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microRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled

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World Journal of Gastroenterology 2013年第32期19卷 5212-5226页

作者： catherine m greene Robert B Varley matthew W Lawless Respiratory Research Division Department of MedicineEducation and Research CentreRoyal College of Surgeons In IrelandBeaumont Hospital Experimental medicine UCD School of Medicine and Medical ScienceMater Misericordiae University Hospital

Primary liver cancer is a global disease that is on the *** carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and ***(miRNAs/miRs)are regulatory RNAs that modulate protein *** are involved in several biological and pathological processes including the development and progression of *** the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic *** studies have demonstrated their role in HCC development and *** many risk factors underlie the development of HCC,one process commonly altered is iron *** overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well *** miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and ***2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic *** studies have since investigated the clinical potential of other miRNAs with one drug,miravirsen,currently in phaseⅡclinical *** also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment *** studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes.

关键词： microRNAs Liver cancer Iron regulation Hepatitis C Therapeutic targets

Adaptation in brain structure and respiratory and olfactory structures across environmental gradients in African and North American muroid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： Peter J.TAYLOR Aluwani NENGOVHELA Christiane DENYS Graham R.SCOTT catherine m.IVY Department of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afromontane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Department of mammalogy National MuseumBloemfonteinSouth Africa Institut de Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Department of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo and Shoemaker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

morphometric studies of 3D micro CT-scanned images can provide insights into the evolution of the brain and sensory structures but such data are still scarce for the most diverse mammalian order of *** reviewed and new data,we tested for convergence to extreme aridity and high elevation in the sensory and brain morphology of rodents,from morphometric data from micro-CT X-ray scans of 174 crania of 16 species of three distantly re-lated African murid(soft-furred mice,Praomyini,laminate-toothed rats,Otomyini,and gerbils,Gerbillinae)clades and one North American cricetid(deer mice and white-footed mice,Peromyscus)*** studies demon-strated convergent evolution acting on the oval window area of the cochlea(enlarged in extremely arid-adapted species of Otomyini and Gerbillinae)and on endocranial volume(reduced in high elevation taxa of Otomyini and Peromyscus).However,contrary to our predictions,we did notfind evidence of convergence in brain struc-ture to aridity,or in the olfactory/respiratory system(turbinate bones)to high *** structure differed,particularly in the petrosal lobules of the cerebellum and the olfactory bulbs,between Otomyini and Gerbillinae,with extreme arid-adapted species in each clade being highly divergent(not convergent)from other species in the same *** observed greater“packing”of the maxillary turbinate bones,which have important respiratory functions,in Peromyscus mice from high and low elevations compared to the high-elevation African Praomyini,but more complex patterns within Peromyscus,probably related to trade-offs in respiratory physiology and heat exchange in the nasal epithelium associated with high-elevation adaptation.

关键词： 3D morphometrics Africa brain size North America Rodentia sensory evolution

Limosilactobacillus mucosae FZJTZ26m3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li mengfan Ding RPaul Ross catherine Stanton Jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,model,FZJTZ26m3,FGSYC17L3).*** FZJTZ26m3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26m3 *** pathology showed that *** FZJTZ26m3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26m3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26m3 ***,*** FZJTZ26m3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

mass spectrometry-based proteomics technology in pancreatic cancer research

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胰腺病学杂志(英文) 2024年第2期07卷 145-163页

作者： Sun Xue Wang Siyuan Wong catherine C.L. First School of Clinical medicine Peking University Health Science Center Peking University Beijing China School of Pharmacy University of Wisconsin-Madison Madison Wisconsin United States State Key Laboratory of Complex Severe and Rare Diseases Clinical Research Institute Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union medical College Beijing China Tsinghua-Peking University Joint Center for Life Sciences Tsinghua University Beijing China

Pancreatic ductal adenocarcinoma (PDAC) has become a significant health concern with increasing incidence and mortality rates over the past few decades. Researchers have turned their attention to cutting-edge mass spectrometry (mS) technology due to its high-throughput and accurate detection capacity, which plays a vital role in understanding the mechanisms and discovering biomarkers for pancreatic diseases. In this review, we comprehensively investigate various methodologies of quantitative and qualitative proteomics mS technologies, alongside bioinformatical platforms employed in pancreatic cancer research. The integration of these optimized approaches provides novel insights into the molecular mechanisms underlying tumorigenesis and disease progression, ultimately facilitating the discovery of potential diagnostic, prognostic biomarkers, and therapeutic targets. The robust mS-based strategy shows promise in paving the way for early diagnosis and personalized medicine for pancreatic cancer patients.

关键词： Biomarkers mass spectrometry Pancreatic cancer Pancreatic ductal adenocarcinoma Proteomics

Optimization and Characterization of Cellulose Extraction from Grevillea robusta (Silky Oak) Leaves by Soda-Anthraquinone Pulping Using Response Surface methodology

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Green and Sustainable Chemistry 2024年第3期14卷 43-65页

作者： catherine N. muya John m. Onyari Lydia W. Njenga Joab O. Onyango Wilson m. Gitari Department of Chemistry The University of Nairobi Nairobi Kenya School of Chemical and material Science The Technical University of Kenya Nairobi Kenya

Response surface methodology (RSm) using the central composite design (CCD) was applied to examine the impact of soda-anthraquinone pulping conditions on Grevillea robusta fall leaves. The pulping factors studied were: NaOH charge 5% to 20% w/v, pulping time 30 to 180 minutes, and the anthraquinone charge 0.1 to 0.5% w/w based on the oven-dried leaves. The responses evaluated were the pulp yield, cellulose content, and the degree of delignification. Various regression models were used to evaluate the effects of varying the pulping conditions. The optimum conditions attained were;NaOH charge of 14.63%, 0.1% anthraquinone, and a pulping period of 154 minutes, corresponding to 20.68% pulp yield, 80.56% cellulose content, and 70.34% lignin removal. Analysis of variance (ANOVA), was used to determine the most important variables that improve the extraction process of cellulose. The experiment outcomes matched those predicted by the model (Predicted R2 = 0.9980, Adjusted R2 = 0.9994), demonstrating the adequacy of the model used. FTIR analysis confirmed the elimination of the non-cellulosic fiber constituents. The lignin and hemicellulose-related bands (around 1514 cm−1, 1604 cm−1, 1239 cm−1, and 1734 cm−1) decreased with chemical treatment, indicating effective cellulose extraction by the soda-anthraquinone method. Similar results were obtained by XRD, SEm and thermogravimetric analysis of the extracted cellulose. Therefore, Grevillea robusta fall leaves are suitable renewable, cost-effective, and environmentally friendly non-wood biomass for cellulose extraction.

关键词： Cellulose Extraction Response Surface methodology Central Composite Design Delignification

Variations of properties across plate thickness for Al alloy 7010

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中国有色金属学会会刊：英文版 2005年第6期15卷 1258-1263页

作者： m.Salazar-Guapuriche Y.Y.Zhao A.Pitman A.greene materials Laboratory Airbus UK Broughton Chester CH4 0DR UKDepartment of Engineering The University of Liverpool Liverpool L69 3GH UK Department of Engineering The University of Liverpool Liverpool L69 3GH UK materials and Process Group Airbus UK Filton Bristol BS99 7AR UK

The variations of electrical conductivity and hardness across the thickness of an Al alloy 7010 plate under the temper condition T7651 were investigated. The electrical conductivity and hardness respond in a reciprocal manner. Cross-sectional slices of the plate subjected to re-solutionising/natural ageing and re-solutionising/artificial ageing show the similar tendencies in property changes as in the as-received raw material. This clearly suggests that the property inhomogeneity across the plate thickness is inherent of the manufacturing route. The differences in properties through the plate thickness are due to the changes in the concentrations of the strengthening alloying elements in the solid solution and the associated changes in microstructure; these are believed to be mainly due to the nature of plate solidification and prolonged high temperature during the rolling operation. The combination of electrical conductivity and hardness can be used as an integral quality property indicator for assessing inhomogeneity of thick products.

关键词：铝合金镀层厚度硬度导电性

Experimental evidence of obesity as a risk factor for severe acute pancreatitis

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World Journal of Gastroenterology 2009年第42期15卷 5260-5265页

作者： Jean-Louis Frossard Pierre Lescuyer catherine m Pastor Service of Gastroenterology Geneva University HospitalsGeneva 1205Switzerland Laboratory of pathophysiology and molecular imaging Geneva University HospitalsGeneva 1205Switzerland Service of Genetics and Central Laboratory Geneva University HospitalsGeneva 1205Switzerland

The incidence of acute pancreatitis, an inflammation of the pancreas, is increasing worldwide. Pancreatic injury is mild in 80%-90% of patients who recover without complications. The remaining patients may develop a severe disease with local complications such as acinar cell necrosis, abscess and remote organ injury including lung injury. The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications. For that purpose, multiple clinical scale scores have been applied to patients with acute pancreatitis. Recently, a new problem has emerged： the increased severity of the disease in obese patients. However, the mechanisms by which obesity increases the severity of acute pancreatitis are unclear. Several hypotheses have been suggested：（1） obese patients have an increased inflammation within the pancreas; （2） obese patients have an increased accumulation of fat within and around the pancreas where necrosis is often located; （3） increase in both peri- and intra-pancreatic fat and inflammatory cells explain the high incidence of pancreatic inflammation and necrosis in obese patients; （4） hepatic dysfunction associated with obesity might enhance the systemic inflammatory response by altering the detoxiflcation of inflammatory mediators; and （5） ventilation/perfusion mismatch leading to hypoxia associated with a low pancreatic flow might reduce the pancreatic oxygenation and further enhance pancreatic injury. Recent experimental investigations also show an increased mortality and morbidity in obese rodents with acute pancreatitis and the implication of the adipokines leptin and adiponectin. Such models are important to investigate whether the inflammatory response of the disease is enhanced by obesity. It is exciting to speculate that manipulation of the adipokine milieu has the potential to influence the severi

关键词： Acute pancreatitis Obesity Adiponectin Leptin

What do teachers see?Perceptions of school-time physical activity programs on student behavior

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Journal of Sport and Health Science 2020年第1期9卷 50-52,F0003页

作者： Jennifer m.Sacheck catherine m.Wright Department of Exercise and Nutrition Sciences Milken Institute School of Public HealthThe George Washington UniversityWashingtonDC 20052USA Gerald J.and Dorothy R.Friedman School of Nutrition Science and Policy Tufts UniversityBostonMA 02111USA

In the United States, children are not meeting daily recommendationsfor 60 min of moderate・to・vigorous activity.1Because children spend a large portion of their days in school, ithas been further recommended that children accumulate 30 minof their physical activity (PA) during school hours.2 Our previousresearch has demonstrated with objective measures that only8%—9% of elementary school children meet this goal, with anaverage accumulation of 18 min/day.3,4 This finding is of concerngiven the numerous benefits that PA has not only on healthoutcomes,5-8 but also on academic achievement.9 For example,there is heightened awareness that children benefit from PAthroughout the school day in terms of attention to task, memory,behavior, and, ultimately, academic performance.10 Schooladministrators acknowledge this link, but still face barriers toincorporating PA for schoolchildren, including limited time andresources for physical education (PE) and recess.

关键词： spend behavior school

Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2020年第6期15卷 1039-1040页

作者： Jean Pierre Pallais catherine m.Kotz milos Stanojlovic Integrative Biology and Physiology University of MinnesotaMinneapolisMNUSA(Pallais JPKotz CMStanojlovic M)Minneapolis VA Health Care SystemGeriatric ResearchEducation and Clinical CenterMinneapolisMNUSA(Kotz CM)

multiple sclerosis(mS)is a T-cell-mediated autoimmune disease of the central nervous system(CNS).Worldwide,more than 2.3 million people are diagnosed with *** its clinical manifestations appear typically in the third and fourth decades of life,mS is a major cause of neurological disability in young adults and has wide health,psychological,economic,and social *** are three key pathological features of mS:inflammation;demyelination and oligodendrocyte loss;axonal loss and *** are two main hypotheses regarding mechanisms of mS ***“outside-in”concept is an older,widely recognized hypothesis that describes neurodegeneration as a consequence of inflammatory induced demyelination,which is caused by immune system activation(Lassmann et al.,2012).mechanisms of T-cell mediated myelin destruction are extensively studied,but the manner by which the immune system perceives myelin as foreign.

关键词： autoimmune sclerosis inflammation