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Fibrinogen-thrombin collagen patch reinforcement of highrisk colonic anastomoses in rats

World Journal of Gastrointestinal Surgery 2016年第9期8卷 627-633页

作者： Juan Manuel Suárez-Grau Carlos Bernardos García carmen cepeda franco Cristina Mendez García Salud García Ruiz Fernando Docobo Durantez Salvador Morales-Conde Javier Padillo Ruiz Department of General and Digestive Surgery Riotinto Hospital 21660 Huelva Spain Division of General and Laparoscopic Surgery Clinic Quiron Sagrado Corazón 41013 Seville Spain Institute of Biomedicine of Seville Research center University Hospital Virgen del Rocio 41013 Seville Spain Division of General Surgery Hospital of San Juan de Dios 41930 Bormujos Spain Department of General and Digestive Surgery University Hospital Virgen del Rocio 41013 Seville Spain Department of General surgery Hospital of Jerez 11407 Jerez de la Frontera Cadiz Spain Division of Surgery Clinic Quiron Donostia 20012 Donostia Spain Clinic Quiron Sagrado Corazón 41013 Seville Spain

AIMTo evaluate the effectiveness of human fibrinogen-thrombin collagen patch (TachoSil®) in the reinforcement of high-risk colon *** quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group (24 rats) and treatment group (24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil® (a piece of TachoSil® was applied over this high-risk anastomosis, covering the gap). Leak incidence, overall survival, intra-abdominal adhesions, and histologic healing of anastomoses were analyzed. Survivors were divided into two subgroups and euthanized at 15 and 30 d after intervention in order to analyze the adhesions and histologic *** survival was 71.4% and 57.14% in the TachoSil® group and control group, respectively (P = 0.29); four rats died from other causes and six rats in the treatment group and 10 in the control group experienced colonic leakage (P > 0.05). The intra-abdominal adhesion score was similar in both groups, with no differences between subgroups. We found non-significant differences in the healing process according to the histologic score used in both groups (P = 0.066).CONCLUSIONIn our study, the use of TachoSil® was associated with a non-statistically significant reduction in the rate of leakage in high-risk anastomoses. TachoSil® has been shown to be a safe product because it does not affect the histologic healing process or increase intra-abdominal adhesions.

关键词： Colon Rats Anastomosis Leak TachoSil® Surgery

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Mucosal biomarkers in inflammatory bowel disease:Key pathogenic players or disease predictors?

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World Journal of Gastroenterology 2010年第21期16卷 2616-2625页

作者： franco Scaldaferrii carmen Correale Antonio Gasbarrini Silvio Danese Department of Internal Medicine Catholic University of Rome00168 RomeItaly Division of Gastroenterology IRCCSIstituto Clinico Humanitas20089 RozzanoMilanItaly

Inflammatory bowel diseases(IBDs) are chronic inflammatory disorders of the bowel,including ulcerative colitis and Crohn's disease.A single etiology has not been identified,but rather the pathogenesis of IBD is very complex and involves several major and minor contributors,employing different inflammatory pathways which have different roles in different *** new and powerful medical treatments are available,many are biological drugs or immunosuppressants,which are associated with significant side effects and elevated *** a result,the need for predicting disease course and response to therapy is *** attempts have been made at identifying clinical characteristics,concurrent medical therapy,and serological and genetic markers as predictors of response to biological *** few reports exist on how mucosal/tissue markers are able to predict clinical behavior of the disease or its response to *** aim of this paper therefore is to review the little information available regarding tissue markers as predictors of response to therapy,and reevaluate the role of tissue factors associated with disease severity,which can eventually be ranked as "tissue factor predictors".Five main categories are assessed,including mucosal cytokines and chemokines,adhesion molecules and markers of activation,immune and non-immune cells,and other mucosal *** in the design and specificity of clinical studies are mandatory to be able to classify tissue markers as predictors of disease course and response to specific therapy,obtain the goal of achieving "personalized pathogenesisoriented therapy" in IBD.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course predictors Cytokines Chemokines Intestinal mucosa

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Antioxidant,cytotoxic,and anti-venom activity of Alstonia parvifolia ***

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Asian Pacific Journal of Tropical Biomedicine 2021年第10期11卷 460-468页

作者： Maria carmen S.Tan Mary Stephanie S.Carranza Virgilio C.Linis Raymond S.Malabed Yves Ira A.Reyes Francisco C.franco,Jr. Glenn G.Oyong Chemistry Department De La Salle University2401 Taft AvenueManila 1004Philippines Biology Department De La Salle University2401 Taft AvenueManila 1004Philippines Department of Chemistry Graduate School of ScienceOsaka UniversityOsaka 563-0034Japan Molecular Science Unit Laboratory Center for Natural Sciences and Environmental ResearchDe la Salle University2401 Taft AvenueManila 1004Philippines

Objective:To evaluate antioxidant,cytotoxic,and anti-venom capacity of crude bark extracts of Alstonia parvifolia ***:Gas chromatography-mass spectrometry(GC-MS)and energy dispersive X-ray analyses were accomplished to characterize the chemical constituents of Alstonia *** characterization was evaluated using an inhibitory phospholipase A_(2)(PLA_(2))assay,DPPH,and cytotoxicity *** the constituents listed in the GC-MS analyses,molecular docking was conducted to inspect the binding energies between the chosen compounds and selected PLA_(2) ***:GC-MS analyses showed that the Alstonia parvifolia crude extract consisted predominantly of acetylmarinobufogenin(14.89%),γ-sitosterol(10.44%),3-O-methyl-D-glucose(5.88%),3,5-dimethoxy-4-hydroxyphenylacetic acid(5.30%),(2α,5α)-17-methoxyaspidofractinin-3-one(AFM)(4.08%),and 2,3,5,6,7,8,9-heptahydro-1-phenyl-5-(p-chlorophenylimino)-1H-benzo[e][1,4]thiazepine(HPT)(1.37%).The principal elemental components of Alstonia parvifolia were Ca(4.012%)and K(1.496%),as exhibited by energy dispersive X-ray *** parvifolia showed significant free radical scavenging ability(IC_(50):0.287 mg/mL)and was non-cytotoxic to normal HDFn cells(IC_(50)>100μg/mL).Moreover,Alstonia parvifolia was favorably cytotoxic to MCF-7(IC_(50):4.42µg/mL),followed by H69PR,HT-29,and THP-1,with IC_(50) values of 4.94,5.07,and 6.27µg/mL,*** parvifolia also displayed notable inhibition against PLA_(2) activity of Naja philippinensis Taylor venom with IC_(50) of(15.2±1.8)μg/*** and cluster analyses projected negative binding energies from AFM(−6.36 to−9.68 kcal/mol),HPT(−7.38 to−9.77 kcal/mol),and acetylmarinobufogenin(−7.22 to−9.59 kcal/mol).These calculations were for the particular interactions of Alstonia parvifolia constituents to PLA_(2) homologues where the utmost affinity was detected in HPT owing to the dipole interactions with amino acid ***:The bark e

关键词： Alstonia parvifolia Merr. Naja philippinensis Taylor Gas chromatography-electron ionization-mass spectrometry Secretory phospholipase A_(2) Cytotoxicity assay Anti-venom

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Optimization of Zeaxanthin Production by Immobilized <i>Flavobacterium</i>sp. Cells in Fluidized Bed Bioreactor

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Advances in Microbiology 2012年第4期2卷 598-604页

作者： Ma Del carmen Chavez-Parga Alejandro Munguia-franco Mayanin Aguilar-Torres Eleazar M. Escamilla-Silva Division de Estudios de Posgrado Facultad de Ingeniería Química Universidad Michoacana de San Nicolas de Hidalgo Morelia Mexico Laboratorio de Biotecnologia y Bioingenieria Departamento de Ingenieria Quimica Instituto Tecnologico de Celaya Celaya Mexico

From time immemorial, human beings have used pigments made from vegetables, fruits, superior plants, animal tissues and cereals. One of the greatest sources of pigments is the bacterium that, with the use of the modern technology, has increased the production of metabolites of interest. The microbiological production of carotenoids has not been optimized to obtain pigment production quantities of pigments and carotenoids recovery that lower production costs. The aim of this work was to design a Zeaxanthin production process with Flavobacterium sp. immobilized cells in a fluidized bed bioreactor. An optimum culture medium for Zeaxanthin production in stirred flasks (2.46 g·L–1) was obtained. Furthermore, optimum process conditions for a maximum yield of Zeaxanthin production, by fluidized bed bioreactor, were established. A statistical analysis showed that the most significant factors were air flow, pH and NaCl concentration (4.5 g·L–1). In this study a maximum Zeaxanthin production of 3.8 g·L–1 was reached. The highest reported yield to date was 0.329 g·L–1.

关键词： Fluidized Bed Bioreactor Orthogonal Design Flavobacterium sp. Zeaxanthin

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Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO

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Cellular & Molecular Immunology 2010年第6期7卷 459-470页

作者： Antonella de Luca Silvia Bozza Teresa Zelante Silvia Zagarella carmen D’Angelo Katia Perruccio Carmine Vacca Agostinho Carvalho Cristina Cunha franco Aversa Luigina Romani Department of Experimental Medicine and Biochemical Sciences University of PerugiaPerugiaItaly Life and Health Sciences Research Institute(ICVS) School of Health SciencesUniversity of MinhoBragaPortugal

Innate responses combine with adaptive immunity to generate the most effective form of anti-Aspergillus immune *** the pivotal role of dendritic cells in determining the balance between immunopathology and protective immunity to the fungus is well established,we determined that epithelial cells(ECs)also contributes to this ***,EC-mediated protection occurred through a Toll-like receptor 3/Toll/IL-1 receptor domain-containing adaptor-inducing interferon(TLR3/TRIF)-dependent pathway converging on indoleamine 2,3-dioxygenase(IDO)via non-canonical nuclear factor-kB *** with the high susceptibility of TRIF-deficient mice to pulmonary aspergillosis,bone marrow chimeric mice with TRIF unresponsive ECs exhibited higher fungal burdens and inflammatory pathology than control mice,underexpressed the IDO-dependent T helper 1/regulatory T cell(Th1/Treg)pathway and overexpressed the Th17 pathway with massive neutrophilic inflammation in the *** studies with interferon(IFN)-c,IDO or IL-17R unresponsive cells confirmed the dependency of immune tolerance to the fungus on the IFN-c/IDO/Treg pathway and of immune resistance on the MyD88 pathway controlling the fungal ***,distinct immune pathways contribute to resistance and tolerance to the fungus,to which the hematopoietic/non-hematopoietic compartments contribute through distinct,yet complementary,roles.

关键词： aspergillosis epithelial cells IDO Th17/Treg transplantation tolerance

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Valorization of Kraft Lignin as Thickener in Castor Oil for Lubricant Applications

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Journal of Renewable Materials 2018年第4期6卷 347-361页

作者： A.M.Borrero-Lopez F.J.Santiago-Medina C.Valencia M.E.Eugenio R.Martin-Sampedro J.M.franco Department of Chemical Engineering University of HuelvaEl Carmen CampusAgrifood Campus of International Excellence(ceiA3)21071 HuelvaSpain Pro2TecS-Chemical Process and Product Technology Research Center University of Huelva21071 HuelvaSpain INIA-CIFOR Ctra de la Coruñakm 7.5.28040MadridSpain

It is known that large amounts of residual lignin are generated in the pulp and paper industry.A new alternative for Kraft lignin valorization,which consists of first a chemical modification using a diisocyanate and then the efficient dispersion in castor oil to achieve stable gel-like systems,is proposed in this *** properties and microstructure of these materials were determined by means of small amplitude oscillatory shear tests and viscous flow measurements and atomic force microscopy observations,***,both standardized penetration tests and tribological assays,usually performed in the lubricant industry,were carried out to evaluate the performance characteristics as lubricating *** viscoelasticity functions are affected by the lignin/diisocyanate ratio and thickener *** thermorheological response evidenced a softening temperature of around 105°*** microstructure of these gel-like dispersions is composed of interconnected thin fibers,homogeneously distributed in castor ***,the NCO-functionalized lignin gel-like dispersions studied show lower friction coefficients than traditional lubricating greases.

关键词： Kraft lignin diisocyanate gel-like dispersion rheology thermal properties

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How Do People Understand Urban Air Pollution? Exploring Citizens’ Perception on Air Quality, Its Causes and Impacts in Colombian Cities

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Open Journal of Air Pollution 2017年第1期6卷 1-17页

作者： Omar Ramírez Ivan Mura Juan Felipe franco Environmental Engineering Program Group of Applied Environmental Studies—GEAA Universidad Nacional Abierta y a Distancia—UNAD Bogotá Colombia Associate Unit CSIC-University of Huelva “Atmospheric Pollution” Centre of Research in Sustainable Chemistry—CIQSO Campus de El Carmen s/n Huelva Spain COPA Research Group Department of Industrial Engineering Universidad de los Andes Bogotá Colombia Group of Studies on Urban and Regional Sustainability (SUR) School of Engineering Universidad de los Andes Bogotá Colombia

Similarly to other Latin American countries, urban air quality is a major concern in Colombia. The purpose of the present study was to explore citizens’ perception on local air pollution, its causes and impacts. A questionnaire was individually applied to a sample of 994 participants. Relationships between demographic features and the perception on air quality were analyzed using a logistic regression, its odds ratio (OR), and a Chi-square test. Eighty percent of the respondents perceive their local air quality as either bad or fair, 65% recognize particulate matter as the main local air pollutant, and 90% recognize negative impacts on people’s health as the main consequence of air pollution. In contrast to other studies where age and economic status are variables highly related with public perception on the level of atmospheric pollution, in this study only the size of the cities has a statistically significant relationship with the perception on local air quality regarding the level of pollution(OR ≥ 1, confidence intervals > 1 and p-values < 0.05). While area sources such as mining and infrastructure construction are identified as the main sources of pollutant emissions in small towns (less than 50,000 inhabitants), in big cities, road traffic is identified as the main source contributor to atmospheric pollution. Opposite to data from official reports, and regardless of the size of the city, households are perceived as the place with greatest contribution to personal air pollution exposure. Results show that citizens are aware of the state of air quality and its health impact is a major concern. Such findings suggest people’s opinions can be used as provisional indicators in cities without data, as well as to monitor the results of local air quality management. As a complementary process, or at the same level of importance given to technical-based policy, citizen participation can contribute to a collective construction of urban air pollution control strategies.

关键词： Public Perception Citizen Participation Air Quality Air Pollution Colombia

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Enhancement of fruit byproducts through bioconversion by Hermetia llucens(Diptera:Stratiomyidae)

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Insect Science 2023年第4期30卷 991-1010页

作者： carmen Scieuzo Antonio franco Rosanna Salvia Micaela Triunfo Nicola Francesco Addeo Simone Vozzo Giovanni Piccolo Fulvia Bovera Alberto Ritieni Antonio Di Francia Ambrogio Laginestra Eric Schmitt Patrizia Falabella Department of Sciences University of BasilicataPotenzaItaly Spinoff XFlies s.r.l University of BasilicataPotenzaItaly Department of Veterinary Medicine and Animal Production University of Naples Federico IlNaplesItaly Department of Pharmacy University of Naples Federico llNaplesItaly Departmentof Agriculture University of Naples Federico llPorticiItaly Department of Relations with the Territory TotalEnergies EP Italia S.p.APotenzaItaly Protix B.V. DongenThe Netherlands

Bioconversion is a biological process by which organic materials are converted into products with higher biological and commercial *** its larval stage the black soldier fly Hermetia illucens is extremely voracious and can feed on a wide vari-ety of organic *** study the impact of different fruit byproducts on the insect's growth,final larval biomass,substrate reduction,bioconversion parameters,and larval nu-tritional composition,10000 black soldier fly larvae(BSFL)were reared on 7.0 kg of one of three substrates(strawberry,tangerine,or orange)or on a standard diet as a *** results highlight that BSFL can successfully feed and grow on each of these diets,though their development time,growth rate,and final biomass were differently impacted by the substrates,with strawberry being the most *** lipid and protein contents of BSFL were similar among larvae fed on different substrates;however,major differences were detected in ash,micronutrient,fiber,fatty acid,and amino acid ***,the results indicate that fruit waste management through the BSFL bioconversion process rep-resents a commercially promising resource for regional and national agrifood *** study offers new perspectives for sustainable and environmentally friendly industrial development by which fruit byproducts or waste might be disposed of or unconventionally enhanced to create secondary products of high biological and economic value,including BSFL biomass as animal feed or,in perspective,as alternative protein source for human nutrition.

关键词： bioconversion black soldier fly byproducts circular economy feed

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Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography

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World Journal of Cardiology 2019年第1期11卷 24-36页

作者： Rafael Vidal-Perez Raúl franco-Gutiérrez Alberto J Pérez-Pérez Virginia franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María Testa-Fernández Carlos González-Juanatey Department of Cardiology Hospital Universitario Lucus Augusti Department of Otolaryngology Hospital Carmen y Severo Ochoa Faculty of Medicine University of Santiago de Compostela

BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese *** To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography *** Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular

关键词： Carotid intima media thickness Carotid plaque Carotid disease Myocardial infarction Mortality Stroke Exercise stress echocardiography

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González carmen Gómez-González Rocío González-León carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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