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Facial nerve monitoring in parotid gland surgery:Design and feasibility assessment of a potential standardized technique

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第4期9卷 280-287页

作者： carlos S.duque Andrés F.Londoño Ana M.duque Jhon J.Zuleta Marcela Marulanda Lina M.Otálvaro Miguel Agudelo Juan P.Dueñas María F.Palacio Gianlorenzo Dionigi Hospital Pablo Tobón Uribe Departmento deCancerologíaMedellinColombia Clínica de Otorrinolaringología de Antioquia“Orlant” MedellínColombia Sección Otorrinolaringología Departamentode CirugíaFacultad de MedicinaUniversidadde AntioquiaMedellínColombia Hospital Pablo Tobón Uribe DirecciónCientíficaMedellinColombia Sección Cirugia de Cabeza y Cuello Departamento de CirugíaFacultad deMedicinaUniversidad de AntioquiaMedellinColombia Department of Internal Medicine IsraelMedical CenterNewarkNew JerseyUSA Departamento de Cirugía Clínica El RosarioEl TesoroMedellínColombia Sección Cabeza y Cuello Instituto deCancerologíaClínica Las Américas–AunaMedellínColombia Chirurgia Generale Capitanio AuxiologicoMilanItaly

Background:Even though the use of nerve monitoring during parotid gland surgery is not the gold standard to prevent damage to the nerve,it surely offers some advantages over the traditional *** from thyroid surgery,where a series of steps in intraoperative nerve monitoring have been described to confirm not only the integrity but—most importantly—the function of the recurrent laryngeal nerve,in parotid gland surgery,a formal guideline to follow while dissecting the facial nerve has yet to be ***:A five‐year retrospective study was done reviewing the intraoperative records of patients who underwent parotid gland surgery under neural *** operative findings regarding the neuromonitoring process,particularly in regard to the amplitude of two main branches,were revised.A literature search was done to search for guidelines to follow when a facial nerve loss of signal is ***:Fifty‐five patients were operated on using the Nim 3 Nerve Monitoring System(Medtronic);31 were female patients,and 47 patients had benign *** changes were observed in the amplitude records after a comparison was made between the first and the last *** were only three articles discussing the term loss of signal during parotid gland ***:Today,no sufficient attention has been given to the facial nerve monitoring process during *** study proposes a formal guideline to follow during this procedure as well as an instruction to consider when a loss of signal is observed to develop a uniform technique of facial nerve stimulation.

关键词： amplitude facial nerve intraoperative neural monitoring latency loss of signal nerve monitoring parotid gland

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Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

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Protein & Cell 2020年第3期11卷 187-201页

作者： Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park simon Rousseau Lorenzo E.Ferri Thoracic and Upper GI Cancer Research Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada Department of Experimental Surgery and Department of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-Christie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind and Morris Goodman Cancer Research Centre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada Department of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA Department of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely ***,we sought to determine the effects of NOD1 on ***1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate ***130,a specific NOD1 inhibitor,was used to block C12-iE-DAP *** knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus ***,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase *** data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell ***,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with ***,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and *** effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)*** is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.

关键词： NOD1 iE-DAP ML130 colon cancer metastasis cancer-extracellular matrix adhesion cancer migration p38 MAPK activation intravital microscopy survival analysis

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Probabilistic Distributions for <i>Acacia Mearnsii</i>De Wild Total Height and the Influence of Environmental Factors

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Journal of Applied Mathematics and Physics 2014年第3期2卷 1-10页

作者： carlos Roberto Sanquetta Alexandre Behling Allan Libano Pelissari Ana Paula Dalla Corte Sylvio Péllico Netto Augusto Arlindo simon Department of Forest Science University Federal of Paraná Curitiba Brazil

This paper discusses the hypothesis of height distribution on a forest stand of Acacia mearnsii De Wild, known as black wattle. It remains constant at varied growing environments and, in addition, they are not influenced by age factor. The Wakeby equation was applied. The research was carried out in a black wattle stand at varied age levels and over two different agroecological regions where plantations are found: Serra do Sudeste and Encosta do Sudeste, Rio Grande do Sul State, Brazil. It was observed that as the age rises there is an increase in the stand total height;while the number of trees decreases for the lower classes, it increases for the upper ones. This resulted in lengthening of the curve tail to the left and mode shift to the right, generating negative asymmetrical curves. Two types of height distribution were found: the sharp increase of probability in a specific class and some similar probabilities in successive classes. The distribution curves between the cultivation areas were statistically different and therefore the height distribution was dependent of environment.

关键词： Wakeby Distribution Forest Stand Age Cultivation Area Forest Structure

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Epidemics on networks: Reducing disease transmission using health emergency declarations and peer communication

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Infectious Disease Modelling 2020年第1期5卷 12-22页

作者： Asma Azizi Cesar Montalvo Baltazar Espinoza Yun Kang carlos Castillo-Chavez School of Human Evolution and Social Change Simon A.Levin Mathematical Computational Modeling Science CenterArizona State UniversityTempeAZ85281USA Division of Applied Mathematics Brown UniversityProvidenceRI02906USA Sciences and Mathematics Faculty College of Integrative Sciences and ArtsArizona State UniversityMesaAZ85212USA

Understanding individual decisions in a world where communications and information move instantly via cell phones and the internet,contributes to the development and implementation of policies aimed at stopping or ameliorating the spread of *** this manuscript,the role of official social network perturbations generated by public health officials to slow down or stop a disease outbreak are studied over distinct classes of static social *** dynamics are stochastic in nature with individuals(nodes)being assigned fixed levels of education or *** may change their epidemiological status from susceptible,to infected and to *** importantly,it is assumed that when the prevalence reaches a pre-determined threshold level,P*,information,called awareness in our framework,starts to spread,a process triggered by public health *** is assumed to spread over the same static network and whether or not one becomes a temporary informer,is a function of his/her level of education or wealth and epidemiological *** simulations show that threshold selection Pand the value of the average basic reproduction number impact the final epidemic size *** the ErdÖos-Rényi and Small-world networks,an optimal choice for Pthat minimize the final epidemic size can be identified under some conditions while for Scalefree networks this is not case.

关键词： Awareness spread Behavior change Outbreak and epidemic threats ErdÖos-rényi network Small-world network Scale-free network

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轨枕间距对钢轨波磨的影响

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都市快轨交通 2010年第2期23卷 13-17页

作者： Ernesto García Vadillo José A.Tárrago Gorka Garate Zubiaurre carlos Angulo duque 孙晓静聂志理巴斯克大学机械工程系北京交通大学北京100044

主要研究轨枕间距对钢轨波磨发展的影响。研究小半径曲线内轨的小矢跨比波磨。这些出现问题的曲线段属于西班牙毕尔巴鄂区域的地铁轨道,铺设着混凝土道床和两层STEDEF型支承垫层。当初始轨枕间距为1000mm时,仅有92万组轮对通过后所测得... 详细信息

主要研究轨枕间距对钢轨波磨发展的影响。研究小半径曲线内轨的小矢跨比波磨。这些出现问题的曲线段属于西班牙毕尔巴鄂区域的地铁轨道,铺设着混凝土道床和两层STEDEF型支承垫层。当初始轨枕间距为1000mm时,仅有92万组轮对通过后所测得的波磨深度峰-峰值已经达到0.42mm。随后更换产生波磨的钢轨,比较列车通过时轨枕上方和轨间中部的内轨垂向、横向加速度。当轨枕间距为1000mm时,轨间中部出现频率为204和244Hz的强烈响应,在轨枕上方却未出现。在相邻轨枕中间铺设一个轨枕,使轨枕间距变为500mm,钢轨波磨停止发展。该结论是根据2年的观测结果得到的。

关键词：铜轨波磨轨道动力学小曲线半径轨枕间距

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Role of short-term dispersal on the dynamics of Zika virus in an extreme idealized environment

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Infectious Disease Modelling 2017年第1期2卷 21-34页

作者： Victor M.Moreno Baltazar Espinoza Derdei Bichara Susan A.Holechek carlos Castillo-Chavez simon A.Levin Mathematical Computational and Modeling Sciences CenterArizona State UniversityP.O.Box 873901TempeAZ 85287-3901United States Biodesign Center for Infectious Diseases and Vaccinology Biodesign InstituteArizona State UniversityTempeAZ 85287-5401United States School of Life Sciences Arizona State UniversityTempeAZ 85287-4501United States Department of Mathematics and Center for Computational and Applied Mathematics California State UniversityFullertonCA 92831United States Departamento the Ingenieria Biomedica Universidad de Los AndesBogotaColombia Rector's Office Yachay Tech UniversityUrcuquiEcuador

In November 2015,El Salvador reported their first case of Zika virus(ZIKV)infection,an event followed by an explosive outbreak that generated over 6000 suspected cases in a period of two *** agencies began implementing control measures that included vector control and recommending an increased use of ***,in response to the alarming and growing number of microcephaly cases in Brazil,the importance of avoiding pregnancies for two years was *** this paper,we explore the role of mobility within communities characterized by extreme poverty,crime and ***,the role of short term mobility between two idealized interconnected highly distinct communities is explored in the context of ZIKV *** make use of a Lagrangian modeling approach within a two-patch setting in order to highlight the possible effects that short-term mobility,within highly distinct environments,may have on the dynamics of ZIKV outbreak when the overall goal is to reduce the number of cases not just in the most affluent areas but *** depend on existing mobility patterns,levels of disease risk,and the ability of federal or state public health services to invest in resource limited areas,particularly in those where violence is *** results of simulations in highly polarized and simplified scenarios are used to assess the role of *** quickly became evident that matching observed patterns of ZIKV outbreaks could not be captured without incorporating increasing levels of *** number of distinct patches and variations on patch connectivity structure required to match ZIKV patterns could not be met within the highly aggregated model that is used in the simulations.

关键词： Vector-borne diseases Zika virus Residence times Multi-patch model

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HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio Perez-simon Maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

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Nutritional Characteristics of <i>Brachiaria brizantha</i>Cultivars Subjected to Different Intensities Cutting

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American Journal of Plant Sciences 2014年第13期5卷 1961-1972页

作者： Kátia Aparecida de Pinho Costa Eduardo da Costa Severiano Gustavo André simon Patrícia Soares Epifanio Alessandro Guerra da Silva Raoni Ribeiro Guedes Fonseca Costa Charles Barbosa Santos carlos Ribeiro Rodrigues Goiano Federal Institute Rio Verde Brazil University of Rio Verde Rio Verde Brazil

This study evaluated the nutritional characteristics of Brachiaria brizantha cultivars subjected to three cutting intensities in the course of one year. The experiment was conducted at the University of Rio Verde. The experiment was performed as a randomized 3 × 3 factorial in complete block design with three replications and repeated measures in the time. Three Brachiaria brizantha cultivars (Marandu palisadegrass, Xaraes palisadegrass, and Piata palisadegrass), were tested at three cutting intensities (10, 20, and 30 cm sward height). The evaluations were conducted on the same plots throughout one year and during all four seasons (autumn, winter, spring, and summer). The results showed that the Piata palisadegrass had the best chemical composition compared to the Marandu palisadegrass and Xaraes palisadegrass. The management of Brachiaria brizantha cultivars at the lowest residual height (10 cm) affected the nutritional value of these feed grasses. Seasonality also influenced the nutritional value of these forages.

关键词： Marandu Palisadegrass Piata Palisadegrass Sward Height Xaraes Palisadegrass

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卢塞恩Sempachersee高尔夫俱乐部

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设计家 2012年第3期 68-73页

作者： oseph Smolenicky simon Kr enbhl Dirk-Oliver Haid Juan-carlos Smolenicky-Munoz Walter Mair Christoph Reinhard Pauline Pan

扩建后的Sempachersee高尔夫俱乐部成为瑞士最大的高尔夫俱乐部，它距离瑞士的中心城市卢塞恩约15公里。Smolenicky建筑事务所被委托为新扩建的网球场设计两栋新楼——栋用作会所和餐厅，一栋用作新的维修建设。新建的会所恰好位于地嵴... 详细信息

扩建后的Sempachersee高尔夫俱乐部成为瑞士最大的高尔夫俱乐部，它距离瑞士的中心城市卢塞恩约15公里。Smolenicky建筑事务所被委托为新扩建的网球场设计两栋新楼——栋用作会所和餐厅，一栋用作新的维修建设。新建的会所恰好位于地嵴上．正是在这个位置上，绿色的球场急剧下降成一个斜坡。可以看到湖泊和瑞士境内的阿尔卑斯山的景色。球场内弯曲延伸的公共行道也是按照这个地形建造的。设计方案：建筑和新楼的室内设计旨在把两处视觉效果明显不同的场景结合成一个单一效果的场景。这种全新的塑造一方面表现出Sempachersee高尔夫文化的城郊特色，另一方面也表现出高尔夫运动的复杂性。由温暖质感的木材建造的谷仓形建筑和清晰的Masserati跑车路线串联起了整个球场的造型外观。这种大胆的尝试正是为了体现出建筑本身的二元性．既是现实的，又具有无限的发展可能。

关键词：高尔夫俱乐部建筑事务所室内设计阿尔卑斯山高尔夫运动网球场中心城市视觉效果

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Assessment of faunal communities and habitat use within a shallow water system using non-invasive BRUVs methodology

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Aquaculture and Fisheries 2020年第5期5卷 224-233页

作者： Henriette M.V.Grimmel Robert W.Bullock simon L.Dedman Tristan L.Guttridge Mark E.Bond Bimini Biological Field Station Foundation South BiminiBahamas Hull International Fisheries Institute University of HullHullHU67RXUnited Kingdom Independent Researcher San CarlosCAUSA Department of Biological Sciences Florida International University3000 NE 151th StreetNorthMiamiFL33181USA Saving the Blue KendallMiami33186USA

Seagrass and mangrove habitats have long been established as critical for diverse species at various life-stages,particularly as nursery ***,despite their intrinsic and environmental value,these ecosystems are increasingly threatened by anthropogenic *** Bimini,Bahamas,where ongoing development threatens ecosystem integrity,baited remote underwater video surveys(BRUVs)were used to examine faunal communities in both nearshore habitat and a shallow water central lagoon(average depth 1 m).The study assessed species abundances and spatial distribution in a currently unperturbed of the North Bimini Marine Reserve(NBMR).A total of 140 BRUVs,conducted over a 13-month period,recorded 62 species from 27 different *** was used to assess relative abundances and multivariate analyses(***,PCA,PERMANOVA)investigated differences in community composition across discrete factors and environmental *** Regression Trees(BRTs)were used to explore environmental variables for their uncorrelated influences on recorded species *** evidenced the importance of habitat diversity and particularly mangroveadjacent habitat for teleost fishes in Bimini with species diversity and abundance being significantly greater in the mangrove-adjacentdge ***,the study highlighted differences in environmental conditions between habitat types and the association this had with species diversity,abundance and *** the shallow water environment,BRUVs served as a scalable,non-invasive technique to assess community structures within the study *** from this study should inform ongoing decision-making processes regarding the protection of the Bimini Islands ecosystem.

关键词： Baited remote underwater video MaxN Mangrove edge habitat Bahamas Bimini

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