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Parallel personal measurements of diesel engine exhaust and crystalline silica using dual sampling port

International Journal of mining Science and Technology 2020年第3期30卷 313-319页

作者： Alan Fleck caroline Couture Virginie Cabelguen Patrick Eddy Ryan Ross Thuot Guillaume Lachapelle Hugo Coulombe maximilien Debia Department of Environmental and Occupational Health University of MontrealMontreal H3T 1A8Canada Health and Safety Agnico Eagle MinesToronto M5C 2Y7Canada Health and Safety Westwood Mine(IAMGOLD)Preissac J0Y 2E0Canada

Diesel engine exhaust(DEE) and crystalline silica exposures occur simultaneously in the mining industry,and occupational sampling campaigns can be time-and cost-consuming. The authors evaluated a dualport system for simultaneous sampling of DEE and crystalline silica in laboratory and field *** tests evaluated the operation of pumps during 8 h sampling and the intensity of the flow variation for various filter loading conditions and for different modes of operation. Field validation was performed in an underground mine. Pumps operated in constant flow or constant pressure *** in constant flow mode showed that when the flowrate increased on one side of the system, it decreased on the opposite side according to the loading intensity. Tests in constant pressure mode showed that flowrates systematically decreased when using loaded cassettes. However, the higher the backpressure setting, the lower the flow variation was. Flow variations during field tests were generally within the acceptable ±5% range. However, significant flow variations were identified in higher concentrations. A significant negative correlation was found between flowrate variation and total carbon concentration. While the majority of tests support the use of the dual-port for evaluating concomitant exposures, results highlight the possibility of filter overloading as a cause of flowrate changes.

关键词： Crystalline silica Diesel engine exhaust Dual-port mining monitoring

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Digital earth:yesterday,today,and tomorrow

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International Journal of Digital Earth 2023年第1期16卷 1022-1072页

作者： Alessandro Annoni Stefano Nativi ArzuÇöltekin Cheryl Desha Eugene Eremchenko caroline m.Gevaert Gregory Giuliani min Chen Luis Perez-mora Joseph Strobl Stephanie Tumampos International Society for Digital Earth BeijingPeople’s Republic of China National Research Council RomeItaly University of Applied Sciences and Arts Northwestern Switzerland FHNW School of EngineeringInstitute of Interactive Technologies IITBrugg-WindischSwitzerland Nathan Campus Griffith UniversityCities Research InstituteBrisbaneAustralia Lomonosov moscow State University MoscowRussia Department of Earth Observation Science University of TwenteTwenteThe Netherland Institute for Environmental Sciences/enviroSPACE University of GenevaGenevaSwitzerland Key Laboratory of Virtual Geographic Environment(ministry of Education of PRC) Nanjing Normal UniversityNanjingPeople’s Republic of China Cities Research Institute Nathan CampusGriffith UniversityBrisbaneAustralia Department of Geoinformatics University of SalzburgSalzburgAustria Chair of Remote Sensing Technology Technical University of MunichMunichGermany Big Geospatial Data management Technical University of MunichMunichGermany

The concept of Digital Earth(DE)was formalized by Al Gore in *** that time the technologies needed for its implementation were in an embryonic stage and the concept was quite *** then digital technologies have progressed significantly and their speed and pervasiveness have generated and are still causing the digital transformation of our *** creates new opportunities and challenges for the realization of DE.‘What is DE today?’,‘What could DE be in the future?’,and‘What is needed to make DE a reality?’.To answer these questions it is necessary to examine DE considering all the technological,scientific,social,and economic aspects,but also bearing in mind the principles that inspired its *** understanding the lessons learned from the past,it becomes possible to identify the remaining scientific and technological challenges,and the actions needed to achieve the ultimate goal of a‘Digital Earth for all’.This article reviews the evolution of the DE vision and its multiple definitions,illustrates what has been achieved so far,explains the impact of digital transformation,illustrates the new vision,and concludes with possible future scenarios and recommended actions to facilitate full DE implementation.

关键词： Digital Earth digital transformation sustainable development data governance and ethic citizen empowerment and industry engagement

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Implementation and evaluation of Exercise is medicine in primary care clinics within a large academic health system

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Family medicine and Community Health 2024年第1期12卷 16-27页

作者： John Kevin Ong Dayao caroline E L Duffy Amalia m Cristiano Gene'Rusty'Kallenberg Sarah E Linke University of California San Diego School of medicine La JollaCaliforniaUSA milken Institute of Public Health The George Washington UniversityWashingtonDistrict of ColumbiaUSA The University of Texas medical Branch at Galveston School of medicine GalvestonTexasUSA Scripps Family medicine Residency Scripps Mercy Hospital Chula VistaChula VistaCaliforniaUSA Herbert Wertheim School of Public Health&Human Longevity Science University of California San DiegoLa JollaCaliforniaUSA Department of Family medicine University of California San DiegoLa JollaCaliforniaUSA Omada Health San FranciscoCaliforniaUSA

Objective Exercise is medicine(EIm)is a global initiative encouraging healthcare providers to routinely assess and promote physical activity(PA)among *** objective of this study was to evaluate the feasibility,adoption,implementation and effectiveness of EIm from patient,clinician and healthcare staff perspectives using a combination of electronic health record(EHR),survey and interview *** This study used a combination of the Practical Robust Implementation and Sustainability model(PRISm)and the Learning Evaluation model to implement *** captured from the EHR,including Physical Activity Vital Sign(PAVS)scores,and data collected from qualitative surveys and interviews were used to evaluate the programme’s Reach,Effectiveness,Adoption,Implementation,maintenance(RE-AIm,which is embedded within PRISm)from provider,staff and patient *** Five primary care clinics within a large academic health *** A total of 24443 patients from all participating clinics had at least one PAVS score during the study period.A total of 17 clinicians completed surveys,and 4 clinicians,8 medical assistants and 9 patients completed *** Implementation fidelity metrics varied widely between components and across clinics but were generally consistent over time,indicating a high degree of programme *** was highest during the first 6 months of the COVID-19 pandemic when most visits were *** PAVS scores increased from 57.7(95%CI:56 to 59.4)to 95.2(95%CI:91.6 to 98.8)min per week at 6 months for patients not meeting PA guidelines at baseline and decreased from 253.84(95%CI:252 to 255.7)to 208.3(95%CI:204.2 to 212.4)min per week at 6 months for patients meeting PA guidelines at *** EIm implementation,clinician-estimated time spent discussing PA with patients increased for 35%of providers and stayed the same for 53%.Conclusion Overall,this study established EIm’s feasibility,adoption,implementation

关键词： routine qualitative completed

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Direct Comparison of Catalyst-Free and Catalyst-Induced GaN Nanowires

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Nano Research 2010年第7期3卷 528-536页

作者： caroline Chèze Lutz Geelhaar Oliver Brandt Walter m.Weber Henning Riechert Steffen münch Ralph Rothemund Stephan Reitzenstein Alfred Forchel Thomas Kehagias Philomela Komninou George P.Dimitrakopulos Theodoros Karakostas Paul-Drude-Institut für Festkörperelektronik 5-7 HausvogteiplatzBerlin 10117Germany NamLab gGmbH Dresden 01187Germany Technische Physik Universität WürzburgAm HublandWürzburg 97074Germany Physics Department Aristotle UniversityThessaloniki 54124Greece

GaN nanowires have been grown by molecular beam epitaxy either catalyst-free or catalyst-induced by means of Ni *** identical growth conditions of temperature andⅤ/Ⅲratio,both types of GaN nanowires are of wurtzite structure elongated in the Ga-polar direction and are constricted by m-plane ***,the catalyst-induced nanowires contain many more basal-plane stacking faults and their photoluminescence is *** differences can be explained as effects of the catalyst Ni seeds.

关键词： Nanowire nanocolumn molecular beam epitaxy(mBE) photoluminescence stacking faults catalyst

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Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

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Translational Neurodegeneration 2020年第2期9卷 309-321页

作者： Julia Remnestål Linn Oijerstedt Abbe Ullgren Jennie Olofsson Sofia Bergström Kim Kultima martin Ingelsson Lena Kilander mathias Uhlén Anna månberg caroline Graff Peter Nilsson Division of Affinity Proteomics Department of Protein ScienceKTH Royal Institute of TechnologySciLifeLabTomtebodavägen 23 AAlpha 217165 SolnaStockholmSweden Swedish FTD Initiative StockholmSweden Division of Neurogeriatrics Centre for Alzheimer ResearchDepartment of NeurobiologyCare Sciences and SocietyKarolinska Institutet17164SolnaSweden Unit for hereditary dementias Theme AgingKarolinska University HospitalStockholmSweden Department of medical Sciences Clinical ChemistryUppsala UniversityUppsalaSweden Department of Public Health and Caring Sciences GeriatricsUppsala UniversityUppsalaSweden Department of Neuroscience Karolinska InstitutetSolnaSweden

Background The clinical presentations of frontotemporal dementia(FTD)are diverse and overlap with other neurological *** are,as of today,no biomarkers in clinical practice for diagnosing the ***,we aimed to find protein markers in cerebrospinal fluid(CSF)from patients with FTD,presymptomatic mutation carriers and *** Antibody suspension bead arrays were used to analyse 328 proteins in CSF from patients with behavioural variant FTD(bvFTD,n=16)and progressive primary aphasia(PPA,n=13),as well as presymptomatic mutation carriers(PmC,n=16)and non-carriers(NC,n=8).A total of 492 antibodies were used to measure protein levels by direct labelling of the CSF *** findings were further examined in an independent cohort including 13 FTD patients,79 patients with Alzheimer’s disease and 18 healthy *** We found significantly altered protein levels in CSF from FTD patients compared to unaffected individuals(PmC and NC)for 26 *** analysis show patterns of separation between unaffected individuals and FTD patients,especially for those with a clinical diagnosis of *** most statistically significant differences in protein levels were found for VGF,TN-R,NPTXR,TmEm132D,PDYN and *** with FTD were found to have higher levels of TN-R and NF-m,and lower levels of VGF,NPTXR,TmEm132D and PDYN,compared to unaffected *** main findings were reproduced in the independent *** In this pilot study,we show a separation of FTD patients from unaffected individuals based on protein levels in *** investigation is required to explore the CSF profiles in larger cohorts,but the results presented here has the potential to enable future clinical utilization of these potential biomarkers within FTD.

关键词： Frontotemporal dementia Cerebrospinal fluid Biomarkers Proteomics Antibody suspension bead array

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Predictors for perioperative blood transfusion in elderly patients with extra capsular hip fractures treated with cephalo-medullary nailing

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Chinese Journal of Traumatology 2018年第1期21卷 16-19页

作者： m, All Fazal caroline Bagley Parag Garg Royal Free NHS Foundation Trust The Ridgeway Enfield EN2 8JL United Kingdom

The aim of our study was to determine predictive factors and requirement for perioperative blood transfusion in elderly patients with extra capsular hip fractures treated with cephalo-medullary device. methods： Seventy-nine patients with extra capsular hip fractures treated with cephalo-medullary nailing were included in the study. Age, sex, ASA grade, timing of surgery, preoperative and postoperative haemoglobin, length of hospital stay, fracture type, number of units transfused and 30-day mortality were recorded. Results： The mean age was 82.3 years. Forty-seven patients underwent a short nail and 32 patients a long nail; 53.4% patients required blood transfusion postoperatively. Transfusion was required in 71,8% of the long nails （p 〈 0.05）, 65.8% patients above the age of 80 （p 〈 0.05）, 100% of the patients with hemoglobin below 90 g/L and 20 patients with a ASA grade of 3 （p 〈 0.05）. 78.5% patients with A2 fracture and 75% of A3 fractures needed blood transfusion （p 〉 0.05）. Length of hospital stay in non-transfusion group was 13 days and in transfusion group was 19 days （p 〈 0.05）. 55.1% operated within 36 h and 47,B% operated after 3B h of admission needed transfusion （p 〉 0.05）. Thirty-day mortality in patients needing blood transfusion was 5% and in non-transfusion group was 3.7% （p 〉 0.05）, Conclusion： Patient age, ASA grade, preoperative haemoglobin and length of nail are reliable predictors for perioperative blood transfusion in extra capsular hip fractures in elderly patients treated with cephalo-medullary nailing and reinforce a selective transfusion policy.

关键词： Hip fractures Fracture fixation Cephalo-medullary nailing Blood transfusion

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Precise Synthesis at the Atomic Scale

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Precision Chemistry 2023年第4期1卷 199-225页

作者： Shufang Ji caroline Jun Yuanjun Chen Dingsheng Wang Department of Chemistry University of TorontoTorontoOntario M5S 3H6Canada Department of Chemistry Tsinghua UniversityBeijing 100084China

Precise synthesis at the atomic scale is a highly desirable and controllable route for the preparation of heterogeneous catalysts with the desired structure and properties,which promotes the rational design of highly efficient catalysts and facilitates the understanding of structure-properties *** precise construction of the active sites of the catalysts provides important opportunities for atomic insight into the correlation between structure and catalytic *** this review,the atomic-level tuning strategies for the precise synthesis of heterogeneous catalysts are summarized with the emphasis on the precise control of the structure of active sites,including single atom sites,dual atom sites and complex active ***,we illustrate the crucial role of atomic-level regulation of structure in determining the catalytic performance by providing typical catalysis examples in different *** the end,some perspectives on the further development of precise synthesis of catalysts at the atomic level are presented.

关键词： Precise synthesis heterogeneous catalysts active sites atomic scale catalysis

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High temperature X-ray diffraction study of the formation of Na_(2)Ti_(3)O_(7) from a mixture of sodium carbonate and titanium oxide

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Journal of Energy Chemistry 2022年第2期31卷 210-218页

作者： caroline Piffet Bénédicte Vertruyen Frédéric Hatert Rudi Cloots Frédéric Boschini Abdelfattah mahmoud GREENmAT CESAM Research UnitChemistry DepartmentUniversity of Liège4000 LiègeBelgium Laboratory of mineralogy Geology Research UnitUniversity of Liège4000 LiègeBelgium

Na2Ti3O7 has attracted much attention in the field of anode materials for Na-ion batteries thanks to its non-toxicity and very low working potential of 0.3 V vs Na0/Na+.Building a clearer picture of its formation from cheap Na_(2)CO_(3) and TiO_(2) starting materials is therefore of obvious ***,we report new insights from an in-situ high temperature X-ray diffraction study conducted from room temperature to 800°C,complemented by ex-situ *** were thereby able to position the previously reported Na_(4)Ti_(5)O_(12) and Na_(2)Ti_(6)O_(13) intermediate phases in a reaction scheme involving three successive steps and temperature *** and/or broadening of a subset of the Na_(2)Ti_(6)O_(13) reflections suggested a combination of intra-layer disorder with the well-established ordering of successive *** in-situ study was carried out on reproducible mixtures of Na_(2)CO_(3) and TiO_(2) in 1:3 molar ratio prepared by spraydrying of mixed aqueous ***-phase Na_(2)Ti_(3)O_(7) was obtained after only 8 h at 800°C in air,instead of a minimum of 20 h for a conventional solid-state route using the same *** analysis revealed~15 mm diameter granules made up from rectangular rods of a fewmm length presenting electrochemical properties in line with *** the absence of grinding or formation of intimate composites with conductive carbon,the specific capacity of 137 m Ah/g at C/5 decreased at higher rates.

关键词： Formation mechanism High temperature XRD Na_(2)Ti_(3)O_(7) Spray-drying synthesis Na-ion batteries

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Immortalized Sertoli cell lines sk11 and sk9 and binding of spermatids in vitro

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Asian Journal of Andrology 2007年第3期9卷 312-320页

作者： Katja m. Wolski caroline Feig Christiane Kirchhoff Don F. Cameron Department of Pathology and Cell Biology School of Basic Biomedical Sciences University of South Florida Collegeof Medicine Tampa Florida 33612 USA Department of molecular Andrology University Clinics Eppendorf University of Hamburg Hamburg Germany

Aim： To determine the effectiveness of the ski 1, sk9 and ski 1 TNUA5 Sertoli cell lines in binding germ cells in vitro. methods： The immortalized Sertoli cell lines sk9, ski 1 and ski 1 TNUA5 were used in co-culture experiments with germ cells in media with or without reproductive hormones and incubated for 44 h at 32℃. The number of germ cells bound to Sertoli cells was then determined and statistically analyzed. Western blot analysis and reverse transcriptasepolymerase chain reaction （RT-PCR） studies were employed to investigate the presence of cell adhesion proteins and follicle stimulating hormone （FSH） receptor, respectively. Results： No statistical difference between the number of bound step-8 spermatids and bound pre-step 8 spermatids on Sertoli cells from any of the cell lines existed. After the addition of germ cells, Sertoli ceils showed more lipid accumulation in their cytoplasm, indicating active phagocytosis. Western blot analysis in the ski I TNUA5 line indicated the expression of N-cadherin. FSH-only and testosterone-only treatments increased N-cadherin expression, regardless of germ cell addition. The addition of germ cells to the ski l TNUA5 Sertoli cells increased the expression of espin, as did the addition of FSH with germ cells. RT-PCR studies of the ski I TNUA5 cells indicated that the mRNA for FSH receptor decreased with successive passages. Conclusion： In vitro binding between isolated germ cells and sk9, skll or skll TNUA5 Sertoli cells is not feasible, and therefore these cell lines are not useful for the in vitro investigation of Sertoli-germ cell interactions and primary Sertoli cell isolates must still be used.

关键词： sk Sertoli cells immortalized Sertoli cells Sertoli-germ cell binding Sertoli-germ cell co-culture Sertoli-spermatid junctionalcomplex in vitro cell-cell binding

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Systems Biology of Plant-microbiome Interactions

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molecular Plant 2019年第6期12卷 804-821页

作者： Patricia A.Rodriguez michael Rothballer Soumitra Paul Chowdhury Thomas Nussbaumer caroline Gutjahr Pascal Falter-Braun Institute of Network Biology (INET) Helmholtz Zentrum Munchen German Research Center for Environmental Health Munich Germany Institute of Environmental medicine (IEm) UNIKA-T Technical University of Munich Augsburg Germany Plant Genetics TUM School of Life Science Weihenstephan Technical University of Munich (TUM) Freising Germany microbe-Host Interactions Faculty of Biology Ludwig-Maximilians-Universitat (LMU) Mijnchen Munich Germany

In natural environments,plants are exposed to diverse microbiota that they interact with in complex *** plant-pathogen interactions have been intensely studied to understand defense mechanisms in plants,many microbes and microbial communities can have substantial beneficial effects on their plant *** beneficial effects include improved acquisition of nutrients,accelerated growth,resilience against pathogens,and improved resistance against abiotic stress conditions such as heat,drought,and ***,the beneficial effects of bacterial strains or consortia on their host are often cultivar and species specific,posing an obstacle to their general ***,many of the signals that trigger plant immune responses are molecularly highly similar and often identical in pathogenic and beneficial ***,it is unclear what determines the outcome of a particular microbe-host interaction and which factors enable plants to distinguish beneficials from *** unravel the complex network of genetic,microbial,and metabolic interactions,including the signaling events mediating microbe-host interactions,comprehensive quantitative systems biology approaches will be needed.

关键词： plant systems biology plant microbiome microbial communities SynComs microbe-host interactions

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