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Simultaneous Intravitreal Ranibizumab and Dexamethasone Implant Administration at the Same Setting in Eyes with Severe Diabetic Macular Edema

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Open Journal of Ophthalmology 2016年第2期6卷 112-118页

作者： Ali Osman Saatci Ziya Ayhan ceren Durmaz Engin Department of Ophthalmology Dokuz Eylul University Izmir Turkey

Aim: To share our experience in eyes with severe DME (exhibiting serous retinal detachment or large cysts) treated with simultaneous intravitreal ranibizumab and dexamethasone implant administration at the same setting as the first treatment step. Subjects and Results: Five eyes of three patients with DME who were either treatment naive or relatively undertreated were presented in this report. As optical coherence tomography exhibited serous retinal detachment or severe cystoid edema with large cysts, intravitreal ranibizumab and dexamethasone implant were simultaneously employed at the same setting as the first treatment step in those eyes. Panretinal photocoagulation was also commenced bilaterally a week after the start of injections when at least one eye had retinal neovascularization. Subsequent treatments of intravitreal ranibizumab and/or dexamethasone implant were administered. Patients were followed up for seven, eight and 13 months respectively. All five eyes achieved a relative anatomic stability and experienced visual improvement at the end of follow-up. Conclusion: In some cases with severe DME with or without proliferative diabetic retinopathy, simultaneous intravitreal ranibizumab and dexamethasone implant administration at the same setting may be a better option to initiate the treatment over mono ranibizumab treatment. A randomized study comparing the mono anti-VEGF therapy and mono dexamethasone implant administration with simultaneous treatment may outline the place of this type of therapy in the treatment armamentarium of severe DME.

关键词： Dexamethasone Implant Diabetic Macular Edema Optical Coherence Tomography Ozurdex Ranibizumab

Experimental models of cholesteatoma: A review

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World Journal of Otorhinolaryngology 2014年第4期4卷 23-27页

作者： Onur Ismi Murat unal Department of Otorhinolaryngology Faculty of Medicine University Hospital of Mersin 33343-?iftlikk?y Mersin Turkey

Cholesteatoma describes the keratinized, stratified squamous epithelium in the middle ear and mastoid, which has osteoclastic activity and is capable of bone resorption. Its origin is unknown and remains a topic of current investigation. In addition, ongoing studies are investigating new molecules for treatment. This review summarizes the various experimental models of cholesteatoma.

关键词： Animal Cholesteatoma Chronic otitis media Experimental Murine

Combination of allopurinol and hyperbaric oxygen therapy:A new treatment in experimental acute necrotizing pancreatitis?

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World Journal of Gastroenterology 2007年第46期13卷 6203-6207页

作者： Bilgin Comert Ahmet Turan Isik Sezai Aydin Ergun Bozoglu Bulent unal Salih Deveci Nuket Mas Esref Cinar Mehmet Refik Mas Division of Intensive Care Departments of Internal MedicineGulhane School of MedicineAnkara 06018Turkey Division of Geriatric Medicine Department of Internal MedicineGulhane School of MedicineAnkara 06018Turkey Department of Surgery Guven HospitalA.AyranciAnkara 06018Turkey Department of Surgery Numune Training HospitalSihhiyeAnkara 06018Turkey Department of Pathology Gulhane School of MedicineAnkara 06018Turkey Department of Anatomy Medical FacultyBaskent UniversityAnkara 06018Turkey Department of Infection Disease Gulhane School of MedicineAnkara 06018Turkey Department of Internal Medicine Gulhane School of MedicineAnkara 06018Turkey

AIM： To investigate the individual and combined effects of allopurinol and hyperbaric oxygen （HBO） therapy on biochemical and histopathological changes, oxidative stress, and bacterial translocation （BT） in the experimental rat acute pancreatitis （AP）. METHODS： Eighty-five Sprague-Dawley rats were included in the study. Fifteen of the eighty-five rats were used as controls （sham, Group I ）. AP was induced via intraductal taurocholate infusion in the remaining seventy rats. Rats that survived to induction of acute necrotizing pancreatitis were randomized into four groups. Group H received saline, Group m allopurinol, Group IV allopurinol plus HBO and Group v HBO alone. Serum amylase levels, oxidative stress parameters, BT and histopathologic scores were determined. RESULTS： Serum amylase levels were lower in Groups Ⅲ, Ⅳ and v compared to Group H （974 ± 110, 384 ± 40, 851 ＋ 56, and 1664 Ⅳ 234 U/L, respectively, P 〈 0.05, for all）. Combining the two treatment optionsrevealed significantly lower median [25-75 percentiles] histopathological scores when compared to individual administrations （13 [12.5-15] in allopurinol group, 9.5 [7-11.75] in HBO group, and 6 [4.5-7.5] in combined group, P 〈 0.01）. Oxidative stress markers were significantly better in all treatment groups compared to the controls. Bacterial translocation into the pancreas and mesenteric lymph nodes was lower in Groups m, iV and v compared to Group H （54%, 23%, 50% vs 100% for translocation to pancreas, and 62%, 46%, 58% vs 100% for translocation to mesenteric lymph nodes, respectively, P 〈 0.05 for all）. CONCLUSION： The present study confirms the benefit of HBO and allopurinol treatment when administered separately in experimental rat AP. Combination of these treatment options appears to prevent progression of pancreatic injury parameters more effectively.

关键词： Experimental pancreatitis AIIopurinol Hyperbaric oxygen

Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers

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World Journal of Hepatology 2023年第6期15卷 775-785页

作者： Betul unal Mennan Yigitcan Celik Elif Ocak Gedik Cumhur Ibrahim Bassorgun Gulsum Ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular(HCC)and intrahepatic cholangiocarcinoma(ICC),the most common primary tumors of the liver,are among the most important causes of cancer deaths *** patients with primary liver tumors are frequently diagnosed at an advanced stage and have high mortality,many efforts have been made to identify new markers to determine their behavior and treatment,similar to those in other solid organ ***,morphological assessment of tumor budding(TB)has been revealed as a promising prognostic finding to predict tumor behavior and survival across several different tumor ***,the TB score in colorectal cancer has been revealed as an important parameter in pathology report protocols to determine the course of the *** the liver,despite enormous data showing that many mechanisms involved in TB are associated with tumor behavior in both HCC and ICC,studies focusing on the role of TB in predicting the behavior and prognosis of these tumors have started to be investigated very *** purpose of this review is to present data about TB in primary tumors of the liver,pointing out the potential role of this parameter in determining the course of the disease,and emphasize the need to increase the number of further studies focusing on the evaluation of this parameter with an overview of the mechanisms involved in TB.

关键词： Tumor budding Hepatocellular carcinoma Cholangiocarcinoma Prognosis Liver cancer Epithelial-mesenchymal transition

Correction to:Applying multivariate‑fractionally integrated volatility analysis on emerging market bond portfolios

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Financial Innovation 2021年第1期7卷 37-38页

作者： Mustafa Demirel Gazanfer unal Treasury Department Isbank AG60313 Frankfurt am MainGermany Financial Economics Department Yeditepe University34755 IstanbulTurkey Administrative Sciences Bahcesehir University34349 IstanbulTurkey

Correction to:Demirel and unal Financial Innovation(2020)6:50 https://***/10.1186/s40854-020-00203-3 After publication of this article(Demirel and unal 2020),it is noticed that Table 7 contained an *** heading‘Long Term Bond Portfolio’should be replaced by two subheadings“MV-Optimal Portfolios Average(Short-Term)”and“MV-Optimal Portfolios Average(Long-Term)”.

关键词： heading Financial fractional

Better outcomes with desmopressin melt than enuretic alarm therapy in children with nocturnal enuresis during coronavirus disease 2019(COVID-19)

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Current Urology 2022年第2期16卷 70-73页

作者： Umut unal Hakan Anil Mehmet Eflatun Deniz Ediz Vuruskan Adem Altunkol Hakan Ercil Department of Urology Health Sciences UniversityAdana City Teaching and Research HospitalAdana01370Turkey Department of Urology Adana Seyhan State HospitalAdanaTurkey Department of Urology Kozan State HospitalAdanaTurkey

Objectives:This study aimed to investigate the effect of the coronavirus disease 2019(COVID-19)pandemic on the treatment of children with primary monosymptomatic nocturnal enuresis(MNE)with desmopressin melt versus an enuresis *** and methods:This study included 56 children with primary MNE who were taking desmopressin melt or using an *** anxiety levels were evaluated using the Social Anxiety Scale for *** both treatment methods,data from a 3-month bedwetting diary between the third and sixth months of the pre-pandemic treatment were compared with those assessed during the same period during the ***:Prior to the COVID-19 pandemic,the median 3-month mean frequency of MNE was 1(0-7.67)in children using desmopressin melt versus 1.33(0-6)in those using alarm treatment(p=0.095).During the COVID-19 pandemic period,the median monthly mean frequency of MNE was 1.33(0-7.33)in children using desmopressin melt versus 6(1.33-13)in those using alarm treatment(p<0.001).Conclusions:The COVID-19 pandemic and its accompanying psychological effects did not affect the treatment efficacy of desmopressin melt in children with primary MNE but did adversely affect that of enuresis alarms.

关键词： COVID-19 Desmopressin melt Enuresis alarm Nocturnal enuresis

Replacement of Process Scale Chromatography by Counterflow Membrane Cascades

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Advances in Bioscience and Biotechnology 2014年第11期5卷 915-923页

作者： Edwin N.Lightfoot Baris unal Department of Chemical Engineering University of WisconsinMadisonWIUSA Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Invention and innovation, always important, become ever more so in these fast changing and competitive times. They are in addition primarily dependent upon the dynamic behavior of the human mind. Our underlying purpose here is to examine these creative processes and to provide means to make them more effective. This is a timely effort because our understanding of perception and its interpretation by the human brain is very rapidly advancing. Even experimental insights into mental activity can be determined with rapidly increasing effectiveness. The framework of our discussion is that of evolution dynamics, and the scientific bases are rapidly developing neural sciences. However the bulk of our discussion deals with a specific example: the replacement of process scale chromatography by membrane-mediated steady counterflow in downstream processing. We do this because inventive activities must depend upon intimate knowledge of the systems available.

关键词： Invention Innovation Membrane Chromatography

Inflammatory bowel disease in Turkish children

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World Journal of Pediatrics 2015年第4期11卷 331-337页

作者： Murat Cakir Fatih unal Gonul Dinler Masallah Baran Hasan Ali Yuksekkaya Gokhan Tumgor Erhun Kasirga Ayhan Gazi Kalayci Sema Aydogdu Department of Pediatric Gastroenterology Hepatology and Nutrition Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Dortcelik Children Hospital BursaTurkey 19 Mayis University SamsunTurkey Tepecik Education and Research Hospital IzmirTurkey Necmettin Erbakan University KonyaTurkey Cukurova University AdanaTurkey Celal Bayar University ManisaTurkey Ege University IzmirTurkey

Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in ***:We analyzed the medical records of 127 children diagnosed with IBD(under 18 years old)between January 2004 and January 2012 in 8 pediatric gastroenterology ***:Of the 127 patients,90(70.9%)suffered from ulcerative colitis(UC),29(22.8%)from Crohn's disease(CD),and 8(6.3%)from IBD *** mean age of the 127 patients was 11.6±4.1 years,and 11.8%of the patients were below 5 years *** the patients,49.6%were male,and males were more predominant in patients with CD than in those with UC(72.4%vs.42.2%,P=0.008;a male/female ratio of 2.62 in CD,P=0.0016).Approximately one fifth of the patients had extra-intestinal manifestations and 13.3%of the patients had associated *** manifestations and associated diseases were more common in early onset disease[P=0.017,odds ratio(OR)=4.02;P=0.03,OR=4.1].Of the patients,15%had normal laboratory parameters including anemia,high platelet count,hypoalbuminemia,hypoferritinemia,and high sedimentation *** under receiver operation characteristics was used to predict pancolitis in patients with *** values of C-reactive protein,sedimentation rate and pediatric ulcerative colitis activity were 0.61(P=0.06),0.66(P=0.01)and 0.76(P=0.0001),***(4.4%)patients with UC underwent colectomy,andfi nally two(1.5%,95%confidence interval:0-3.7%)patients died from primary disease or ***:IBD is an increasing clinical entity in *** of IBD are similar to those in other populations,but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.

关键词： associated diseases Crohn's disease infl ammatory bowel disease outcome ulcerative colitis

Co-movement and Forecasting Analysis of Major Real Estate Markets by Wavelet Coherence and Multiple Wavelet Coherence

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Chinese Journal of Urban and Environmental Studies 2017年第2期5卷 37-54页

作者： Cengiz KARATAS Gazanfer unal Adil YILMAZ Financial Economics Graduate Program Yeditepe University

Wavelet coherence of time series provides valuable information about dynamic correlation and its impact on time scales. Here, the authors analyze the wavelet coherence of major real estate markets data, and take the USA, Hong Kong of China, Canada, Japan, and Developed Europe real estate market prices as time series. The wavelet coherence results show relationships among these markets, the correlations between the two and three markets(by multiple wavelet coherence) and how these relationships vary in the time-frequency space. These relationships allow the authors to build VARMA models of real estate data which produce forecasts with small errors.

关键词： Real estate markets REIT co-movement wavelet coherence MWC VARMA