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Impact of chitosan-based nanocarriers on cytoskeleton dynamics:Current status and challenges

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BIOCELL 2022年第4期46卷 885-891页

作者： M.carolina DI SANTO AGUSTINA ALAIMO ANA PAULA DOMÍNGUEZ RUBIO OSCAR E.PÉREZ Departamento de Química Biológica Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales Consejo Nacional de Investigaciones Científicas y Técnicas(IQUIBICENCONICET)Buenos AiresArgentina

Chitosan-based nanocarriers(CS-NCs)show a promising role in improving drugs and bioactive compounds delivery for ***,the effects exerted by CS-NCs at the cellular level,including their recognition and uptake,have not been fully investigated *** factors,including size,shape,concentration,and surface chemistry of CS-NCs,play an important role in determining the types of intracellular signals *** mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside *** the present work,we discuss the effects induced by CS-NCs per se on the cytoskeleton,a key component in cell architecture and *** focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell *** recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and *** mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-added formulations in the biomedical ***,this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-tumoral effects.

关键词： Cytoskeletal dynamics Cellular uptake Endocytosis Nanocarriers Chitosan Bioactive compounds

Soil ecosystem changes by vegetation on old-field sites over five decades in the Brazilian Atlantic forest

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Journal of Forestry Research 2022年第2期33卷 667-677页

作者： Danielle Cristina Ortiz Tancredo Augusto Feitosa de Souza Tatiani Maria Pech Marie Luise carolina Bartz Dilmar Baretta Alexandre Siminski Júlia Carina Niemeyer Federal University of Santa Catarina Ulysses Gaboardikm 3CuritibanosSC 89520-000Brazil Postgraduate Programme in Agricultural and Natural Ecosystems(PPGEAN) Federal University of Santa CatarinaUlysses Gaboardikm 3CuritibanosSC 89520-000Brazil Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal Department of Animal Science UDESC OesteSanta Catarina State UniversityChapecóSC 89815-630Brazil

Vegetation types alter soil ecosystems by changing soil fauna community activities and soil physi-cal-chemical ***,it is unclear how tree species(natural forest,native and exotic tree plantations)promote changes in the soil ecosystem,and if these changes alter functional groups of soil fauna and ecosystem *** determine the effects of five decades of old-field veg-etation on soil ecosystems in the Brazilian Atlantic Forest,field sampling of three ecosystems(exotic tree species Pinus elliottii ***,endangered tree species Arau-caria angustifolia(Bertol.)Kuntze plantation,and a natural ecosystem)were carried out,as well using bait-lamina tests and bioassays with collembolans,earthworms and seeds of Lactuca sativa *** sampling evaluated the soil fauna community and soil physical-chemical *** bait-lamina test in situ was carried out for 14-days to deter-mine fauna feeding activity,and the bioassays evaluated the reproduction of Folsomia candida,the avoidance of Eisenia andrei,and germination of *** in the soil from each *** results are:(1)vegetation type altered the soil fauna community composition;(2)soil fauna feeding was reduced in the plantations compared to the natural eco-system;(3)a physical barrier was created by recalcitrant litter that compromised fauna community structure and seed bank germination in situ;and,(4)changes in soil physical-chemical properties promoted decomposers.

关键词： Endangered tree species Exotic tree species Forest ecosystem Soil fauna functional groups Soil invertebrates

Liver graft procurement in neurologically deceased donor:Hospital Italiano of Buenos Aires approach

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 80-82页

作者： Juan Glinka carolina Vanetta Juan Pekolj Juan Mattera Eduardo de Santibañes Martín de Santibañes Department of General Surgery Hospital Italiano de Buenos AiresBuenos AiresArgentina Section of HPB Surgery&Liver Transplantation Unit Hospital Italiano de Buenos AiresBuenos AiresArgentina

To the Editor:Liver procurement(LP)from a neurologically deceased donor(NDD)is one of the most important spotlights in liver transplanta-tion(LT)[1,2].The commonly used approaches include the“rapid”en-bloc dissection,the in vivo normothermic dissection,or a com-bination of both,according to the preferences and/or the experi-ence of the LP/LT team.A correct LP is essential to achieve optimal *** the counterpart,defective execution of any of its steps can leave the liver graft unusable and/or cause severe complica-tions in the recipient[3].

关键词： Liver neurological dissection

Multi-gigahertz mode-locked femtosecond Yb:KLuW waveguide lasers

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Photonics Research 2022年第11期10卷 2584-2589页

作者： JI EUN BAE XAVIER MATEOS MAGDALENA AGUILÓ FRANCESC DÍAZ JAVIER GARCÍA AJATES carolina ROMERO JAVIER RODRÍGUEZ VÁZQUEZ DE ALDANA FABIAN ROTERMUND Department of Physics Korea Advanced Institute of Science and Technology(KAIST)34141 DaejeonRepublic of Korea Universitat Rovira i Virgili(URV) Fı´sica i Cristal·lografia de Materials i Nanomaterials(FiCMA)43007 TarragonaSpain Grupo de Investigación en Aplicaciones del Láser y Fotónica University of Salamanca37008 SalamancaSpain

We demonstrate multi-gigahertz continuous-wave mode-locking of a Yb:KLuW waveguide laser. A femtosecondlaser-inscribed Yb:KLuW channel waveguide in an extended laser cavity delivers a fundamentally mode-locked laser near 1030 nm. A tunable few-centimeter-long cavity containing a single-walled carbon nanotube saturable absorber as mode-locker generates self-starting femtosecond pulses with average output powers exceeding210 mW at repetition rates of 2.27, 2.69, and 3.55 GHz. The laser cavity, which includes a wedged waveguide,is extended by using a lens pair that controls the laser fluence on the saturable absorber for reliable mode-locked operation without instability. The presented laser performance, mode-locked up to 3.55 GHz, highly suggests the potential of crystalline Yb:KLuW waveguides for realizing high-power ultrafast lasers with higher GHz repetition rates in a quasi-monolithic cavity.

关键词： waveguide femtosecond mode

Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de Almeida Fernandes Guilherme de Freitas Camoes Diana Ferreira carolina Queijo Carlos Fontes-Ribeiro Lino Gongalves Rui Pina Natalia Antonio Department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED ***: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;P<0.001) and were more frequently on QT prolonging drugs(77.3%;P=0.025). Main contributing factor was intake of antibiotics(odds ratio [OR] 4.680) followed by female gender(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

Nutritional therapy for hospitalized patients with COVID-19:A narrative and integrative review

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Journal of Intensive Medicine 2022年第4期2卷 249-256页

作者： Beatriz H.Grecco Paula A.O.Araújo-Rossi carolina F.Nicoletti Department of Nutrition School of Public HealthUniversity of São PauloSão PauloSPBrazil Applied Physiology and Nutrition Research Group Rheumatology DivisionFaculty of MedicineUniversity of São PauloAv Dr Arnaldo 455São PauloSP 01246-903Brazil

Hospitalized patients affected by coronavirus disease 19(COVID-19)have a sustained pro-inflammatory state and recurrent gastrointestinal symptoms that correlate with a decline in the nutritional status,which is directly related to poor immune response and clinical *** therapy has proven crucial in COVID-19 treatment through the provision of adequate amounts of *** the beginning of the pandemic,medical societies have mobilized to provide practical nutritional guidelines to support decision-making;despite this,there are only a few studies dedicated to compiling the most relevant *** this narrative review,we aimed to summarize and stratify the current scientific literature on nutritional support for hospitalized COVID-19 *** carried out a literature review from three databases between January 2020 and July 2021,using nutrition therapy(or medical nutrition or enteral nutrition or parental nutrition or nutritional support)and COVID-19(SARS-CoV-2 infection)as the search *** those studies that evaluated adult hospitalized patients with admissions to wards,specific clinics,or intensive care units were *** nutritional intervention considered was that of specific nutritional support via oral,enteral,or parenteral modes.A total of 37 articles were *** general,the nutritional care provided to COVID-19 patients follows the same premises as for other patients,i.e.,it opts for the most physiological route and meets nutritional demands based on the clinical ***,some protocols that minimize the risk of contamination exposure for the health team have to be *** requirements varied from 15 kcal/kg/day to 30 kcal/kg/day and protein goals from 1.2 g/kg/day to 2 g/kg/*** both cases,the ramp protocol for increased supply should be *** cases of enteral therapy,ready-to-use diet and continuous mode are *** to refeeding syndrome is essential when parenteral n

关键词： COVID-19 Nutritional support Enteral nutrition Parenteral nutrition Energy requirement Protein supply

Rehabilitation of degraded areas in northeastern Patagonia, Argentina: Effects of environmental conditions and plant functional traits on performance of native woody species

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Journal of Arid Land 2020年第4期12卷 653-665页

作者： Juan M ZEBERIO carolina A PÉREZ National University of Río Negro Atlantic HeadquartersCenter for Environmental Studies from Norpatagonia(CEANPa)Viedma 8500Argentina National Council of Scientific and Technical Research(CONICET) Viedma 8500Argentina Ecological and Environmental Systems Research Laboratory(LISEA) National University of La PlataLa Plata 1900Argentina

Degradation processes affect a vast area of arid and semi-arid lands around the world and damage the environment and people′s health. Degradation processes are driven by human productive activities that cause direct and indirect effects on natural resources, such as species extinction at regional scale, reduction and elimination of vegetation cover, soil erosion, etc. In this context, ecological rehabilitation is an important tool to recover key aspects of the degraded ecosystem. Rehabilitation trials rely on the use of native plant species with characteristics that allow them to obtain high survival and growth rates. The aim of this work was to assess the survival and growth of native woody species in degraded areas of northeastern Patagonia and relate them to plant functional traits and environmental variables. We observed high early and late survival rates, and growth rates in Prosopis flexuosa DC. var. depressa F.A. Roig and Schinus johnstonii F.A. Barkley, and low values in Condalia microphylla Cav. and Geoffroea decorticans(Gillies ex Hook. & Arn.) Burkart. Early survival rates were positively associated with specific leaf area(SLA) and precipitation, but negatively associated with wood density, the maximum mean temperature of the warmest month and the minimum mean temperature of the coldest month. Late survival rates were positively associated with SLA and soil organic matter, but negatively associated with plant height and precipitation. The temperature had a positive effect on late survival rates once the plants overcame the critical period of the first summer after they were transplanted to the field. Prosopis flexuosa and S. johnstonii were the most successful species in our study. This could be due to their functional traits that allow these species to acclimatize to the local environment. Further research should focus on C. microphylla and G. decorticans to determine how they relate to productive conditions, acclimation to environmental stress, auto-eco

关键词： arid lands Condalia microphylla Geoffroea decorticans Prosopis flexuosa Schinus johnstonii survival rates height growth basal diameter growth

Chemical and spectroscopic characterization of humic substances from sediment and riparian soil of a highly polluted urban river(Suquía River,Córdoba,Argentina)

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International Journal of Sediment Research 2020年第3期35卷 287-294页

作者： carolina Merlo carolina Vázquez Ana Graciela Iriarte Carlos Matías Romero Instituto Multidisciplinario de Biologia Vegetal (CONICET) Facultad de Ciencias Agropecuarias Universidad Nacional de Cordoba INFIQC Departament of FisicoquimicaFacultad de Ciencias QuimicasUniversidad Nacional de Cordoba Agriculture and Agri-Food Canada Lethbridge Research and Development Centre Department of Biological Sciences University of Lethbridge

The Suquia River,the largest urban river in Cordoba(Argentina),has been severely polluted for *** must be taken to restore its environmental quality by managing riparian zones for increased water-self *** current study aimed to characterize organic matter(OM) dynamics and humic substances(HS) spectrochemical properties along the lower-middle basin of the Suquia *** soil(0-20 cm) and sediment(0-10 cm) samples were collected from a reference location(S1)and four polluted sites(S2-S5) during a low-flow *** contents of soil and sedimentary OM and HS fractions were analyzed by wet oxidation,as well as HS Fourier transform infrared(FT-IR) and ultraviolet-visible(UV-Vis) spectrochemical *** OM and HS fractions from riparian soil were high upstream of Cordoba City(S1 and S2,50.2-50.4 g/kg OM) and within a 50 km downstream location(S5,30.9 g/kg OM) owing to a surplus of fresh plant biomass-carbon(C) *** heterogeneous sediment samples did not show any significant differences among sites(P> 0.05).The lowest values of the ratio of absorbances at 465 and 665 nm(E4/E6)(1.78) and the Δ log K(0.15) coefficient(a measure of HS maturity degree) were obtained downstream of Cordoba City,for both riparian soil and sediment,indicating that HS were enriched by more condensed aromatic structures within highly degraded portions of the *** samples exhibited similar IR spectra,implying overlapping recalcitrant-C structures at the functional group level,but with different absorbance *** from the current study constitute a baseline for understanding the chemical nature of HS from sediment and riparian soil along the Suquia River and can be used as a reference for future studies tracking OM compositional changes over time.

关键词： Lotic ecosystems Organic matter Humic acids FT-IR spectroscopy UV-Vis spectroscopy

Estimating the Components of a Mixture of Extremal Distributions under Strong Dependence

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Advances in Pure Mathematics 2023年第7期13卷 425-441页

作者： carolina Crisci Gonzalo Perera Lia Sampognaro Departamento Modelización Estadística de Datos e Inteligenica Artificial (MEDIA) CURE Rocha Universidad de la República Rocha Uruguay

In this paper, we provide a method based on quantiles to estimate the parameters of a finite mixture of Fréchet distributions, for a large sample of strongly dependent data. This is a situation that appears when dealing with environmental data and there was a real need of such method. We validate our approach by means of estimation and goodness-of-fit testing over simulated data, showing an accurate performance.

关键词： Mixture of Extremal Distributions Strongly Dependent Data