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China's Economic Boom Brings A PR Explosion

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国际公关 2005年第6期 92-95页

作者： carole Gorney APR.Fellow PRSA is director or the Center for Crisis Public Relations and Litigation Studies at Lehigh University in Bethlehem

Formulation, stability testing, and analytical characterization of melatonin-based preparation for clinical trial

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Journal of Pharmaceutical Analysis 2017年第4期7卷 237-243页

作者： Samira Filali Charlotte Bergamelli Mamadou Lamine Tall Damien Salmon Diane Laleye carole Dhelens Elhadji Diouf Christine Pivot Fabrice Pirot Service pharmaceutique Plateforme FRIPHARMGroupement Hospitalier Edouard Herriot5 Place d′ArsonvalF-69437 Lyon Cedex 03France Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle Plateforme FRIPHARMFaculté de PharmacieLaboratoire de Biologie Tissulaire et Ingénierie Thérapeutique – UMR 5305Université Claude Bernard Lyon 18 Avenue RockefellerF-69373 Lyon Cedex 08France

A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens(0.5 mg, 2 mg, and 6 mg daily) for one month. The objectives of present study were to(i) prepare low-dose melatonin hard capsules for pediatric use controlled by two complementary methods and(ii) carry out a stability study in order to determine a use-bydate. Validation of preparation process was claimed as ascertained by mass uniformity of hard *** analysis by attenuated total reflectance Fourier transformed infrared(ATR-FTIR) of melatonin/microcrystalline cellulose mixture allowed to identify and quantify relative content of active pharmaceutical ingredients and excipients. Absolute melatonin content analysis by high performance liquid chromatography in 0.5 mg and 6 mg melatonin capsules was 93.6% ± 4.1% and 98.7% ± 6.9% of theoretical value, respectively. Forced degradation study showed a good separation of melatonin and its degradation products. The capability of the method was 15, confirming a risk of false negative < 0.01%. Stability test and dissolution test were compliant over 18 months of storage with European Pharmacopoeia. Preparation of melatonin hard capsules was completed manually and melatonin in hard capsules was stable for 18 months, in spite of low doses of active ingredient. ATR-FTIR offers a real alternative to HPLC for quality control of highdose melatonin hard capsules before the release of clinical batches.

关键词： Melatonin Stability-indicating method High-performance liquid chromatography Multicomponent infrared analysis Clinical trial Autism

Development of a Proof-of-Concept Multi-Method Computer Simulation to Support Rural Healthcare Disaster Preparedness Planning

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International Journal of Disaster Risk Science 2024年第3期15卷 346-358页

作者： Thomas A.Berg Kristina W.Kintziger Julie Suzuki Crumly Scott A.Lawson carole R.Myers Tracey T.Stansberry College of Nursing University of Tennessee KnoxvilleKnoxvilleTN37996USA Department of Environmental Agriculturaland Occupational HealthUniversity of Nebraska Medical CenterOmahaNE68198USA Public Health and Healthcare Oak Ridge Associated UniversitiesOak RidgeTN37831USA

Due to a lack of resources,rural communities often face challenges when planning catastrophic *** project involved applying systems thinking and model-based systems engineering to develop a proof-of-concept,multi-method computer simulation and then determining whether the simulation could be used to assess the efficacy of disaster planning approaches on health outcomes in rural communities,as a function of primary *** project focus was a rural or non-urban healthcare system experiencing a natural *** system dynamics and discrete event models were incorporated to represent subsystem operations,crucial disaster responses,as well as three key response systems:public health,emergency management,and *** subsystem models included several components:policies/procedures,communications,resources,exercises/drills/training,healthcare space and staff,and the flow of affected people into and through the *** combined simulation can serve as a first step to a more comprehensive approach to helping rural communities achieve more efficient and effective healthcare planning for disaster responses.

关键词： Computer simulation Disaster preparedness Model-based systems engineering Rural healthcare System dynamics model Systems thinking

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Andy Warhol

Cell-specific pathways recruited for symbiotic nodulation in the Medicago truncatula legume

作者： Klaus Honnef translation carole Fahy and I. Burns.

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Molecular Plant 2023年第2期16卷 481-483页

作者： Sergio Alan Cervantes-Perez Sandra Thibivilliers carole Laffont Andrew D.Farmer Florian Frugier Marc Libault 不详

In the originally published version of this work,a mistake appeared in Figure 1A wherein the red circles,meant to highlight differing areas of the two side-by-side UMAPs,were misaligned in the *** corrected Figure 1,in which the red circles indicate areas of differing density within cluster#2,now appears both in the online article and *** authors apologize for the confusion.

关键词： Figure circles mistake

Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells

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维普期刊数据库

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World Journal of Gastroenterology 2014年第15期20卷 4189-4196页

作者： Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot Department of Digestive Surgery Limoges University Hospital87042 LimogesFrance Homéostasie Cellulaire at Pathologies Faculty of MedicineUniversity of Limoges87025 LimogesFrance Institut 145 GEIST UMR CNRS 7276Faculty of MedicineUniversity of Limoges87025 LimogesFrance

Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human *** major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative *** properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers *** treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant ***,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like *** cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor *** stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor ***-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC ***,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show *** article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their *** personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy.

关键词： Colon cancer Stem cell Cancer stem-like cell Tumor-initiating cell Microenvironment

The Specimen Data Refinery:A Canonical Workflow Framework and FAIR Digital Object Approach to Speeding up Digital Mobilisation of Natural History Collections

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Data Intelligence 2022年第2期4卷 320-341页

作者： Alex Hardisty Paul Brack carole Goble Laurence Livermore Ben Scott Quentin Groom Stuart Owen Stian Soiland-Reyes School of Computer Science and Informatics Cardiff UniversityCardiff CF243AAUK The Department of Computer Science The University of ManchesterManchester M139PLUK The Natural History Museum London SW75BDUK Meise Botanic Garden 1860 MeiseBelgium Informatics Institute Faculty of ScienceUniversity of Amsterdam1090 GH AmsterdamThe Netherlands

A key limiting factor in organising and using information from physical specimens curated in natural science collections is making that information computable,with institutional digitization tending to focus more on imaging the specimens themselves than on efficiently capturing computable data about *** data are traditionally manually transcribed today with high cost and low throughput,rendering such a task constrained for many collection-holding institutions at current funding *** show how computer vision,optical character recognition,handwriting recognition,named entity recognition and language translation technologies can be implemented into canonical workflow component libraries with findable,accessible,interoperable,and reusable(FAIR)*** libraries are being developed in a cloudbased workflow plaform-the Specimen Data Refinery'(SDR)-founded on Galaxy workflow engine,Common Workflow Language,Research Object Crates(RO-Crate)and WorkflowHub *** SDR can be applied to specimens'labels and other artefacts,offering the prospect of greatly accelerated and more accurate data capture in computable *** kinds of FAIR Digital Objects(FDO)are created by packaging outputs of SDR workflows and workflow components as digital objects with metadata,a persistent identifier,and a specific type *** first kind of FDO are computable Digital Specimen(DS)objects that can be consumed/produced by workflows,and other applications.A single DS is the input data structure submitted to a workflow that is modified by each workflow component in turn to produce a refined DS at the *** Specimen Data Refinery provides a library of such components that can be used individually,or in *** cofunction,each library component describes the fields it requires from the DS and the fields it will in turn populate or *** second kind of FDO,RO-Crates gather and archive the diverse set of digital and real-world resources,configurations,a

关键词： Digital Specimen Workflow FAIR Digital Object RO-Crate

Advances in Research on the Relationship between Diet, Gut Microbes, and Health

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Journal of Clinical and Nursing Research 2024年第8期8卷 213-217页

作者： carole Hai Zhu University of Colorado Boulder BoulderColorado 80309United States

In recent years,as research on gut microbiota has deepened,the relationship between diet,gut microbiota,and health has garnered widespread *** the largest micro-ecosystem in the human body,gut microbiota not only participates in physiological processes such as food digestion and nutrient absorption but also exerts a profound impact on human health through its metabolic products and interactions with the *** paper reviews the impact of diet on gut microbiota,and the relationship between gut microbiota and health,aiming to provide new strategies and ideas for promoting human ***,the article summarizes the effects of different dietary components and dietary patterns on the structure and function of gut ***,it analyzes the role of gut microbiota in maintaining human health and preventing diseases and further explores the relationship between gut microbiota and intestinal diseases and metabolic *** analysis reveals that diet affects human health by influencing the structure and function of gut microbiota,while gut microbiota,as a complex ecosystem within the human body,plays an indispensable role in maintaining human health.

关键词： Diet Gut microbiota Health Microbial community structure Function Disease

Traffic Calming in Quebec： Speed Humps and Speed Cushions

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Journal of Civil Engineering and Architecture 2013年第4期7卷 456-465页

作者： Catherine Berthod carole Leclerc Ministere des Transports du Quebec Quebec G1R 5H1 Canada

Speed management is an essential tool in ensuring the improved safety of users of urban roads, particularly vulnerable users. It relies on several measures： awareness campaigns, speed control, as well as the development and operation of the road infrastructure. Municipalities in Quebec are increasingly resorting to the development of traffic calming measures, and are facing numerous questions concerning their installation and their effectiveness. To respond to this need, the ministere des Transports du Quebec （Quebec Department of Transport） has begun publishing a series of fact sheets on a variety of traffic calming measures, including speed humps and speed cushions, raised crosswalks and intersections, neckdowns, centre islands and chicanes. A general fact sheet introduces all of the measures and notably outlines the procedure for pre-implementation analysis. Each fact sheet dedicated to an individual measure outlines the implementation context, advantages and disadvantages, geometric characteristics, effectiveness at reducing speed, and maintenance requirements, including winter maintenance. Two fact sheets are already published： the general fact sheet and the fact sheet on speed humps and speed cushions. The fact sheets as well as examples of measures implemented in municipalities are available on the minist6re＇s web site under Partenaires-Municipalites-Securite routiere.

关键词： Traffic calming speed management road safety urban streets speed humps.