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What can we learn on rodent fearfulness/anxiety from the genetically heterogeneous NIH-HS rat stock?

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Open Journal of Psychiatry 2013年第2期3卷 238-250页

作者： Sira Diaz-Moran Esther Martinez-Membrives Regina Lopez-Aumatell Toni Canete Gloria Blazquez Marta Palencia carme Mont-Cardona Celio Estanislau Adolf Tobena Alberto Fernandez-Teruel Medical Psychology Unit Department of Psychiatry&Forensic MedicineInstitute of NeurosciencesSchool of MedicineAutonomous University of BarcelonaBarcelonaSpain Welcome Trust Centre for Human Genetics OxfordUK Grupo de Pesquisa em Psicobiologia Departamento de Psicologia Geral e Análise do ComportamentoUniversidade Estadual de LondrinaLondrinaBrazil

The “National Institutes of Health” genetically heterogeneous (NIH-HS) rat stock was created in the 1980s through an eight-way cross of as much as possible separate inbred rat strains (i.e. the MR/N, WN/N, WKY/N, M520/N, F344/N, ACI/N, BN/SsN and BUF/N strains) which were readily available at that time. Hansen and Spuhler [1] developed a more naturalistic, genetically heterogeneous rat stock with the aim of optimizing the distribution of genotypic frequencies and recombination and under the hypothesis that the NIH-HS stock could yield a broad-range distribution of responses (broader than commonly used laboratory rat strains) to experimental conditions, and thus serve as a base population for selection studies. Along the last decade, in a series of studies we have phenotypically characterized the NIH-HS rat stock (a colony exists at our laboratory since 2004) for their anxiety/fearfulness profiles (using a battery of both unconditioned and conditioned tests/tasks), as well as regarding their stress-induced hormonal responses, coping style under inescapable stress and spatial learning ability. We have also compared the phenotypic profiles of NIH-HS rats with those of the low anxious RHA-I and the high anxious RLA-I rat strains. The NIH-HS rat stock is, as a population, a rather anxious type of rat, with predominantly reactive/passive coping style in unlearned and learned anxiety/fear tests, and elevated stress hormone responses (as well as enhanced “depressive” symptoms in the forced swimming test). Genetic studies currently under way have thus far revealed that the genetically heterogeneous NIH-HS rat stock constitutes a unique tool for fine mapping of QTL (for multiple behavioural and biological complex traits) to megabase resolution levels, thus enabling candidate gene identification. We give some examples of this in the present paper, while also highlighting that microarray gene expression studies reveal that HPA-axis- and prolactin-related genes (among others) in

关键词： Anxiety Fearfulness Stress Hormones HPA Axis Responses Forced Swimming Test Genetically Heterogeneous NIH-HS Stock RHA-I/RLA-I Rats

Helplessness-like escape deficits of NIH-HS rats predict passive behavior in the forced swimming test:Relevance for the concurrent validity of rat models of depression

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World Journal of Neuroscience 2013年第2期3卷 83-92页

作者： Marta Palencia Sira Diaz-Moran carme Mont-Cardona Toni Canete Gloria Blazquez Esther Martinez-Membrives Regina Lopez-Aumatell Adolf Tobena Alberto Fernandez-Teruel Medical Psychology Unit Department of Psychiatry&Forensic MedicineInstitute of NeurosciencesSchool of MedicineAutonomous University of BarcelonaBarcelonaSpain Welcome Trust Centre for Human Genetics OxfordUK

The genetically heterogeneous NIH-HS rat stock has been characterized by its response to anxiety- and fear-inducing situations, thus leading to the conclusion that they are a rather anxious and passive coping type of rats. Taking advantage of these profiles, and knowing that they show very poor performance in the two-way active (shuttle box) escape/avoidance task, we have tested NIH-HS rats (n = 80) in the forced swimming test (FST) as well as we have studied escape response deficits (i.e. response failures) of the same animals in the two-way shuttle box task. They were also tested for anxiety in the elevated zero-maze. The goal of such a study was that of investigating whether there are associations or relationships among helplessness-like or passive coping responses between both models of depression, i.e. the FST and the helplessness-like escape deficits in the shuttle box task. The results for the first time show associations among responses from both depression models and that selecting rats for displaying extreme (active or passive) responses in one of the models predict in a coherent manner (according to the hypothesis) their behaviour in the other model. These findings are discussed in the context of the concurrent validity of both models of depression as well as concerning the possible relevance of NIH-HS rats as a tool for future studies on this field.

关键词： Genetically Heterogeneous Rats NIH-HS Stock Forced Swimming Test Helplessness Passive Coping Depression Anxiety

rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study

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World Journal of Gastroenterology 2017年第47期23卷 8405-8414页

作者： Henry Córdova Lidia Argüello carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach Endoscopy Unit.Institut de Malalties Digestives Hospital ClínicIDIBAPSCIBERehdUniversitat de Barcelona Digestive Endoscopy Unit Digestive Diseases DepartmentGastrointestinal Endoscopy Research GroupIISLa Fe Polytechnic University Hospital Hospital Universitari Mútua de Terrassa CIBERehd Hospital Reina Sofía Hospital Del Mar Hospital Universitari de Bellvitge IDIBELLUniversitat de BarcelonaHospitalet de Llobregat Hospital Universitario de Canarias Hospital Santos Reyes Aranda de Duero Hospital San Jorge Consorci Hospitalari de Vic Universitat de Vic Hospital de Viladecans Hospital Morales Meseguer Hospital Moisès Broggi Sant Joan Despí Hospital Joan XXIII Complejo Hospitalario de Pontevedra

AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of *** Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location.

关键词： Polypectomy Bleeding Adverse events Protruded polyps Gastroduodenal Foregut

新型冠状病毒肺炎疫情下大学生学习倦怠和网络成瘾的关系:生涯适应力的中介效应

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中国健康心理学杂志 2021年第5期29卷 695-701页

作者：万恒阳余俊渠颜农秋黄家瀚佛山科学技术学院 528200

目的:考察大学生在新型冠状病毒肺炎疫情下的学习倦怠现状,探讨疫情下大学生学习倦怠、网络成瘾与生涯适应力间的关系。方法:本研究分层抽取1587名大学生,运用大学生学习倦怠量表、中文网络成瘾量表和生涯适应力问卷对样本进行调查,采用... 详细信息

目的:考察大学生在新型冠状病毒肺炎疫情下的学习倦怠现状,探讨疫情下大学生学习倦怠、网络成瘾与生涯适应力间的关系。方法:本研究分层抽取1587名大学生,运用大学生学习倦怠量表、中文网络成瘾量表和生涯适应力问卷对样本进行调查,采用SPSS 20.0和AMOS 24.0统计软件进行关系分析及模型检验。结果:个体在疫情下的学习倦怠性(r=-0.57,P<0.001)、网络成瘾性(r=-0.78,P<0.001)均与生涯适应力存在显著负相关;学习倦怠与网络成瘾存在显著正相关(r=0.61,P<0.001);生涯适应力在学习倦怠与网络成瘾之间起完全中介作用(中介效应占总效应的比例为82.56%)。结论:疫情下大学生个体的生涯适应力能够有效调节学习倦怠对网络成瘾的影响,降低大学生网络过度依赖现象。

关键词：新型冠状病毒肺炎学习倦怠网络成瘾生涯适应力

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关于成人高等教育学生法制教育的思考

继续教育研究 2006年第3期 34-36页

作者：余俊渠李文慧佛山科学技术学院机电与信息工程学院广东佛山528000

成人高等教育学生法制教育是继续教育的重要组成部分,为了提高成人高等教育学生法制教育的有效性,需要在法制教育目标、教育资源整合、教育方法及教育内容等方面进行补充和完善。

关键词：成人高等教育法制教育大学生继续教育教育目标教育资源教育方法教育内容

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ESR测量中的快扫描技术

波谱学杂志 1988年第2期 193-196页

作者：孙君渠陈涛华东化工学院分析测试中心

本文介绍了电子自旋共振快扫描技术的基本原理、仪器结构、技术特点以及在光致ESR测量中的应用。

关键词：快扫描 ESR 测量

东莞市石碣镇小学生牙窝沟封闭项目的封闭率调查及封闭剂保留的影响因素分析

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中国医药科学 2018年第20期8卷 193-196页

作者：胡运苑巫俊躯周碧连广东省东莞市石碣医院口腔科广东东莞523290

目的调查东莞市石碣镇实施小学生牙窝沟封闭项目的封闭率,并探讨封闭剂脱落的影响因素。方法采用随机抽样方法选择2017年东莞市石碣镇参加免费窝沟封闭防龋项目的 14所小学二年级学生2195例为研究对象。对2017年东莞市石碣镇小学生牙窝... 详细信息

目的调查东莞市石碣镇实施小学生牙窝沟封闭项目的封闭率,并探讨封闭剂脱落的影响因素。方法采用随机抽样方法选择2017年东莞市石碣镇参加免费窝沟封闭防龋项目的 14所小学二年级学生2195例为研究对象。对2017年东莞市石碣镇小学生牙窝沟封闭项目情况进行调查分析,在封闭完成后3、6、12个月进行复查窝沟封闭剂的保留情况,并对可能影响封闭剂保留的相关因素进行分析。结果本组研究完成窝沟封闭人数2195例(窝沟封闭牙齿数6347颗),封闭率为55.14%。本组窝沟封闭术后12个月复查发现封闭剂脱落的牙数699颗,脱落率为11.01%。单因素分析,年龄、刷牙次数、封闭人员职称、饮用碳酸饮料频率、乳牙龋补面数、牙位与封闭剂脱落率密切相关(P 0.05)。多因素逐步Logistic回归结果发现年龄(OR=0.817)、刷牙次数(OR=0.307)、乳牙龋补面数(OR=1.722)是影响封闭剂脱落率的独立危险因素,其中年龄和刷牙次数是保护因素。结论临床应重视乳牙萌出,减少乳牙的患龋率,关注年龄小儿童的随访和复查,加强健康教育,引导学龄儿童建立良好的刷牙习惯,降低窝沟封闭剂的脱落率,进而提高窝沟封闭防龋效果。

关键词：窝沟封闭封闭率因素脱落率

微创拔牙技术应用于下颌低位埋伏阻生智齿拔除中的临床效果

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数理医药学杂志 2020年第10期33卷 1485-1486页

作者：吴詹强林汉武巫俊躯东莞市石碣医院口腔科东莞523290

目的:探讨微创拔牙技术用于下颌低位埋伏阻生智齿拔除中的临床效果。方法:择取2018年7月~2020年5月期间某院口腔科收治的下颌低位埋伏阻生智齿患者63例参与研究,根据数字表法随机分为对照组(n=31)和观察组(n=32),对照组行传统凿骨劈冠... 详细信息

目的:探讨微创拔牙技术用于下颌低位埋伏阻生智齿拔除中的临床效果。方法:择取2018年7月~2020年5月期间某院口腔科收治的下颌低位埋伏阻生智齿患者63例参与研究,根据数字表法随机分为对照组(n=31)和观察组(n=32),对照组行传统凿骨劈冠法治疗,观察组行微创拔牙技术治疗,比较两组手术用时、牙齿完整性评分、肿胀评分及术后并发症情况。结果:观察组手术用时短于对照组,牙齿完整性评分、肿胀评分和术后并发症发生率低于对照组(P<0.05)。结论:针对下颌低位埋伏阻生智齿患者行微创拔牙技术治疗可以有效缩短手术时间,降低并发症风险,因此该种治疗方法值得用于临床推广。

关键词：微创拔牙技术下颌低位埋伏阻生智齿凿骨劈冠法并发症

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垂直剖面上玄武岩红土的分形结构

大坝观测与土工测试 2001年第2期25卷 31-33页

作者：黄英符必昌李琴书付君蕖昆明理工大学电力工程学院昆明650051

本文借助分形几何理论 ,探讨垂直剖面上玄武岩红土在加分散剂前后颗粒粒度的分维变化特性。研究结果表明 :不论是否加分散剂 ,红土的颗粒粒度都存在线性分形结构。不加分散剂 ,存在两个无标度区 ,沿剖面从上到下 ,分维值逐渐增大 ;加分... 详细信息

本文借助分形几何理论 ,探讨垂直剖面上玄武岩红土在加分散剂前后颗粒粒度的分维变化特性。研究结果表明 :不论是否加分散剂 ,红土的颗粒粒度都存在线性分形结构。不加分散剂 ,存在两个无标度区 ,沿剖面从上到下 ,分维值逐渐增大 ;加分散剂 ,存在一个无标度区 ,沿剖面从上到下 ,分维值逐渐减小。

关键词：垂直剖面红土颗粒料度分形结构