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The relationships between selected soil properties and caesium-137 identify organic carbon,nitrogen and water soluble phenols as indicators of soil erosion processes in different forest stands

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Journal of Forestry Research 2021年第6期32卷 2589-2598页

作者： Federico Romeo Paolo Porto carmelo Mallamaci Adele Muscolo Department of Agriculture Mediterranea UniversityFeo di Vito89122Reggio CalabriaItaly

In the last few decades,the use of environmental radionuclides,particularly caesium-137(^(137)Cs),represented one of the most valid methods for estimating soil ***,the cost associated with the use of the equipment needed for radiometric analyses is still high and,for this reason,finding more easily measurable indicators can be *** is a strong correlation between^(137)Cs,organic carbon(OC),nitrogen(N)and water soluble phenols(WSP)exists,indicating the latter parameters as possible early indicators of soil *** on the above assumptions,the main purpose of this work is to identify specific soil chemical parameters able to indicate early triggering of soil ***,several soil parameters such as pH,electric conductivity(EC),WSP,OC,N and C/N have been evaluated against^(137)Cs and on a comparative *** addition,since the rate of soil erosion depends on the degree of coverage and canopy structure,two different tree species(Pinus nigra laricio *** Fagus sylvatica l.)have been considered in this contribution in which ten different scenarios of forest management have been *** results show that the reduction in tree cover of managed sites triggers erosion and nutrient loss *** has been observed that the loss of^(137)Cs,compared to the control areas,is closely correlated with those of WSP,OC and *** parameters(WSP,OC and N),more easily assessable,can be a valid tool to understand easily,triggering of erosive phenomena.

关键词： ^(137)Cs Erosion indicators Forest thinning Beech forest Pine forest

Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors

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World Journal of Clinical Oncology 2017年第4期8卷 320-328页

作者： carmelo Tibaldi Alice lunghi Editta Baldini Division of Oncology Department of OncologyS. Luca Hospital

The recent discovery of immune checkpoints inhibitors, especially anti-programmed cell death protein 1(PD-1)and anti-programmed cell death protein ligand 1(PD-l1) monoclonal antibodies, has opened new scenarios in the management of non-small cell lung cancer(NSClC) and this new class of drugs has achieved a rapid development in the treatment of this disease. However, considering the costs of these drugs and the fact that only a subset of patients experience long-term disease control, the identification of predictive biomarkers for the selection of candidates suitable for treatment has become a priority. The research focused mainly on the expression of the PD-l1 receptor on both tumor cells and/or immune infiltrates determined by immunohistochemistry(IHC). However, different checkpoint inhibitors were tested, different IHC assays were used, different targets were considered(tumor cells, immune infiltrates or both) and different expression thresholds were employed in clinical trials. In some trials the assay was used prospectively to select the patients, while in other trials it was evaluated retrospectively. Some confusion emerges, which makes it difficult to easily compare the literature data and to translate them in practice management. This mini-review shows the possibilities and pitfalls of the PD-l1 expression to predict the activity and efficacy of anti PD1/PD-l1 monoclonal antibodies in the treatment of NSClC.

关键词： Predictive biomarkers Immunotherapy Checkpoint inhibitors Programmed cell death protein ligand 1 Non-small cell lung cancer

Effects of l-carnitine in patients with hepatic encephalopathy

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World Journal of Gastroenterology 2005年第45期11卷 7197-7202页

作者： Mariano Malaguarnera Giovanni Pistone Rampello Elvira carmelo leotta linda Scarpello Rampello liborio Department of Senescence Department of Neurosciences

AIM： To evaluate the influence of locarnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy （HE）. METHODS： One hundred and fifty patients （10 patients with alcoholism, 41 patients with hepatitis virus B infection, 78 patients with hepatitis C virus infection, 21 patients with cryptogenetic cirrhosis） meeting the inclusion criteria were randomized into group A receiving a 90-d treatment with l-carnitine （2 g twice a day） or into group B receiving placebo in double blind. RESUlTS： At the end of the study period, a significant decrease in NI-14 fasting serum levels was found in patients with hepatic encephalopathy （P〈0.0S） after the treatment with levocarnitine （lC）. Significant differences were also found between symbol digit modalities test and block design in patients with hepatic encephalopathy （P〈0.0S）. CONClUSION： Results of our study suggest an important protective effect of l-carnitine against ammonia-precipitated encephalopathy in cirrhotic patients.

关键词： Hepatic encephalopathy Carnitine Cirrhosis Ammonia Treatment

Habitat, occurrence and conservation status of the Saharo-Macaronesian and Southern-Mediterranean element Fagonia cretica l. (Zygophyllaceae) in Italy

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Journal of Arid land 2018年第1期10卷 140-151页

作者： giovanni spampinato carmelo m musarella ana cano-ortiz giuseppe signorino department of agriculture mediterranea university of reggio calabriaFeo di Vito89124 Reggio CalabriaItaly department of animal and plant biology and ecology section of botanyuniversity of jaéncampus universitario las lagunillas s/n23071 jaénSpain

Fagonia cretica l. is an important component of Mediterranean dry grasslands and a rare and isolated species of Italian flora. In this study, an assessment is presented on the distribution, habitat, and conservation status of F. cretica in Italy. The results of field investigation and herbarium analysis show that this species grows in a small area within the southern Calabria region characterized by a warmest and driest Mediterranean climate on the Italian peninsula. F. cretica is a semi-desert plant species growing in Italy in only one peripheral and isolated population at the northern limit of its distribution. Plant community analysis, using the phytosociological method, shows that F. cretica grows in wintergreen perennial dry grasslands dominated by lygeum {partum and Hyparrhenia hirta. F. crelica plant communities are located in thermo-xeric habits such as south-, southeast- and east-facing slopes on clays and sandy clays in southern Calabria. The population of F. cretica is fragmented in six neighbouring localities, with two of which belonging to a Site of Community Importance （SC1）. The conservation status of F. cretica population is not very good, and is defined as ＂Critically Endangered＂ in accordance with IUCN criteria. There are many threats affecting the F. crelica population in ltaly, primarily the changes in land uses due to urban expansion and reforestation with exotic plants. The southern end of the Italian peninsula hosts other plants from thermo-xeric habits that do not adapt to the current local climate. This territory can be considered as a microrefugia for plants currently distributed in the arid territory of the southern Mediterranean. These results contribute to the discussion of some conservation measures, and the possibility of establishing a micro-reserve. For all these reasons, we propose to include F. cretica in the lists of protected plant species at regional （Calabria） and country （Italy） scales in Italy.

关键词： biodiversity ecology peripheral isolated populations phytosociology microrefugia southern Italy

In vitro effects of polyphenols on colorectal cancer cells

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World Journal of Gastrointestinal Oncology 2014年第8期6卷 289-300页

作者： Barbara Pampaloni Gaia Palmini carmelo Mavilia Roberto Zonefrati Annalisa Tanini Maria luisa Brand Department of Surgery and Translational Medicine University of Florence Florence 50139 Italy

AIM:To investigate the effects of quercetin and genistein on colon cancer cell proliferation and their estrogen receptorβ(ERβ)***:Colon cancer cells were stably transfected with a mammalian expression vector to overexpress ERβ(HCT8-β8-expressing cells)or a control vector(HCT8-pSV2neo-expressing cells).The proliferation of these cells was examined after treatment with quercetin or genistein(5-100μmol/l),or 10 nmol/l17β-estradiol(17β-E2).Cell viability was examined by acridine orange staining following treatments for 48 or144 *** of quercetin and genistein on ERβtranscriptional transactivation were examined by luciferase activity in HCT8-β8-expressing cells transiently transfected with a pEREtklUC reporter *** addition,the regulation of ERβtranscription by phytoestrogens and 17β-E2 was examined by quantitative polymerase chain ***:Proliferation of HCT8-β8-expressing cells was not reduced low doses(5μmol/l)of quercetin and genistein,while it was reduced at 25-50μmol/l with an effect similar to 10 nmol/l 17β-*** with doses of phytoestrogens≥75μmol/l completely blocked cell growth and reduced overall cell counts,however no effects at any dose were observed in HCT8-pSV2neoexpressing *** results were supported by viability staining that revealed acridine orange-stained lysosomes with high doses or extended treatment *** and quercetin(50μmol/l)significantly increased ER-responsive luciferase activity similar to 10nmol/l 17β-E2(Pl/l),as well as 10 nmol/l 17β-E2significantly increased ERβmRNA levels in HCT8-β8-expressing cells(Plls with 50μmol/l quercetin or 10 nmol/l 17β-E2 significantly increased ERβmRNA levels compared to untreated controls(Plute levels were much lower than in HCT8-β8-expressing ***:The antitumorigenic effects of the phytoestrogenic compounds querc

关键词： Estrogen receptor HCT8-β8 cells HCT8pSV2neo Quercetin Genistein

Corrosion and tribocorrosion behavior of Ti6Al4V/xTiN composites for biomedical applications

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Transactions of Nonferrous Metals Society of China 2022年第2期32卷 540-558页

作者： J.CHÁVEZ O.JIMÉNEZ D.BRAVO-barcenas l.OlMOS F.AlVARADO-HERNÁNDEZ M.A.GONZÁlEZ A.BEDOllA-JACUINDE M.FlORES Departamento de Ingeniería Mecánica Eléctrica CUCEIUniversidad de GuadalajaraBlvd.Marcelino García Barragán#1421GuadalajaraC.P.44430México Departamento de Ingeniería de Proyectos CUCEIUniversidad de GuadalajaraJoséGuadalupe Zuno#48Los BelenesZapopanC.P.45150México Departamento de Ingeniería de Proyectos CUCEIUniversidad de Guadalajara-CONACyTBlvd.Marcelino García Barragán#1421GuadalajaraC.P.44430México Instituto de Investigaciones en Ciencias de la Tierra INICITUniversidad Michoacana de San Nicolás de HidalgoAv.Francisco J.Mujica S/NCiudad UniversitariaMoreliaMichoacánC.P.58030México Unidad Académica de Ingeniería I Universidad Autónoma de ZacatecasAv.López Valverde 801ZacatecasZacatecasC.P.98060México Instituto de Investigaciones Metalúrgicas IIMMUniversidad Michoacana de San Nicolás de HidalgoEdificio‘‘U-5’’Ciudad UniversitariaMoreliaMichoacánC.P.58030México

The corrosion and tribocorrosion behavior of Ti6Al4V/xTiN(x=0,5,10 and 15,vol.%)composites fabricated by solid-state sintering and their relationship with the microstructure and microhardness were *** body conditions such as a temperature of 37℃ and a simulated body fluid were *** main results demonstrated a microstructural change caused by theα-Ti stabilization due to solid-solution of nitrogen(N)into the titanium(Ti)lattice,producing a maximum hardening effect up to 109%for the Ti64 matrix by using 15 vol.%*** potentials of composites changed to more noble values with the TiN particle addition,while corrosion current density of samples increased as an effect of the remaining porosity,decreasing the corrosion resistance of ***,changes to a less passive behavior were observed for samples with 15 vol.%*** non-passive behavior of composites resulted in the reduction of the potential drops during rubbing in tribocorrosion ***,an improvement of up to 88%of the wear rate of composites was seen from the solid-solution *** results allowed to understand the relationship between composition and sintering parameters with the improved tribocorrosion performance of materials.

关键词： Ti64 alloy composites powder metallurgy microstructure corrosion tribocorrosion

litchi-derived platinum groupmetal-free electrocatalysts for oxygen reduction reaction and hydrogen evolution reaction in alkalinemedia

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SusMat 2023年第2期3卷 248-262页

作者： Seyed Ariana Mirshokraee Mohsin Muhyuddin Roberto lorenzi Giorgio Tseberlidis carmelo lo Vecchio Vincenzo Baglio Enrico Berretti Alessandro lavacchi Carlo Santoro Department of Materials Science University of Milano-BicoccaMilanoItaly Istituto di Tecnologie Avanzate per l’Energia“Nicola Giordano”(ITAE) Consiglio Nazionale delle Ricerche(CNR)Via Salita S.MessinaItaly Istituto di Chimica Dei Composti OrganoMetallici(ICCOM) Consiglio Nazionale Delle Ricerche(CNR)Sesto FiorentinoFirenzeItaly

Within the framework of the circular economy,the waste litchi’s skins were upgraded and transformed into electrocatalysts for oxygen reduction reaction(ORR)and hydrogen evolution reaction(HER).The waste litchi’s skins were pyrolyzed,activated,and then used as carbon support for fabricating metal–nitrogen–carbons(M–N–Cs)which belong to a promising class of platinum group metal-free *** activated char was functionalized with transition metal(Fe,Ni,and Co)-phthalocyanine(Pc)in monometallic and bimetallic fashion by subjecting it to a thermal treatment at 600 and 900◦*** samples functionalized at 900℃ showed higher performance for HER due to the formation of metal nanoparticles,whereas the samples functionalized at 600℃ showed higher performance for ***,sample Ni–Co 900 had an overpotential of−0.38 V for HER,while the sample Fe 600 was the most active electrocatalyst for ORR by demonstrating the onset potential of∼0.9 V(a half-wave potential of∼0.81 V)with the least production of unwanted peroxide anion.

关键词： circular economy hydrogen evolution reaction oxygen reduction reaction PGM-free electrocatalyst

The contribution of the European Society for Soil Conservation (ESSC) to scientific knowledge, education and sustainability

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International Soil and Water Conservation Research 2019年第1期7卷 102-107页

作者： carmelo Dazzi Wim Comelis Edoardo A.C.Costantini Mihail Dumitru Michael A.Fullen Donald Gabriels Raimonds Kasparinskis Adam Kertész Giuseppe lo Papa Guenola Pérès Jane Rickson Josél.Rubio Thomas Sholten Sid Theocharopoulos Ivan Vasenev Department of Agricultural Food and Forest SciencesUniversity of PalermoItaly Department of Environment University of GhentBelgium CREA-AA Research Centre for Agriculture and Environment Firenze/FlorenceItaly Institute for Soil Science Agrochemistry&Environment Protection ICPA BucharestRomania Faculty of Science and Engineering The University of WolverhamptonWV1 1LYUK UNESCO Chair on Eremology Faculty of Biosciences EngineeringGhent UniversityBelgium University of latvia Faculty of Geography and Earth SciencesRigaLatvia Geographical Institute Research Centre for Astronomy and Earth SciencesHungarian Academy of SciencesBudapestHungary UMR SAS INRA Agrocampus 65 rue de Saint BrieucRennesFrance Cranfield Soil and AgriFood Institute Cranfield UniversityCranfieldUK IDE-CSIC Ctra Moncada-Naquera km 4.546113 MoncadaValenciaSpain Department of Geosciences Soil Science and GeomorphologyUniversity of TübingenGermany Hao-Demeter Institute of Soil and Water Resources14123 AthensGreece Ecology Department Russian State Agrarian UniversityTimiryazev Agricultural AcademyMoscowRussia

Soil is an integral component of the global environmental system which supports the quality and diversity of terrestrial life on ***,it is vital to consider the processes and impacts of soil degradation on society,especially on the provision of environmental goods and services,including food security and climate change mitigation and *** societies devoted to soil science play significant roles in reducing soil degradation and promoting soil conservation by advancing scientificknowledge,education and environmental *** ESSC was founded on 4 November 1988,with the aims to:*** research on soil degradation,soil protection and soil and water *** a network for the exchange of knowledge about soil degradation processes and soil conservation research and *** publications on major issues relating to soil degradation and soil and water *** regulators and policy-makers on soil issues,especially soil degradation,protection and *** societal challenges that can be addressed through better soil protection,advancing knowledge and scientific approaches to soil protection and sustainable management,mean the ESSC embraces the on-going development,application,review and constructive criticism of highly innovative scientific soil conservation methods,In this context,the ESSC analyses and publicizes the roles and functions of soil in natural and human-modified systems and the functional optimization of soils to ensure sustainable environmental protection.'The thin layer of soil that forms a patchy covering over the continents controls our awn existence and that of every other animal of the land' (Rachel Carson (1962) in'Silent Spring).

关键词： Soil degradation Soil education Soil functions Soil health Soil knowledge

Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第28期14卷 4454-4461页

作者： luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi carmelo Damiano Salpietro Walter Fries Dipartimento di Scienze Pediatriche Mediche e Chirurgiche Università di MessinaMessina 98125Italy Dipartimento di Patologia Umana Università di MessinaMessina 98125Italy Dipartimento di Medicina Interna e Terapia Medica Università di MessinaMessina 98125Italy

AIM： To evaluate the role of genetic factors in the pathogenesis of Crohn＇s disease （CD） and ulcerative colitis （UC）, we investigated the single nucleotide polymorphisms （SNPs） of NOD2/CARD15 （R702W, Gg08R and l1007finsC）, and Toll-like receptor 4 （TlR4） genes （D299G and T399I） in a selected inflammatory bowel disease （IBD） population coming from Southern Italy. METHODS： Allele and genotype frequencies of NOD2/ CARD15 （R702W, Gg08R and l1007finsC） and TlR4 （D299G and T399I） SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESUlTS： NOD2/CARD15 R702W mutation was significantly more frequent in CD （9.8%） than in controls （2.4%, P = 0.001） and in UC （2.3%, P = 0.03）. No significant difference was found between UC patients and control group （P 〉 0.05）. In CD and UC patients, no significant association with G908R variant was found. l1007finsC SNP showed an association with CD （9.8%） compared with controls （2.9%, P = 0.002） and UC patients （2.3%, P = 0.01）. Moreover, in CD patients, G908R and l1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TlR4 SNPs was found in either cohort （allele frequencies： D299G-controls 3.9%, CD 3.7%, UC 3.4%, P 〉 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P 〉 0.05）. CONClUSION： These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TlR4 SNPs, are associated with increased risk of CD.

关键词： Crohn's disease Ulcerative colitis NOD2/ CARD15 gene Toll-like receptor 4 gene Single nucleotide polymorphisms