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Journal of Geoscience and Environment Protection 2019年第10期7卷 23-48页

作者： Richard Ayuk II Akoachere Takahiro Hosono Thomson Areakpoh Eyong Marcelle-carole Pami Ngassam Tom Tabi Oben Department of Geology University of Buea Buea Cameroon Priority Organizations for Innovation and Excellence Kumamoto University Kurokami Japan Department of Agricultural and Environmental Engineering Pan African University/University of Ibadan Ibadan Nigeria Department of Agronomy and Applied Molecular Sciences University of Buea Buea Cameroon

The present work assesses the trace metal content in groundwater from Akwa-Mundemba, Bakassi Peninsular in Cameroon. 12 groundwater samples were analyzed using Inductively Coupled Plasma Mass Spectroscopy ICP-MS. Field measurement of physicochemical parameters was determined. R-mode statistical analysis;Pearson’s Correlation Analysis (PCA) together with Hierarchical Cluster Analysis (HCA) between the trace metals and the physico-chemical parameters was carried out. Ten indices were determined: Four trace metal hazard indices;the average daily dose ADD (2.5E—07 to 0.2)) carcinogenic risks CR (2.1E—06 to 9.9E—04) and the non-carcinogenic risk hazard quotient HQ (5.7E—04 to 0.78) which yields the hazard indices HI (0.1 - 0.78), and six trace metal pollution indices;Degree of contamination DC (—13.53 to —11.02), Enrichment factor EF (0.26 - 35.47), Ecological risk factor Er (—29.92 - 7.04), Potential ecological risk index RI (-61.2-43.43), Pollution load index PLI (—0.01 - 0.04) and Geo-accumulation index Igeo (4.8E-09-3.0). From health risk indices and pollution evaluation indices on trace metals, the groundwater in Akwa-Mundemba area is safe for drinking. The enrichment factors show that the sources of the trace metals are from geogenic and anthropogenic processes. Arsenic, Lead and Vanadium are enriched although they are below the hazard risk values;this shows they have pollution potential that could be attributed to weathering and agricultural wastes. The severity of metal toxicity is governed by several factors, such as dose, nutrition, age, and even life style. Therefore, these low trends might not guarantee the complete absence of human health risks. Generally, from risk assessment on trace metals using risk indices in the analyzed groundwater samples might not cause any health risk. However, due to an increasing level of environmental pollution that might be imposed by increasing human activity in this area, ground

关键词： Trace-Metals Pollution Indices Hazard Indices Bakassi-Peninsular Rio-del-Rey Cameroun

NF-κB Controls Resistance of Human Salivary Gland (HSG) Cells to Apoptosis in an <i>in Vitro</i>Model of Sjogren’s Syndrome

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Open Journal of Rheumatology and Autoimmune Diseases 2014年第3期4卷 178-191页

作者： Yan Wang Syed A. Jamal Luis F. Torres-Romero Agostino Molteni Alexander Shnyra carole McArthur Department of Molecular Biosciences Lawrence USA Department of Oral and Craniofacial Science School of Dentistry Kansas City USA Kansas City University of Medicine and Biosciences Kansas City USA

Aim: To elucidate the anti-apoptotic properties of nuclear factor kappa light-chain-enhancer of activated B cells (NF-κB) and feedback regulation of NF-κB by nuclear factor of kappa light-chain-enhancer of activated B-cells inhibitor alpha (IκBα). Methods: We developed an in vitro model of Sjogren’s syndrome by transfecting human salivary gland (HSG) and acinar cells (NS-SV-AC) with a plasmid-encoding IκBαM (pCMV-IκBαM), a degradation-resistant IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)-mutant, and examined TNF-induced apoptosis and anti-apoptotic properties of NF-κB. Apoptosis and induction of pro-apoptotic and anti-apoptotic genes were investigated by cDNA arrays, RT-PCR, electrophoretic mobility shift assays, and western blot. Results: In the presence of NF-κB inhibitors, TNF-induced apoptosis was markedly increased in both salivary gland and acinar cells. Increased caspase-3 activity was present in both HSG and NS-SV-AC cells. IκBαM-transfected salivary gland cells were more sensitive to TNF-induced apoptosis than IκBαM-transfected acinar cells. Transcription of pro-apoptotic genes was confirmed in both HSG and NS-SV-AC cells that were transfected with IκBαM. Results from caspase-3 activity assay confirmed previous experiments showing an apoptotic role for NF-κB. Conclusion: Data from gene expression arrays suggest that different mechanisms may operate during TNF-induced apoptosis in salivary gland ductal and acinar cells.

关键词： Acinar Ductal Cytokines Salivary Glands Sjogren’s Syndrome Tumor Necrosis Factor-Alpha

Stratification of the Degree of Hepatic Involvement in HIV-HCV Coinfection Using Two Biomarkers: APRI and FIB-4

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Journal of Biosciences and Medicines 2023年第8期11卷 60-70页

作者： Serge Kouakou Kouassi Doumbia Moussa Alexis Bahi carole N’Guessan Djaman Obouayeba Françis Adou Yapo Joseph Allico Djaman Biology and Health Laboratory Félix Houphou&eumlt-Boigny University Abidjan C&ocircte d’Ivoire Department of Bacteriology-Virology Bacterial and Viral Serology Unit Institut Pasteur of C&ocircte d’Ivoire Abidjan C&ocircte d’Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocircte d’Ivoire Abidjan C&ocircte d’Ivoire

Hepatitis C infection in people living with Human Immunodeficiency Virus (HIV) poses management challenges. Of the world’s population, 3% are estimated to have chronic Hepatitis C Virus (HCV) infection, which is responsible for about 70% of cases of chronic hepatitis (accelerated chronicity in the presence of HIV and for such major complications as cirrhosis and hepatocellular carcinoma. The fibrosis 4 (FIB-4) and Aspartate aminotransferase/platelet ratio index (APRI) scores are simple, inexpensive tests accessible to most people, and their performance has not yet been studied in C?te d’Ivoire. Objective: To prospectively evaluate the diagnostic performance of APRI and FIB-4 scores in liver damage in those co-infected with HIV/HCV in C?te d’Ivoire. Methods: This study was conducted over three months. The patients came from national blood transfusion center of the cities of Man and Daloa. The criteria for selecting respondents were at least 18 years of age and a positive test for HIV and HCV. APRI and FIB-4 scores were calculated for each patient from biological data obtained by COBAS C311 (Roche Hitachi, Japan). Statistical analyses were performed using GraphPad and MED-CALC software. Results: Our study involved 30 patients (men) of middle age (25 - 52 years), with extremes ranging from 0.67 to 8 for APRI and 0.201 to 22 for FIB-4. A predictive APRI and FIB4 score of significant hepatic fibrosis was observed in 23% of patients;however, 46% and 54% of patients for the APRI and FIB-4 score, respectively, would not have significant fibrosis. An APRI and FIB4 score not included in the classification limits of the type of fibrosis hepatitis was observed in 31% and 23% of patients, respectively. Conclusion: The performance of the APRI and FIB-4 biological scores analyzed according to the interpretation of their cut-off values would enable classifying about 70% and 77%, respectively, of the patient population in the stages of hepatitis C fibrosis.

关键词： Co-Infected Patients HIV HCV APRI and FIB-4

Mechanistic Model versus Artificial Neural Network Model of a Single-Cell PEMFC

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Engineering（科研） 2014年第8期6卷 418-426页

作者： Brigitte Grondin-Perez Sébastien Roche carole Lebreton Michel Benne Cédric Damour Jean-Jacques Amangoua Kadjo University of La Reunion Saint-Denis France

Model-based controllers can significantly improve the performance of Proton Exchange Membrane Fuel Cell (PEMFC) systems. However, the complexity of these strategies constraints large scale implementation. In this work, with a view to reduce complexity without affecting performance, two different modeling approaches of a single-cell PEMFC are investigated. A mechanistic model, describing all internal phenomena in a single-cell, and an artificial neural network (ANN) model are tested. To perform this work, databases are measured on a pilot plant. The identification of the two models involves the optimization of the operating conditions in order to build rich databases. The two different models benefits and drawbacks are pointed out using statistical error criteria. Regarding model-based control approach, the computational time of these models is compared during the validation step.

关键词： Mechanistic Model Artificial Neural Network Model Proton Exchange Membrane Fuel Cell Real-Time Experiment

利用PCR技术同时鉴定番茄抗根结线虫和抗斑萎病毒基因

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园艺学报 2003年第6期30卷 678-682页

作者：李君明宋燕徐和金周永健 carole Caranta 冯兰香中国农业科学院蔬菜花卉研究所 Institute National Breeding of Fruits and Vegetables Montfavet Avignon 84143France

利用同-PCR反应体系,对分别与番茄抗根结线虫的Mi基因和抗斑萎病毒(TSWV)的Sw-5基因紧密连锁的SCAR标记进行了同时扩增筛选,扩增的特异性片段与单引物扩增片段完全吻合,其中与Mi基因紧密连锁的SCAR1标记为共显性标记,抗感试材均产生750... 详细信息

利用同-PCR反应体系,对分别与番茄抗根结线虫的Mi基因和抗斑萎病毒(TSWV)的Sw-5基因紧密连锁的SCAR标记进行了同时扩增筛选,扩增的特异性片段与单引物扩增片段完全吻合,其中与Mi基因紧密连锁的SCAR1标记为共显性标记,抗感试材均产生750 bp的特异片段,纯合和杂合抗病基因型试材存在rqp I酶切位点,酶切后分别产生了570 bp、160 bp和750 bp、570 bp、160 bp的不同特异性片段,而感病基因型试材无Taq I酶切位点;与Sw-5基因紧密连锁的SCAR2标记为显性标记,只有抗病试材扩增出400 bp的特异性片段。经反复验证,结果稳定准确可靠,可用于在同-PCR反应体系中对两个抗病基因进行同时筛选鉴定。

关键词： PCR技术鉴定技术番茄抗根结线虫基因抗斑萎病毒基因

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“鬼节”施孤

英语沙龙（高中） 2015年第10期 26-27,37页

作者： carole Baldock 孔如聃

中国传统的饿鬼节在八月至九月间举行，又称“七月半”、“中元节”或“盂兰盆会”。据传，到了午夜时分，鬼门关大开，阴间的孤魂野鬼被放出幽冥界，在一个月的时间里可随处流浪。这些鬼有的预谋盗尸还魂，“鸠占鹊巢”。这些饿鬼嘴巴... 详细信息

中国传统的饿鬼节在八月至九月间举行，又称“七月半”、“中元节”或“盂兰盆会”。据传，到了午夜时分，鬼门关大开，阴间的孤魂野鬼被放出幽冥界，在一个月的时间里可随处流浪。这些鬼有的预谋盗尸还魂，“鸠占鹊巢”。这些饿鬼嘴巴极其小，只能发出一种微弱的声响，类似哨声。中国人为了表示对祖先的尊重，会在节日期间购买上供用品：食品、冥币、纸衣，还有祭祀用的香、烛以及各类纸货，以告慰祖先在天之灵，免受其鬼魂缠身。然而，这些礼品也会招来别的鬼无端生出怨恨。因为这些鬼没有子嗣后人，或死后未能妥善安葬。有人还会在大海里撒大米，或放入载满礼物的纸船，以祭奠在海中遇难的亡灵。生者摆戏台，上供吃喝，以告慰死者。

关键词：鬼节中国传统盂兰盆会节日期间中元节中国人祖先

熟练的检查技能能为病人护理提供一个牢固的基础

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国际护理学杂志 1986年第3期7卷 100-101页

作者： carole Smith ,马晓英

想一想每一个检查步骤——询问病史(History)、望诊(Inspection)、触诊(Palpation)、叩诊(Percu-ssion)、听诊(Auscultation)(HIPPA)。其中询问病史、望诊在每天工作中都用得到,对你来说毫无问题,但对于触诊、叩诊、听诊——这些都是不... 详细信息

想一想每一个检查步骤——询问病史(History)、望诊(Inspection)、触诊(Palpation)、叩诊(Percu-ssion)、听诊(Auscultation)(HIPPA)。其中询问病史、望诊在每天工作中都用得到,对你来说毫无问题,但对于触诊、叩诊、听诊——这些都是不常用的技能,下文将指导并提高你的检查技能。

关键词：双手触诊中指病人第一只

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脊柱外科手术图谱 1

Respiratory Distress in Full and Post Term Neonates: Prevalence, Etiologies and Outcomes in a Tertiary Health Center in Yaoundé

丛书名： = An atlas of surgery of the spine eng

2006年

作者：（美）HAWARD S AN & LEE H RILEY Ⅲ carole Russell Hilmer绘图阎作勤董健姚振均译

本书包括了手术体位、脊柱内固定与融合、侧弯矫形、脊柱肿瘤的切除重建等内容，以经典的手术操作技术为切入点，并配有精美的插图。

ISBN: (纸本)730904911X

本书包括了手术体位、脊柱内固定与融合、侧弯矫形、脊柱肿瘤的切除重建等内容，以经典的手术操作技术为切入点，并配有精美的插图。

关键词：脊椎病外科手术图谱

来源：汇雅图书（南通市图书馆... 评论

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Open Journal of Pediatrics 2021年第3期11卷 351-359页

作者： Didi Stanine Mefo Kue Jeannette Epee Ngoue Annie carole Nga Motaze Aude Sabine Nanfack Anne Esther Njom-Nlend Higher Institute of Medical Technology Nkolondom Department of Clinical Sciences University of Douala Douala Cameroon Department of Pediatrics Faculty of Medicine and Biomedical Sciences Yaoundé Cameroon Cameroon Society of Perinatal Medicine Yaoundé Cameroon Essos Hospital Centre National Social Insurance Fund Yaoundé Cameroon Ministry of Economy and Development Yaoundé Cameroon

Introduction: Respiratory pathologies are top listed amongst neonatal morbidities. Our objective was to describe the clinical features, causes and treatment of respiratory distress (RD) in full and post term neonates in a tertiary health center in Yaoundé, the Essos Hospital Centre (EHC). Patients and Method: This was a retrospective study. Full/post term neonates with RD from January 2017-December 2018 were included. Main parameters: incidence of RD, etiologies, risk factors for severity and mortality. Results: We included 186 neonates among 2312 newborn babies. The RD prevalence rate was 8%. Sex ratio of 2.15 was favoring male, median gestational age of 38 weeks. Clinical signs of RD were dominated by a Silverman score above 4/10 in 64%. Main etiologies were pneumonia (44%), followed by transient tachypnea (35.4). Perinatal asphyxia (OR = 9.412, P