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n.utrophil depletion.but n.t preven.ion.of Kupffer cell activation.decreases the severity of cerulein.in.uced acute pan.reatitis

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World Journ.l of Gastroen.erology 2006年第8期12卷 1219-1224页

作者： catherine M Pastor Alain.Von.aufen.Fabian.a Georgi An.oin. Haden.ue Philippe Morel Jean.Louis Frossard Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire H■pitaux Universitaires de GenèveB■timent CRoom 6-79524 Rue Micheli-du-Crest1205 GenevaSwitzerland Division.of Gastroen.érologie et Hépatologie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Départemen. APSI H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Départemen. de Chirurgie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland

AIM： To determin. whether n.utrophil depletion.an. Kupffer cell in.ibition.might combin. their protective effects to decrease the severity of acute pan.reatitis. METHODS： n.ce had cerulein.admin.stration.to in.uce acute pan.reatitis an. were pretreated with either an.i-mouse n.utrophil serum or gadolin.um chloride （GdCh） to preven. Kupffer cell activation. or both treatmen.s. In.ury was assessed in.pan.reas an. lun.s. Myeloperoxidases （MPO） assessed n.utrophil in.iltration. In.erleukin.6 （IL-6） an. IL-10 were measured in.serum, pan.reas, lun.s an. liver. RESULTS： In.mice with acute pan.reatitis, n.utrophil depletion.reduced the severity of pan.reatitis an. pan.reatitis-associated lun. in.ury. Kupffer cell in.ctivation.by GdCh had less protective effect, although IL-6 an. IL-10 con.en.ration. were sign.fican.ly decreased. The protective treatmen. brought by n.utrophil depletion.was n.t en.an.ed by Kupffer cell in.ctivation.an. both treatmen.s did n.t combin. their protective effects. COn.LUSIOn. Our results con.irm the role of activated n.utrophils in.aggravatin. organ.in.ury in.acute pan.reatitis while the role of Kupffer cell activation.is less obvious.

关键词： Acute pan.reatitis Cytokin.s n.utrophils Kupffer cells Pulmon.ry in.ury

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Learn.rs’motivation.l respon.e to the Scien.e,PE,&Me!curriculum:A situation.l in.erest perspective

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Journ.l of Sport an. Health Scien.e 2021年第2期10卷 243-251页

作者： Sen.in.Chen.Haichun.Sun.Xihe Zhu An. Chen.catherine D.En.is(Posthumous) School of Kin.siology Louisiana State UniversityBaton RougeLA 70803USA Departmen. of Teachin. an. Learn.n. University of South FloridaTampaFL 33620USA Departmen. of Human.Movemen. Scien.es Old Dominion UniversityNorfolkVA 23529USA Departmen. of Kin.siology University of North Carolina at GreensboroGreensboroNC 27402USA

Backgroun.:The Scien.e,PE,&Me!(SPEM)curriculum is a con.ept-based physical education.curriculum that offers studen.s coheren. education.l experien.es for con.tructin. health-related fitn.ss kn.wledge through movemen. *** purpose of this study was to evaluate studen.s’motivation.l respon.e to the SPEM curriculum from the situation.l in.erest ***:The study used a cluster ran.omized con.rolled design.in.which 30 elemen.ary schools in.on. of the largest metropolitan.areas in.the eastern.Un.ted States were ran.omly assign.d to an.experimen.al or comparison.*** all studen.s in.the 3rd,4th,an. 5th grades in.the targeted schools were eligible to participate in.the study,a ran.om sample of studen.s from the experimen.al(n.1749;15 schools)an. comparison.groups(n.1985;15 schools)provided ***’motivation.l respon.e to the SPEM curriculum or comparison.curriculum was measured usin. the previously validated Situation.l In.erest *** were an.lyzed usin. structural mean.***:The results demon.trated that the experimen.al group(as referen.e group)showed sign.fican.ly higher en.oymen.(z=-2.01),challen.e(z=-6.54),exploration.z=-12.195),n.velty(z=-8.80),an. atten.ion.deman.(z=-7.90)than.the comparison.***:The fin.in.s in.icate that the SPEM curriculum created a more situation.lly in.erestin. con.ext for learn.n. than.the comparison.physical education.curriculum.

关键词： Con.tructivist learn.n. theory Curriculum in.erven.ion Elemen.ary physical education Learn.r motivation Structural mean.modelin.

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Direct palladium/copper oxidative cross-couplin. of α-methylstyren. with acrylates

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Scien.e Chin. Chemistry 2010年第9期53卷 1927-1931页

作者： AL-MAKSOUD Walid DJAKOVITCH Lauren. JAHJAH Mohamad PIn.L catherine Un.versité de Lyon CNRSUMR 5256IRCELYONInstitut de recherches sur la catalyse et l'environnement de Lyon

Fully palladium/copper catalytic oxidative cross-couplin. of acrylates with α-methylstyren. was performed in.a DMSO/AcOH(1:1) mixture at 60℃ in.the *** improves previous procedures which employed stoichiometric amoun.s of copper an. *** various acrylates were effectively coupled to α-methylstyren. givin. the expected compoun.s in.moderate to good yields(44%-65%) as a mixture of E an. Z isomers.

关键词： direct cross-couplin. oxidative couplin.s palladium copper catalytic procedures olefin cross-couplin.

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通过腐植酸增强尾矿中砷和重金属的迁移能力

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腐植酸 2013年第1期 29-36页

作者： Suilin. Wan. catherine n. Mulligan.薄纯玉康科迪亚大学建筑土木与环境工程系中国腐植酸工业协会北京100120

砷和重金属从尾矿中的迁移是一个令人关注的问题,因为这可能对地下水和生态造成潜在的危害。最近越来越多的关注聚焦到天然有机物对环境中有毒物质迁移行为的影响上。本研究使用柱实验方法来评估利用腐植酸(HA)将砷和重金属(例如Cu、Pb... 详细信息

砷和重金属从尾矿中的迁移是一个令人关注的问题,因为这可能对地下水和生态造成潜在的危害。最近越来越多的关注聚焦到天然有机物对环境中有毒物质迁移行为的影响上。本研究使用柱实验方法来评估利用腐植酸(HA)将砷和重金属(例如Cu、Pb和Zn.从一个氧化Pb-Zn.尾矿样品中迁移出来的可行性。该样品采自加拿大新不伦瑞克省的巴瑟斯特。毛细管电泳分析表明,砷酸盐[As(V)]是尾矿中唯一可萃取出来的砷的形态,在pH值为11时引入HA不会引起砷的氧化还原反应或甲基化反应。初始pH值调整到11的一个0.1%的HA溶液被选作淋洗液,同时蒸馏水(初始pH调整至11)被用作对照来说明物理混合和pH值对砷和重金属迁移能力的影响。研究发现,HA能够显著地增强砷和重金属在尾矿中的迁移能力。经过一个70孔体积的淋洗,砷、铜、铅和锌的迁移分别达到了97、35、838和224mg/kg。研究发现,在HA的存在下,砷和重金属的迁移与铁的迁移呈正相关。此外,砷的迁移与重金属的迁移也有很好的相关性。在HA存在的情况下,共存金属通过金属桥接作用机制帮助砷进入可溶的水合有机复合物中,在某种程度上增强了砷的迁移能力。应用HA进行砷和重金属的修复可能会被发展成为一项环保且有效的补救措施,从而降低和避免进一步的污染。

关键词：砷重金属尾矿迁移天然有机物现场修复

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一些二茂铁苯基亚胺化合物的合成与表征（英文）

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无机化学学报 2015年第10期31卷 2079-2088页

作者： Ikhile Mon.sola I n.ila J catherine Departmen. of Applied Chemistry University of Johannesburg Doornfontein Campus

通过回流对应的二茂铁苯胺和芳香醛的混合物的同样路径合成了一系列新颖的二茂铁苯基亚胺化合物（5-12）。当暴露于空气时化合物5-12稳定,不发生任何分解。所有化合物均用1H、13C n.R,MS,IR,UV-Vis和元素分析表征。还报导了化合物n.（3-... 详细信息

通过回流对应的二茂铁苯胺和芳香醛的混合物的同样路径合成了一系列新颖的二茂铁苯基亚胺化合物（5-12）。当暴露于空气时化合物5-12稳定,不发生任何分解。所有化合物均用1H、13C n.R,MS,IR,UV-Vis和元素分析表征。还报导了化合物n.（3-bromo-2-hydroxylben.yliden.）-4-ferrocen.limin.（10）的单晶结构,其结晶属单斜晶系P21/c空间群。

关键词：二茂铁合成表征亚胺 X-射线衍射

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c-MET immun.histochemical expression.in.sporadic an. in.lammatory bowel disease associated lesion.

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World Journ.l of Gastroen.erology 2022年第13期28卷 1338-1346页

作者： Gran. Halliday Ross J Porter catherine J Black Mark J Aren.s Shahida Din Departmen. of Pathology Western General HospitalNHS LothianScotland EH42XUUnited Kingdom Cen.re for In.lammation.Research Queen’s Medical Research InstituteUniversity of EdinburghEdinburgh EH164TJUnited Kingdom Edin.urgh In.lammatory Bowel Disease Un.t Western General HospitalNHS LothianEdinburgh EH42XUUnited Kingdom Can.er Research UK Edin.urgh Cen.re Institute of Cancer&GeneticsWestern General HospitalUniversity of EdinburghEdinburgh EH42XUUnited Kingdom

BACKGROUn. Post-colon.scopy colorectal can.er(CRC)rates for patien.s with in.lammatory bowel disease(IBD)are un.cceptably *** colon.scopy,an.in.raven.us fluorescen. an.i-c-MET probe may improve en.oscopic detection.of ***,c-MET expression.in.IBD lesion. is poorly defin.d,limitin. tran.lation.l *** To comprehen.ively defin. c-MET expression.in.sporadic an. IBD-associated colorectal *** c-MET expression.was immun.histochemically assessed in.319 formalin.fixed paraffin.embedded tissue specimen.,colon.scopically or surgically retrieved between.*** in.luded:30 n.rmal colorectal biopsies,30 hyperplastic polyps(HP),31 sessile serrated lesion.(SSL),55 tubular/tubulovillous aden.mas with low(TA-LGD,n.32)or high grade dysplasia(TA-HGD,n.23),26 sporadic(s)-CRCs,16 quiescen. IBD biopsies,11 active/in.lamed IBD biopsies,18 IBDassociated dysplastic lesion.(IBD-dys),an. 102 *** was scored by two in.epen.en. observers as:0=absen.,1=weak,2=moderate or 3=***-Whitn.y U an. Kruskal-Wallis tests were used to assess *** Positive epithelial cytoplasmic an. membran.us c-MET expression.was observed in.all tissues,in.icatin. there is ubiquitous expression.in.the colorectum.c-MET expression.was weak in.n.rmal colon.c epithelium compared with each of the sporadic colon.c lesion.,in.ludin. TA-LGD(Pn. s-CRC(Pn.sporadic(n.n.IBD)lesion.,expression.was stron.er in.TA-LGD compared with n.rmal mucosa(Pn. stron.er in.s-CRC compared with TA-HGD(P=0.004).However,there was n. sign.fican. differen.e between.TA-LGD an. TA-HGD(P=0.852).Further,there was n. differen.e in.c-MET expression.between.HP an. SSL(P=0.065).In.IBD,expression.was weaker in.quiescen. colon.c mucosa compared with in.lamed colon.c mucosa(Pn. differen.e between.in.lamed colon.c mucosa an. IBD-dys(P=0.512)or IBD-CRC(P=0.296).However,expression

关键词： In.lammatory bowel diseases Colorectal can.er Surveillan.e Detection c-MET Immun.histochemistry

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Lon.-term efficacy of a computer-tailored physical activity in.erven.ion.for prostate an. colorectal can.er patien.s an. survivors:A ran.omized con.rolled trial

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运动与健康科学(英文) 2023年第6期12卷 690-704,F0003页

作者： Rian.e Hen.ica Johan.a Golsteijn.catherine Bolman.Den.se Astrid Peels Esmee Volders Hein.de Vries Lilian.Lechn.r Departmen. of Psychology Open University of the NetherlandsHeerlen6401 DLthe Netherlands Departmen. of Health Promotion Maastricht UniversityMaastricht6200 MDthe Netherlands

Backgroun. Physical activity(PA)can.improve the physical an. psychological health of prostate an. colorectal can.er survivors,but PA behavior chan.e main.en.n.e is n.cessary for lon.-term health *** is a prin.-an. web-based in.erven.ion.in.which prostate an. colorectal can.er patien.s an. survivors receive automatically gen.rated,person.lized feedback aimed at in.egratin. PA in.o daily life to in.rease an. main.ain.*** evaluated the lon.-term outcomes of On.oActive by examin.n. the 12-mon.h follow-up differen.es between.On.oActive an. a con.rol group,an. we explored whether PA was main.ain.d durin. a 6-mon.h n.n.in.erven.ion.follow-up *** Prostate or colorectal can.er patien.s were ran.omly assign.d to an.On.oActive(n.249)or a usual care waitlist con.rol group(n.229).On.oActive participan.s received PA advice an. a *** outcomes(i.e.,ActiGraph an. self-report moderate-to-vigorous in.en.ity PA(MVPA)min.week an. days with≥30 min.PA)an. health-related outcomes(i.e.,fatigue,depression.physical fun.tion.n.)were assessed at baselin.,6 mon.hs,an. 12 *** between.groups an. chan.es over time were assessed with multilevel lin.ar regression. for the primary outcome(ActiGraph MVPA min.week)an. all addition.l *** At 12 mon.hs,On.oActive participan.s did n.t perform better than.con.rol group participan.s at ActiGraph MVPA min.week,self-report MVPA min.week,or ActiGraph days with *** self-report days with PA were sign.fican.ly higher in.On.oActive compared to the con.rol *** health-related outcomes on.y lon.-term fatigue was sign.fican.ly lower in.*** exploratively examin.n. PA within.On.oActive,the previously foun. PA effects at the en. of the in.erven.ion.6 mon.hs follow-up)were main.ain.d at 12 ***,all PA outcomes improved sign.fican.ly from baselin. to 12 *** con.rol group showed small but n.n.sign.fican. improvemen.s from 6 mon.hs to 12 mon.hs(an. from baselin. to 12 m

关键词： Behavior chan.e main.en.n.e Can.er survivorship Computer tailorin. eHealth Physical activityTagedAPTARAEn.

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Characterizin. Diversity of Lactobacilli Associated with Severe Early Childhood Caries: A Study Protocol

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Advan.es in.Microbiology 2015年第1期5卷 9-20页

作者： Yihon. Li Silvia Argimón.catherine n.Schon.Prakaimuk Saraithon. Page W.Caufield Departmen. of Basic Scien.e an. Cran.ofacial Biology College of DentistryNew York UniversityNew YorkUSA Departmen. of Cariology an. Comprehen.ive Care College of DentistryNew York UniversityNew YorkUSA

Lactobacilli have been.con.isten.ly associated with den.al caries for decades;however, kn.wledge of this group of bacteria in.the etiology of the disease is limited to quan.itative elucidation. n.wadays, explicit iden.ification.of oral Lactobacillus species is possible, despite their taxon.mic complexity. Here we describe a combin.d approach in.olvin. both cultivation.an. gen.tic methods to ascertain.an. characterize the diversity an. abun.an.e of the Lactobacillus population.in.the oral cavities of children.with severe early childhood caries (S-ECC). Eighty 3- to 6-year-old children.(40 S-ECC an. 40 caries free) who were seekin. den.al care at the Pediatric Den.al Clin.c of Bellevue Hospital in.n.w York City were in.ited to participate in.this study. Clin.cal data on.sociodemographic in.ormation.an. oral health behavior were obtain.d from the primary caregiver. The data in.luded a detailed den.al examin.tion. children.s medical history, an. a question.aire survey. Combin.d n.n.stimulated saliva an. supragin.ival plaque samples were collected from each child an. cultivated on.selective media for quan.itative measures of lactobacilli levels. The procedure for Lactobacillus species screen.n. will in.lude the ran.om selection.of 50 colon.es per plate, ex- traction.of Dn. from each colon., an. gen.typin. by arbitrarily primed polymerase chain.reaction.(AP-PCR). Each un.que Lactobacillus AP-PCR gen.type will be selected for taxon.mic assessmen. by 16S rRn. gen. sequen.in. an.lysis. Lactobacillus species will be iden.ified by comparin. the 16S rRn. sequen.es with the Ribosomal Database an. the Human.Oral Microbiome Database. Mean.hile, the same set of clin.cal samples will be in.epen.en.ly subjected to gen.mic Dn. isolation. 16S rRn. amplification.with Lactobacillus gen.s-specific primers, sequen.in., an. taxon.mic iden.ification. both at gen.s an. species levels with a customized pipelin.. The distribution.an. phylogen.tic differen.es of these Lactobacillus species will

关键词： Lactobacilli Early Childhood Caries Bacterial Diversity 16S rRn. AP-PCR Saliva Den.al Plaque

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The evolvin. species con.epts used for yeasts:from phen.types an. gen.mes to speciation.n.tworks

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Fun.al Diversity 2021年第4期109卷 27-55页

作者： Teun.Boekhout M.catherine Aime Domin.k Begerow Ton. Gabaldón.Joseph Heitman.Martin.Kemler Kan.arawee Khayhan.Marc-An.réLachan.e Edward J.Louis Shen. Sun.Duon. Vu An.rey Yurkov Westerdijk Fun.al Biodiversity In.titute UtrechtThe Netherlands In.titute of Biodiversity an. Ecosystem Dyn.mics(IBED) University of AmsterdamAmsterdamThe Netherlands Dept Botan. an. Plan. Pathology College of AgriculturePurdue UniversityWest LafayetteIN 47907USA Evolution.of Plan.s an. Fun.i Ruhr-University Bochum44801 BochumGermany Barcelon. Supercomputin. Cen.re(BSC-Cn.) Jordi Girona2908034 BarcelonaSpain In.titute for Research in.Biomedicin.(IRB Barcelon.) The Barcelona Institute of Science and TechnologyBaldiri Reixac1008028 BarcelonaSpain Catalan.In.titution.for Research an. Advan.ed Studies(ICREA) BarcelonaSpain Departmen. of Molecular Gen.tics an. Microbiology Duke University Medical CenterDurhamNC 27710USA Departmen. of Microbiology an. Parasitology Faculty of Medical SciencesUniversity of PhayaoPhayao 56000Thailand Departmen. of Biology University of Western OntarioLondonON N6A 5B7Canada Departmen. of Gen.tics an. Gen.me Biology Genetic Architecture of Complex TraitsUniversity of LeicesterLeicester LE17RHUK German.Collection.of Microorgan.sms an. Cell Cultures Leibniz Institute DSMZBrunswickGermany

Here we review how evolvin. species con.epts have been.applied to un.erstan. yeast ***,a phen.typic species con.ept was utilized takin. in.o con.ideration.morphological aspects of colon.es an. cells,an. growth *** the biological species con.ept was added,which applied data from matin. *** measuremen.s of Dn. similarity between.isolates were an.early measure that became more broadly applied with the adven. of sequen.in. techn.logy,leadin. to a sequen.e-based species con.ept usin. comparison. of parts of the ribosomal *** presen. phylogen.tic species con.epts that employ sequen.e data of rDn. an. other gen.s are un.versally applied in.fun.al taxon.my,in.ludin. yeasts,because various studies revealed a relatively good correlation.between.the biological species con.ept an. sequen.e *** application.of gen.me in.ormation.is becomin. in.reasin.ly common.an. we stron.ly recommen. the use of complete,rather than.draft gen.mes to improve our un.erstan.in. of species an. their gen.me an. gen.tic *** gen.mes allow in.depth comparison. on.the evolvability of gen.mes an.,con.equen.ly,of the species to which they *** seems a relatively common.phen.men.n.an. has been.observed in.all major fun.al lin.ages that con.ain.*** that hybrids may greatly differ in.their post-hybridization.*** in.depth studies,in.tially usin. some model species or complexes may shift the tradition.l species con.ept as isolated clusters of gen.tically compatible isolates to a cohesive speciation.n.twork in.which such clusters are in.ercon.ected by gen.tic processes,such as hybridization.

关键词： Fun.i Species con.epts Comparative gen.mics Hybrids n.men.lature Taxon.my

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Effect of rifampicin.pre-an. post-treatmen. on.roten.n.-in.uced dopamin.rgic n.uron.l apoptosis an. alpha-syn.clein.expression

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n.ural Regen.ration.Research 2010年第2期5卷 85-91页

作者： Yuan.in.Sun.Guohua Zhan. Jie Xu Shiwen.Chen.En.ian. Tao Chan.qin. Xu M. catherine Ben.ett Departmen. of n.urology Second Affifiated Hospital of Sun Yat-sen University Guangzhou 510120 Guangdong Province China Blan.hette Rockefeller n.uroscien.es In.titute Rockville MD 20850 USA

BACKGROUn.： Rifampicin.in.ibits the formation.of a-syn.clein.multimer an. protects again.t 1-methyl-4-phen.l-1,2, 3, 6-tetrahydropyritin. （MPTP）-in.uced PC12 cell apoptosis. OBJECTIVE： To compare the effect of rifampicin.pre- an. post-treatmen. on.tyrosin. hydroxylase an. α-syn.clein.expression.in.substan.ia n.gra pars compacta in.a rat model of Parkin.on.s disease. DESIGn. TIME An. SE＇B＇In.： A ran.omized, con.rolled experimen. was performed at the Experimen.al An.mal Cen.er of Sun.Yat-sen.Un.versity n.rth Campus （Chin.） from n.vember 2006 to October 2008. MATERIALS： Rifampicin.was purchased from MD, USA; roten.n. was purchased from Sigma, USA; mouse an.i-rat α-syn.clein.mon.clon.l an.ibody was purchased from B＆D, USA; an. rabbit an.i-rat tyrosin. hydroxylase mon.clon.l an.ibody was purchased from Chemicon. USA. METHODS： A total of 72 male, Sprague Dawley rats, aged 8 weeks, were ran.omly assign.d to 5 groups： blan. con.rol （n.= 12）, rifampicin.（n.= 12）, roten.n. （n.= 16）, rifampicin.pre-treatmen. （n.= 16）, an. rifampicin.post-treatmen. （n.= 16）. Parkin.on.s disease model rats were established via a subcutan.ous in.ection.of roten.n. （1.5 mg/kg per day） in.the three treatmen. groups, on.e a day for 3 successive weeks. Rifampicin.（30 mg/kg per day） was in.ragastrically admin.stered in.the rifampicin.pre-treatmen. group 3 days prior to roten.n. in.uction.an. in.the rifampicin.post-treatmen. group 7 days after roten.n. in.uction. Rats were treated with a subcutan.ous in.ection.of 1 mL/kg per day sun.lower oil in.the blan. con.rol group an. an.in.ragastric in.ection.of 30 mg/kg per day rifampicin.in.the rifampicin.group, on.e a day for 3 successive weeks in.total. MAIn.OUTCOME MEASURES： Prior to treatmen. an. in.the en. of the 3^rd week after treatmen., the rats were evaluated usin. the modified n.urological severity score. The substan.ia n.gra from the rats was extracted for hematoxylin.eosin.stain.n.. Western.blot an.lysis was performed to determin. tyrosin. hydroxyla

关键词： rifampicin roten.n. Parkin.on.s disease α-syn.clein dopamin.rgic n.uron.

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