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Obesity is associated with decreased risk of microscopic colitis in women

World Journal of Gastroenterology 2022年第2期28卷 230-241页

作者： Robert S Sandler Temitope O Keku John T Woosley Dale P Sandler Joseph A Galanko Anne f Peery Department of Medicine University of North CarolinaChapel HillNC 27514-7555United States Department of Medicine University of North CarolinaChapel HillNC 27514-7555United States Department of PathologyUniversity of North CarolinaChapel HillNC 27514United States Department of Health and Human Services National Institute of Environmental Health SciencesDurhamNC 27709United States

BACKGROUND Microscopic colitis is a leading cause of diarrhea in the older *** is limited information about risk *** hypothesized that obesity would be associated with microscopic *** To examine the association between obesity and microscopic colitis in men and women undergoing *** We conducted a case-control study at the University of North carolina *** identified and enrolled men and women referred for elective,outpatient colonoscopy for chronic *** excluded patients with a past diagnosis of Crohn’s disease or ulcerative colitis.A research pathologist reviewed biopsies on every patient and classified them as microscopic colitis cases or non-microscopic colitis *** provided information on body weight,height and exposure to medications via structured interviews or Internet based *** analysis included 110 patients with microscopic colitis(cases)and 252 nonmicroscopic colitis *** analyses were performed using logistic regression to estimate odds ratios and 95%confidence *** Cases were older and more likely than controls to be white *** subjects were well educated,but cases were better educated than *** with microscopic colitis had lower body mass index than controls and reported more weight loss after the onset of *** to patients who were normal or under-weight,obese(BMI>30 kg/m2)patients were substantially less likely to have microscopic colitis after adjusting for age and education,adjusted OR(aOR)0.35,95%confidence interval(CI)0.18-0.66).When stratified by sex,the association was limited to obese women,aOR 0.21,95%CI:*** with microscopic colitis were more likely to report weight loss after the onset of *** stratifying by weight loss,there remained a strong inverse association between obesity and microscopic colitis,aOR 0.33,95%CI:0.10-1.11 among the patients who did not lose *** use of birth

关键词： Colitis Microscopic/epidemiology Humans Diarrhea/epidemiology Obesity

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人体肢体隐性发汗及其降温效应机理的热物理分析

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中国生物医学工程学报 2004年第2期23卷 163-168页

作者：朱光明刘伟杨昆 T.f.Zeng 华中科技大学能源与动力工程学院武汉430074 Department of Mechanical and Aerospace Engineering North carolina State University

立人体皮肤组织内汗液流动和传热的数学模型 ,把Darcy定律引入到对汗液迁移的数学描述 ,从热物理的角度解释人体隐性发汗的机理 ,定量分析隐性发汗对肢体的降温效应。

关键词：人体肢体隐性发汗多孔介质模型

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Method to assess component contribution to toxicity of complex mixtures： Assessment of puberty acquisition in rats exposed to disinfection byproducts

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Journal of Environmental Sciences 2017年第8期29卷 311-321页

作者： Shahid Parvez Glenn E.Rice Linda K.Teuschler Jane Ellen Simmons Thomas f.Speth Susan D.Richardson Richard J.Miltner E.Sidney Hunter Ⅲ Jonathan G.Pressman Lillian f.Strader Gary R.Klinefelter Jerome M.Goldman Michael G.Narotsky Indiana University Richard M. fairbanks School of Public Health Department of Environmental Health Sciences IUPUI Campus Indianapolis IN 46202 USA National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Lincla Teuschler and Associates St. Petersburg FL 33707 USA National Health and Environmental Effects Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park NC 27711 USA National Risk Management Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Department of Chemistry and Biochemistry University of South Carolina Columbia SC 29208 USA

A method based on regression modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts（DBPs）. Chemical disinfection of drinking water forms DBP *** of concerns about possible reproductive and developmental toxicity, a whole mixture（WM） of DBPs produced by chlorination of a water concentrate was administered as drinking water to Sprague–Dawley（S–D） rats in a multigenerational study. Age of puberty acquisition,i.e., preputial separation（PPS） and vaginal opening（VO）, was examined in male and female offspring, respectively. When compared to controls, a slight, but statistically significant delay in puberty acquisition was observed in females but not in males. WM-induced differences in the age at puberty acquisition were compared to those reported in S–D rats administered either a defined mixture（DM） of nine regulated DBPs or individual DBPs. Regression models were developed using individual animal data on age at PPS or VO from the DM study. Puberty acquisition data reported in the WM and individual DBP studies were then compared with the DM models. The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed in the WM. This method is applicable to mixtures of other types of chemicals and other endpoints.

关键词： Drinking water disinfection byproducts DBP Puberty delay four Lab Study Mixtures risk assessment

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Acid stress response in environmental and clinical strains of enteric bacteria

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frontiers in Biology 2012年第6期7卷 495-505页

作者： Gabriel J. SWENSON J. STOCHASTIC franklyn f. BOLANDER, Jr. Richard A. LONG Biological Sciences University of South Carolina Columbia SC 29208 USA Marine Science Program University of South Carolina Columbia SC 29208 USA Biology Department Paine College Augusta GA 30901 USA

The success of many enteric bacteria is hinged on the ability to tolerate environmental stress such as extreme acidity. The acid stress response （ASR） has been investigated in many enteric bacteria and has been shown to involve variable expression of a broad spectrum of genes involved in transcriptional regulation, metabolism, colonization and virulence; representing a linkage between acid tolerance and pathogenicity. Though the majority of ASR studies have been conducted in laboratory conditions and from the perspective of pathogenicity, the role of environmental reservoirs on acid adaptation has recently emerged as an important aspect of pathogenic microbial ecology. This mini-review profiles ASR in three opportunistic enteric pathogens and synthesizes recent work pertaining to the study of this dynamic response.

关键词： acid stress response enteric bacteria microbial ecology transcriptional regulation virulence

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Approach to Paroxysmal Atrial fibrillation Type Arrhythmia in a Cardiology Service:A Case Report

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Modern Research in Inflammation 2020年第2期9卷 9-17页

作者： Miriam Viviane Baron Luis Manuel Ley Dominguez carolina Paz Mohamad Isa Gabriela Di Lorenzo Garcia Scherer Michele Paula dos Santos Vitoria Pereira Itaquy Talia Guimaraes dos Santos Julia Braga da Silveira Paulo Ricardo Martins Amanda Correa dos Santos Marcus Vinicius de Mello Pinto Janine Koepp Daiana Klein Weber Carissimi Joice Nedel Ott carolina Goncalves Pinheiro Nathalia Ken Pereira Iketani Gabriela feltez Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil Improvement of Higher Education Personnel Brazil(CAPES)Distrito FederalBrazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil School of Health and Life Sciences of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil Celulare Institute PetrópolisBrazil Undergraduate Nursing Course of the University of Santa Cruz do Sul(UNISC) Santa Cruz do SulBrazil Postgraduate Program in Health Sciences of the faculty of Medicine of ABC(fMABC) Sao PauloBrazil Undergraduate Physiotherapy Course of the Vale do Salgado faculty(fVS) CearáBrazil Physiotherapy of the Hospital Beneficiente Portuguesa of Belém ParáBrazil Rehabilitation Sciences of the federal University of Health Sciences of Porto Alegre Porto AlegreBrazil Postgraduate Program in Medicine and Health Sciences School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS)Porto AlegreBrazil

Atrial fibrillation is a cardiac arrhythmia of high prevalence in the population, especially in the elderly. Its main electrical characteristics are the interval between two successive irregular R waves, absence of P waves and presence of f waves between QRS complexes. The most common symptoms of atrial fibrillation are irregular palpitations associated with dyspnea, dizziness, feeling tired, fatigue and general malaise, but not all patients have any symptoms. The present report presents the history of an elderly patient who arrived at the hospital’s emergency department with irregular heart rhythm and palpitations. The patient’s symptoms, associated with the electrocardiogram results, indicated paroxysmal atrial fibrillation. Electrical cardioversion was performed, and after, cardiac ablation via the femoral vein at the hospital’s cardiology service. There were no complications during the procedure. As a routine imaging exam after ablation, control esophagogastroduodenoscopy was requested to verify that there was no formation of atrio-esophageal fistula developed by the invasive ablation procedure and electrocardiogram, which showed normal sinus rhythm. The patient remained in the cardiac intensive care unit for observation for 24 hours. After the electrical cardioversion and catheter ablation procedures, the patient improved his clinical picture of atrial fibrillation and was discharged after 24 hours of hospitalization. He received treatment to perform at home, to reduce acid reflux into the esophagus and to prevent thrombosis. He did not present pulmonary thromboembolism after hospital discharge. It is believed, therefore, that this form of treatment and management of paroxysmal atrial fibrillation is effective for the solution of the proposed problem and can also serve as a reference for other professionals within the cardiology service.

关键词： Atrial fibrillation Electrical Cardioversion Catheter Ablation Hypertension Obstructive Sleep Apnea Syndrome

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Microstructural designs of plate-type elastic metamaterial and their potential applications: a review

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International Journal of Smart and Nano Materials 2015年第1期6卷 14-40页

作者： R.Zhu X.N.Liu G.K.Hu f.G.Yuan G.L.Huang Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNC 27695USA School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Department of Mechanical and Aerospace Engineering University of MissouriColumbiaMO 65211USA

Elastic metamaterials are of growing interest due to their unique effective properties and wave manipulation *** phononic crystals based on the Bragg scattering mechanism,elastic metamaterials(EMMs)are based on the locally resonant(LR)mechanism and can fully control elastic waves at a subwavelength *** designs of EMMs in plate-like structures have attracted a great deal of *** this paper,the recent advances in the microstructural designs of LRbased EMM plates are *** potential applications in the fields of low frequency guided wave attenuation,wave manipulation and energy trapping at a subwavelength scale,and structural health monitoring are discussed.

关键词： metamaterial composite structural dynamics nondestructive evaluation structural health monitoring

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Physical activity and exercise in children with chronic health conditions

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Journal of Sport and Health Science 2013年第1期2卷 12-20页

作者： William f. Riner Sarah Hunt Sellhorst Health Services University of South Carolina Lancaster Lancaster SC 29720 USA Gregory Health and Wellness Center University of South Carolina Lancaster Lancaster SC 29720 USA

In the last two or three decades,physical activity(PA) has gained increasing recognition as being essential for maintaining good health and improving quality of life for all *** have traditionally been active in both free play and organized ***,there has been a recent decline in the PA levels among children for various *** lifestyle change has resulted in increased obesity accompanied by a rise in diabetes and cardiovascular risk among otherwise healthy *** lifestyle changes have been shown to be even more a problem when the child is already affected by a chronic *** to medical limitations and contraindications,much care must be taken to make certain that these children are involved in the appropriate volume and intensity of *** type of activity must also be given careful consideration to avoid undue risk for the child who may have problems such as poor balance,limited strength,poor vision,or cognitive *** complications are either caused or exacerbated by lack of sufficient *** priority beyond concern for safety should be focused on ensuring the highest quality of life *** purpose of this review is to examine how PA can benefit children with selected chronic health conditions.

关键词： Children Chronic health condition Exercise Physical activity

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Long COVID: A Molecular, Cellular and Histopathology Overview

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Journal of Biosciences and Medicines 2023年第9期11卷 90-113页

作者： Bárbara Rafaela da Silva Barros Leonardo Carvalho de Oliveira Cruz Georon ferreira de Sousa Guilherme Antonio Souza-Silva Marília R. C. f. de Lima Elifrances G. Oliveira Anna Jéssica Duarte Silva Larissa S. Macêdo Lígia R. S. Leal Bianca f. São Marcos carolina Elsztein Maria da Conceição V. Invenção Antonio Carlos de freitas Cristiane Moutinho-Melo Immunological and Antitumor Analysis Laboratory (LAIA) and Keizo Asami Immunopathology Laboratory Institute (iLIKA) Federal University of Pernambuco Recife Brazil Laboratory of Neuroendocrinology and Metabolism Federal University of Pernambuco Recife Brazil Laboratory of Molecular Studies and Experimental Therapy Federal University of Pernambuco Recife Brazil

Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of the disease. Persistent symptoms such as dry cough, fatigue, and dyspnea can remain after six months of COVID-19 cure. Others such as lung fibrosis, kidney injury, and thrombotic risk also are observed. Here, a deep review of each human organ and system infected by the virus was performed aiming to show how molecules expression and cell signaling can induce the organism cure or injuries and, subsequently sequelae. The review also suggests the importance of public health surveillance for these cases including a more comprehensive analysis of molecular biology tools that can clarify and assist in the prognosis, treatment, and preventive methods for potentially more serious disorders in post-COVID-19 patients.

关键词： Long COVID COVID-19 Sequelae Public Health Surveillance

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A Single Transcript CRISPR-Cas9 System for Efficient Genome Editing in Plants

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Molecular Plant 2016年第7期9卷 1088-1091页

作者： Tang, Xu Zheng, Xuelian Qi, Yiping Zhang, Dengwei Cheng, Yan Tang, Aiting Voytas, Daniel f. Zhang, Yong Univ Elect Sci & Technol China Sch Life Sci & Technol Dept Biotechnol Chengdu 610054 Peoples R China Univ Minnesota Dept Genet Cell Biol & Dev Minneapolis MN 55455 USA Univ Minnesota Ctr Genome Engn Minneapolis MN 55455 USA East carolina Univ Dept Biol Greenville NC 27834 USA

The Streptococcus pyogenes CRISPR-Cas9 system effectively mediates RNA-guided DNA double-strand breaks and is used for genome editing in many different organisms, including plants （Puchta, 2016）. CRISPR-Cas9 is a two-component system in which the Cas9 protein is expressed from a Pol II promoter （Lowder et al., 2015）. In contrast, the sgRNAs are typically expressed from Pol III promoters, such as U6 and U3.

关键词： system multiple heterologous

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Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems

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Molecular Plant 2018年第2期11卷 245-256页

作者： Levi G. Lowder Jianping Zhou Yingxiao Zhang Aimee Malzahn Zhaohui Zhong Tzung-fu Hsieh Daniel f. Voytas Yong Zhang Yiping Qi Department of Biology East Carolina University Greenville NC 27858 USA Department of Biotechnology School of Life Science and Technology Center for informational Biology University of Electronic Science and Technology of ChinaChengdu 610054 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA Department of Plant and Microbial Biology and Plants for Human Health Institute North Carolina State University North Carolina Research Campus KannapolisNC 28O81 USA Department of Genetics Ceil Biology and Development Center for Genome Engineering University of Minnesota Minneapolis MN 55455 USA Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA

User-friendly tools for robust transcriptional activation of endogenous genes are highly demanded in plants. We previously showed that a dCas9-VP64 system consisting of the deactivated CRISPR- associated protein 9 （dCasg） fused with four tandem repeats of the transcriptional activator VP16 0/1=64） could be used for transcriptional activation of endogenous genes in plants. In this study, we developed a second generation of vector systems for enhanced transcriptional activation in plants. We tested multiple strategies for dCasg-based transcriptional activation, and found that simultaneous recruitment of VP64 by dCas9 and a modified guide RNA scaffold gRNA2.0 （designated CRISPR-Act2.0） yielded stronger transcrip- tional activation than the dCas9-VP64 system. Moreover, we developed a multiplex transcription activator- likeeffector activation （mTALE-Act） system for simultaneous activation of up to four genes in plants. Our results suggest that mTALE-Act is even more effective than CRISPR-Act2.0 in most cases tested. In addition, we explored tissue-specific gene activation using positive feedback loops. Interestingly, our study revealed that certain endogenous genes are more amenable than others to transcriptional activation, and tightly regulated genes may cause target gene silencing when perturbed by activation probes. Hence, these new tools could be used to investigate gene regulatory networks and their control mechanisms. Assembly of multiplex CRISPR-Act2.0 and mTALE-Act systems are both based on streamlined and PCR-independent Golden Gate and Gateway cloning strategies, which will facilitate transcriptional activation applications in both dicots and monocots.

关键词： CRISPR gRNA2.0 MS2-VP64 TALE-VP64 multiplex transcriptional activation

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