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Vulvar Swelling in a 12-Year-Old Girl: An Early Manifestation of Crohn’s Disease

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Case Reports in Clinical Medicine 2024年第7期13卷 219-226页

作者： Stefania Rendina Dolores Ferrara Rosanna Mamone Sara Isoldi Massimo Zeccolini Francesco esposito Department of Radiology Universit degli studi di Napoli Luigi Vanvitelli Naples Italy Department of Radiology A.O.R.N. Santobono-Pausilipon Children Hospital Naples Italy Pediatric Gastroenterology and Hepatology Unit Santobono-Pausilipon Childrens Hospital Naples Italy

Vulvar Crohn’s disease (VCD) is a rare complication of Crohn’s disease, especially in pediatric population. An early diagnosis can result difficult if the complication does not present in conjunction with the classic gastrointestinal symptoms that characterize this disease. In this study we present the case of a 12-year-old girl whose initial symptom of Crohn’s disease was a symptomatic vulvar swelling promoted by a rectovaginal fistula. We also provide an overview of Crohn’s disease and the vulvar changes found in the course of this disease.

关键词： Recto-Vaginal Fistula Vulvar Swelling Metastatic Crohn’s Disease

Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis

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World Journal of Virology 2024年第4期13卷 120-134页

作者： Mutali Musa Babatunde Ismail Bale Ayuba Suleman Gladness Aluyi-Osa Ekele Chukwuyem FabianaD’esposito Caterina Gagliano Antonio Longo Andrea Russo Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser Centre LtdBenin 300105Nigeria Department of Ophthalmology Centre for Sight Africa LtdNkpor 434212Nigeria Imperial College Ophthalmic Research Group Unit Imperial CollegeLondon NW15QHUnited Kingdom GENOFTA srl Via A.Balsamo93Naples 80065Italy Department of Medicine and Surgery University of Enna"Kore"Catania 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Ophthalmology University Hospital of CataniaCatania 95123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

BACKGROUND Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology,including viral *** can be acute or chronic,selflimiting,or needing medical *** To review possible viral agents crucial for accurate differential diagnosis in cases of *** The PubMed database was searched for records relating to viral *** search string generated was“("virally"[All Fields]OR"virals"[All Fields]OR"virology"[MeSH Terms]OR"virology"[All Fields]OR"viral"[All Fields])AND"Blepharoconjunctivitis"[All Fields]".RESULTS A total of 24 publications were generated from the search *** lists from each relevant article were also searched for more information and included in this *** etiologies such as adenovirus,herpes simplex virus(HSV),varicella-zoster virus(VZV),and Epstein-Barr virus(EBV)are frequently *** infections manifest with follicular conjunctivitis and preauricular lymphadenopathy,often presenting as epidemic *** and VZV infections can result in herpetic keratitis and may exhibit characteristic dendritic corneal ***,although less common,can cause unilateral or bilateral follicular conjunctivitis,particularly in immunocompromised *** potential viral agents,such as enteroviruses and molluscum contagiosum virus,should also be considered,especially in pediatric *** Prompt recognition of these viral etiologies is essential for appropriate management and prevention of ***,a thorough understanding of the clinical presentation,epidemiology,and diagnostic modalities is crucial for accurate identification and management of viral blepharoconjunctivitis.

关键词： Viral Blepharoconjunctivitis Herpes simplex virus Varicella-Zoster Epstein-Barr

Pseudo-orthogonality for graph 1-Laplacian eigenvectors and applications to higher Cheeger constants and data clustering

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Frontiers of Mathematics in China 2022年第4期17卷 591-623页

作者： Antonio Corbo esposito Gianpaolo PISCITELLI Dipartimento di Ingegneria Elettrica e dell’Informazione“M.Scarano” Universitàdegli Studi di Cassino e del Lazio MeridionaleVia G.Di Biasio n.4303043Cassino(FR)Italy

The data clustering problem consists in dividing a data set into prescribed groups of homogeneous *** is an NP-hard problem that can be relaxed in the spectral graph theory,where the optimal cuts of a graph are related to the eigenvalues of graph *** this paper,we first give new notations to describe the paths,among critical eigenvectors of the graph 1-Laplacian,realizing sets with prescribed *** introduce the pseudo-orthogonality to characterize m_(3)(G),a special eigenvalue for the graph ***,we use it to give an upper bound for the third graph Cheeger constant h_(3)(G),that is,h_(3)(G)≤m_(3)(G).This is a first step for proving that the k-th Cheeger constant is the minimum of the 1-Laplacian Raylegh quotient among vectors that are pseudo-orthogonal to the vectors realizing the previous k−1 Cheeger ***,we apply these results to give a method and a numerical algorithm to compute m3(G),based on a generalized inverse power method.

关键词： Graph 1-Laplacian graph Cheeger constants pseudo-orthogonality critical values data clustering

Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson’s disease

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Neural Regeneration Research 2020年第6期15卷 1037-1038页

作者： Luisa Seguella Giovanni Sarnelli Giuseppe esposito Department of Physiology and Pharmacology“V.Erspamer”-Sapienza University RomeItaly(Seguella LEsposito G)Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly(Sarnelli G)

Early diagnosis of Parkinson’s disease(PD):how we can improve the therapeutic approach:PD is a neurodegenerative disease characterized by motor dysfunctions(tremor,rigidity,bradykinesia and impaired posture/balance)elicited by selective depletion of dopaminergic(DA)neurons in substantia nigra pars *** neuron loss is associated with neuronal inclusions of the phosphorylatedα-synuclein protein called Lewy body(Shults,2006).Although the underlying neurodegenerative process is not affected,the management of PD patients has been revolutionized with the introduction of levodopa and DA drugs in the routine therapy,which ensures initial symptomatic relief of motor functions through the DA supply in the nigrostriatal *** drugs are currently the best option for treating PD,although their chronic use is associated with progressive dopamine resistance and loss of effectiveness in the recovery of motor *** therapeutic strategies,including agonists of DA receptors,monoamine oxide B inhibitors,and even deep brain stimulation techniques have been developed to overcome these clinical ***,these therapeutic approaches cannot restore PD-compromised functions,as irreversible DA neurodegeneration has occurred in substantia nigra pars compacta when first motor symptoms *** nigrostriatal system is traditionally considered as the first region affected by neuronal impairment in Parkinsonisms;however,α-synuclein aggregation appears in a pre-motor stage of the disease in the enteric nervous system(ENS).

关键词： impaired routine overcome

Experience with intraoperative radiotherapy for breast cancer: the Geneva University Hospital's experience

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Chinese Journal of Cancer Research 2016年第4期28卷 463-466页

作者： Emanuela esposito Michael Douek Division of Cancer Studies King's College London Department of Breast Surgery Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"–IRCCS

Background Breast conserving surgery along with adjuvant radiotherapy is effective in terms of local control and survival for early- stage breast cancer （1）. External beam radiotherapy （EBRT） following breast conserving surgery has been shown to improve survival by preventing local recurrence, in the Early Breast Cancer Trialists＇ Collaborative Group meta-analysis （2）. Standard radiotherapy typically requires numerous fractions over a 3-5 week period and is performed weeks or months after surgery or chemotherapy.

关键词： IORT Experience with intraoperative radiotherapy for breast cancer the Geneva University Hospital’s experience

Essential infantile esotropia with inferior oblique hyperfunction：long term follow-up of 6 muscles approach

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1802-1807页

作者： Adriano Magli Roberta Carelli Elisabetta Chiariello Vecchio Francesca esposito Luca Rombetto Paolo esposito Veneruso Department of Pediatric Ophthalmology University of Salerno Baronissi (SA) 84081 Italy GI. MA Eye Center Naples 80122 Italy Department of Ophthalmology University Federico IINaples 80131 Italy

AIM： To evaluate long term follow-up （10y） of 6 muscle surgical approach in essential infantile esotropia （EIE）.METHODS： A 6 muscle approach to EIE was retrospectively evaluated in patients with inferior oblique （IO） hyperfunction and lateral rectus （LR） pseudoparalysis, who underwent surgery at different ages. Different clinical characters were analyzed pre- and postoperatively, in patients who underwent a 6 muscles approach ≤4 years of age. All patients underwent a multiple muscles approach： bilateral medial recti （MR） recession （4-5 mm）, bilateral LR resection （lower than 7 mm） and bilateral IO recession and anteroposition. Of 108 children with preoperative angle ≥＋30 prism diopters （PD） and IO hyperfunction were selected from larger cohort of patients （n=213, 103 females and 110 males） after excluding patients with： angle variability, who underwent reoperation and with incomplete follow up. Preoperative assessment and complete orthoptic examination were performed. Follow-up was performed 3mo, 2, 5 and 10y after surgery. Statistical analysis was performes using SAS statistical software package （version 9.1, SAS Institute Inc., Cary, NC, USA）.RESULTS： Ten years follow up data analysis showed the following percentage of orthotropic patients：（0 PD）： 3mo, 22.2%; 2y, 16.7%; 5y, 25.0% and 10y, 27.8%. A slight, significant （P〈0.01）, increase of 2y follow up residual deviation was found when compared to 3mo one. Stationary surgical results is reported during time, with a trend of mean residual deviation reduction （P=0.04）.CONCLUSION： Our results confirm the reliability of multiple muscles surgical approach in the treatment of patients affected by EIE with OI hyperfunction.

关键词： essential infantile esotropia surgical treatment follow-up

Testicular parenchymal abnormalities in Klinefelter syndrome： a question of cancer？ Examination of 40 consecutive patients

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Asian Journal of Andrology 2015年第1期17卷 154-158,I0012页

作者： Giacomo Accardo Gianfranco Vallone Daniela esposito Filomena Barbato Andrea Renzullo Giovanni Conzo Giovanni Docimo Katherine esposito Daniela Pasquali Department of Cardiothoracic and Respiratory Sciences Endocrine Unit Department of Biomorphological and Functional Sciences Second University of Naples Naples Italy Department of Clinical and Experimental Medicine Second University of Naples Naples Italy.

Klinefelter syndrome （KS） is a hypergonadotropic hypogonadism characterized by a 47, XXY karyotype. The risk of testicular cancer in KS is of interest in relation to theories about testicular cancer etiology generally; nevertheless it seems to be low. We evaluated the need for imaging and serum tumor markers for testicular cancer screening in KS. Participants were 40 consecutive KSpatients, enrolled from December 2009 to January 2013. Lactate dehydrogenase （LDH）, alpha-fetoprotein （AFP）, and beta-human chorionic gonadotrophin subunit （^-HCG） serum levels assays and testicular ultrasound （US） with color Doppler, were carried out at study entry, after 6 months and every year for 3 years. Abdominal magnetic resonance （MR） was performed in KS when testicular US showed micro-calcifications, testicular nodules and cysts. Nearly 62% of the KS had regular testicular echotexture, 37.5% showed an irregular echotexture and 17.5% had micro-calcifications and cysts. Eighty seven percent of KS had a regular vascular pattern, 12.5% varicocele, 12.5% nodules 〈1 cm, but none had nodules 〉1 cm. MR ruled out the diagnosis of cancer in all KS with testicular micro calcifications, nodules and cysts. No significant variations in LDH, AFP, and ^-HCG levels and in US pattern have been detected during follow-up. We compared serum tumor markers and US pattern between KS with and without cryptorchidism and no statistical differences were found. We did not find testicular cancer in KS, and testicular US, tumor markers and MR were, in selected cases, useful tools for correctly discriminating benign from malignant lesions.

关键词： abdomen magnetic resonance alpha-fetoprotein beta-human chorionic gonadotrohin subunit klinefelter syndrome lactate dehydrogenase testicular ultrasound

Vulvar Swelling in a 12-Year-Old Girl: An Early Manifestation of Crohn’s Disease

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Prevention of vertical transmission of hepatitis B virus infection

Case Reports in Clinical Medicine（临床医学病理报告） 2024年第7期 219页

作者： Stefania Rendina Dolores Ferrara Rosanna Mamone Sara Isoldi Massimo Zeccolini Francesco esposito

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World Journal of Gastroenterology 2021年第26期27卷 4182-4193页

作者： Piero Veronese Icilio Dodi Susanna esposito Giuseppe Indolfi Department of Medicine and Surgery University of ParmaParma 43121Italy Department of Pediatrics Pietro Barilla Children's HospitalParma 43121Italy Department Neurofarba University of FlorenceFlorence 50129Italy Department Neurofarba Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B virus(HBV)is the leading cause of chronic viral ***,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early *** transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative *** viraemia is a preeminent risk factor for vertical transmission of *** screening is the first step to prevent vertical transmission of *** B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV *** are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest.

关键词： Hepatitis B Vertical transmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunoprophylaxis Tenofovir alafenamide fumarate