate that at higher powers,the refractive index grating becomes more sensitive to such phase shifts,which will ultimately trigger ***,the experimental results demonstrate beam cleaning above the TMI threshold via the introduction of a positive phase *** finding paves the way for the development of a new class of mitigation strategies for TMI that are based on controlling the phase shift between the thermally induced refractive index grating and modal interference pattern.

关键词： amplifier pump refractive

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