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A computational fluid dynamics model for wind simulation:model implementation and experimental validation

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第4期13卷 274-283页

作者： Zhuo-dong ZHANG Ralf WIELAND Matthias REICHE Roger FUNK carsten hoffmann Yong LI Michael SOMMER Institute of Soil Landscape Research Leibniz-Centre for Agricultural Landscape Research(ZALF)Muencheberg 15374Germany Institute of Landscape System Analysis Leibniz-Centre for Agricultural Landscape Research(ZALF)Muencheberg 15374Germany Institute of Agricultural Environment and Sustainable Development Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Institute of Earth and Environmental Science University of PotsdamPotsdam 14476Germany

To provide physically based wind modelling for wind erosion research at regional scale, a 3D computational fluid dynamics (CFD) wind model was developed. The model was programmed in C language based on the Navier-Stokes equations, and it is freely available as open source. Integrated with the spatial analysis and modelling tool (SAMT), the wind model has convenient input preparation and powerful output visualization. To validate the wind model, a series of experiments was con- ducted in a wind tunnel. A blocking inflow experiment was designed to test the performance of the model on simulation of basic fluid processes. A round obstacle experiment was designed to check if the model could simulate the influences of the obstacle on wind field. Results show that measured and simulated wind fields have high correlations, and the wind model can simulate both the basic processes of the wind and the influences of the obstacle on the wind field. These results show the high reliability of the wind model. A digital elevation model (DEM) of an area (3800 m long and 1700 m wide) in the Xilingele grassland in Inner Mongolia (autonomous region, China) was applied to the model, and a 3D wind field has been successfully generated. The clear imple- mentation of the model and the adequate validation by wind tunnel experiments laid a solid foundation for the prediction and assessment of wind erosion at regional scale.

关键词：风模型计算液体动力学(CFD ) 风侵蚀风隧道实验空间分析和建模工具(SAMT ) 开放源代码

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Using a Parafoil Kite for Measurement of Variations in Particulate Matter—A Kite-Based Dust Profiling Approach

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Atmospheric and Climate Sciences 2012年第1期2卷 41-51页

作者： Matthias Reiche Roger Funk Zhuodong Zhang carsten hoffmann Yong Li Michael Sommer 不详

This paper reports on the use of a kite-based system for measuring low-altitude particulate matter (PM) concentrations over grassland in Inner Mongolia. The motivation came from PM-concentration measurements at heights below 3 m over non-erodible surfaces which showed constant concentrations and made flux calculations relatively uncertain. One aim was the quantification of wind-driven matter fluxes across ecosystem boundaries, where the relevant layer can be assumed at heights below 100 m. Compared to other measurement techniques (e.g. LIDAR, towers and airborne systems) kite-based systems represent an inexpensive, highly flexible research tool which is well-suited for application in remote sites. The basis of the introduced system is a 4 m2 Parafoil kite which has enough lifting capacity to carry equipment of about 6 kg at wind velocities between 3 ms-1 to nearly 20 ms-1. A self-adjusting platform was constructed to balance moves and to carry a portable Environmental Dust Monitor (EDM), anemometer and a GPS receiver. So, all parameters necessary for a vertical profile of dust fluxes could be measured. In the first flights the applied kite-based dust profiling system (KIDS) was examined according to general technical application problems. Firstly, the influence of diverse surface characteristics, the flying condition and height-stability was tested. The result suggests that surface characteristics in general have a higher influence than the optimal wind velocity, which ranged from 9 ms-1 to 17 ms-1. Secondly, uncertainties in the measured data were quantified and assessed. The uncertainties in wind velocity measurements due to motion in horizontal and vertical direction were not higher than 0.45% - 0.65% and 1.8% - 2.2% during the kite ascent. The outcome of the study illustrates the suitable application of KIDS for low-altitude measurements in remote sites.

关键词： Grassland Wind Erosion Particular Matter PM1 PM2.5 PM10 PM-Ratio

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Outcome Results of Treatment with Selective Internal Radiation Therapy (SIRT) in Patients with Hepatocellular Carcinoma: A Single Center Experience

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Journal of Cancer Therapy 2017年第4期8卷 349-359页

作者： Jan Pfeiffenberger Tatjana Zimmermann Daniel N. Gotthardt Christoph Springfeld Wolfgang Stremmel Peter Schirmacher Henning Schulze-Bergkamen Arianeb Mehrabi Christoph W. Michalski Katrin hoffmann Nikolas Kortes Boris Radeleff Uwe Haberkorn Clemens Kratochwil Karl Heinz Weiss carsten Grüllich Department of Gastroenterology and Hepatology University Hospital Heidelberg Heidelberg Germany Department of Medical Oncology National Center for Tumor Diseases Heidelberg University Hospital Heidelberg Heidelberg Germany Institute of Pathology University Hospital Heidelberg Heidelberg Germany Department of Gastroenterology and Oncology Marien-Hospital Wesel Germany Department of General and Transplant Surgery University Hospital Heidelberg Heidelberg Germany Department of Diagnostic and Interventional Radiology University Hospital Heidelberg Heidelberg Germany Department of Nuclear Medicine University Hospital Heidelberg Heidelberg Germany Liver Cancer Center Heidelberg University Hospital Heidelberg Heidelberg Germany

Background: Hepatocellular carcinoma (HCC) has a poor prognosis. Selective internal radiation therapy (SIRT) with microspheres is a treatment option for HCC. This study aimed to assess safety and survival (OS) in patients with HCC treated with SIRT, to stratify patients with tumor vascularization and analyze the impact of sequential sorafenib treatment. Methods: Thirty-nine patients who received SIRT for HCC between 2010 and 2013 at our center were included in this retrospective analysis. Tumor vascularization was assessed using a combination of MRI, MAA-scintigraphy and angiography. Tumor vascularization was correlated with survival. Subgroups are treated with two commercially available 90Y-labeled products SIR-Spheres (n = 16) and TheraSpheres (n = 23) and sequential therapy with sorafenib compared to SIRT only was analyzed. Results: Adverse events occurred in 49% of patients with only four grade 3 and no grade 4 event. Median survival for all patients was 12.5 months (95% CI: 8.7 - 16.3). No significant differences were detectable between Thera Spheres or SIR Spheres. Survival was shorter in patients with low tumor vascularization score (OS: 3.8 months (95% CI 0 - 15.0), p = 0.043). Survival was longer with sorafenib upon progression after SIRT (n=16) with an OS of 17.4 months (95% CI: 12.1 – 22.7) compared to no sorafenib (n = 13;9.1 months;95% CI: 3.0 - 15.1) or progression upon sorafenib before SIRT (n = 10;8.6 months;95% CI: 5.5 - 11.7). Conclusions: SIRT is safe in HCC patients. Tumor vascularization by radiography and scintigraphy may predict survival benefit. Sorafenib is active after SIRT and significantly prolongs survival.

关键词： SIRT Sorafenib Liver Cancer Y90

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