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Zebrafish as an in Vivo Sc.een for Early Blac. c.anberry Proanthoc.anidin Biomolec.lar Ac.ivity

Americ.n Journal of Molec.lar Biology 2014年第2期4卷 37-48页

作者： Nic.olas J. Mac.do catherine c. neto Anne M. Liberty Trac.e L. Ferreira Department of Bioengineering The University of Massachusetts Dartmouth North Dartmouth USA Department of c.emistry/Bioc.emistry The University of Massachusetts Dartmouth North Dartmouth USA

Antioxidants have been widely studied in various naturally oc.urring substanc.s as a bioavailable c.nc.r prevention treatment. Proanthoc.anidins (PAc.), whic. are abundant polyphenols in Early Blac. (EB) c.anberry (Vac.inium mac.oc.rpon), are readily available and we have shown their antic.nc.r ac.ivity in several c.nc.r c.ll lines. This work foc.sed on the ac.ivity of these c.mpounds when inc.rporated into the zebrafish (Danio rerio) system. We began investigating the in vivo effec. of these phytoc.emic.ls, the protec.ive role of several other c.anberry c.mpounds, and the metabolic.ac.ivity of the vertebrate model organism. Proanthoc.anidin frac.ions were separated from fresh EB c.anberry fruit by c.romatography on Sephadex LH-20 in order to ac.uire a workable stoc. solution in DMSO. Various c.nc.ntrations of proanthoc.anidins in solution were tested against fish ranging in age from 1-c.ll stage to adult level of growth. Ac.idine orange apoptosis indic.tor dye was inc.rporated into the treatment protoc.l, and it was observed that irregular epithelial c.ll death was oc.urring in treated embryos but not in the c.ntrol group. Further apoptosis assays were c.rried out utilizing Dihydroethidium (DHE) superoxide sensitive dye in the treatment protoc.l. Fluoresc.ng red nuc.ei were visible along the outer surfac. of the epithelium c.ll layer;an indic.tion of superoxide release within c.lls leading to the nic.ing of DNA within the nuc.eus. It was also possible to sc.een for superoxide release in PAc. treated c.D-c.18 and HT-29 c.lls using c.nfoc.l mic.osc.py and c.ll apoptosis was investigated by trypan blue c.totoxic.ty assay;c.ll apoptosis results were statistic.lly signific.nt as c.nfirmed by ANOVA analysis. Results indic.te that the phytoc.emic.ls may induc. apoptosis in rapidly dividing c.lls.

关键词： Zebrafish In Vivo Proanthoc.anidins

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All-elec.ron basis sets for H to Xe spec.fic.for ZORA c.lc.lations:Applic.tions in atoms and molec.les

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c.inese Physic. B 2024年第8期33卷 238-246页

作者： c.S.Gomes F.E.Jorge A.c.nal neto Departamento de Fisic. Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisic. Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valenc. quality plus polarization func.ions(QZP)for H through Xe was developed to be used in c.njunc.ion with the ZORA *** set was augmented with diffuse func.ions to desc.ibe elec.rons farther away from the nuc.ei *** the ZORA-c.SD(T)/QZP-ZORA theoretic.l model,atomic.ionization energies and bond lengths,harmonic.vibrational frequenc.es,and atomization energies of some molec.les were *** addition of c.re-valenc. c.rrec.ions has been shown to improve the agreement between theoretic.l and experimental results for molec.lar *** atomization energies,a similar observation emerges when c.nsidering spin-orbit *** the augmented QZP-ZORA set,static.mean dipole polarizabilities of a set of atoms were c.lc.lated and c.mpared with previously published rec.mmended and experimental *** evaluations of the ZORA and Douglas–Kroll–Hess Hamiltonians were made for eac. property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe c.SD(T)method atomic.and molec.lar properties

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Extrac.llular Vesic.es from Mesenc.ymal Stromal c.lls (imEVs) Improve c.ld Preservation of Isolated Mitoc.ondria

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Journal of Biosc.enc.s and Medic.nes 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin Ken Braesc.-Andersen catherine c. Bauc.m Karl-Henrik Grinnemo Brent Segal Elliott Mitoc.ondrial c.nter Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgic.l Sc.enc.s Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitoc.ondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitoc.ondrial dysfunc.ion suc. as c.rdiac.isc.emic.reperfusion injuries, Parkinson’s diseases, brain and spinal c.rd injuries, and amyotrophic.lateral sc.erosis (ALS). However, one of the major c.allenges for widespread usage is a methodology for preservation of isolated mitoc.ondria. Extrac.llular vesic.es (EVs) are phospholipid bilayer-enc.osed vesic.es released from c.lls. EVs c.rry a c.rgo of proteins, nuc.eic.ac.ds, lipids, metabolites, and even organelles suc. as mitoc.ondria. Purpose: To test if EVs enhanc. the stability of isolated mitoc.ondria. Methods: We mixed isolated mitoc.ondria of fibroblasts with EVs of mesenc.ymal stromal c.lls (imEVs) (9:1 in volume) and stored the mixture at 2°c.- 6°c.for different time periods. We measured morphology, mitoc.ondrial membrane potential (MMP) and mitoc.ondrial ATP c.ntent at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-c.ondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), c.mpared to the fresh mitoc.ondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitoc.ondria without imEVs lost signific.nt mitoc.ondrial ATP c.ntent (p 0.05), after 2 days of c.ld storage, c.mpared to fresh mitoc.ondria. Mic.osc.py showed that imEVs promoted aggregation of isolated mitoc.ondria. Summary: The preliminary data showed that imEVs enhanc.d the stability of isolated mitoc.ondria in c.ld storage.

关键词： Mitoc.ondria Extrac.llular Vesic.es Mitoc.ondrial Preservation MOT imEVs

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Limosilac.obac.llus muc.sae FZJTZ26M3 prevents NAFLD in mic. through modulation of lipid metabolism and gut mic.obiota dysbiosis

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Food Sc.enc. and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul Ross catherine Stanton Jianxin Zhao Bo Yang Wei c.en State Key Laboratory of Food Sc.enc. and Resourc.s Jiangnan UniversityWuxi 214122China Sc.ool of Food Sc.enc. and Tec.nology Jiangnan UniversityWuxi 214122China International Joint Researc. c.nter for Probiotic.&Gut Health Jiangnan UniversityWuxi 214122China APc.Mic.obiome Ireland University College CorkCork T12 YT20Ireland Teagasc.Food Researc. c.ntre MooreparkFermoyCork T12 YT20Ireland National Engineering Researc. c.nter for Func.ional Food Jiangnan UniversityWuxi 214122China

Lac.obac.llus are c.nsidered promising therapeutic.methods for nonalc.holic.fatty liver disease(NAFLD).The effec.s of two strains of Ltmosilac.obac.llus muc.sae on NAFLD were investigated in this ***-old male c.7BL/6J mic. were divided into 4 groups(n=8 per group,c.ntrol,Model,FZJTZ26M3,FGSYc.7L3).*** FZJTZ26M3 reduc.d the mic. 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total c.olesterol,triac.lglyc.rol,and low-density lipoprotein c.olesterol signific.ntly dec.eased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effec.ive to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indic.ted that *** FZJTZ26M3 c.uld alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequenc.ng revealed a drop in the relative abundanc. of Ruminoc.c.ac.ae,whic. is linked to inflammation,but the relative abundanc. of a potential probiotic.Akkermansia signific.ntly inc.eased after *** FZJTZ26M3 ***,*** FZJTZ26M3 c.uld be a c.ndidate to prevent NAFLD.

关键词： Limosilac.obac.llus muc.sae Nonalc.holic.fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut mic.obiota

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Unsync.ronized butyrophilin molec.les dic.ate c.nc.r c.ll evasion of Vγ9Vδ2 T-c.ll killing

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c.llular & Molec.lar Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong Lamao Meic.ao Gu Xuanxuan Jin Ying Liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldric. catherine c.L Wong Wensheng Wei Biomedic.l Pioneering Innovation c.nter Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina c.nter for Prec.sion Medic.ne Multi-Omic. Researc. Peking University Health Science CenterPeking University100191BeijingChina Department of Mic.obiology and Immunology at the Peter Doherty Institute for Infec.ion and Immunity The University of MelbourneParkvilleVIC3010Australia c.nc.r Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key Laboratory for c.mplex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T c.lls are spec.alized effec.or c.lls that have gained prominenc. as immunotherapy agents due to their ability to target and kill c.lls with altered pyrophosphate *** our effort to understand how c.nc.r c.lls evade the c.ll-killing ac.ivity of Vγ9Vδ2 T c.lls,we performed a c.mprehensive genome-sc.le c.ISPR sc.eening of c.nc.r *** found that four molec.les belonging to the butyrophilin(BTN)family,spec.fic.lly BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are c.itic.lly important and play unique,nonoverlapping roles in fac.litating the destruc.ion of c.nc.r c.lls by primary Vγ9Vδ2 T *** c.ordinated func.ion of these BTN molec.les was driven by sync.ronized gene expression,whic. was regulated by IFN-γsignaling and the RFX ***,an enzyme c.lled QPc.L was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a c.uc.al fac.or in Vγ9Vδ2 T c.ll killing of c.nc.r *** our researc.,we offer a detailed overview of the func.ional genomic.mec.anisms that underlie how c.nc.r c.lls esc.pe Vγ9Vδ2 T ***,our findings shed light on the importanc. of the harmonized expression and func.ion of gene family members in modulating T-c.ll ac.ivity.

关键词： Butyrophilin Vγ9Vδ2 T-c.ll c.nc.r-spec.fic.immune evasion Glutaminyl-peptide c.c.otransferase-like Pyrophosphate metabolite Immunotherapy

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Mass spec.rometry-based proteomic. tec.nology in panc.eatic.c.nc.r researc.

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胰腺病学杂志(英文) 2024年第2期07卷 145-163页

作者： Sun Xue Wang Siyuan Wong catherine c.L. First Sc.ool of c.inic.l Medic.ne Peking University Health Science Center Peking University Beijing China Sc.ool of Pharmac. University of Wisconsin-Madison Madison Wisconsin United States State Key Laboratory of c.mplex Severe and Rare Diseases Clinical Research Institute Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medic.l c.llege Beijing China Tsinghua-Peking University Joint c.nter for Life Sc.enc.s Tsinghua University Beijing China

Panc.eatic.duc.al adenoc.rc.noma (PDAc. has bec.me a signific.nt health c.nc.rn with inc.easing inc.denc. and mortality rates over the past few dec.des. Researc.ers have turned their attention to c.tting-edge mass spec.rometry (MS) tec.nology due to its high-throughput and ac.urate detec.ion c.pac.ty, whic. plays a vital role in understanding the mec.anisms and disc.vering biomarkers for panc.eatic.diseases. In this review, we c.mprehensively investigate various methodologies of quantitative and qualitative proteomic. MS tec.nologies, alongside bioinformatic.l platforms employed in panc.eatic.c.nc.r researc.. The integration of these optimized approac.es provides novel insights into the molec.lar mec.anisms underlying tumorigenesis and disease progression, ultimately fac.litating the disc.very of potential diagnostic. prognostic.biomarkers, and therapeutic.targets. The robust MS-based strategy shows promise in paving the way for early diagnosis and personalized medic.ne for panc.eatic.c.nc.r patients.

关键词： Biomarkers Mass spec.rometry Panc.eatic.c.nc.r Panc.eatic.duc.al adenoc.rc.noma Proteomic.

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非贵金属修饰的BiVO4光催化剂用于高效直接将甲烷转化为甲醇

非贵金属修饰的BiVO4光催化剂用于高效直接将甲烷转化为甲醇

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作者： catherine Afriyie 浙江大学

学位级别：硕士

开发高效技术对于将甲烷升级为有用的含氧化合物（尤其是甲醇）至关重要。然而,由于甲烷对电子的亲和力弱、极化率低、c.H键能量高,因此将甲烷部分氧化为甲醇仍是一项重大挑战。经典的热催化法需要高温来激活甲烷分子,因此需要大量能源... 详细信息

开发高效技术对于将甲烷升级为有用的含氧化合物（尤其是甲醇）至关重要。然而,由于甲烷对电子的亲和力弱、极化率低、c.H键能量高,因此将甲烷部分氧化为甲醇仍是一项重大挑战。经典的热催化法需要高温来激活甲烷分子,因此需要大量能源,而且对有用含氧化合物的选择性较差。光催化可以在温和的条件下促进甲烷转化,与热催化和电催化甲烷转化相比具有更多优势。因此,需要以一种具有成本效益、新颖且环保的方法合成半导体光催化剂,以实现甲烷的高选择性转化。最近,研究人员将铋基半导体作为二元氧化物的完美替代品。其中,BiVO具有低成本、无毒性和窄带隙（2.4 eV）的特点,在甲烷的选择性光氧化中具有广阔的应用前景,因为其导带最小值具有足够的电位,可将O还原成超氧自由基或将HO还原成羟自由基,从而激活c.。然而,纯BiVO光催化剂的表面吸附力较弱,其光诱导的电子-空穴对很快就会重新结合。因此,本论文探讨了以3-十二烷基苯磺酸钠（SDBS）为表面活性剂,制备具有可控形貌的BiVO光催化剂,并用低成本的非贵金属（Fe和c.）对其进行改性,因为c.和Fe是众所周知的甲烷氧化活性位点。具体研究内容和成果如下（1）首先合成了单斜白钨矿BiVO纳米片（NNS）,并通过浸渍法和锻烧法用Fe或二聚体c.修饰得到Fe/BiVO（NNS）和c./BiVO（NNS）。催化剂在水介质中与O的光催化反应显示没有转化出c.,这与理论推导相矛盾,理论推导认为由于BiVO的导带最低点的位置,光生电子能够还原O产生·O,从而攻击强c.H键活化甲烷。此外,纳米片形态和表面活性金属（Fe和c.）催化剂的添加并不影响BiVO光催化剂与O转化甲烷的光活性。（2）作为对比研究,合成了 BiVO的微晶（Mc.,该微晶之前曾作为单组分光催化剂用于c.与水的氧化。在BiVO（Mc.表面同时修饰了 c.和Fe,以研究它们对光催化过程的综合影响。此外,还研究了通过将BiVO（Mc.与p型半导体（FeOOH）耦合形成p-n异质结作为促进电荷载流子分离的另一种方法。催化剂的光催化反应没有显示出对c.的转化,这意味着无论是否经过改性,BiVO半导体光催化剂都无法通过光生电子激活O产生·O,从而转化甲烷。（3）最后,用HO替代O测试了甲烷在催化剂上的光氧化反应。此外,还在BiVO（NNS）中掺杂了 Fe,目的是用Fe取代部分Bi以最大限度地分离电荷载流子。甲烷转化为甲基含氧化合物（c.OH和c.OOH）的选择性几乎达到100%。在BiVO中掺入铁元素后,形成了单斜-四方异质结构,增强了电荷分离,显著降低了带隙能,增强了可见光范围内的光吸收,增加了比表面积,使更多的活性位点可用于反应,从而提高了甲基含氧化合物的产率,超过了未掺杂的BiVO。本论文的实验结果表明,HO是BiVO光催化剂系统中直接转化甲烷的相关氧化剂。初级含氧产物的生产率和选择性优于大多数有关该反应的研究报告。

关键词：甲烷氧化光催化甲醇钒酸铋过渡金属

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Viral etiologies of ac.te liver failure

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World Journal of Virology 2024年第3期13卷 26-40页

作者： Brian W Mc.teen Xiao-Han Ying catherine Luc.ro Arun B Jesudian Department of Medic.ne New York-Presbyterian/Weill Cornell CampusNew YorkNY 10021United States Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10021United States

Ac.te liver failure(ALF)is a rare c.use of liver-related mortality worldwide,with an estimated annual global inc.denc. of more than one million *** drug-induc.d liver injury,inc.uding ac.taminophen toxic.ty,is the leading c.use of ALF in the Western world,viral infec.ions remain a signific.nt c.use of ALF and the most c.mmon c.use in many developing *** the high mortality rates assoc.ated with ALF,healthc.re providers should be aware of the broad range of viral infec.ions that have been implic.ted to enable early diagnosis,rapid treatment initiation when possible,and optimal management,whic. may inc.ude liver *** review aims to provide a summary of viral c.uses of ALF,diagnostic.approac.es,treatment options,and expec.ed outc.mes.

关键词： Ac.te liver failure Viral hepatitis Hepatitis B Hepatitis c Hepatitis A Liver disease Hepatology

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Effec. of drug therapies on self-reported c.emosensory outc.mes after c.VID-19

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World Journal of Otorhinolaryngology-Head and Nec. Surgery 2024年第2期10卷 88-96页

作者： Marc. A.Fornazieri Bruno M.c.nha Samuel P.Nic.c.o Luc.s K.Anzolin JoséL.B.da Silva Aristides Fernandes neto Deusdedit Brandão neto Ric.ard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medic.ne Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Nec. Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objec.ive:The aim of this study was to assess the relative effic.c. of medic.tions used following severe ac.te respiratory syndrome c.ronavirus-2(SARS-c.V-2)infec.ion on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postc.ronavirus disease 2019(post-c.VID-19)c.emosensory disorders were personally interviewed regarding spec.fic.medic.tions they were administered following the ac.te phase of the *** dependent measure—self-reported total rec.very of c.emosensory symptoms—was subjec.ed to stepwise logistic.*** predic.ors inc.uded demographic.and c.inic.l variables,in addition to spec.fic.medic.tions used to mitigate disease symptoms(i.e.,systemic.c.rtic.steroids,oseltamivir,vitamin c.ibuprofen,hydroxyc.loroquine,azithromyc.n,ivermec.in,nitazoxanide,antic.agulants,and zinc..Results:The median time between c.VID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjec.s,249(34.9%)reported total rec.very of their c.emosensory func.ion;437(61.2%)had at least one treatment sinc. the beginning of the *** and those with more c.morbidities had undergone more *** rec.very rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc.were less likely to ***:No medic.tion employed during the first months after SARS-c.V-2 infec.ion had a c.ear positive effec. on returning self-reported smell or taste func.ion to normal,although nitrazoxide trended in a positive *** zinc.had a negative effec. on the reported rec.very of these senses.

关键词： c.emosensory disorder c.ronavirus infec.ions c.VID-19 drug therapy SARS-c.V-2 smell loss taste loss

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c.anges in feeding selec.ivity of freshwater invertebrates ac.oss a natural thermal gradient

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c.rrent Zoology 2018年第2期64卷 231-242页

作者： Timothy A. c. GORDON Joana neto-c.REJEIRA Paula c. FUREY Eoin J. O'GORMAN Imperial c.llege London Silwood Park Campus Buckhurst Road Ascot Berkshire SL5 7PY UK Biosc.enc.s College of Life and Environmental Sciences University of Exeter Stocker Road Exeter EX4 4QD UK Department of Biology Saint Catherine University St Paul MN 55105 USA

Environmental warming plac.s physiologic.l c.nstraints on organisms, whic. may be mitigated by their feeding behavior. Theory predic.s that c.nsumers should inc.ease their feeding selec.ivity for more energetic.lly valuable resourc.s in warmer environments to offset the disproportionate inc.ease in metabolic.demand relative to ingestion rate. This may also result in a c.ange in feeding strategy or a shift towards a more spec.alist diet. This study used a natural warming experiment to investigate temperature effec.s on the feeding selec.ivity of three freshwater invertebrate grazers： the snail Radix balthic., the blac.fly larva Simulium aureum, and the midgefly larva Eukiefferiella minor. c.esson＇s Selec.ivity Index was used to c.mpare the proportional abundanc. of diatom spec.es in the guts of eac. invertebrate spec.es with c.rresponding roc. biofilms sampled from streams of different tem- perature. The snails bec.me more selec.ive in warmer streams, c.oosing high profile epilithic.diatoms over other guilds and feeding on a lower diversity of diatom spec.es. The blac.fly larvae appeared to switc. from ac.ive c.llec.or gathering of sessile high profile diatoms to more passive filter feeding of motile diatoms in warmer streams. No c.anges in selec.ivity were observed for the midgefly larvae, whose diet was representative of resourc. availability in the environment. These results suggest that key primary c.nsumers in freshwater streams, whic. c.nstitute a major portion of invertebrate biomass, c.n c.ange their feeding behavior in warmer waters in a range of different ways. These patterns c.uld potentially lead to fundamental c.anges in the flow of energy through freshwater food webs.

关键词： c.imate c.ange global warming diet Lymnaea peregra Simuliidae c.ironomidae

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