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Determination of 3-MeO-PCP in human blood and urine in a fatal intoxication case,with a specific focus on metabolites identification

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Forensic Sciences Research 2021年第4期6卷 208-214页

作者： Nadia Arbouche Pascal Kintz cecile zagdoun Laurie Gheddar Jean-Sébastien Raul Alice Ameline ainstitut de Médecine Légale strasbourgFrance X-Pertise consulting MittelhausbergenFrance UnitéMédico-Judiciaire hôpital emile MullerMulhouseFrance

3-Methoxyphencyclidine(3-MeO-PCP)is a new psychoactive substance that belongs to the phencyclidines family,first identified in Europe in *** drug presents a stronger binding to N-methyl-D-aspartate(NMDA)receptors when compared to phencyclidine,which results in more potent effects,even at low *** few articles have been published regarding 3-MeO-PCP in forensic *** this paper,the authors present a fatal 3-MeO-PCP intoxication *** addition to the detection of the parent drug,metabolites were investigated in urine and,for the first time in the scientific literature,in blood.3-MeO-PCP and its metabolites were quantitated by liquid chromatography-tandem mass spectrometry system(LC-MS/MS).Identification was confirmed by liquid chromatography-high resolution mass spectrometry(LC-HRMS).3-MeO-PCP tested positive in femoral blood(3525 ng/mL)and urine(7384 ng/mL).The femoral blood concentration was higher than the fatal concentrations range already reported in the literature(from 50 to 3200 ng/mL).3-MeO-PCP metabolites,including O-demethyl-3-MeO-PCP,piperidine-OH-3-MeO-PCP,O-demethyl-piperidine-di-OH-3-MeO-PCP and piperidine-di-OH-3-MeO-PCP,were detected in *** addition,two new metabolites,O-demethyl-piperidine-OH-3-MeO-PCP and O-demethyl-cyclohexyl-OH,were identified in both blood and ***,due to the lack of reference material on the market,it was not possible to measure the concentration of these ***,the ratios between the metabolites and the parent drug were useful to estimate their analytical response and *** this time,considering the low ratios(<1)between metabolites and parent drug,metabolites testing does not seem useful to increase the detection window of the drug.

关键词： Forensic sciences forensic toxicology 3-MeO-PCP metabolites fatal intoxication blood urine

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