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红曲对中度血脂升高美国人调节血脂作用的临床研究

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上海预防医学 2013年第9期25卷 501-506页

作者：陆继红 Kermit Bonovich Harry Colfer Michael Davidson Carlos A.Dujovne David L.fried Mitchell Greenspan Ronald P.Karlsberg Stephen P.King Craig f.Laforce Marc Litt J.Robert McGhee 曾润海朱佳石谈宁芝华茂北京临床药理研究中心北京100088 Healthy Options Burns Clinic Rush-Presbyterian-St. Luke's Medical Center Kansas University Medical Center and Kansas foundation for Clinical Pharmacology Omega Medical Research Lifemark Medical Center Cardiovascular Research Institute of So. CA future Scripts North carolina Clinical Research Jacksonville Heart Center Mediquest Research Group Nu Skin Center for Anti-aging Research 香港理工大学

[目的]评价在饮食控制的情况下红曲（RYRCholestin）对美国高血脂人群的降脂作用和安全性。[方法]开放标记，自身对照，多中心临床试验。187名美国高血脂人群入选（血清低密度脂蛋白胆固醇3．50—4．92mmol／L，总胆固醇5．18—7．25mmo... 详细信息

[目的]评价在饮食控制的情况下红曲（RYRCholestin）对美国高血脂人群的降脂作用和安全性。[方法]开放标记，自身对照，多中心临床试验。187名美国高血脂人群入选（血清低密度脂蛋白胆固醇3．50—4．92mmol／L，总胆固醇5．18—7．25mmol／L；男116人，女71人），162入完成试验。在整个试验中受试者遵照美国国家胆固醇教育计划的饮食要求。试验的前4周仅控制饮食，第5周至第12周连续服用8周RYRCholestin（每日2．4g）。[结果]经前4周饮食控制，血清脂质各指标无显著变化。口服RYRCholestin8周后，血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油分别降低16．6％，24．O％和25．2％，高密度脂蛋白胆固醇升高14．3％（P〈0．001）。显效率为79．0％，有效率为97．5％。停服14d（2周）后，血脂各指标回到试验前水平。试验中共发现可能与服用产品相关的、轻度的29项不良反应。[结论]RYRCholestin的耐受性良好，它可降低血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油，升高血清高密度脂蛋白胆固醇。停服2用后受试者的血脂各项指标均恢复到试验前水平。

关键词：红曲高脂血症低密度脂蛋白胆固醇三酰甘油高密度脂蛋白胆固醇

Notes for genera:Ascomycota

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fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David L.Hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree V.Singh Pedro W.Crous Martin Kukwa Robert Lücking Cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura Selbmann Monika C.Dayarathne Gothamie Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael f.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová Lorenzo Lombard Belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati O.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb Marcela E.S.Caceres Sergio Perez-Ortega Patrícia O.fiuza Josiane Santana Monteiro Larissa N.Vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena Oset Mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.Senanayake Subashini C.Jayasiri Milan C.Samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma Luis f.P.Gusmao Darshani Weerahewa Samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National fungal Culture Collection of India(NfCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany farlow Reference Library and Herbarium of Cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for fungi(NCf).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy

Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari fernanda de Alves freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.f.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-food Canada fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA Department of Plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCDf1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDf1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in f1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

真空负压助产中胎头枕后位增加肛门括约肌损伤风险

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 18-18页

作者： Wu J.M. Williams K.S. Hundley A.f 朱晓明 Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill Chapel Hill NC United States Dr

Objective: The purpose of this study was to determine whether an occiput posterior (OP) fetal head position increases the risk for anal sphincter injury when compared with an occiput anterior (OA) position in vacuum-assisted deliveries. Study design: We conducted a retrospective cohort study of 393 vacuum-assisted singleton vaginal deliveries. Maternal demographics and obstetric and neonatal data were collected from an obstetric database and chart review. Results: Within the OP group, 41.7% developed a third -or fourth-degree laceration compared with 22.0% in the OA group (OR 2.5, 95% CI 1.4- 4.7). In a logistic regression model that controlled for BMI, race, nulliparity, length of second stage, episiotomy, birth weight, head circumference, and fetal head position, OP position was 4.0 times (95% CI 1.7- 9.6) more likely to be associated with an anal sphincter injury than OA position. Conclusion: Among vacuum deliveries, an OP head position confers an incrementally increased risk for anal sphincter injury over an OA position.

关键词：枕后位括约肌损伤真空负压胎头位置外阴切开术第二产程单胎妊娠枕前位会阴撕裂产科学

报告非药物随机对照临床试验的CONSORT扩展声明:说明与详述(一)

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中西医结合学报 2009年第5期7卷 491-494页

作者： Isabelle Boutron David Moher Douglas G. Alt man Kenneth f. Schulz Philippe Ravaud INSERM U738 AP-HPHpital Bichat-Claude BernardUniversité Paris 7 Denis DiderotParisFrance Chalmers Research Group Children s Hospital of Eastern Ontario Research InstituteUniversity of OttawaOttawaOntarioCanada University of Oxford OxfordUnited Kingdom Quantitative Sciences Family Health InternationalResearch Triangle ParkNorth CarolinaUSA

正确报告随机对照临床试验(randomized controlled trial,RCT)是严格评价试验结果真实性与有效性的必要前提。含22项条目清单和流程图的CONSORT(Consolidated Standards of Reporting Trials)声明旨在通过改进RCT的报告来解决这一问题... 详细信息

正确报告随机对照临床试验(randomized controlled trial,RCT)是严格评价试验结果真实性与有效性的必要前提。含22项条目清单和流程图的CONSORT(Consolidated Standards of Reporting Trials)声明旨在通过改进RCT的报告来解决这一问题。然而,《CONSORT声明》中没有专门论及那些适用于非药物治疗(如手术、技术干预、仪器设备、康复理疗、心理治疗和行为干预等)临床试验的具体问题。此外,相当多的证据表明非药物临床试验的报告仍然需要改进,因此CONSORT小组针对评估非药物治疗的临床INfORMATION fOR AUTHORS试验制定了《CONSORT扩展声明》。为制定《CONSORT扩展声明》以规范非药物临床试验的报告,33名专家于2006年2月在法国巴黎组织召开了讨论会议,并就此达成了共识。与会者扩充了原有《CONSORT声明》中的11项条目,新增了1项条目,修改并重新制定了报告流程图。为便于充分理解和执行《CONSORT扩展声明》,CONSORT小组通过对文献的回顾编制了这一说明与详述文本,旨在为正确报告非药物临床试验提供范例。本扩展声明,连同《CONSORT声明》以及《CONSORT声明》的其他扩展本,将有助于改进非药物治疗领域RCT的报告。

关键词： CONSORT声明随机对照临床试验非药物治疗药物临床试验评价试验技术干预仪器设备康复理疗

报告非药物随机对照临床试验的CONSORT扩展声明:说明与详述(二)

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中西医结合学报 2009年第6期7卷 593-598页

作者： Isabelle Boutron David Moher Douglas G. Alt man Kenneth f. Schulz Philippe Ravaud for the CONSORT Group Hpital Bichat-Claude Bernard UniversitéParis7Denis DiderotParisFrance Chalmers Research Group Children's Hospital of Eastern Ontario Research InstituteUniversity of OttawaOttawaOntarioCanada University of Oxford OxfordUnited Kingdom Quantitative Sciences Family Health InternationalResearch Triangle ParkNorth CarolinaUSA

为便于更好地理解和传播该,与会者建议编制一份说明与详述文本,类似之前为CONSORT声明修订版[2]、诊断试验准确性研究的报告规范(Standards for Reporting of Diagnostic Accuracy, STARD)[17]和观察性流行病学研究报告规范(Strengtheni... 详细信息

为便于更好地理解和传播该,与会者建议编制一份说明与详述文本,类似之前为CONSORT声明修订版[2]、诊断试验准确性研究的报告规范(Standards for Reporting of Diagnostic Accuracy, STARD)[17]和观察性流行病学研究报告规范(Strengthening the Reporting of Observational Studies in Epidemiology, STROBE)[18]制定的说明与详述文本.The International Society for Complementary Medicine Research简介

关键词： CONSORT声明随机对照临床试验 Epidemiology 药物报告规范诊断试验流行病学文本

Search for two-neutrino double-beta decay of^(136)Xe to the 0^(+)_(1)excited state of 136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 1-9页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.f.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.Daniels L.Darroch S.J.Daugherty J.Davis S.Delaquis A.Der Mesrobian-Kabakian R.DeVoe J.Dilling A.Dolgolenko M.J.Dolinski J.Echevers W.fairbank Jr. D.fairbank J.farine S.feyzbakhsh P.fierlinger Y.S.fu D.fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen J.Hoessl P.Hufschmidt M.Hughes A.Iverson A.Jamil C.Jessiman M.J.Jewell A.Johnson A.Karelin L.J.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.MacLellan T.McElroy T.Michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar f.Retière A.L.Robinson P.C.Rowson J.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado J.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel J.-L.Vuilleumier M.Wagenpfeil J.Watkins M.Weber L.J.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler 无 Physics Department McGill UniversityMontrealQuebec H3A 2T8Canada Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-University Erlangen-NürnbergErlangen 91058Germany Physics Department Carleton UniversityOttawaOntario K1S 5B6Canada Department of Physics Duke Universityand Triangle Universities Nuclear Laboratory(TUNL)DurhamNorth Carolina 27708USA Physics Department University of IllinoisUrbana-ChampaignIllinois 61801USA Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre“Kurchatov Institute” Moscow 117218Russia Department of Physics University of South DakotaVermillionSouth Dakota 57069USA SLAC National Accelerator Laboratory Menlo ParkCalifornia 94025USA TRIUMf VancouverBritish Columbia V6T 2A3Canada Institute of High Energy Physics Beijing 100049China Department of Physics Laurentian UniversitySudburyOntario P3E 2C6Canada Physics Department Colorado State UniversityFort CollinsColorado 80523USA Department of Physics and Physical Oceanography University of North Carolina at WilmingtonWilmingtonNC 28403USA Physics Department and CEEM Indiana UniversityBloomingtonIndiana 47405USA Physics Department Stanford UniversityStanfordCalifornia 94305USA Department of Physics Drexel UniversityPhiladelphiaPennsylvania 19104USA Amherst Center for fundamental Interactions and Physics Department University of MassachusettsAmherstMA 01003USA Technische Universität München Physikdepartment and Excellence Cluster UniverseGarching 80805Germany Physics Department University of MarylandCollege ParkMaryland 20742USA Department of Physics and Astronomy University of AlabamaTuscaloosaAlabama 35487USA Wright Laboratory Department of PhysicsYale UniversityNew HavenConnecticut 06511USA IBS Center for Underground Physics Daejeon 34126Korea Department of Physics and Astronomy Stony Brook UniversitySUNYStony BrookNew York 11794USA Kellogg Lab CaltechPasadenaCalifornia 91125USA LHEP Albert Einstein CenterUniversi

A new search for two-neutrino double-beta(2νββ)decay of^(136)Xe to the 0+1 excited state of 136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase II dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2νββdecay to the 0+1 state of 136Ba is 2.9×10^(24)yr using a total^(136)Xe exposure of 234.1 kg *** statistically significant evidence for 2νββdecay to the 0^(+)_(1)state is observed,leading to a lower limit of T2ν1/2(0^(+)→0^(+)_(1))>1.4×10^(24)yr at 90%confidence level,improved by 70%relative to the current world's best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

新生儿及儿童的心血管CT血管成像:迭代影像重建技术的影像质量及降低放射剂量的可能性

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国际医学放射学杂志 2013年第4期 392-392页

作者： f. Tricarico A.M. Hlavacek U.J. Schoepf U. Ebersberger J.W. Nance Jr R. Vliegenthart 乔辉 Department of Radiology and Radiological Science Medical University of South CarolinaAshley River Tower 25 Courtenay Drive MSC 226 Charleston SC 29401 USA

目的评估小儿低剂量心血管CT血管成像(CTA)的影像质量(IQ),将影像空间迭代重建(IRIS)及基于原始数据的迭代重建(SAfIRE)技术与滤过反向投影(fBP)技术进行比较,并评价进一步降低剂量的可能性。方法 40例有或无心电门控的新生儿和儿童行... 详细信息

目的评估小儿低剂量心血管CT血管成像(CTA)的影像质量(IQ),将影像空间迭代重建(IRIS)及基于原始数据的迭代重建(SAfIRE)技术与滤过反向投影(fBP)技术进行比较,并评价进一步降低剂量的可能性。方法 40例有或无心电门控的新生儿和儿童行低剂量CTA检查。应用fBP、IRIS及SAfIRE技术进行数据重建。对于ECG门控的研究,模拟半剂量影像采集。测量信号噪声并对IQ进行分级。评价有效剂量(ED)。结果应用IRIS及全剂量SAfIRE技术,影像噪声平均绝对值和相对值低于fBP(PfBP(PfBP研究相比,半剂量SAfIRE影像噪声也较低,SNR及CNR较高(PfIRE及半剂量SAfIRE的IQ评分高于全剂量fBP,半剂量SAfIRE的IQ评分高于半剂量fBP(PfIRE研究的ED评价为0.68mSv。结论在低剂量小儿CTA检查中,与fBP相比,IR技术可改善影像噪声、SNR、CNR及主观的IQ,并可在不影响诊断IQ的前提下进一步降低剂量。要点①迭代重建技术显著改善儿童无创性心血管CT检查。②使用一半常规放射剂量时,迭代重建的影像质量更高。③应用迭代重建技术可以进一步降低小儿心血管CT的放射剂量。

关键词： CT 先天性心脏病放射剂量迭代影像重组儿科影像学

采用迭代图像重建对冠状动脉支架进行CT评估:改善影像质量和降低辐射剂量的潜力

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国际医学放射学杂志 2013年第2期 185-185页

作者： U. Ebersberger f. Tricarico U.J. Schoepf P. Blanke J.R. Spears G.W. Rowe 李宁 Heart and Vascular Center Medical University of South CarolinaAshley River Tower 25 Courtenay Drive Charleston SC 29425-2260USA

目的比较心脏CT血管成像(cCTA)采用滤波反投影(fBP)技术和基于原始数据的迭代重建(SAfIRE)技术进行半剂量和全剂量图像数据重建对冠状动脉支架的评估能力。方法对双源cCTA研究的37枚植入支架采用fBP和SAfIRE进行全剂量和半剂量重建。半... 详细信息

目的比较心脏CT血管成像(cCTA)采用滤波反投影(fBP)技术和基于原始数据的迭代重建(SAfIRE)技术进行半剂量和全剂量图像数据重建对冠状动脉支架的评估能力。方法对双源cCTA研究的37枚植入支架采用fBP和SAfIRE进行全剂量和半剂量重建。半剂量数据基于一个双源CT(DSCT)探测器支架内噪声、信噪比(SNR)和支架腔衰减增强比(SAIR),并对影像质量进行分级。通过测量支架容积来评估管腔硬化的严重程度。结果全剂量SAfIRE重建在支架内噪声[(21.2±6.6)∶(35.7±17.5);PfBP重建。SAfIRE测量的支架容积较小[(119.9±53.7)mm3∶(129.8±65.0)mm3;P>0.05]。半剂量SAfIRE重建与全剂量fBP重建相比,支架内噪声[(26.7±13.0)∶(35.7±17.5);P0.05]、支架容积[(129.6±57.3)mm3∶(129.8±65.0)mm3;P>0.05]和影像质量[(3.5±1.0)∶(3.7±1.1);P>0.05]没有差别。辐射剂量从(8.7±5.2)mSv降低到(4.3±2.6)mSv。结论与fBP相比,迭代重建明显提高了CT冠状动脉支架的成像能力,即使在辐射剂量减半的情况下。要点①CT正成为一种越来越重要的研究心脏病变的方法。②CT迭代重建技术明显提高了对冠状动脉支架的评估能力。③迭代重建具有降低辐射剂量要求的潜力。④支架的显示能力提高可以更好地发现相关并发症,从而进一步减少了导管插入术。

关键词：迭代重建基于原始数据的迭代重建双源CT 冠状动脉支架 CT冠状动脉血管成像