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Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

High frequency of severe liver dysfunction in critically ill Dengue patients in the French West Indies

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Journal of Intensive Medicine 2024年第3期4卷 403-404页

作者： Laurent Camous Samuel Markowicz cecile Loraux Julien Jabot Jean David Pommier Réanimation Médicale et Chirurgicale CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Service de Maladies infectieuses et tropicales CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Service de Microbiologie CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Médecine Intensive et Réanimation Centre hospitalier universitaire de la Réunion 97460 Saint-PaulFrance Institut Pasteur de la Guadeloupe Morne Jolivière97183 AbymesFrance

Dear Editor,Dengue is a worldwide zoonosis,transmitted by mosquitoes and highly prevalent in tropical and subtropical *** recent years,its incidence has increased with a massive healthcare burden worldwide[1]and recent climatic changes have expanded the geographic range of the insect vector with described outbreaks in Europe.[2]Most patients present pauci-symptomatic infections,but some patients could present severe manifestations with high reported mortality[[3],[4],[5]]and no specific *** bleeding,hemodynamic failure and various organ damage(cardiac,renal,neurological,and hepatic)are described in severe dengue(SD)patients.[5]In the future,intensivists worldwide will be increasingly treating SD and the spectrum of severe organ impairment should be well known.

关键词： patients mortality expanded

Physicochemical and Bacteriological Profile of Bilanko and Ngamakala Peat Bog Soils (Republic of Congo)

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Journal of Environmental Protection 2024年第8期15卷 842-862页

作者： Gatsé Elgie Viennechie Mboukou Kimbatsa Irène Marie cecile Ignoumba Evariste Mesmin Morabandza Cyr Jonas Nguimbi Etienne Laboratory of Microbiology Infectiology and Immunology ENS-UMNG Brazzaville Republic of Congo Laboratory of Cellular and Molecular Biology FST-UMNG Brazzaville Republic of Congo Laboratory of Remote Sensing and Forest Ecology ENS-UMNG Brazzaville Republic of Congo

Peatlands are unique and complex natural ecosystems that are part of the most important carbon reservoirs on our planet, home to a diversity of microorganisms responsible for fermentation, humification or peat. The aim is to understand chemical and biological indicators of peatland soils. This work aims to determine the physicochemical and bacteriological profile and lipolytic activity of soil bacteria in Bilanko peatlands. The bacterial profile with the production of lipases is carried out by classical microbiology techniques. The results show that the soils are moderately acidic with temperatures of 27.8˚C ± 0.01˚C for Bilanko and 27.1˚C ± 0.57˚C for Ngamakala. The electroconductivity (EC) varies from (9.52 ± 0.002) μS/cm to (39.01 ± 1.4) μS/cm with low turbidity of (2.04 ± 0.66) mg/L to (31.02 ± 0.84) mg/L and low ion concentrations with, however, a richness in phenolic compounds for Bilanko compared to Ngamakala. FMAT diversity ranged from (1.71 ± 0.88)∙104 UFC/g to (2.92 ± 0.07)∙105 UFC/g for Bilanko and (1.30 ± 0.73)∙104 UFC/g to (2.89 ± 0.06)∙104 UFC/g for Ngamakala. Bacillus loads ranged from (5.20 ± 1.40)∙103 CFU/g to (1.22 ± 0.13)∙104 CFU/g and from (1.11 ± 0.13)∙104 CFU/g to (9.20 ± 2.05)∙103 CFU/g;enterobacteria loads from (1.40 ± 0.76)∙103 CFU/g to (8.80 ± 1.73)∙103 CFU/g and from (1.01 ± 0.02)∙103 CFU/g to (9.20 ± 2.05)∙103 CFU/g;in Pseudomonas from 0 to (2.30 ± 0.53)∙102 CFU/g and from 0 to (8.90 ± 2.35)∙102 CFU/g for Bilanko and Ngamakala respectively. These results reveal a variation in bacterial similarity and distribution in the Bilanko and Ngamakala peat bogs.

关键词： Bacteria Lipase Polyphenol Soil Peat Bog Republic of Congo

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廉价债券到期押注企业破产小心为上

商业周刊（中文版） 2024年第3期 24-25页

作者： Natasha Doff cecile Gutscher 永年(译) 不详

金融家正用自己的钱来押注超廉价债券到期后的违约潮,但并一定能获得丰厚回报,2020年,对冲基金经理亚当·施瓦茨(Adam Schwartz)因预测公司债券市场的大起大落而大赚了一把。现在,他把所管理基金的大部分资金和自己的钱都用来再次下注,... 详细信息

金融家正用自己的钱来押注超廉价债券到期后的违约潮,但并一定能获得丰厚回报,2020年,对冲基金经理亚当·施瓦茨(Adam Schwartz)因预测公司债券市场的大起大落而大赚了一把。现在,他把所管理基金的大部分资金和自己的钱都用来再次下注,赌那些面临创纪录债务到期潮的公司将出现一波违约潮。

关键词：企业破产对冲基金公司债券市场施瓦茨债券到期大起大落债务

CD36： linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis

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Cellular & Molecular Immunology 2014年第1期11卷 8-10页

作者： cecile Oury GIGA-Research Human Genetics Unit Laboratoryof Thrombosis and Hemostasis University of LiegeLiege Belgium

Arecent study published in Nature Immunology by Sheedy et al.1 indicates that uptake of modified low-den- sity lipoprotein （LDL） by the scavenger receptor CD36 primes and activates the NLRP3 inflammasome, providing an early pathogenic pathway that links cho- lesterol accumulation to the chronic inflammatory process of atherosclero- sis.1 Atherosclerosis arises from chronic vascular inflammation elicited by lipids.

关键词： STERILE INFLAMMATION ACTIVATION DEUBIQUITINATION LIGANDS MICE

When parasitoids deal with the spatial distribution of their hosts: consequences for both partners

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Insect Science 2019年第5期26卷 923-931页

作者： Philippe Louapre cecile Le Lann Thierry Hance Earth and Life Institue Universite Catholique de LouvainLouvain-la-NeuveBelgium CNRS Biogeosciences UMR 6282Universite Bourgogne Franche-ComteDijonFrance UMR CNRS 6553 Ecobio University of Rennes 1Rennes CedexFrance

Insect parasitoids developing inside hosts face a true challenge: hosts are scattered in the field and their localization and selection require the use of complex and sometime confusing information. It was assumed for a long time that small-brained organisms like parasitoids have evolved simple and efficient behavioral mechanisms, leading them to be adapted to a given ecological situation, for example, the spatial distribution o f hosts in the habitat. However, hosts are not static and their distribution may also vary through generations and within the life of parasitoid individuals. We investigated if and how parasitoids deal with such a spatial com plexity in a m esocosm experiment. We used the Aphidius rhopalosiphi/Sitobion avenae parasitoid/host system to investigate if parasitoid females experiencing different host aggregation levels exhibit different foraging behaviors independently of the number of hosts in the environment. We showed that A. rhopalosiphi females exploited hosts more intensively both within and among patches at higher host aggregation levels. We discussed the adaptiveness of such behaviors in the light of evolution and biological control.

关键词： Aphidius rhopalosiphi foraging behavior parasitoid sequential adjustment Sitobion avenae spatial distribution

Optimal Low-voltage Distribution Topology with Integration of PV and Storage for Rural Electrification in Developing Countries:A Case Study of Cambodia

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Journal of Modern Power Systems and Clean Energy 2020年第3期8卷 531-539页

作者： Vannak Vai Marie-cecile Alvarez-Herault Bertrand Raison Long Bun Department of Electrical and Energy Engineering(GEE) Institute of Technology of Cambodia(ITC)Phnom Penh 12150Cambodia Institute of Engineering UniversitéGrenoble Alpes38000 GrenobleFrance

This paper addresses an optimal design of low-voltage(LV)distribution network for rural electrification considering photovoltaic(PV)and battery energy storage(BES).It aims at searching for an optimal topology of an LV distribution system as well as the siting and sizing of PV and storage over a time horizon of 30 ***,the shortest-path algorithm(SPA)and first-fit bin-packing algorithm(FFBPA)are used to search for the optimal radial topology that minimizes the total length of the distribution line and improves the load ***,the optimal siting of decentralized BES(DeBES)is determined using a genetic algorithm(GA)to eliminate the undervoltage constraints due to the load *** iterative techniques are elaborated to size the maximum peak power of PV and the minimum number of DeBES that can be connected to an LV network without violating the voltage and current ***,the sizing strategy of centralized BES(CeBES)is developed to avoid reverse power flows into the medium-voltage(MV)***,a Monte Carlo approach is used to study the impact of load profile uncertainties on the topology.A non-electrified village in Cambodia has been chosen as a case study.

关键词： Battery energy storage(BES) low-voltage(LV)distribution network Monte Carlo photovoltaic(PV) electrification planning

Population genetic structure of the biological control agent Macrolophus pygmaeus in Mediterranean agroecosystems

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Insect Science 2017年第5期24卷 859-876页

作者： Jean-Claude Streito cecile Clouett Faten Hamdi Nathalie Gauthier IRD UMR (INRA/IRDICiradlMontpellier SupAgro) Centre de Biologie pour la Gestion des Populations INRA UMR (INRA/IRDI CiradlMontpellier SupAgro) Centre de Biologie pour la Gestion des Populations 755 avenue du Campus Agropolis CS 30016 34988Montferrier-sur-Lez France

Biological control of agricultural pests relies on knowledge of agroecosystem functionality, particularly when affected by the use of mass-produced biological agents. Incorporating pre- and/or post-release information such as genetic diversity and struc- ture on these agents using molecular-based approaches could advance our knowledge of how they perform in agroecosystems. We evaluated the population genetics of Macrolo- phus pygmaeus, the most widely used predatory mirid against many arthropod pests of greenhouse crops in the Mediterranean region, using the mitochondrial Cytb sequence and microsatellite data, and population genetics and phylogeny approaches. We investigated commercially mass-produced insects （i.e., commercial insects either mass-reared in the laboratory for many generations, or purchased by farmers and released in the greenhouses） and ＂wild＂ insects （i.e., that occur naturally outside or are collected in nature for release in the greenhouses）. The mirids were mainly collected in agroecosystems in which solana- ceous plants are grown in northern Spain, southern France and Greece. Both molecular markers and approaches distinguished 2 genetically differentiated populations. The less genetically diverse population, hereafter named the ＂commercial＂ strain included all indi- viduals from laboratory mass-rearings and most releases of commercially bred individuals. The most genetically diverse population mainly comprised individuals originating from noncultivated environments, or from releases of＂wild＂ individuals. Rare examples of hy- bridization between M. pygmaeus from the 2 populations were observed and asymmetric gene flow was revealed. These findings provide new insights into what happens to M. pyg- maeus released in the agroecosystems we studied, and show that it is possible to monitor some commercial strains.

关键词： biological control commercial vs. wild strains Macrolophus pygmaeus microsatellites mtCytb population genetics

Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells

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Cell Research 2004年第3期14卷 188-196页

作者： cecile CORBIERE,Bertrand LIAGRE,Faraj TERRO,Jean-Louis BENEYTOUT Laboratoire de Biochimie UPRES EA 1085 Faculté de Pharmacie rue du Docteur Marcland 87025 Limoges Cedex France Laboratoire de Biochimie UPRES EA 1085 Faculté de Pharmacie rue du Docteur Marcland 87025 Limoges Cedex France Service d'Histologie et Biologic Cellulaire Faculte de Medecine rue du Docteur Marcland 87025 Limoges Cedex France Laboratoire de Biochimie UPRES EA 1085 Faculté de Pharmacie rue du Docteur Marcland 87025 Limoges Cedex France

Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antiproliferative effect of diosgenin was similar for different human cancer cell lines such as laryngocarcinoma HEp-2 and melanoma M4Beu cells. Moreover, this work essentially focused on the mitochondrial pathway. We found that diosgenin had an important and similar antiproliferative effect on different types of cancer cells. In addition, our new results show that diosgenin-induced apoptosis is caspase-3 dependent with a fall of mitochondrial membrane potential, nuclear localization of AIF and poly (ADP-ribose) polymerase cleavage. Diosgenin treatment also induces p53 activation and cell cycle arrest in the different cell lines studied.

关键词： diosgenin apoptosis p53 AIF caspase cancer cells.