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Nanosilver anchored alginate/poly(acrylic acid/acrylamide) double-network hydrogel composites for efficient catalytic degradation of organic dyes

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Frontiers of Chemical Science and Engineering 2023年第7期17卷 893-905页

作者： Fan Zhang ce gao Shang-Ru Zhai Qing-Da An Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefineryCollege of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China

A novel alginate/poly(acrylic acid/acrylamide)double-network hydrogel composite with silver nanoparticles was successfully fabricated using the sol–gel *** presence of carboxyl and amide groups in the network structure provided abundant active sites for complexing silver ions,facilitating the in situ reduction and confinement of silver *** batch experiments,the optimal silver loading was 20%,and 5 mmol·L^(–1) of p-nitrophenol was completely degraded in 113 s with a rate constant value of 4.057×10^(−2) s^(–1).In the tap water system and simulated seawater system,the degradation time of p-nitrophenol at the same concentration was 261 and 276 s,respectively,with a conversion rate above 99%.In the fixed-bed experiment,the conversion rate remained above 74%after 3 h at a flowing rate of 7 mL·min^(–1).After 8 cycling tests,the conversion rate remained at 98.7%.Moreover,the catalyst exhibited outstanding performance in the degradation experiment of four typical organic dyes.

关键词： double-network hydrogel dye degradation silver nanoparticles alginate

All routes lead to Rome:multifaceted origin of hepatocytes during liver regeneration

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cell Regeneration 2021年第1期10卷 17-26页

作者： ce gao Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China

Liver is the largest internal organ that serves as the key site for various metabolic activities and maintenance ofhomeostasis. Liver diseases are great threats to human health. The capability of liver to regain its mass after partialhepatectomy has widely been applied in treating liver diseases either by removing the damaged part of a diseasedliver in a patient or transplanting a part of healthy liver into a patient. Vast efforts have been made to study thebiology of liver regeneration in different liver-damage models. Regarding the sources of hepatocytes during liverregeneration, convincing evidences have demonstrated that different liver-damage models mobilized differentsubtype hepatocytes in contributing to liver regeneration. Under extreme hepatocyte ablation, biliary epithelial cellscan undergo dedifferentiation to liver progenitor cells (LPCs) and then LPCs differentiate to produce *** we will focus on summarizing the progresses made in identifying cell types contributing to producing newhepatocytes during liver regeneration in mice and zebrafish.

关键词： homeostasis removing extreme

Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification

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Journal of Genetics and Genomics 2022年第12期49卷 1101-1113页

作者： Qingxia Jin Yuqi gao Shimin Shuai Yayue Chen Kaiyuan Wang Jun Chen Jinrong Peng ce gao College of Animal Sciences Zhejiang UniversityHangzhouZhejiang 310058China Department of Human cell Biology and Genetics School of MedicineSouthern University of Science and TechnologyShenzhenGuangdong 518055China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China

In mammals,the expression of the homeobox family member Cdx2/CDX2 is restricted within the *** ablation of the mouse Cdx2 in the endodermal cells causes a homeotic transformation of the intestine towards the esophagus or gastric *** this report,we show that null mutants of zebrafish cdx1b,encoding the counterpart of mammalian CDX2,could survive more than 10 days post fertilization,a stage when the zebrafish digestive system has been well *** RNA sequencing(RNA-seq)and single-cell sequencing(sc RNA-seq)of the dissected intestine from the mutant embryos,we demonstrate that the loss-of-function of the zebrafish cdx1b yields hepatocyte-like intestinal cells,a phenotype never observed in the mouse *** RNA-seq data analysis,and genetic double mutants and signaling inhibitor studies reveal that Cdx1b functions to guard the intestinal fate by repressing,directly or indirectly,a range of transcriptional factors and signaling pathways for liver ***,we demonstrate that heat shock-induced overexpression of cdx1b in a transgenic fish abolishes the liver ***,we demonstrate that Cdx1b is a key repressor of hepatic fate during the intestine specification in zebrafish.

关键词： Cdx1b CDX2 Hhex Intestine development Liver development Prox1a Zebrafish

Preparation of a novel lactose-lignin hydrogel catalyst with self-reduction capacity for nitrogenous wastewater treatment

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 25-36页

作者： Fan Zhang Yanzhu Guo Xianhong Wu ce gao Qingda An Zhongjian Tian Runcang Sun Key Laboratory of Pulp and Paper Science&Technology of Ministry of Education Qilu University of TechnologyShandong Academy of SciencesJinan 250353China The Liaoning Province Key Laboratory of Paper and Pulp Engineering The Dalian Key Laboratory of High Value Application and Development of Botanical ResourcesThe Key Laboratory of High Value Utilization of Botanical Resources of China Light IndustryDalian Polytechnic UniversityDalian 116034China

A novel carboxylated lactose/sodium lignosulfonate/polyacrylic acid hydrogel composites with self-reduction capacity was successfully synthesized by self-assembly *** hydrogel with well-developed porous structure provided abundant anchoring points and reduction capacity for transforming Ag^(+)into silver *** nanoparticles dispersed among the network of hydrogel and the composites exhibited catalytic *** catalytic performance was evaluated via degradation of p-nitrophenol,rhodamine B,methyl orange and methylene blue,which were catalyzed with corresponding reaction rate constants of 0.04338,0.07499,0.04891,and 0.00628 s^(–1),*** addition,the catalyst exhibited stable performance under fixed-bed condition and the corresponding conversion rate still maintained more than 80%after 540 ***,the catalytic performance still maintained effective in tap water and simulated *** catalytic efficiency still remained 99.7%with no significant decrease after 8 cycles.

关键词： carboxylated lactose Ag NPs self-reduction nitrogenous wastewater

Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

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Journal of Molecular cell Biology 2019年第6期11卷 448-462页

作者： ce gao Weidong Huang Yuqi gao Li Jan Lo Lingfei Luo Honghui Huang Jun Chen Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal Sciences Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China College of Life Sciences Southwest University Chongqing 400715 China College of Life Sciences Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China

The hepatopancreatic duct (HPD) system links the liver and pancreas to the intestinal tube and is composed of the extrahepatic biliary duct, gallbladder, and pancreatic duct. Haematopoietically expressed-homeobox (Hhex) protein plays an essential role in the establishment of HPD;however, the molecular mechanism remains elusive. Here, we show that zebrafish hhex-null mutants fail to develop the HPD system characterized by lacking the biliary marker Annexin A4 and the HPD marker sox9b. The hepatobiliary duct part of the mutant HPD system is replaced by an intrahepatic intestinal tube characterized by expressing the intestinal marker fatty acid-binding protein 2a (fabp2a). cell lineage analysis showed that this intrahepatic intestinal tube is not originated from hepatocytes or cholangiocytes. Further analysis revealed that cdx1b and pdx1 are expressed ectopically in the intrahepatic intestinal tube and knockdown of cdx1b and pdx1 could restore the expression of sox9b in the mutant. Chromatin-immunoprecipitation analysis showed that Hhex binds to the promoters of pdx1 and cdx1b genes to repress their expression. We therefore propose that Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish.

关键词： liver development hepatopancreatic duct (HPD) hhex pdx1 cdxlb

Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes

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Journal of Genetics and Genomics 2018年第3期45卷 173-175页

作者： ce gao Zhihui Zhu Yuqi gao Li Jan Lo Jun Chen Lingfei Luo Jinrong Peng College of Animal Sciences Zhejiang University College of Life Sciences Zhejiang University College of Life Sciences Southwest University

In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood（e.g.,～20 folds for a mouse）.Considering the fact that the liver-to-body weight ratio（LBR）stays relatively constant within species（Weglarz and Sandgren,2000;Kan et al.,2009）,the cell number in a liver must therefore keep increasing along with the growth of an individual organism. For example, during the growth of the zebrafish from 5 days post-fertilization （dpf） to 1.5 years old, the number of liver cells increased -900 folds （Figs. 1A and S1 ）.

关键词： In Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes ERT RSG

Comparison of evaluation indexes for Gastroenterology and Hepatology journals in different databases

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World Journal of Gastroenterology 2022年第38期28卷 5648-5657页

作者： Jia-Yuan Li Zhi-Han Yan Ze Xiang ce gao Jian Wu Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of Hepatology Wuxi Fifth People's Hospital Affiliated to Jiangnan UniversityWuxi 214005Jiangsu ProvinceChina Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008Jiangsu ProvinceChina

BACKGROUND Accurate assessment of the quality of academic journals is of great *** Journal Impact Factor(JIF),calculated by Clarivate and based upon the Web of Science literature database,and CiteScore(CS),developed by Elseiver and based upon the Scopus database,have enjoyed high uptake worldwide,efforts continue towards creation of other scientometric indexes that will provide evergreater qualitative insights into journal *** efforts have yielded the newly-launched Journal Article Influence Index(JAII),which is based on the Reference Citation Analysis(RCA)database,an open multidisciplinary citation analysis database based on artificial intelligence *** To evaluate and summarize the similarities and differences between JAII and JIF/CS as journal evaluation indicators,and provide an intuitive method for visual representation of the related *** We searched the Journal Citation Reports to obtain the 2021 JIF list,downloaded the CS list updated in July on the Scopus website,and collected the comprehensive list of 2022 JAIIs from the RCA database(***).RESULTS Our research results revealed that by breaking through the time limit of mainstream journalevaluation methods, the JAII is able to perform well in data reliability, establishing its benefit as acomplementary scientometric index to JIF and *** provides comprehensive assessment of the quality and performance of journals.

关键词： Journal Article Influence Index Journal Impact Factor CiteScore Gastroenterology and Hepatology Scientometric index

20S proteasome and glyoxalase 1 activities decrease in erythrocytes derived from Alzheimer’s disease patients

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Neural Regeneration Research 2020年第1期15卷 178-183页

作者： Hui Lv Gui-Yuan Wei Can-Shou Guo Yu-Feng Deng Yong-Ming Jiang ce gao Chong-Dong Jian Youjiang Medical University for Nationalities

As a result of accumulating methylglyoxal and advanced glycation end products in the brains of patients with Alzheimer’s disease,it is considered a protein precipitation *** ubiquitin proteasome system is one of the most important mechanisms for cells to degrade proteins,and thus is very important for maintaining normal physiological function of the nervous *** study recruited 48 individuals with Alzheimer’s disease(20 males and 28 females aged 75±6 years)and 50 healthy volunteers(21 males and 29 females aged 72±7 years)from the Affiliated Hospital of Youjiang Medical University for Nationalities(Baise,China)between 2014 and *** levels of malondialdehyde and H2O2 were measured by colorimetry,while glyoxalase 1 activity was detected by *** addition,20S proteasome activity in erythrocytes was measured with a fluorescent substrate *** and glyoxalase 1 protein expression in erythrocyte membranes was detected by western blot *** results demonstrated that compared with the control group,patients with Alzheimer’s disease exhibited increased plasma malondialdehyde and H2O2 levels,and decreased glyoxalase 1 activity;however,expression level of glyoxalase 1 protein remained ***,activity of the 20S proteasome was decreased and expression of ubiquitin protein was increased in *** findings indicate that proteasomal and glyoxalase activities may be involved in the occurrence of Alzheimer’s disease,and erythrocytes may be a suitable tissue for Alzheimer’s disease *** study was approved by the Ethics Committee of Youjiang Medical University for Nationalities(approval ***12017013)on May 3,2017.

关键词： 20S proteasomal activity Alzheimer’s disease erythrocytes glyoxalase 1 H2O2 malondialdehyde nerve regeneration total ubiquitin

Research progress in CALPHAD assisted metal additive manufacturing

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China Foundry 2024年第4期21卷 295-310页

作者： Ya-qing Hou Xiao-qun Li Wei-dong Cai Qing Chen Wei-ce gao Du-peng He Xue-hui Chen Hang Su China Iron&Steel Research Institute Group Beijing 100081China Thermo-Calc Software AB SolnaSE-169Sweden KTH Royal Institute of Technology StockholmSE-100Sweden central Iron and Steel Research Institute Beijing 100081China

Metal additive manufacturing(MAM)technology has experienced rapid development in recent *** both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of *** calculation of phase diagrams(CALPHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple *** combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal *** development of CALPHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural *** endeavor carries considerable theoretical and practical *** paper summarizes the important achievements of CALPHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties ***,the limitations of applying CALPHAD technology to MAM technology are discussed,along with prospective research directions.

关键词： metal additive manufacturing CALPHAD integrated computational material engineering powder bed fusion material design microstructure simulation