检索结果-南通市图书馆

Comparison of Three Experimental Models for Rat Osteoarthritis Induction

Journal of Biosciences and Medicines 2016年第12期4卷 62-69页

作者： Henrique Ribeiro Rodrigues-Neto Edilson Ferreira Andrade-Junior Denilson Jose Silva Feitosa-Junior André Lopes Valente Thiago cesar Xavier Bianca Caroline do Nascimento Alho Renan Kleber Costa Teixeira Fabio Vidal Moriya Rui Sérgio Monteiro de Barros Department of Orthopaedics and Traumatology Porto Dias Hospital Bel&eacute m Brazil Experimental Surgery Laboratory Par&aacute State University Bel&eacute m Brazil

Background: Osteoarthritis is a slowly progressive and debilitating disease with high prevalence in adult population. Knee is one of the joints most affected by this disorder. There are several models for animals’ osteoarthritis induction, however it is not identified any paper that compares these techniques. The present study was aimed to define the most appropriate model for rats osteoarthritis induction. Material and Methods: 40 Wistar rats were distributed into 4 groups of 10 animals each: normality group (NG);meniscectomy group (MG);quinolone group (QG) and iodoacetate group (IG). Radiographic images of the rat’s knees were analyzed as well as the amount of chondrocytes in the epiphyseal and articular cartilage. Results: In the radiographic analysis, there was a low correlation between the raters. Regarding the amount of chondrocytes in the epiphyseal cartilage, it was noticed that the IG and QG groups had fewer chondrocytes than NG, in contrast to MG that reported similar results to normality (p > 0.05). There was no significant difference between IG and QG groups (p > 0.05). Regarding the amount of chondrocytes in articular cartilage, it was noticed that the IG group showed fewer chondrocytes than NG (p 0.05). There was no significant difference between QG and MG groups (p > 0.05). Conclusion: Intraarticular injection of iodoacetate in rats is the model with greatest effect on reduction of chondrocytes amount.

关键词： Osteoarthritis Knee Joint Experimental Arthritis Animal Disease Models Rats

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

引用

Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Impact of the Essential Fatty Acids (EFA) in Human Health

引用

Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 98-104页

作者： Alberto Krayyem Arbex Vagner Rosa Bizarro Julio cesar Salles Santos Lis Marina Mesquita Araújo Ana Luísa Conceicao de Jesus Minelli Salles Alves Fernandes Marcela Miranda Salles Denise Rosso Tenório Wanderley Rocha Aline Marcadenti Division of Endocrinology Faculdade IPEMED de Ciências Médicas (IPEMED) Rio de Janeiro Brazil Visiting Scientist of the Harvard School of Public Health Harvard University Boston USA Postgraduate Studies Program in Cardiology Instituto de Cardiologia/Fundacao Universitária de Cardiologia do Rio Grande do Sul (IC/FUC) Porto Alegre Brazil Department of Nutrition Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA) Porto AlegreBrazil

Linoleic (LA) and α-linolenic acids (ALA) are considered essential fatty acids (EFA) because they are not produced by the human body. This way, EFAs sources must come from the diet. The primary dietary source of n-3 fatty acids is ALA, found in seeds and seed oils. Other important sources are fish oils such as tuna, salmon and herring. Currently, numerous studies suggest possible benefits of essential fatty acids in human health, such as in cardiovascular, cognitive and eye health, and also during pregnancy and childhood. This paper also discusses the impact of fatty acids in human metabolism, and the available evidence regarding its risks. It addresses the relevant debate regarding a general ban of trans fatty acids (TFA) from the world food market, because of the cardiovascular risks associated with its consumption.

关键词： Fatty Acids Linoleic Acid Alpha-Linolenic Acid Cardiovascular Health Trans Fatty Acids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

D-Transposition of Great Arteries in a Primigravida of 35 Years Old-Case Report and Literature Review

引用

Journal of Pharmacy and Pharmacology 2018年第7期6卷 674-678页

作者： Ali Kassen Omais Camila Martines Mello Nathalia Suzan Camarao Martins Natália Regina Alécio Mettelo Diehl Alethéia Carpine Favini Schefer Felipe Amorim Zarour Julio cesar de Oliveira Janice Lanzarin Gisele do Couto Oliveira Department of Cardiology General University Hospital of Cuiabá Cuiabá 78025-000 Mato Grosso Brazil Department of Pediatry General University Hospital of Cuiabá Cuiabá 78025-000 Mato Grosso Brazil

This is a case report with discussion of the maternal-fetal outcome of pregnant women with uncorrected transposition of the great arteries （TGA） associated with pulmonary arterial hypertension and a large ventricular septal defect. This case draws attention to the severity of the pathology and maternal symptoms prior to gestation, and how an adequate clinical management of both obstetrics and cardiology can provide a favorable outcome for mother and fetus.

关键词： Transposition of great arteries congenital heart disease bosentan pregnancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ursolic Acid Derivatives Induced Apoptosis and Reduces the NF-κB in Human Lung Adenocarcinoma Cells

引用

Journal of Cancer Therapy 2019年第10期10卷 863-876页

作者： Elaine Carlos Scherrer Ydia Mariele Valadares Caio cesar Souza Alves Gabriella Freitas Ferreira Marcela Pereira Leao Jessica Aline Soares Fernando Sa Silva Alessandra Paula Carli Oswaldo Cardoso Jr. Fabiana Simao Machado Sandra Bertelli Ribeiro Castro Life Sciences Institute Federal University of Juiz de ForaGovernador ValadaresMGBrazil Faculty of Medicine Federal University of the Valleys of Jequitinhonha and MucuriTeofilo OtoniMGBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo HorizonteMGBrazil

Lung cancer is the major cause of death in the neoplastic diseases. In spite of the advances in the chemotherapy, the lung cancer treatments are still complex and costly, being necessary the seeking of new drugs. In this context, the ursolic acid (UA) becomes the target of studies that investigate its antitumor potential and, thus, structural modifications can enhance its biological activities. Eight UA semisynthetic derivative compounds (UAD1-8) were synthesized and evaluated their cytotoxic activity against human alveolar adenocarcinoma cells (A549). UAD1, UAD3, UAD5, UAD6 and UAD8 were able to reduce the viability of the A549 cells. Only UAD1 and UAD6 reduced the viability at 24 h, and only UAD3 didn’t reduce the NF-κB expression. The compound UAD1 showed the greater apoptosis induction. Moreover, the compound UAD1 showed better results than UA in all assays. The present study shows, for the first time, the action of these compounds in the apoptotic effect, in the expression of NF-κB and in the A549 cell line. The ursolic acid derivatives showed substantial results in the apoptosis, cytotoxicity and NF-κB inhibition of A549 cells, and further studies are necessary for the development of possible new therapeutic drugs.

关键词： Ursolic Acid Apoptosis NF-κB A549 Cells Tumoral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

引用

Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da Costa Sousa Gabriela Conceiçao de Almeida Danilo cesar Martins Mota Rosiane Andrade da Costa Simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo Daniel Pletzer Letícia Chaves de Souza Glaucia Schuindt Teixeira Renato M.Silva Robert E.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Notification Oriented and Object Oriented Paradigms Comparison via Sale System

引用

Journal of Software Engineering and Applications 2012年第9期5卷 695-710页

作者： Jean M.Simao Danillo L.Belmonte Adriano F.Ronszcka Robson R.Linhares Glauber Z.Valenca Roni F.Banaszewski Joao A.Fabro cesar A.Tacla Paulo C.Stadzisz Márcio V.Batista Graduate School in Electrical Engineering&Industrial Computer Science(CPGEI) Federal University of Technology-ParanáCu-ritibaBrazil Graduate School of Applied Computing(PPGCA) Federal University of Technology-ParanáCuritibaBrazil

This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow causal-knowledge organization and decoupling better than standard solutions based upon current paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and lesser flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease software performance and processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based on sequential evaluation searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based on small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. This paper presents a quantitative comparison between two equivalent implementations of a sale system, one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in C++ and other developed according to the principles of NOP based on a NOP framework in C++. The results showed that NOP implementation obtained quite equivalent results with respect to OOP implementation. This happened because the NOP framework uses considerable expensive data-structures over C++. Thus, it is necessary a new compiler to NOP in order to actually use its potentiality.

关键词： Notification Oriented Paradigm Notification Oriented Inference NOP and OOP Comparison

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The capabilities of the EISCAT Svalbard Radar for inter-hemispheric coordinated studies

引用

Chinese Journal of Polar Science 2002年第1期13卷 55-66页

作者： Tom Grydeland 1, Anja Strmme 1, Tony van Eyken 2 and cesar La Hoz 1 1 Department of Physics, University of Troms, Troms N 9037, Norway 2 EISCAT Scientific Association, Currently at SRI International, Menlo Park , California 94025, USA Department of Physics University of Tromsφ Tromsφ N-9037 Norway EISCAT Scientific Association Currently at SRI International Menlo Park California 94025 USA

In this article we want to present the EISCAT Svalbard Radar (ESR) in some detail, as well as some of the instruments of interest for ionospheric and magnetospheric research that are located in the vicinity of it. We particularly describe how this instrument cluster, close to the geomagnetic conjugate point of the Chinese Antarctic Zhongshan Station, can contribute to inter hemispheric coordinated studies of the polar ionosphere.

关键词： EISCAT Incoherent Scatter Radar conjugate studies.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Game Comparative Study:Object-Oriented Paradigm and Notification-Oriented Paradigm

引用

Journal of Software Engineering and Applications 2012年第9期5卷 722-736页

作者： Jean M.Simao Danillo L.Belmonte Glauber Z.Valenca Márcio V.Batista Robson R.Linhares Roni F.Banaszewski Joao A.Fabro cesar A.Tacla Paulo C.Stadzisz Adriano F.Ronszcka Graduate School in Electrical Engineering&Industrial Computer Science(CPGEI) Federal University of Technology-ParanáCu-ritibaBrazil Graduate School of Applied Computing(PPGCA) Federal University of Technology-ParanáCuritibaBrazil

This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow better performance, causal-knowledge organization, and decoupling than standard solutions based upon usual paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and less flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease the software performance and the processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based upon sequential evaluation by searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based upon small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. In this context, this paper presents a quantitative comparison between two equivalent implementations of a computer game simulator (Pacman simulator), one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in C++ and other developed according to the principles of NOP. The results obtained from the experiments demonstrate, however, a quite lower performance of NOP implementation. This happened because NOP applications are still developed using a framework based on C++. Besides, the paper shows that optimizations in the NOP framework improve NOP program performance, thereby evidencing the necessity of developing a NOP language/compiler.

关键词： Notification Oriented Paradigm Notification Oriented Inference NOP and OOP Comparison

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

口内颌骨牵引成骨治疗颌骨畸形2例报告

引用

沈阳部队医药 2003年第1期16卷 59-62页

作者：朱力张熙恩刘兵惠勇刚李宁梁伟 William H.Bell cesar A.Guerrero Stephen Chu 第202医院口腔科 110003 北京医科大学口腔医学院颌面外科 Department of Oral Maxillofacial Surgery Baylor College of Dentistry The Texas A & M University System. Dallas Texas.

严重的颌骨发育不良因病情复杂,使修复重建治疗非常棘手。牵引成骨技术(distraction osteogenesis,简称DO技术)通过特殊的装置,使截开的骨断面之间在定向牵引力作用下产生新骨,并使骨段周围软组织同步生长。这一新技术的临床应用,为复... 详细信息

严重的颌骨发育不良因病情复杂,使修复重建治疗非常棘手。牵引成骨技术(distraction osteogenesis,简称DO技术)通过特殊的装置,使截开的骨断面之间在定向牵引力作用下产生新骨,并使骨段周围软组织同步生长。这一新技术的临床应用,为复杂颌骨畸形的矫正提供了一个新的途径。我们应用口内颌骨DO技术治疗2例常规外科手术难以矫治的颌骨发育畸形。

关键词：治疗颌骨畸形牵引成骨技术病例报告手术方法

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：