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Successful treatment of psychosis induced by interferon alpha and ribavirin with paliperidone:first case reported

General Psychiatry 2019年第4期32卷 214-217页

作者： carmen maura carrillo de albornoz calahorro Maria Isabel Navarrete Paez Margarita Guerrero Jimenez Luis Gutierrez Rojas Psychiatry Hospital Universitario Virgen de las NievesGranadaSpain Hospital Universitario San Cecilio University of GranadaGranadaSpain

Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anxiety, psychosis and delirium, associated with other non-specific symptoms such as fatigue, irritability, psychomotor retardation, decreased libido, insomnia, difficulty in concentration and attention. Having a history of mental disorder contraindicates the use of IFN-alpha. These adverse effects that affect the mental state appear usually at the beginning of the treatment (most after 3 weeks of treatment). The incidence of psychotic episodes is low and the episodes usually remit when treatment is interrupted;only some cases require antipsychotic treatment. We present the case of a patient affected with hepatitis C who began to present self-referential delirious symptoms after receiving the treatment with IFN and who was successfully treated with paliperidone. This patient could be classified within the group of high-risk psychiatric patients given the family history of schizophrenia and his personal history of illegal drug consumption. The pharmacological actions of paliperidone are similar to other high potency atypical antipsychotics.丁he receptorbinding profile of paliperidone most closely resembles that of risperidone and ziprasidone. Paliperidone differs from risperidone and most other antipsychotics by its relatively low extent of enzymatic hepatic metabolism. To the best of our knowledge, this is the first case described that was successfully treated with paliperidone.

关键词： psychosis interferon alpha ribavirin

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Psychosis and Dandy-Walker syndrome:a case report and review of the literature

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General Psychiatry 2021年第2期34卷 111-115页

作者： Alejandro Porras Segovia Margarita Guerrero-Jiménez carmen maura carrillo de albornoz calahorro Luis Gutierrez-Rojas department of Psychiatry Hospital Universitario Fundación Jiménez DíazMadridMadridSpain department of Psychiatry Hospital Universitario Virgen de las NievesGranadaAndalucíaSpain department of Psychiatry University of GranadaGranadaAndalucíaSpain

Dandy-Walker syndrome(DWS)is a group of brain malformations which sometimes present with psychotic *** present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis.A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions,auditory hallucinations and violent *** MRI performed showed the typical alterations of Dandy-Walker variant:vermian hypoplasia and cystic dilatation of the fourth *** also suffered from mild intellectual *** being treated with olanzapine 10 mg/d for a month,his psychotic symptoms greatly improved and he was *** conclusion,DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal,thalamic and cerebellar *** association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia.

关键词： admitted connecting conclusion

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Wilson disease and psychiatric symptoms: A brief case report

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General Psychiatry 2019年第3期32卷 155-158页

作者： Margarita Guerrero-Jimenez carmen maura carrillo de albornoz calahorro Luis Gutierrez Rojas department of Psychiatry Hospital Universitario Virgen de las Nieves Granada Spain department of Psychiatry University of Granada Granada Spain department of Psychiatry Hospital Universitario San Cecilio Granada Spain

Wilson disease (WD) is an uncommon recessive genetic disorder affecti叩 copper metabolism. Cardiac, neurological, hepatic and renal manifestations are well defined, nevertheless approximately 30% of patients debut with neuropsychiatric symptoms. These psychiatric alterations resulting from the accumulation of this heavy metal in the basal ganglia are some how less specific. We present a short review of psychiatric symptoms of WD and describe a case of a 37-year-old woman diagnosed with WD who presented neuropsychiatric symptoms and had a consequent delay in diagnosis and causal treatment. Patients who develop WD starti叩 with a predominance of neuropsychiatric symptoms tend to manifest hepatic symptoms later, therefore have a longer delay of diagnosis and a poorer outcome than patients with hepatic symptoms. An early diagnosis ofWD can avoid irreversible neurological damage.

关键词： Wilson disease psychiatric symptoms A brief case report

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