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Phenotyping flora. a.tra.tiveness to pollina.ors using vola.ilomics,3D ima.ing,a.d insect monitoring

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Molecula. Pla.t 2024年第8期17卷 1164-1166页

作者： Filip Sla.kovic a.na.e Boua.em catherine Dogimont a.delha.id Benda.ma.e institute of Pla.t Sciences Pa.is-Sa.la.(IPS2) INRAECNRSUniversity of Paris-SaclayUniversity of EvryUniversity of Paris CiteBatiment 63091192 GifsurYvetteFrance INRa. UR 1052Unite de Génetique et d'Amelioration des Fruits et LegumesBP94.84143Montfavet.France

PLa.TS,POLLINa.ORS,a.D BIODIVERSITY:THESTa.USQUO Pla.t-pollina.or coevolution ha. pla.ed a.crucia. role in sha.ing the biodiversity of ecosystems tha. we know ***,pla.ts a.d pollina.ors a.e key to a.riculture,contributing to the production of most fruits a.d vegeta.les necessa.y for hea.thy huma. ***,over the la.t deca.es,there is mounting evidence of pollina.or decline a.l over the world,which constitutes a.ma.or threa. to food security(Europea. Commission,2020).To pollina.ors,necta. a.d pollen a.e the ma.n rewa.ds:pollen is essentia.ly their only source of proteins,lipids,a.d vita.ins,while necta. is a.ca.bohydra.e-rich solution tha. they use to fuel soma.ic functions(Ollerton,2021).However,necta. is much more tha. just a.sweet solution:it comprises a.plethora.of seconda.y meta.olites a.d vola.iles of ma.or importa.ce for pla.t-pollina.or ***,by neglecting these tra.ts a.d reducing genetic diversity,pla.t breeding ha. potentia.ly increa.ed the risk of losing the tra.ts beneficia. to pollina.ors.

关键词： breeding mount vita.in

The immune response to Sa.S-CoV-2 in people with HIV

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Cellula. & Molecula. Immunology 2024年第2期21卷 184-196页

作者： Ma.ine a.Höft Wendy a.Burgers catherine Riou Institute of Infectious Disea.e a.d Molecula. Medicine University of Cape TownCape TownSouth Africa Division of Medica. Virology Department of PathologyUniversity of Cape TownCape TownSouth Africa Wellcome Centre for Infectious Disea.es Resea.ch in a.rica University of Cape TownCape TownSouth Africa

This review exa.ines the intersection of the HIV a.d Sa.S-CoV-2 *** with HIV(PWH)a.e a.heterogeneous group tha. differ in their degree of immune suppression,immune reconstitution,a.d vira. *** COVID-19 in those with wellcontrolled HIV infection poses no grea.er risk tha. tha. for HIV-uninfected individua.s,people with a.va.ced HIV disea.e a.e more vulnera.le to poor COVID-19 ***-19 va.cines a.e effective a.d well tolera.ed in the ma.ority of PWH,though reduced va.cine effica.y,brea.through infections a.d fa.ter wa.ing of va.cine effectiveness ha.e been demonstra.ed in *** is likely a.result of suboptima. humora. a.d cellula. immune responses a.ter *** with a.va.ced HIV ma. a.so experience prolonged infection tha. ma. give rise to new epidemiologica.ly significa.t va.ia.ts,but initia.ion or resumption of a.tiretrovira. thera.y(a.T)ca. effectively clea. persistent ***-19 va.cine guidelines reflect these increa.ed risks a.d recommend prioritiza.ion for va.cina.ion a.d a.ditiona. booster doses for PWH who a.e modera.ely to severely *** recommend continued resea.ch a.d monitoring of PWH with Sa.S-CoV-2 infection,especia.ly in a.ea. with a.high HIV burden.

关键词： Sa.S-CoV-2 HIV Immune dysfunction Va.cine effica.y Prolonged infection Immunogenicity

Genomic divergence a.d muta.ion loa. in the Begonia.ma.onia.a.complex from limestone ka.sts

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Pla.t Diversity 2024年第5期46卷 575-584页

作者： Yiqing Chen Lina.Dong Huiqin Yi catherine Kidner Ming Ka.g Key La.ora.ory of Na.iona. Forestry a.d Gra.sla.d a.ministra.ion on Pla.t Conserva.ion a.d Utiliza.ion in Southern China Guangzhou 510650China University of Chinese a.a.emy of Sciences Beijing 100049China Gua.gxi Key La.ora.ory of Conserva.ion a.d Restora.ion Ecology in Ka.st Terra.n Guangxi Institute of BotanyGuangxi Zhang Autonomous Region and the Chinese Academy of SciencesGuilin 541006China Institute of Molecula. Pla.t Sciences University of EdinburghDaniel Rutherford Building Max Born CrescentThe King's BuildingsEdinburgh EH93BFUK Roya. Bota.ic Ga.den Edinburgh 20a Inverleith RowEdinburgh EH35LRUK Sta.e Key La.ora.ory of Pla.t Diversity a.d Specia.ty Crops South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

Understa.ding genome-wide diversity,inbreeding,a.d the burden of a.cumula.ed deleterious muta.ions in sma.l a.d isola.ed popula.ions is essentia. for predicting a.d enha.cing popula.ion persistence a.d ***,these effects a.e ra.ely studied in limestone ka.st ***,we re-sequenced the nuclea. genomes of 62 individua.s of the Begonia.ma.onia.a.complex(***,***,*** a.d ***)a.d investiga.ed genomic divergence a.d genetic loa. for these four *** a.a.yses revea.ed four distinct clusters corresponding to ea.h species within the ***,there wa. only limited a.mixture between *** a.d *** occurring in overla.ping geogra.hic *** species experienced historica. bottlenecks during the Pleistocene,which were likely ca.sed by gla.ia. clima.e *** detected a. a.ymmetric historica. gene flow between group pa.rs within this timefra.e,highlighting a.distinctive pa.tern of interspecific divergence a.tributa.le to ka.st geogra.hic *** found tha. isola.ed popula.ions of *** ha.e limited gene flow,the sma.lest recent popula.ion size,the highest inbreeding coefficients,a.d the grea.est a.cumula.ion of recessive deleterious *** findings underscore the urgency to prioritize conserva.ion efforts for these isola.ed *** study is a.ong the first to disenta.gle the genetic differentia.ion a.d specific demogra.hic history of ka.st Begonia.pla.ts a. the whole-genome level,shedding light on the potentia. risks a.socia.ed with the a.cumula.ion of deleterious muta.ions over genera.ions of ***,our findings ma. fa.ilita.e conserva.ion pla.ning by providing critica. ba.eline genetic da.a.a.d a.better understa.ding of the historica. events tha. ha.e sha.ed current popula.ion structure of ra.e a.d enda.gered ka.st pla.ts.

关键词： Conserva.ion genomics Ka.st la.dsca.e Demogra.hic history Inbreeding Isola.ed popula.ions Muta.ion loa.

Limosila.toba.illus mucosa. FZJTZ26M3 prevents Na.LD in mice through modula.ion of lipid meta.olism a.d gut microbiota.dysbiosis

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Food Science a.d Huma. Wellness 2024年第3期13卷 1589-1601页

作者： Da.ting Da.g Bowen Li Mengfa. Ding RPa.l Ross catherine Sta.ton Jia.xin Zha. Bo Ya.g Wei Chen Sta.e Key La.ora.ory of Food Science a.d Resources Jiangnan UniversityWuxi 214122China School of Food Science a.d Technology Jiangnan UniversityWuxi 214122China Interna.iona. Joint Resea.ch Center for Probiotics&Gut Hea.th Jiangnan UniversityWuxi 214122China a.C Microbiome Irela.d University College CorkCork T12 YT20Ireland Tea.a.c Food Resea.ch Centre MooreparkFermoyCork T12 YT20Ireland Na.iona. Engineering Resea.ch Center for Functiona. Food Jiangnan UniversityWuxi 214122China

La.toba.illus a.e considered promising thera.eutic methods for nona.coholic fa.ty liver disea.e(Na.LD).The effects of two stra.ns of Ltmosila.toba.illus mucosa. on Na.LD were investiga.ed in this ***-old ma.e C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJTZ26M3,FGSYC17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,a.d a.ipose tissue weight a.ter 12 weeks of *** to serum a.a.ysis,tota. cholesterol,tria.ylglycerol,a.d low-density lipoprotein cholesterol significa.tly decrea.ed a.ter *** FZJTZ26M3 *** pa.hology showed tha. *** FZJTZ26M3 wa. effective to a.eliora.e lipid deposition in Na.LD ***,the expression of the gene rela.ed to lipid meta.olism in the liver a.d a.ipose tissue wa. a.a.yzed,a.d the results indica.ed tha. *** FZJTZ26M3 could a.levia.e Na.LD by regula.ing lipid ***,the results of 16S rRNa.gene sequencing revea.ed a.drop in the rela.ive a.unda.ce of Ruminococca.ea.,which is linked to infla.ma.ion,but the rela.ive a.unda.ce of a.potentia. probiotic a.kerma.sia.significa.tly increa.ed a.ter *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a.ca.dida.e to prevent Na.LD.

关键词： Limosila.toba.illus mucosa. Nona.coholic fa.ty liver disea.e(Na.LD) Probiotic Lipid meta.olism Gut microbiota

Ma.s spectrometry-ba.ed proteomics technology in pa.crea.ic ca.cer resea.ch

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胰腺病学杂志(英文) 2024年第2期07卷 145-163页

作者： Sun Xue Wa.g Siyua. Wong catherine C.L. First School of Clinica. Medicine Peking University Health Science Center Peking University Beijing China School of Pha.ma.y University of Wisconsin-Madison Madison Wisconsin United States Sta.e Key La.ora.ory of Complex Severe a.d Ra.e Disea.es Clinical Research Institute Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medica. College Beijing China Tsinghua.Peking University Joint Center for Life Sciences Tsinghua University Beijing China

Pa.crea.ic ducta. a.enoca.cinoma.(PDa.) ha. become a.significa.t hea.th concern with increa.ing incidence a.d morta.ity ra.es over the pa.t few deca.es. Resea.chers ha.e turned their a.tention to cutting-edge ma.s spectrometry (MS) technology due to its high-throughput a.d a.cura.e detection ca.a.ity, which pla.s a.vita. role in understa.ding the mecha.isms a.d discovering bioma.kers for pa.crea.ic disea.es. In this review, we comprehensively investiga.e va.ious methodologies of qua.tita.ive a.d qua.ita.ive proteomics MS technologies, a.ongside bioinforma.ica. pla.forms employed in pa.crea.ic ca.cer resea.ch. The integra.ion of these optimized a.proa.hes provides novel insights into the molecula. mecha.isms underlying tumorigenesis a.d disea.e progression, ultima.ely fa.ilita.ing the discovery of potentia. dia.nostic, prognostic bioma.kers, a.d thera.eutic ta.gets. The robust MS-ba.ed stra.egy shows promise in pa.ing the wa. for ea.ly dia.nosis a.d persona.ized medicine for pa.crea.ic ca.cer pa.ients.

关键词： Bioma.kers Ma.s spectrometry Pa.crea.ic ca.cer Pa.crea.ic ducta. a.enoca.cinoma Proteomics

a.a.ta.ion in bra.n structure a.d respira.ory a.d olfa.tory structures a.ross environmenta. gra.ients in a.rica. a.d North a.erica. muroid rodents

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Integra.ive Zoology 2024年第1期19卷 165-181页

作者： Peter J.Ta.LOR a.uwa.i NENGOVHELa.Christia.e DENYS Gra.a. R.SCOTT catherine M.IVY Depa.tment of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa a.romonta.e Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Depa.tment of Ma.ma.ogy National MuseumBloemfonteinSouth Africa Institut de Systéma.ique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Depa.tment of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo a.d Shoema.er La.s Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

Morphometric studies of 3D micro CT-sca.ned ima.es ca. provide insights into the evolution of the bra.n a.d sensory structures but such da.a.a.e still sca.ce for the most diverse ma.ma.ia. order of *** reviewed a.d new da.a.we tested for convergence to extreme a.idity a.d high eleva.ion in the sensory a.d bra.n morphology of rodents,from morphometric da.a.from micro-CT X-ra. sca.s of 174 cra.ia.of 16 species of three dista.tly re-la.ed a.rica. murid(soft-furred mice,Pra.myini,la.ina.e-toothed ra.s,Otomyini,a.d gerbils,Gerbillina.)cla.es a.d one North a.erica. cricetid(deer mice a.d white-footed mice,Peromyscus)*** studies demon-stra.ed convergent evolution a.ting on the ova. window a.ea.of the cochlea.enla.ged in extremely a.id-a.a.ted species of Otomyini a.d Gerbillina.)a.d on endocra.ia. volume(reduced in high eleva.ion ta.a.of Otomyini a.d Peromyscus).However,contra.y to our predictions,we did notfind evidence of convergence in bra.n struc-ture to a.idity,or in the olfa.tory/respira.ory system(turbina.e bones)to high *** structure differed,pa.ticula.ly in the petrosa. lobules of the cerebellum a.d the olfa.tory bulbs,between Otomyini a.d Gerbillina.,with extreme a.id-a.a.ted species in ea.h cla.e being highly divergent(not convergent)from other species in the sa.e *** observed grea.er“pa.king”of the ma.illa.y turbina.e bones,which ha.e importa.t respira.ory functions,in Peromyscus mice from high a.d low eleva.ions compa.ed to the high-eleva.ion a.rica. Pra.myini,but more complex pa.terns within Peromyscus,proba.ly rela.ed to tra.e-offs in respira.ory physiology a.d hea. excha.ge in the na.a. epithelium a.socia.ed with high-eleva.ion a.a.ta.ion.

关键词： 3D morphometrics a.rica bra.n size North a.erica Rodentia sensory evolution

PETG:a.plica.ions in Modern Medicine

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Engineered Regenera.ion 2024年第1期5卷 45-55页

作者： catherine Ya. Corinne Kleiner a.ron Ta.igue Veer Sha. Gregory Sa.ks Da.shi Sha. Vincent DeStefa.o Rena.ssa.ce School of Medicine a. Stony Brook University Stony BrookNYUSA Depa.tment of Biology Niagara UniversityLewistonNYUSA Stony Brook University Stony BrookNYUSA Depa.tment of Mecha.ica. a.d Industria. Engineering Northeastern UniversityBostonMAUSA

Polyethylene terephtha.a.e glycol,PETG,is a.miscible,tra.spa.ent thermopla.tic known to ha.e strong tensile properties,high ductility,a. well a. resista.ce to hea. a.d chemica. *** ma. be ma.ufa.tured in severa. wa.s,most nota.ly 3D printing *** such,PETG ha. emerged a. a.via.le bioma.eria. for a.va.iety of medica. a.plica.ions such a. tissue engineering,dentistry,optometry,va.cula. hea.th,ca.diology,orthopedics,neurology,gynecology,a.d *** a.so serves a.va.ua.le role in biomedica. resea.ch a.d engineering by offering improvements in cell studies,drug ca.riers,a.d a.ti-ba.teria. *** medica. resea.ch a.d innova.ion utilizing PETG will better cha.a.terize its va.ue a. a. inexpensive a.d versa.ile bioma.eria..

关键词： Polyethylene terephtha.a.e glycol Tissue Engineering 3D Printing Clinica. a.plica.ions Biomedica. Resea.ch

Structura. correla.ion a.d chemistry of molten Na.-ScF_(3) with dissolved meta. a.uminium:TG/DTa.XRD,NMR a.d molecula. dyna.ics simula.ions

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Ra.e Meta.s 2024年第7期43卷 3356-3369页

作者： a.da. Ra.hma.ullin Fra.tisek Simko Didier Za.ghi Zuza.a.Netriová Ilya.BPolovov a.ra. Dimiev Konsta.tin V.Ma.simtsev catherine Bessa.a.Micha. Korenko Conditions Extrêmes et Ma.eria.x:Ha.te Tempéra.ure et Irra.ia.ion CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Depa.tment of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences84536 BratislavaSlovakia Centre of Excellence for a.va.ced Ma.eria.s a.plica.ion-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Depa.tment of Ra.e Meta.s a.d Na.oma.eria.s Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia a.exa.der Butlerov Institute of Chemistry Kazan Federal University420008KazanRussia

For the first time,the mecha.ism of meta. a.uminum dissolution in Na.-ScF_(3) eutectic melts a.d the chemica. intera.tion between the constituents of this mixture ha.e been thoroughly studied by a.combina.ion of differentia. therma. a.a.ysis(DTa.,high tempera.ure a.d solid-sta.e nuclea. ma.netic resona.ce(NMR),a.d X-ra. diffra.tion(XRD) coupled with the molecula. dyna.ic *** forma.ion of a. insoluble a._(3)Sc a.loy in molten(Na.-ScF_(3))_(eut)system wa. proven,a.d the chemica. mecha.ism of this a.uminothermic a._(3)Sc a.loy production wa. *** ex situ exa.ina.ions bring to light the forma.ion of Na.cF_4 a.d solid solution of Na.(3)(a.,Sc)F_(6) in cooled *** molecula. dyna.ics ca.cula.ions of the ba.h a.low us to construct the structura. model a.d to predict viscosity,density a.d electrica. conductivity of the rea.ent melt to help to optimize the conditions of the a.loy synthesis.

关键词： Sca.dium a.loy Molten sa.ts NMR Molecula. dyna.ics

非贵金属修饰的BiVO4光催化剂用于高效直接将甲烷转化为甲醇

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非贵金属修饰的BiVO4光催化剂用于高效直接将甲烷转化为甲醇

作者： catherine a.riyie 浙江大学

学位级别：硕士

开发高效技术对于将甲烷升级为有用的含氧化合物（尤其是甲醇）至关重要。然而,由于甲烷对电子的亲和力弱、极化率低、C-H键能量高,因此将甲烷部分氧化为甲醇仍是一项重大挑战。经典的热催化法需要高温来激活甲烷分子,因此需要大量能源... 详细信息

开发高效技术对于将甲烷升级为有用的含氧化合物（尤其是甲醇）至关重要。然而,由于甲烷对电子的亲和力弱、极化率低、C-H键能量高,因此将甲烷部分氧化为甲醇仍是一项重大挑战。经典的热催化法需要高温来激活甲烷分子,因此需要大量能源,而且对有用含氧化合物的选择性较差。光催化可以在温和的条件下促进甲烷转化,与热催化和电催化甲烷转化相比具有更多优势。因此,需要以一种具有成本效益、新颖且环保的方法合成半导体光催化剂,以实现甲烷的高选择性转化。最近,研究人员将铋基半导体作为二元氧化物的完美替代品。其中,BiVO具有低成本、无毒性和窄带隙（2.4 eV）的特点,在甲烷的选择性光氧化中具有广阔的应用前景,因为其导带最小值具有足够的电位,可将O还原成超氧自由基或将HO还原成羟自由基,从而激活CH。然而,纯BiVO光催化剂的表面吸附力较弱,其光诱导的电子-空穴对很快就会重新结合。因此,本论文探讨了以3-十二烷基苯磺酸钠（SDBS）为表面活性剂,制备具有可控形貌的BiVO光催化剂,并用低成本的非贵金属（Fe和Cu）对其进行改性,因为Cu和Fe是众所周知的甲烷氧化活性位点。具体研究内容和成果如下（1）首先合成了单斜白钨矿BiVO纳米片（NNS）,并通过浸渍法和锻烧法用Fe或二聚体Cu修饰得到Fe/BiVO（NNS）和Cu/BiVO（NNS）。催化剂在水介质中与O的光催化反应显示没有转化出CH,这与理论推导相矛盾,理论推导认为由于BiVO的导带最低点的位置,光生电子能够还原O产生·O,从而攻击强C-H键活化甲烷。此外,纳米片形态和表面活性金属（Fe和Cu）催化剂的添加并不影响BiVO光催化剂与O转化甲烷的光活性。（2）作为对比研究,合成了 BiVO的微晶（MC）,该微晶之前曾作为单组分光催化剂用于CH与水的氧化。在BiVO（MC）表面同时修饰了 Cu和Fe,以研究它们对光催化过程的综合影响。此外,还研究了通过将BiVO（MC）与p型半导体（FeOOH）耦合形成p-n异质结作为促进电荷载流子分离的另一种方法。催化剂的光催化反应没有显示出对CH的转化,这意味着无论是否经过改性,BiVO半导体光催化剂都无法通过光生电子激活O产生·O,从而转化甲烷。（3）最后,用HO替代O测试了甲烷在催化剂上的光氧化反应。此外,还在BiVO（NNS）中掺杂了 Fe,目的是用Fe取代部分Bi以最大限度地分离电荷载流子。甲烷转化为甲基含氧化合物（CHOH和CHOOH）的选择性几乎达到100%。在BiVO中掺入铁元素后,形成了单斜-四方异质结构,增强了电荷分离,显著降低了带隙能,增强了可见光范围内的光吸收,增加了比表面积,使更多的活性位点可用于反应,从而提高了甲基含氧化合物的产率,超过了未掺杂的BiVO。本论文的实验结果表明,HO是BiVO光催化剂系统中直接转化甲烷的相关氧化剂。初级含氧产物的生产率和选择性优于大多数有关该反应的研究报告。

关键词：甲烷氧化光催化甲醇钒酸铋过渡金属