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Optogenetic inhibition of medial prefrontal cortex projections to the nucleus accumbens core and methyl supplementation via L-Methionine attenuates cocaine-primed reinstatement

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Integrative Zoology 2018年第6期13卷 795-803页

作者： Katherine N.wright Amanda M.DOSSAT caroline E.STRONG Lindsay L.SAILER Samantha M.PAVLOCK Mohamed KABBAJ Department of Biomedical Sciences and Program in Neuroscience Florida State UniversityTallahasseeFloridaUSA National Institute on Drug Abuse BaltimoreMarylandUSA Department of Biomedical Sciences College of MedicineFlorida State UniversityTallahasseeFloridaUSA

DNA methylation has been identified as a powerful and activity-dependent regulator of changes in the brain that may underlie neuroadaptations in response to various types of stimuli,including exposure to drugs of ***,the medial prefrontal cortex(mPFC)projections to the nucleus accumbens(NAc)are critically important for reinstated cocaine-seeking in a rodent model of cocaine *** circuitry undergoes several epigenetic modifications following cocaine exposure,including changes in DNA methylation that are associated with drug-seeking *** have previously shown that methyl supplementation via L-Methionine(MET)administration attenuates cocaine-seeking behavior and reverses expression and methylation patterns of the immediate early gene c-fos,suggesting that MET may act by altering the excitability of this circuitry during cocaine *** the current study,male rats were microinjected with an adeno-associated virus overexpressing halorhodopsin in the mPFC,optical fibers were surgically implanted into the NAc,and the rats were given injections of MET *** underwent acquisition of cocaine self-administration(0.75 mg/kg/infusion,2-h sessions)followed by extinction training in the absence of drug-paired *** reinstatement tests were conducted:cue-induced reinstatement without optogenetic manipulations and cocaine-primed reinstatement with optogenetic inhibition of mPFC-to-NAc *** were no group differences before the cocaine-primed reinstatement session,and all groups showed robust cue-induced *** rats treated with MET and rats that received mPFC-to-NAc inhibition showed an abolishment of cocaine-primed reinstatement,suggesting that systemic methyl supplementation may act through this critical circuity.

关键词： cocaine-primed reinstatement corticolimbic DNA methylation methionine optogenetics

Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

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World Journal of Gastroenterology 2017年第40期23卷 7321-7331页

作者： Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall caroline J Tallis Katherine A Stuart Penny L wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell Pharmacy Department Princess Al-exandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Cancer and Chronic Disease Research Group QIMR Berghofer Medical Research Institute School of Medicine and Public Health The University of Newcastle The Centre for Liver Disease Research Translational Research Institute The University of Queensland Department of Gastroenterology and Hepatology Princess Alexandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Department of Gastroenterology and Hepatology Princess Alexandra Hospital Statistics Unit QIMR Berghofer Medical Research Institute School of Pharmacy The University of Queensland

AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated *** One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = *** Medication adherence was " High " in 42 % o f participants, "Medium" in 37%, and "Low" in 21%. Compared to patients with "High" adherence, those with "Medium" or "Low" adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with "Low" adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of "Low"*** The association between "Low" adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explor

关键词： Medication adherence Medication beliefs Illness perceptions Quality of life Liver cirrhosis

Measuring organ shift and deformation for port placement in robotassisted minimally invasive surgery

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第4期3卷 99-106页

作者： Mohammad R.Maddah Cedric Dumas Olivier Gauthier Marion Fusellier caroline G.L.Cao Department of Biomedical Industrialand Human Factors EngineeringWright State UniversityDayton OHUSA IMT Atlantique NantesFrance Laboratoire des Sciences du Numerique de Nantes(LS2N) NantesFrance ONIRIS Nantes-Atlantic College of Veterinary MedicineFood Science and EngineeringNantesFrance

Objective:Port placement is a crucial pre-operative task in robot-assisted minimally invasive *** to the insufflation process,the abdominal shape is deformed while the internal organs are shifted in *** changes need to be considered when determining the optimal port locations for the robotic ***,intra-operative medical image acquisition systems are not always *** this study,we aim to estimate the shift extent of the abdominal organs in humans by measuring the changed volume and position of the abdominal organs before and after insufflation in three ***:A 3D model of the abdomen and abdominal organs was reconstructed from 3D images of the pigs taken by an MRI scanner before and after *** shift and shape changes of the abdominal organs after insufflation were *** corresponding shift in port location for the robotic manipulators was determined based on the abdominal ***:Organ movements as a result of insufflation ranged from 6.37±0.10 cm for the spleen,to 1.64±0.22 cm for the *** a slight planar motion of the target organ(e.g.,1.33±0.06 cm,2.38±0.21 cm in X-Y plane for the left kidney)can shift the access port for the robot manipulator by about 1.6 cm on the abdominal ***:The target organs’motion due to insufflation is a critical factor in determining port locations in robot-assisted minimally invasive surgery.

关键词： Insufflation 3D abdominal model Organ shift Volume changes

Sub-chronic exposure to jp-8 jet fuel enhances susceptibility to noise induced hearing loss in rats

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Sub-chronic exposure to jp-8 jet fuel enhances susceptibilit...

Application of the Alpha Shape Method to Visualize and Analyze Surgical Motion

Neurotoxicity and Neurodegeneration:Local Effect and Global Impact--13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health

作者： Larry Fechter caroline Gearhart Sherry Fulton Research Service Loma Linda VA Medical CenterLoma LindaCAUSA

Purpose: Both laboratory and occupational epidemiological studies identify specific organic solvents as potential ototoxicants or agents that promote noise-induced hearing *** the presence of several such aromatic hyd... 详细信息

关键词： Sub-chronic exposure to jp-8 jet fuel enhances susceptibility to noise induced hearing loss in rats

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Surgical Science 2017年第11期8卷 464-480页

作者： Mohammad R. Maddah caroline G. L. Cao Department of Biomedical Industrial and Human Factors Engineering Wright State University Dayton OH USA

Simulators play an important role in training surgery residents to perform laparoscopy surgery. Some of these simulators have the capability to track tool motion to assess performance. However, most have not utilized the data to analyze trainee performance in a meaningful way. The alpha shape method can be used to construct a geometric surface based on motion data to enable visualization of the performance, while the surface derivative (surface/time to completion)—efficiency—can be used as a metric to evaluate complex surgical performance. The utility of the alpha shape method was demonstrated in a pick-and-place task, where the motion path of laparoscopic graspers was recorded by a position sensor, miniBIRD 500?. An alpha shape method was used to measure the surface area of the 3D points in space occupied by the tool tips during task performance. Results show that the surface derivative measure alone may be able to model the speed-accuracy tradeoff function, thereby simplifying the analysis and evaluation of complex motion in surgical performance.

关键词： Surface Alpha Shape Motion Visualization Performance Assessment

A decision aid for the port placement problem in robot-assisted hysterectomy

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第2期6卷 43-56页

作者： Mohammad R.Maddah Jean-Marc Classe Isabelle Jaffre Keith A.Watson Katherine S.Lin Damien Chablat Cedric Dumas caroline G.L.Cao Department of Biomedical Industrialand Human Factors EngineeringWright State University3640 Colonel Glenn HwyDaytonOHUSA Department of Automatique Productique et InformatiqueIMT Atlantique4 Rue Alfred KastlerNantesFrance Laboratoire des Sciences Du Numerique de Nantes(LS2N) 2 Chemin de La Houssini?ereNantesFrance Centre Rene Gauducheau ICO Institut de Cancerologie de L'Ouest BD Professeur Jacques MonodSaint-HerblainFrance Brethen Center for Surgical Advancement in Robotics and Minimally Invasive Surgery Miami Valley HospitalOne Wyoming StreetDaytonOHUSA Department of Computer Science IMT AtlantiqueTechnopole Brest-IroiseBrestFrance Laboratoire des Sciences et Techniques de L'information de La Communication et de La Connaissance(Lab-STICC) Technopole Brest-IroiseBrestFrance Future Industries Institute STEMUniversity of South AustraliaMawson Lakes BlvdMawson LakesAustralia

Objective:In robot-assisted minimally invasive surgery,proper port positioning ensures that surgical tools have adequate access to the surgical site and avoids mid-surgery collisions of robotic *** date,several guidelines have been proposed for more accurate port ***,challenges remain due to variations in patient morphology,anatomy,and,in particular,organ displacement due to insuf-flation in certain laparoscopic *** objective of this study was to design and develop a de-cision aid for optimal port placement in robot-assisted hysterectomy that accounts for patient variability and organ displacement due to ***:Three components were constructed:a robot model,a patient-specific model,and an opti-mization *** three components were integrated,and the system was verified using four different patients who underwent robotic *** verified,two expert surgeons were asked to evaluate the decision aid for face and construct validity.A usability test was conducted using a torso phantom with target organs located in three different *** expert surgeons performed a simulated hysterectomy task with and without the decision aid to evaluate performance and ***:The optimization algorithm was sensitive to individual differences in anatomy in the four *** surgeons successfully established face and construct *** test results showed a 28%-40% reduction in time to task completion with the optimized ports compared to expert-determined port locations without using the decision ***:The decision aid,based on an individualized patient-specific model,robot model,and optimization algorithm,was shown to be effective at addressing the challenges of displaced organs due to insufflation in robot-assisted *** face and construct validity of the decision aid was established by expert surgeons,while efficiency gains in task performance were demonstrated experim

关键词： Optimization Planning tool Patient model Robotic hysterectomy

Meeting report:a hard look at the state of enamel research

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International Journal of Oral Science 2017年第4期9卷 193-199页

作者： ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer program in craniofacial biology and department of orofacial sciences university of californiasan franciscoSan FranciscoUSA department of pediatrics and institute for human genetics university of californiasan franciscoSan FranciscoUSA laboratory of skin biology national institute of arthritis and muscular and skin diseasesnational institutes of healthBethesdaUSA physical science division pacific northwest national laboratoriesRichlandUSA department of basic science and craniofacial biology new york university college of dentistryNewYorkUSA department of materials science and engineering northwestern universityevanstonusaEvanstonUSA center for craniofacial molecular biology herman ostrow school of dentistryuniversity of southern californiaLos AngelesUSA the forsyth institute CambridgeUSA department of developmental biology harvard school of dental medicineBostonUSA department of pediatric dentistry university of north caroline school of dentistryChapel HillUSA departments of dermatology and cel&developmental biology perelman school of medicineand department of anatomy&cell biologyschool of dental medicineuniversity of pennsylvaniaPhiladelphiaUSA functional genomics section national institute of dental and craniofacial researchBethesdaUSA division of biosciences ohio state universitycollege of dentistryColumbusUSA department of periodontics and center for craniofacial research and diagnosis texas a&m university college of dentistryDallasUSA center for children’s oral health research and department of orofacial sciences university of californiasan franciscoSan FranciscoUSA biologic and materials sciences and division of prosthodontics university of michiganAnn ArborUSA

The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines （ENAMEL） Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National institute of Dental and Craniofacial Research （NIDCR）. Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids. Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field.

关键词： enamel mineralized tissue mineralization ameloblast stem cell