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Seroprevalence of hepatitis E in adults in Brazil:a systematic review and metaanalysis

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Infectious Diseases of Poverty 2019年第1期8卷 97-97页

作者： Fatima Mitiko Tengan Gerusa M.Figueiredo Arielle K.S.Nunes carol Manchiero Bianca P.Dantas Mariana c.Magri Thamiris V.G.Prata Marisa Nascimento celso c.mazza Edson Abdala Antonio A.Barone Wanderley M.Bernardo Department of Infeaious and Parasitic Diseases School of MedicineUniversity of Sao Paulo(Universidade de Sao Paulo-USP)Sao PauloSPBrazil Laboratory of Viral Medical Research in Hepatology(Laboratorio de Investigagao Medica em Hepatologia por virus-LIM-47) Clinics HospitalSchool of MedicineUSPSao PauloSPBrazil 不详

Background:Hepatitis E virus(HEV)is a member of the Hepeviridae family;it has four main genotypes and one *** genotypes 1 and 2 cause epidemic hepatitis and are transmitted via water and the fecal-oral route,genotypes 3 and 4 are zoonotic In the various seroprevalence studies of hepatitis E in Brazil,the numbers reported vary widely and are difficult to *** aim of this study was to analyze existing seroprevalence studies of hepatitis E in adults in *** text:We searched the PubMed,Latin American and caribbean Health Sciences and Embase databases for studies published from inception to May 12,2018 concerning infection by HEV in Brazil without time period or language *** included studies that presented data concerning hepatitis E seroprevalence in adults in Brazil,had a sample size>50 patients and whose method used for the detection of anti-HEV was standardized and *** also evaluated the quality of the articles using a list of criteria that totalized 9 *** the 20 studies ultimately analyzed,10(50%)were from the southeast region of Brazil,3(15%)were from the central-west region,3(15%)were from the northern region,2(10%)were from the northeast region and 2(10%)were from the southern *** the quality evaluation of the studies,the mean score was 5.6(range:4-8).The estimated overall seroprevalence of HEV infection in the adult population was 6.0%(95%cI:5.0-7.0);in subgroup analyses,we observed that the prevalence of anti-HEV antibodies in blood donors was 7.0%(95%cI:5.0-8.0),whereas in the general population,it was 3.0%(95%cI:2.0-4.0).conclusions:The results of this systematic review indicate that there should be national investment in the prevention of hepatitis E virus infection in Brazil,including the implementation of improvements in basic sanitation and guidance regarding the appropriate handling of animal waste and the optimal cooking of vegetables,meat and their derivatives.

关键词： Hepatitis E Hepatitis E virus Brazil Prevalence Systematic review

current and future perspectives on acute-on-chronic liver failure: challenges of transplantation, machine perfusion, and beyond

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World Journal of Gastroenterology 2022年第48期28卷 6922-6934页

作者： Bianca Della Guardia Amanda P c S Boteon celso E L Matielo Guilherme Felga Yuri L Boteon Liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

Acute-on-chronic liver failure(AcLF)is a syndrome that occurs in patients with chronic liver disease and is characterized by acute decompensation,organ failure and high short-term *** due to the lack of universal diagnostic criteria,the actual AcLF prevalence remains unclear;nevertheless,it is expected to be a highly prevalent condition *** transplantation is an effective protective measure for selected AcLF *** liver transplantation,diagnosing and treating precipitant events and providing supportive treatment for organ failures are currently the cornerstone of AcLF *** new clinical specific therapies have been researched,more studies are necessary to assess safety and ***,future AcLF management strategies must consider measures to improve access to liver transplantation because the time window for this life-saving therapy is frequently ***,an urgent and global discussion about allocation and prioritization for transplantation in critically ill AcLF patients is needed because there is evidence suggesting that the current model may not portray their waitlist *** addition,while donor organ quality is meant to be a prognostic factor in the AcLF setting,recent evidence suggests that machine perfusion of the liver may be a safe tool to improve the donor organ pool and expedite liver transplantation in this scenario.

关键词： Acute-on-chronic liver failure Liver cirrhosis Liver transplantation Machine perfusion Hypothermic oxygenated machine perfusion

Randomized controlled trial comparing open anterograde anatomic radical retropubic prostatectomy with retrograde technique

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Asian Journal of Urology 2023年第2期10卷 151-157页

作者： Fabricio B.carrerette Daniela B.Rodeiro Rui T.F.Filho Paulo A.Santos celso c.Lara Ronaldo Damiao Department of Surgery(Urology) Pedro Ernesto University Hospital of State University of Rio de JaneiroRio de JaneiroBrazil

Objective:Radical prostatectomy is the recommended treatment for localized prostate cancer;however,it is an invasive procedure that can leave serious ***-assisted radical prostatectomy was introduced with the aim of reducing postoperative morbidity and facilitating rapid recovery compared to the traditional Walsh’s open radical retropubic ***,a protocol was developed to perform an open prostatectomy comparable to that performed by robotics,but without involving novel ***:A total of 220 patients diagnosed with localized prostate cancer underwent radical *** were divided into two groups:anterograde technique(115 patients)and the retrograde method(105 patients).The study outcomes were observed 3 months after ***:No differences were found in terms of surgical time,hospital stay,and suction ***,reduced bleeding was observed in the anterograde technique(p=0.0003),with rapid anastomosis duration(p=0.005).Among the patients,60.9% undergoing the anterograde technique were continent 3 months after surgery compared to 42.9%treated by the retrograde method(p=0.007).Additionally,fewer complications in terms of the number(p=0.007)and severity(p=0.0006)were observed in the anterograde ***:The anterograde method displayed increased efficiency in reducing complications,compared to the retrograde technique.

关键词： Prostatectomy Localized prostate cancer Vesicourethral anastomosis continence

Nutritional,rheological and sensory properties of butter processed with different mixtures of cow and sheep milk cream

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Food Bioscience 2022年第2期46卷 487-497页

作者： Renata S Dias celso F.Balthazar Rodrigo N.cavalcanti Louise A.Sobral Jessica F.Rodrigues Roberto P.cNeto Maria Inˆes B.Tavares Ana Paula B.Ribeiro Renato Grimaldi celso Sant’Anna Erick A.Esmerino Tatiana c.Pimentel Marcia cristina Silva Adriano G.cruz Instituto Federal de Educaç˜ao Ciˆencia e Tecnologia do Rio de Janeiro(IFRJ)Departamento de AlimentosRJBrazil Universidade Estadual de campinas(UNIcAMP) Faculdade de Engenharia de AlimentosCampinasSPBrazil Universidade Federal do Rio de Janeiro(UFRJ) Escola de QuimicaRJBrazil Instituto Federal of Minas Gerais(IFMG) Departamento de Ciˆencias Agr´ariasBambuíMGBrazil Universidade Federal do Rio de Janeiro(UFRJ) Instituto de Macromol´eculas Professora Eloisa Mano(IMA)Rio de JaneiroBrazil Instituto Federal do Paran´a(IFPR) ParanavaíPRBrazil g Instituto Nacional de MetrologiaNormalizaç˜ao Qualidade Industrial(affnInmetro) Duque de Caxias25250-020Rio de JaneiroBrazil Universidade Federal Fluminense(UFF) Faculdade de Medicina VeterinariaNiter´oiRJBrazil

This study assessed the quality parameters and consumer perception and behavior of butter processed with different ratios of cow and sheep milk *** milk cream butter(cMcB)showed lower moisture content and higher fat content,smaller fat globules,and higher concentrations of long-chain saturated fatty acids and monounsaturated fatty acids,resulting in improved potential health *** addition,cMcB showed yellow color,little salt,and butter taste as the main sensory characteristics,resulting in grateful and good digestibility *** milk cream addition improved the rheological properties of the products(lower viscosity,consistency index,and rigidity(J0),and higher fluidity and viscoelastic behavior(J1)),mainly due to the increased concentrations of short-chain and medium-chain saturated fatty acids and polyunsaturated fatty ***,sheep milk cream butter(SMcB)was characterized by a greasy and striking aroma,with a lower perception of good digestibility and good appearance,and a higher bitter *** association of cow and sheep milk cream could be an exciting option to obtain products with improved fatty acid profiles,health indices,and yet maintain desired rheological and sensory *** formulation with 60%sheep milk cream and 40%cow milk cream would be the suggested combination.

关键词： Sheep milk Bovine milk Quality parameters Butter

Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso mazza carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.chapman Jonas A.Sellberg carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.c.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS cR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User cryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

Nonlinear analysis of r.c. framed buildings retrofitted with elastomeric and friction bearings under near-fault earthquakes

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Earthquake Science 2015年第5期28卷 365-377页

作者： Mirko mazza Dipartimento di Ingegneria civile Universita della CalabriaPonte Bucci

Reinforced concrete （r.c.） framed buildings designed in compliance with inadequate seismic classifi- cations and code provisions present in many cases a high vulnerability and need to be retrofitted. To this end, the insertion of a base isolation system allows a considerable reduction of the seismic loads transmitted to the super- structure. However, strong near-fault ground motions, which are characterised by long-duration horizontal pulses, may amplify the inelastic response of the superstructure and induce a failure of the isolation system. The above considerations point out the importance of checking the effectiveness of different isolation systems for retrofitting a r.c. framed structure. For this purpose, a numerical inves- tigation is carried out with reference to a six-storey r.c. framed building, which, primarily designed （as to be a fixed-base one） in compliance with the previous Italian code （DM96） for a medium-risk seismic zone, has to be retrofitted by insertion of an isolation system at the base for attaining performance levels imposed by the current Italian code （NTc08） in a high-risk seismic zone. Besides the （fixed-base） original structure, three cases of base isolation are studied： elastomeric bearings acting alone （e.g. HDLRBs）; in-parallel combination of elastomeric and friction bearings （e.g. high-damping-laminated-rubber beatings, HDLRBs and steel-PTFE sliding bearings, SBs）; friction bearings acting alone （e.g. friction pendulum bearings, FPBs）. The nonlinear analysis of the fixed-base and base-isolated structures subjected to horizontal com- ponents of near-fault ground motions is performed for checking plastic conditions at the potential critical （end） sections of the girders and columns as well as critical conditions of the isolation systems. Unexpected high val- ues of ductility demand are highlighted at the lower floors of all base-isolated structures, while re-centring problems of the base isolation systems under near-fault earthquakes a

关键词： R.c. base-isolated structures Elastomericbearings Friction bearings Nonlinear dynamic analysis

Effects of near-fault ground motions on the nonlinear behaviour of reinforced concrete framed buildings

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Earthquake Science 2015年第4期28卷 285-302页

作者： Mirko mazza Dipartimento di Ingegneria civile Università della CalabriaArcavacata di Rende

The design provisions of current seismic codes are generally not very accurate for assessing effects of near-fault ground motions on reinforced concrete （r.c.） spatial frames, because only far-fault ground motions are considered in the seismic codes. Strong near-fault earth- quakes are characterized by long-duration （horizontal） pulses and high values of the ratio ~PGA of the peak value of the vertical acceleration, PGAv, to the analogous value of the horizontal acceleration, PGAH, which can become critical for girders and columns. In this work, six- and twelve-storey r.c. spatial frames are designed according to the provisions of the Italian seismic code, considering the horizontal seismic loads acting （besides the gravity loads） alone or in combination with the vertical ones. The non- linear seismic analysis of the test structures is performed using a step-by-step procedure based on a two-parameter implicit integration scheme and an initial stress-like itera- tive procedure. A lumped plasticity model based on the Haar-K^n~m principle is adopted to model the inelastic behaviour of the frame members. For the numerical investigation, five near-fault ground motions with high values of the acceleration ratio c^p6A are considered. Moreover, following recent seismological studies, which allow the extraction of the largest （horizontal） pulse from a near-fault ground motion, five pulse-type （horizontal） ground motions are selected by comparing the original ground motion with the residual motion after the pulse has been extracted. The results of the nonlinear dynamic analysis carried out on the test structures highlighted thathorizontal and vertical components of near-fault ground motions may require additional consideration in the seis- mic codes.

关键词： Near-fault ground motions Nonlineardynamic analysis r.c. spatial frames

compactPcI/Linux Platform in FTU Slow control System

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Plasma Science and Technology 2004年第6期6卷 2535-2540页

作者： F.Iannone L.Wang c.centioli M.Panella G.mazza V.Vitale AssociazioneEuratom／ENEAsullaFusione CentroRicercheFrascati00044FrascatiItaly InstituteofPlasmaPhysics ChineseAcademyofSciencesHefei230031China

In large fusion experiments, such as tokamak devices, there is a common trendfor slow control systems. Because of complexity of the plants, the so-called 'Standard Model' (SM)in slow control has been adopted on several tokamak machines. This model is based on a three-levelhierarchical control: 1) High-Level control (HLc) with a supervisory function; 2) Medium-Levelcontrol (MLc) to interface and concentrate I/O field equipments; 3) Low-Level control (LLc) withhard real-time I/O function, often managed by PLcs. FTU control system designed with SM concepts hasunderwent several stages of developments in its fifteen years duration of runs. The latestevolution was inevitable, due to the obsolescence of the MLc cPUs, based on VME-MOTOROLA 68030 withOS9 operating system. A large amount of c code was developed for that platform to route the dataflow from LLc, which is constituted by 24 Westinghouse Numalogic Pc-700 PLcs with about 8000field-points, to HLc, based on a commercial Object-Oriented Real-Time database on Alpha/compaqTru64platform. Therefore, we have to look for cost-effective solutions and finally a compactPcI—Intelx86 platform with Linux operating system was chosen. A software porting has been done, taking intoaccount the differences between OS9 and Linux operating system in terms of Inter/Network Processescommunications and I/O multi-ports serial driver. This paper describes the hardware/softwarearchitecture of the new MLc system, emphasizing the reliability and the low costs of the open sourcesolutions. Moreover, a huge amount of software packages available in open source environment willassure a less painful maintenance, and will open the way to further improvements of the systemitself.

关键词： compact PcI/linux control system tokamak

Late cryogenian-Ediacaran magmatism in southern Borborema Province,NE Brazil:Ages,sources,petrogenesis,and tectonic setting

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Geoscience Frontiers 2023年第6期14卷 70-101页

作者： Fábio Santos Pereira Herbet conceição Maria de Lourdes Silva Rosa Moacyr Moura Marinho colombo celso Gaeta Tassinari João Marinho Milhomem Neto Jean-Michel Lafon Programa de Pós-Graduação em Geologia e Geoquímica(PPGG) Instituto de GeociênciasUniversidade Federal do Pará(UFPA)66075-110 BelémParáBrazil Programa de Pós-Graduação em Geociências e Análise de Bacias(PGAB) Universidade Federal de Sergipe(UFS)49100-000 São CristóvãoSergipeBrazil Instituto de Geociências Universidade Federal da Bahia(UFBA)40170-290 SalvadorBahiaBrazil Instituto de Geociências Universidade de São Paulo(USP)05508-900 São PauloBrazil Laboratório de Geologia Isotópica(Pará-Iso) IG-UFPA66075-110 BelémParáBrazil

The Sergipano Orogenic System(SOS)in southern Borborema Province(NE Brazil)hosts voluminous Neoproterozoic plutonism related to the Brasiliano/Pan-African *** paper presents comprehensive whole-rock geochemical data,titanite U-Pb ages,and the first combined zircon U-Pb and Lu-Hf isotope results for plutonic rocks from the MacururéDomain to constrain their sources,petrogenesis,and tectonic *** magmatic episodes are recognized and record the evolutionary stages of the orogen.(i)Early-collisional magmatism(643–628 Ma)comprises gabbros and diorites with minor tonalites characterized by well-developed tectonic foliation and evidence of solid-state *** rocks are magnesian,high-K calc-alkaline,LILE-and LREE-enriched and provide subchondriticε_(Hf)(t)values(6.5 to4.7)and Orosirian Hf-T^(c)_(DM)model ages(1.83–1.94 Ga).Such features indicate derivation from a lithospheric mantle source metasomatized by incorporating crustal components through subduction processes prior to magma generation,possibly related to the Rhyacian Orogeny(2.20–1.96 Ga).Extensive mixing/mingling between basaltic and crust-derived magmas took place at lower crustal depths,producing coeval hybrid diorites and quartz-diorites.(ii)Syn-collisional magmatism(630–624 Ma)encompasses biotite-and muscovite-bearing granodiorites and monzogranites,preserving their structures parallel to the schistosity of the country *** rocks are leucocratic,weakly metaluminous to peraluminous,and contain abundant surmicaceous *** features and geochemical composition suggest an origin related to the partial melting of graywacke protoliths with a subordinate igneous component.(iii)Late-collisional magmatism(625–600 Ma)includes undeformed and isotropic monzonites and granodiorites,which truncate the regional *** rocks are consistently metaluminous and magnesian,showing affinities with the high-K calc-alkaline to shoshonite *** element modeling with su

关键词： Brasiliano/Pan-African Orogeny Western Gondwana Zircon and titanite U-Pb dating Hf isotope data Magma source