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The Younger the Patients the Less Adverse Effect of Diminished Oocyte Reserve on Outcome Following in vitro Fertilization-embryo Transfer as Long as the Proper Ovarian Stimulation Protocol is Used

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Journal of Reproduction and Contraception 2013年第4期24卷 221-227页

作者： Jerome H.CHECK carrie WILSON Cooper Medical School of Rowan University Department of Obstetrics and GynecologyDivision of Reproductive Endocrinology&InfertilityCamdenNew JerseyUSA Cooper Institute For Reproductive Hormonal Disorders P.C. MarltonNew JerseyUSA

Objective To determine the confounding effect of oocyte reserve and age on pregnancy rates per oocyte retrieval and a comparison of the average number of babies born from a given oocyte harvest. Methods In vitro fertilization-embryo transfer （IVF-ET） cycles were retrospectively reviewed over a l O-year period They were stratified according to whether they had normal oocyte reserve （day 3 serum FSH 〈12 mlU/ml and serum estradiol 〈50 pg/ml） or diminished oocyte reserve. Mild stimulation was used if low oocyte reserve. The pregnancy rate per retrieval included all pregnancies （fresh or frozen embryo transfer） resulting from one retrieval. The average number of babies born was also compared according to reserve. Results For the diminished oocyte reserve group, the live delivered pregnancy rates per transfer were 80% as good in women aged 〈35 years, 70% as good in women 3639 years, but only 43% as good as women aged 40-42 years. However, because of more total embryos the pregnancy rate per given oocyte retrieval was only 55% as good for women with diminished oocyte reserve aged 〈39 years. The average number of babies born per retrieval was twice as high as those with normal reserve for this age group. Conclusion The use of mild follicle stimulating hormone （FSH） stimulation allows a live delivered pregnancy rate per transfer that is 75% as good for women aged 〈39 years but because of less embryos a likelihood of pregnancy rate per retrieval only half as good as women with normal reserve.

关键词： live delivered pregnancy rates ovarian reserve mild ovarian hyperstimulation

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你是我的阳光

疯狂英语（初中天地） 2005年第7期 25-27页

作者： carrie 芥子

和任何称职的母亲一样,当凯伦发现她的另一个婴儿就要降临时,她尽力帮助她那3岁的儿子迈克尔为新的家庭成员做好准备。他们得知新生儿将是个女孩。每天每夜,迈克尔都会为妈妈腹中的妹妹唱歌。在见到小妹妹之前,他正在与他的妹妹建立一... 详细信息

和任何称职的母亲一样,当凯伦发现她的另一个婴儿就要降临时,她尽力帮助她那3岁的儿子迈克尔为新的家庭成员做好准备。他们得知新生儿将是个女孩。每天每夜,迈克尔都会为妈妈腹中的妹妹唱歌。在见到小妹妹之前,他正在与他的妹妹建立一种爱的联结。

关键词：迈克尔护士长

Another Undiagnosed Pheochromocytoma Causes Hypertensive Crisis in the Operating Room—What about a Rapid Blood Metanephrine Test?

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Open Journal of Anesthesiology 2013年第2期3卷 93-96页

作者： carrie Rosenberg Ricardo Gomez Department of Anesthesiology New Mexico Veterans Affairs Health Care System Albuquerque USA

Undiagnosed pheochromocytoma is a cause of hypertension intraoperatively. Hypertension from pheochromocytoma catecholamine secretion is potentially fatal and requires immediate treatment with cardiac afterload reduction and preload augmentation for end-organ protection. Diagnosis and management in the acute period can be complex in the context of co-existing disease, other possible causes of hypertension, and the anesthetized patient who is unable to provide historical clues. This case report highlights the plausibility that pheochromocytomas may be more likely to present sub-clinically in elderly patients with severe vascular disease, so we suggest the potential utility of studying whether reduced vascular responsiveness is protective in any way to catecholamine load. Above all, as an increasing number of case reports of pheochromocytoma discovery intra-operatively emerge, many with catastrophic outcomes, the development value and feasibility of a rapid, on-site blood metanephrine test should be considered. Existing diagnostic methods of pheochromocytoma are relatively time-consuming and not useful in the acute situation.

关键词： Pheochromocytoma Metanephrines Catecholamines Perioperative Hypertension

Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?

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World Journal of Gastroenterology 2017年第46期23卷 8193-8199页

作者： carrie Luu marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine Department of Thoracic Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS *** Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy.

关键词： Esophageal cancer Endoscopic ultrasound Staging Early esophageal cancer Endoscopic mucosal resection

The World in a Puddle

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小学生时代（大嘴英语） 2021年第9期 22-25页

作者： carrie Finison Kristina Swarner(图) 不详

一场出其不意的秋雨把来不及打伞的我淋了个“透心凉”,也把路边的小土坑灌成了水坑。雨过天晴,水坑平静得似一面镜子,映出了一个别样的五彩世界。蓝天打底,白云点缀,明晃晃的太阳不再刺眼。凉风习习,染了秋色的叶子挣脱树的怀抱,争先... 详细信息

一场出其不意的秋雨把来不及打伞的我淋了个“透心凉”,也把路边的小土坑灌成了水坑。雨过天晴,水坑平静得似一面镜子,映出了一个别样的五彩世界。蓝天打底,白云点缀,明晃晃的太阳不再刺眼。凉风习习,染了秋色的叶子挣脱树的怀抱,争先恐后地从水底浮.上来:red,yellow,brow.....猛一抬头,明晃晃的太阳还在天上,依然刺眼。

关键词：凉风习习出其不意太阳

骨形态发生蛋白-2对软骨寡聚基质蛋白在软骨细胞内表达的影响

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北京大学学报（医学版） 2003年第3期35卷 317-320页

作者：田华 carrie FANG Paul E.DICESARE 北京大学第三医院骨科北京100083 美国纽约大学关节病医院

目的 :定量研究骨形态发生蛋白 (BMP 2 )对软骨寡聚基质蛋白 (COMP)基因在人软骨细胞及ATDC5 5细胞内表达的影响。方法 :原代培养成人及胚胎的关节软骨细胞 ,经BMP 2刺激后 ,利用real timeRT PCR定量分析COMP基因的表达情况 ;采用静息... 详细信息

目的 :定量研究骨形态发生蛋白 (BMP 2 )对软骨寡聚基质蛋白 (COMP)基因在人软骨细胞及ATDC5 5细胞内表达的影响。方法 :原代培养成人及胚胎的关节软骨细胞 ,经BMP 2刺激后 ,利用real timeRT PCR定量分析COMP基因的表达情况 ;采用静息期不表达COMP基因的鼠源性成软骨细胞株ATDC5 5作为研究对象 ,给以BMP 2刺激 ,通过RT PCR检测COMP表达的变化 ;将COMP基因的全长启动子克隆到报告基因Luciferase的上游并转染入ATDC5 5细胞 ,分别给以 5 0 0 μg·L-1的BMP 2和 /或 10 μg·L-1的Noggin刺激 ,测定其对Luciferase活性的影响。结果 :BMP 2使成人软骨细胞内的COMP基因表达提高近 3倍 ,而对胚胎软骨细胞的作用较弱 ,提高了1.5倍 ;COMP基因在胚胎软骨细胞内的基础表达量约是在成人软骨细胞内的 2倍 ;经BMP 2刺激后ATDC5 5细胞株明显表达COMP基因 ,并且BMP 2的这种效应能够被其拮抗剂Noggin所抑制 ;BMP 2明显促进了Luciferase的活性 ,约提高了 5倍 ,且Noggin特异性的抑制了BMP 2的这种作用。结论 :BMP 2能够明显促进COMP基因在人关节软骨细胞及鼠源性成软骨细胞株ATDC5 5内的表达。

关键词：骨形态发生蛋白-2 软骨寡聚基质蛋白软骨细胞基因表达

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TRAVEL

明日风尚 2009年第7期 72-73页

作者： carrie Tsang 张琛周耀恩

零距离参观巴特农神庙> 01有着人类文明摇篮之称的希腊最近有新博物馆落成,The New Acropolis Museum位于雅典卫城,由建筑师Bernard Tschumi与Michalis Photiadis联袂建造,新馆占地两万平方米,共展出4,000件古希腊文物。展览的重头战是... 详细信息

零距离参观巴特农神庙> 01有着人类文明摇篮之称的希腊最近有新博物馆落成,The New Acropolis Museum位于雅典卫城,由建筑师Bernard Tschumi与Michalis Photiadis联袂建造,新馆占地两万平方米,共展出4,000件古希腊文物。展览的重头战是几乎全数呈现的巴特农神殿雕塑,与参观者仅隔一面玻璃墙,而背景就是400米开外的古代神庙,场景异常壮观。

关键词：巴特农神殿雅典卫城玻璃墙 TRAVEL 埃尔金大理石 Bernard 入住酒店电影欣赏访客

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GREEN LIVING

明日风尚 2009年第12期 70-71页

作者： Ron Lam carrie 周耀恩陈铭恒

01Animal Wall>城市发展一直是左右雀鸟栖息及生态发展的绊脚石,不过,经过设计师略施小计,一堵既富艺术性又不会赶绝雀鸟的"动物墙壁",令英国东南部城市Cardiff的人和鸟继续在社区共存共荣。这面50米长的"动物墙壁"附设了为数一千个长... 详细信息

01Animal Wall>城市发展一直是左右雀鸟栖息及生态发展的绊脚石,不过,经过设计师略施小计,一堵既富艺术性又不会赶绝雀鸟的"动物墙壁",令英国东南部城市Cardiff的人和鸟继续在社区共存共荣。这面50米长的"动物墙壁"附设了为数一千个长方形巢穴,目的是为邻近雀鸟及蝙蝠提供安身之所。主理这项贴心设计的有心人,是长驻英国的德国籍女设计师Gitta Gschwendtner,眼见近年Cardiff Bay日渐衰落的生态环境,激起她从艺术入手,为该区新落成的一千间房屋及单位,设计出同一数目的新式巢穴。"这是一个有趣的设计方案,挑战在于如何吸引雀鸟及蝙蝠来我的人造巢穴栖息。在跟生物学家咨询过后,才明白巢穴洞口是圆是方,原来也是吸引雀鸟的关键,最终我利用一种名为woodcrete的物料为它们度身订做了四款不同尺寸的长方箱子,并以随机方式架设在混凝土墙上。"

关键词：混凝土墙随机方式生态发展 GREEN LIVING 城市发展共存共荣设计方案生态环境气候

Clearing Up Blurry Vision:Causes of Myopia

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当代外语研究 2004年第9期 2-3页

作者： carrie Lock 秦艳艳

近视(myopia)的原因是科学家们正在研究的重点课题之一。英国科学家现已发现,在造成近视的原因中遗传因素占有很大的比例,他们正试图破解导致视力问题的遗传机制。从解剖学的角度来说,问题的根源在于眼球的长度增加,导致光线集中点的偏... 详细信息

近视(myopia)的原因是科学家们正在研究的重点课题之一。英国科学家现已发现,在造成近视的原因中遗传因素占有很大的比例,他们正试图破解导致视力问题的遗传机制。从解剖学的角度来说,问题的根源在于眼球的长度增加,导致光线集中点的偏离。科学家们对此作了系统的调查研究。

关键词： Clearing Up Blurry Vision:Causes of Myopia Vision