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The Younger the Patients the Less Adverse Effect of Diminished Oocyte Reserve on Outcome Following in vitro Fertilization-embryo Transfer as Long as the Proper Ovarian Stimulation Protocol is Used

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Journal of Reproduction and Contraception 2013年第4期24卷 221-227页

作者： Jerome H.CHECK carrie wilson Cooper Medical School of Rowan University Department of Obstetrics and GynecologyDivision of Reproductive Endocrinology&InfertilityCamdenNew JerseyUSA Cooper Institute For Reproductive Hormonal Disorders P.C. MarltonNew JerseyUSA

Objective To determine the confounding effect of oocyte reserve and age on pregnancy rates per oocyte retrieval and a comparison of the average number of babies born from a given oocyte harvest. Methods In vitro fertilization-embryo transfer （IVF-ET） cycles were retrospectively reviewed over a l O-year period They were stratified according to whether they had normal oocyte reserve （day 3 serum FSH 〈12 mlU/ml and serum estradiol 〈50 pg/ml） or diminished oocyte reserve. Mild stimulation was used if low oocyte reserve. The pregnancy rate per retrieval included all pregnancies （fresh or frozen embryo transfer） resulting from one retrieval. The average number of babies born was also compared according to reserve. Results For the diminished oocyte reserve group, the live delivered pregnancy rates per transfer were 80% as good in women aged 〈35 years, 70% as good in women 3639 years, but only 43% as good as women aged 40-42 years. However, because of more total embryos the pregnancy rate per given oocyte retrieval was only 55% as good for women with diminished oocyte reserve aged 〈39 years. The average number of babies born per retrieval was twice as high as those with normal reserve for this age group. Conclusion The use of mild follicle stimulating hormone （FSH） stimulation allows a live delivered pregnancy rate per transfer that is 75% as good for women aged 〈39 years but because of less embryos a likelihood of pregnancy rate per retrieval only half as good as women with normal reserve.

关键词： live delivered pregnancy rates ovarian reserve mild ovarian hyperstimulation

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Determination of the standardized ileal digestible calcium requirement of Ross broilers from hatch to day 14 post-hatch

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Animal Nutrition 2024年第1期16卷 122-129页

作者： carrie L.Walk Raffaella Aureli Pauline Jenn DSM Nutritional Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom Research Center for Animal Nutrition and Health DSM Nutritional ProductsVillage-Neuf68128France

An experiment was conducted to determine the standardized ileal digestible(SID)calcium requirement of fast-growing broilers from hatch to d 14 *** 308(n=360)male broilers were obtained on day of hatch and allocated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formulated to contain 0.60%,0.46%,0.32%or 0.18%SID *** final treatment was formulated using total Ca to meet or exceed all nutrient requirements,including 0.90%total Ca and 0.49%non-phytate P(nPP),using the same *** treatment was the reference diet for comparison and validation of the SID Ca *** and feed were weighed at placement and on d *** and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d *** were analyzed using JMP Pro and requirements were estimated using 3different non-linear regression *** the SID Ca content in the diet from 0.18%to 0.60%improved(quadratic,P<0.05)body weight gain and mortality corrected feed conversion ratio(mFCR).The estimated SID Ca requirement to optimize gain or m FCR was between 0.39%and 0.52%.Tibia ash percent and weight increased(quadratic,P<0.05)as SID Ca content in the diet increased and the estimated SID Ca requirement was between 0.32%and 0.58%.Phosphorus utilization was improved in birds fed diets formulated using SID Ca compared with birds fed the reference *** conclusion,the SID Ca requirement of fast-growing broilers from hatch to d 14 was estimated between 0.534%and 0.398%when quadratic,straight-broken line,or quadratic-broken line regressions were *** results agree with previously published data evaluating the SID Ca requirement of fast-growth broilers from hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium Requirements Retention Tibia ash

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Plane Tracks

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小学生时代（大嘴英语） 2024年第5期 18-20页

作者： carrie Finison Logan Kline(图) 不详

我知道有一架飞机刚刚飞过我没有看到它翱翔的样子,也没有听到它又长又响的隆隆声但是看——它留下了一道航迹云!

关键词： Plane Tracks 翱翔

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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Synchronization of Radar Observations with Multi-Scale Storm Tracking

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Advances in Atmospheric Sciences 2009年第1期26卷 78-86页

作者：杨洪平 Jian ZHANG carrie LANGSTON Wuhan Institute of Heavy Rain China Meteorological Administration Wuhan 430074 Cooperative Institute for Mesoscale Meteorological Studies The University of Oklahoma and NOAA/OAR National Severe Storms Laboratory Norman O.K. U.S.A

The 3-D radar reflectivity data has become increasingly important for use in data assimilation towards convective scale numerical weather prediction as well as next generation precipitation estimation. Typically, reflectivity data from multiple radars are objectively analyzed and mosaiced onto a regional 3-D Cartesian grid prior to being assimilated into the models. One multi-radar observations is the synchronization of all of the scientific issues associated with the mosaic of the observations. Since radar data is usually rapidly updated （-every 5-10 min）, it is common in current multi-radar mosaic techniques to combine multiple radar＇ observations within a time window by assunfing that the storms are steady within the window. The assumption holds well for slow evolving precipitation systems, but for fast evolving convective storms, this assumption may be violated and the mosaic of radar observations at different times may result in inaccurate storm structure depictions. This study investigates the impact of synchronization on storm structures in multiple radar data analyses using a multi-scale storm tracking algorithm.

关键词： synchronization radar multi-scale storm tracking

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Data-driven prediction of temperature variations in an open cathode proton exchange membrane fuel cell stack using Koopman operator

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Energy and AI 2023年第4期14卷 439-450页

作者： Da Huo carrie M.Hall Mechanical Materialsand Aerospace Engineering DepartmentIllinois Institute of Technology10 West 35th StreetChicago60616ILUnited States

In this study,a novel application of the Koopman operator for control-oriented modeling of proton exchange membrane fuel cell(PEMFC)stacks is *** primary contributions of this paper are:(1)the design of Koopman-based models for a fuel cell stack,incorporating K-fold cross-validation,varying lifted dimensions,radial basis functions(RBFs),and prediction horizons;and(2)comparison of the performance of Koopman-based approach with a more traditional physics-based *** results demonstrate the high accuracy of the Koopman-based model in predicting fuel cell stack behavior,with an error of less than 3%.The proposed approach offers several advantages,including enhanced computational efficiency,reduced computational burden,and improved *** study demonstrates the suitability of the Koopman operator for the modeling and control of PEMFCs and provides valuable insights into a novel control-oriented modeling approach that enables accurate and efficient predictions for fuel cell stacks.

关键词： Proton exchange membrane fuel cell(PEMFC) Data-driven modeling Koopman operator Dynamic modeling Control-oriented modeling Physics-based modeling

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Understanding the forces acting in self-assembly and the implications for constructing three-dimensional （3D） supercrystals

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Nano Research 2015年第8期8卷 2445-2466页

作者： Chenyu wang1 carrie Siu Jun Zhang Jiye Fang Department of Chemistry State University of New York at Binghamton Binghamton New York 13902 USA Materials Science and Engineering Program State University of New York at Binghamton Binghamton New York 13902 USA State Key Laboratory of Heavy Oil Processing College of Chemical Engineering China University of Petroleum Qingdao 266580 China

The assembly of nanocrystals into ordered structures called supercrystals or superstructures has become a pivotal frontier owing to numerous useful applications such as correlating the arrangements of atoms in macroscopic crystals and tuning the collective properties to meet the demands of various applications. In this article, recent progress in the preparation of three-dimensional superlattices of nanocrystals is outlined, with a particular emphasis on the driving forces and evolutionary routes beyond orderly assembly. First, the leading or repulsive forces that internally and externally govern the formation of three-dimensional supercrystals are systematically identified and discussed with respect to their origins and functions in three-dimensional self-organization. Then a synoptic introduction of commonly applied means of nanocrystal self-assembly based on growth scenarios such as droplet evaporation and a liquid/liquid interface is presented with specific cases and detailed analyses. Finally, the existing challenges and prospects for this field are briefly highlighted.

关键词： interparticle forces superlattices supercrystals three-dimensional self-assembly

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Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 808-832页

作者： Sakti Chakrabarti carrie Y Peterson Deepika Sriram Amit Mahipal Division of Hematology/Oncology Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States Division of Medical Oncology Mayo ClinicRochesterMN 55905United States

Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective *** majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for *** current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a *** alone is curative for the vast majority of colon cancer ***,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal *** chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical *** research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor *** this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes.

关键词： Adjuvant Circulating tumor DNA Immunoscore Minimally invasive Neoadjuvant FOxTROT Minimal residual disease International duration evaluation of adjuvant chemotherapy

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Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第37期22卷 8294-8303页

作者： carrie R Wong Mindie H Nguyen Joseph K Lim Department of Internal Medicine Yale University School of Medicine Division of Gastroenterology and Hepatology Stanford University School of Medicine Yale Liver Center Section of Digestive Diseases Yale University School of Medicine

Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in the United States and represents an increasingly important etiology of hepatocellular carcinoma(HCC) with annual cumulative incidence rates ranging from 2% to 12% in cohorts of NAFLD cirrhosis. While the risk of progression of NAFLD to HCC remains higher among patients with fibrosis or cirrhosis, an increasing amount of literature describes NAFLD-HCC as a disease that can occur in the absence of cirrhosis. Efforts to characterize the pathogenesis of NAFLD-HCC have suggested mechanisms that strongly associate with states of hyperinsulinemia and chronic inflammation, cellular mechanisms including adaptive immune responses and hepatic progenitor cell populations, and genetic polymorphisms including mutations of PNPLA3. Current literature describes NAFLD-HCC mostly as a disease of late presentation with lower rates of receipt of curative therapy and worse prognosis. However, a growing body of evidence has reported comparable and potentially more favorable disease-free and overall survival rates among patients with NAFLD-HCC after receipt of curative treatment. This review summarizes current evidence of epidemiology, pathophysiology, disease presentation, demand and receipt of curative therapy, post-treatment outcomes, and overall survival of NAFLD-associated HCC.

关键词： Fatty liver Nonalcoholic steatohepatitis Hepatocellular carcinoma Liver cirrhosis Liver cancer

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