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奥运会给巴黎留下宝贵遗产

新体育 2024年第9期 16-16页

作者： catherine Porter 不详

在巴黎奥运会闭幕式上,一群法国消防员像杂技演员那样舞动身体,一位音乐家弹奏着垂悬于半空的钢琴,奥运选手们成了舞台中央的主角,与法国电子流行乐队一起狂欢。2024年巴黎奥运以与开始时相似的方式落幕,欢乐的人群制造出喧闹景象,场面... 详细信息

在巴黎奥运会闭幕式上,一群法国消防员像杂技演员那样舞动身体,一位音乐家弹奏着垂悬于半空的钢琴,奥运选手们成了舞台中央的主角,与法国电子流行乐队一起狂欢。2024年巴黎奥运以与开始时相似的方式落幕,欢乐的人群制造出喧闹景象,场面充满了闪光灯、烟雾和烟花等元素。

关键词：奥运选手奥运会杂技演员消防员闪光灯巴黎

Histological remission of eosinophilic esophagitis under asthma therapy with IL-5 receptor monoclonal antibody:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4502-4508页

作者： Marc Huguenot Anne-catherine Bruhm Manfred Essig Department of Gastroenterology and Internal Medicine Tiefenau HospitalBern 3004Switzerland

BACKGROUND Benralizumab is a monoclonal antibody targeting the IL-5 receptor used in the treatment of *** use of benralizumab in other conditions is only emerging and could represent a therapeutic option for other eosinophil-associated ***,we report the case of a patient suffering from eosinophilic esophagitis and asthma who achieved histological remission of eosinophilic esophagitis(EoE)under benralizumab treatment for his *** SUMMARY Our patient was a 56-year-old white male with a history of eosinophilic esophagitis and severe *** years of usual treatments,including topical steroids,biological treatment with mepolizumab,and standard asthma treatment,only poor control of both conditions was obtained.A control gastroscopy after the initiation of benralizumab showed complete histological remission of his *** Our case shows the effects of therapy with a novel agent not yet approved for this condition but for other diseases,with histological resolution of EoE after *** clinical remission was not observed,which exemplifies the complex nature of EoE,its associated psychosomatic burden,and the chronification of the ***,monoclonal antibodies targeting the Th2 response and,in our case,an IL5 receptor antagonist,achieved complete histological remission,which was not the case with an antibody against IL-5,which was also initiated to treat asthma.

关键词： Eosinophilic esophagitis Benralizumab,Eosinophilic asthma Case report

Numerical computation of hurricane effects on historic coastal hydrology in Southern Florida

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Ecological Processes 2015年第1期4卷 37-56页

作者： Eric D Swain Dennis Krohn catherine A Langtimm U.S.Geological Survey Caribbean-Florida Water Science Center7500 SW 36th StreetDavieFL 33314USA U.S.Geological Survey St.Petersburg Coastal and Marine Science Center600 Fourth Street SouthSt.PetersburgFL 33701USA U.S.Geological Survey Southeast Ecological Science Center7920 NW 71st StreetGainesvilleFL 32653USA

Introduction:Numerical models are critical for assessing the effects of sea level rise(SLR),hurricanes,and storm surge on vegetation change in the Everglades National *** model must be capable of representing short-timescale hydrodynamics,salinity transport,and groundwater ***,there is also a strong need to adapt these numerical models to hindcast past conditions in order to examine long-term effects on the distribution of vegetation that cannot be determined using only the modern ***:Based on parameters developed for a numerical model developed for the recent 1996 to 2004 period,a hindcast model was developed to represent sea level and water management for the period of 1926 to 1932,constrained by the limited hydrology and meteorology data available from the historic *** hurricanewind and storm surge representations,required for the hindcast model,are based on information synthesized from modern storm data.A series of simulation scenarios with various hurricane representations inserted into both hindcast and recent numerical models were used to assess the utility of the storm representation in the model and compare the two ***:The comparison of the hindcast and recent models showed differences in the hydrology patterns that are consistent with known differences in water delivery systems and sea level rise.A 30×lower-resolution spatially variable wind grid for the hindcast produced similar results to the original high-resolution full wind grid representation of the recent *** effects on hydrologic patterns demonstrated with the simulations show hydrologic processes that could have a long-term effect on vegetation ***:The hindcast simulation estimated hydrologic processes for the 1926 to 1932 *** shows promise as a simulator in long-term ecological studies to test hypotheses based on theoretical or empirical-based studies at larger landscape scales.

关键词： Hindcast Numerical models Hurricanes Wind fields Storm surge Sea level rise Coastal hydrology

Providing primary care to transgender patients

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Family Medicine and Community Health 2019年第3期7卷 37-39页

作者： catherine Frances Casey Family Medicine University of VirginiaCharlottesvilleVirginiaUSA

Lara(not an actual patient),a 45-year-old transwoman,presents to your clinic for a yearly *** has no significant medical history except for *** surgical history includes appendectomy and breast *** history is significant for a mother who developed breast cancer at age 55 years and a brother with type 2 *** terms of her social history,she does not smoke,drinks 1-2 glasses of wine on the weekends and has been in a mutually monogamous relationship with a male partner for 2 *** medications include spironolactone,oestradiol and *** people-people who identify as a gender other than the one assigned at birth-have existed throughout human history and in multiple *** at no time have they received as much attention as they have in the last few *** validity of their identities and their corresponding legal rights are a political battleground in the *** the increasing prevalence of people coming out as transgender or gender-expansive,and despite the trend towards greater societal acceptance of non-binary gender identities,transgender patients face significant barriers to accessing basic medical *** schools and residencies have traditionally provided very little training on caring for transgender patients,a paradigm that is only now beginning to *** to popular belief,patients identifying as transgender or gender-expansive span the entire age range,with paediatric to geriatric patients choosing interventions that include pubertyblocking medications,hormone therapy and/or surgical *** care doctors find themselves learning,often from patients,how to provide sensitive,competent care to this underserved and marginalised population.

关键词： patients legal smoke

Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models

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Neural Regeneration Research 2017年第11期12卷 1885-1894页

作者： Tara Nguyen Yilin Mao Theresa Sutherland catherine Anne Gorrie School of Life Sciences Faculty of ScienceUniversity of Technology SydneyNew South WalesAustralia

Traumatic spinal cord injury （SCI） is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells, astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI （n = 9）, sham surgery （n = 8）, or no surgery （n = 8）. Spinal cord and brain tissues were fixed and cut at six regions of the neuroaxis. Immunohistochem- istry showed increased reactivity of neural progenitor cell marker nestin in the central canal at all levels of the spinal cord. Increased reactivity of astrocyte-specific marker glial fibrillary acidic protein was found only at the lesion epicenter. The number of activated microglia was significantly increased at the lesion site, and activated microglia extended to the lumbar enlargement. Phagocytic microglia and macrophages were significantly increased only at the lesion site. There were no changes in nestin, glial fibrillary acidic protein, microglia and macrophage response in the third ventricle of rats subjected to mild-contusion thoracic SCI compared to the sham surgery or no surgery. These findings indicate that neural progenitor cells, astrocytes and microglia respond differently to a localized SCI, presumably due to differences in inflammatory signaling. These different cellular responses may have implications in the way that neural progenitor cells can be manipulated for neuroregeneration after SCI. This needs to be further investigated.

关键词： nerve regeneration contusion spinal cord neuroinflammatory ependymal cell glial fibrillary acidic protein microglia nestin neuroaxis tanycyte third ventricle trauma neural regeneration

Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2020年第6期15卷 1039-1040页

作者： Jean Pierre Pallais catherine M.Kotz Milos Stanojlovic Integrative Biology and Physiology University of MinnesotaMinneapolisMNUSA(Pallais JPKotz CMStanojlovic M)Minneapolis VA Health Care SystemGeriatric ResearchEducation and Clinical CenterMinneapolisMNUSA(Kotz CM)

Multiple sclerosis(MS)is a T-cell-mediated autoimmune disease of the central nervous system(CNS).Worldwide,more than 2.3 million people are diagnosed with *** its clinical manifestations appear typically in the third and fourth decades of life,MS is a major cause of neurological disability in young adults and has wide health,psychological,economic,and social *** are three key pathological features of MS:inflammation;demyelination and oligodendrocyte loss;axonal loss and *** are two main hypotheses regarding mechanisms of MS ***“outside-in”concept is an older,widely recognized hypothesis that describes neurodegeneration as a consequence of inflammatory induced demyelination,which is caused by immune system activation(Lassmann et al.,2012).Mechanisms of T-cell mediated myelin destruction are extensively studied,but the manner by which the immune system perceives myelin as foreign.

关键词： autoimmune sclerosis inflammation

A NOVEL APPLICATION OF A CLASSICAL METHOD FOR CALCULATING THE BASIC REPRODUCTIVE NUMBER, Ro FOR A GENDER AND RISK STRUCTURED TRANSMISSION DYNAMIC MODEL OF HUMAN PAPILLOMAVIRUS INFECTION

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International Journal of Biomathematics 2013年第6期6卷 149-161页

作者： KATY TOBIN catherine COMISKEY Academic Unit of NeurologyTrinity College Dublin Dublin 2 Ireland School of Nursing and MidwiferyTrinity College Dublin Dublin 2 Ireland

Mathematical models are increasingly being used in the evaluation of control strategies for infectious disease such as the vaccination program for the Human PapiUomavirus （HPV）. Here, an ordinary differential equation （ODE） transmission dynamic model for HPV is presented and analyzed. Parameter values for a gender and risk structured model are estimated by calibrating the model around the known prevalence of infection. The effect on gender and risk sub-group prevalence induced by varying the epidemiological parameters are investigated. Finally, the outcomes of this model are applied using a classical mathematical method for calculating R0 in a heterogeneous mixing population. Estimates for R0 under various gender and mixing scenarios are presented.

关键词： Transmission dynamic models HPV ODE SIR model R0

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青岛的啤酒文化

孔子学院（中法文对照版） 2024年第1期 26-29页

作者：刘丰祥唐顺英白洁(翻译) 不详

有人曾说,外国人认识中国通常有两种途径,“一个是通过孔子,另一个就是通过青岛啤酒”。韩国的运输集装箱上画着青岛啤酒的标志和可爱的大熊猫,在他们眼中,青岛啤酒和大熊猫就是中国的象征。啤酒在青岛有100多年的历史,几乎和这座城市... 详细信息

有人曾说,外国人认识中国通常有两种途径,“一个是通过孔子,另一个就是通过青岛啤酒”。韩国的运输集装箱上画着青岛啤酒的标志和可爱的大熊猫,在他们眼中,青岛啤酒和大熊猫就是中国的象征。啤酒在青岛有100多年的历史,几乎和这座城市同龄。

关键词：青岛啤酒啤酒文化集装箱大熊猫外国人

New Insights on US Aggregate and State Level Trade with the China Region

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China & World Economy 2011年第6期19卷 92-108页

作者： catherine Y.Co Department of Economics University of Nebraska at Omaha

Aggregate trade data with breakdown into related and non-related party components show that US multinational enterprises use different trading strategies in the China region relative to other countries. US trade with the China region in 2002-007 is characterized by arm ＇s- length transactions. State-level trade data show great variability in state engagement with the region through trade： exports to the region range from 1 to 28 percent of state exports. In addition, compared to exports to other countries, exports to the region are highly concentrated. At the extreme, for some states, 96-98 percent of exports to the region are computer and electronic products. Finally, gravity regressions show that state exports to Hong Kong are posflively associated with the relative size of the ltong Kong-born population in the states. There is no evidence that stricter labor regimes lead to lower state exports.

关键词： arm's-length trade intra-firm trade multinational finns US-China trade