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A Note on Extreme Points in Dual Spaces

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Acta Mathematica Sinica,English Series 2013年第3期29卷 471-476页

作者： Juan Francisco MENA-JURADO Juan carlos navarro-PASCUAL Departamento de Análisis Matemático Facultad de Ciencias Universidad de Granada Departamento de lgebra y Análisis Matemático Universidad de Almería

Given a normed space X it can be easily proven that every extreme point in Bx＊, the unit ball of X＊, is the restriction of an extreme point in Bx Our purpose is to study when the restrictions of extreme points in B... 详细信息

关键词： Extreme point Ll-predual M-ideal

Deforestation and fragmentation trends of seasonal dry tropical forest in Ecuador: impact on conservation

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Forest Ecosystems 2021年第3期8卷 615-627页

作者： carlos A.Rivas JoséGuerrero-Casado Rafael M.navarro-Cerillo Instituto de Ciencias Básicas Universidad Técnica de ManabíPortoviejoManabíEcuador Department of Forest Engineering Laboratory of DendrochronologySilviculture and Global Change–DendrodatLab–ERSAFUniversity of CordobaCampus de RabanalesCrta.IVkm.396E-14071 CordobaSpain Departamento de Medicina Veterinaria Facultad de Ciencias VeterinariasUniversidad Técnica de ManabíPortoviejoManabíEcuador Department of Zoology University of CordobaCampus de Rabanales14071 CordobaSpain

Background:Fragmentation and deforestation are one of the greatest threats to forests,and these processes are of even more concern in the tropics,where the seasonal dry forest is possibly one of the most threatened ecosystems with the least remaining surface ***:The deforestation and fragmentation patterns that had occurred in Ecuadorian seasonal dry forests between 1990 and 2018 were verified,while geographic information systems and land cover shapes provided by the Ecuadorian Ministry of the Environment were employed to classify and evaluate three types of seasonal dry forests:deciduous,semi-deciduous,and *** study area was tessellated into 10 km2 hexagons,in which six fragmentation parameters were measured:number of patches,mean patch size,median patch size,total edge,edge density and reticular fragmentation index(RFI).The RFI was also measured both outside and inside protected natural areas(unprotected,national protected areas and protected forest).Moreover,the areas with the best and worst conservation status,connectivity and risk of disappearance values were identified by means of a Getis-Ord Gi*statistical ***:The deforestation of seasonal dry forests affected 27.04%of the original surface area still remaining in 1990,with an annual deforestation rate of−1.12%between 1990 and *** RFI has increased by 11.61%as a result of the fact that small fragments of forest have tended to disappear,while the large fragments have been fragmented into smaller *** semi-deciduous forest had the highest levels of fragmentation in *** three categories of protection had significantly different levels of fragmentation,with lower RFI values in national protected areas and greater values in protected ***:The seasonal dry forest is fragmenting,deforesting and disappearing in some *** increased protection and conservation of the Ecuadorian seasonal dry forest is,therefore,necessary owing to the fact that not all prot

关键词： Deciduous forest Semi-deciduous forest Remnant forest Patch isolation Habitat loss Protected areas

The effect of older population on public health spending:Evidence from Spain

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Health Care Science

Health Care Science 2023年第5期2卷 306-316页

作者： carlos navarro-García Antonio Sarria-Santamera Facultad de Medicina Alfonso X UniversityMadridSpain Medicine&Global Health Nazarbayev University School of MedicineAstanaKazakhstan

ackground:The gradual ageing of the population,and its effect on public spending,constitutes an urgent challenge for advanced *** this study,we analyse the effect of older people,and their health and individual characteristics,on public health ***:Using logistic regression methods,we have analysed the use of different health services and health technologies by older people in Spain,controlled for several health,socioeconomic,and other individual ***:The main factors that explain the consumption of both health services and health technology,above age,are related to the so-called need factors:self-reported health status,presence of chronic diseases,and ***:Knowing the main factors that imply greater public health spending is a topic of special interest for designing efficient health policies,in a context of growth in public health *** this way,preventive attention on the so-called need factors may be an important driver to improve the effectiveness of spending.

关键词： ageing health technology older population public health spending Spain use of health services

Generating oligodendroglia from adult mesenchymal cells for transplantation:cell reprogramming or direct lineage conversion?

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Neural Regeneration Research 2023年第7期18卷 1493-1494页

作者： Jorge Pascual-Guerra JoséA.Rodríguez-navarro carlos L.Paíno Service of Neurobiology-Research Ramón y Cajal University Hospital-IRYCISMadridSpain Department of Cellular Biology Complutense UniversityMadridSpain

Cell replacement therapy has long been proposed as a treatment for the damaged nervous *** of the most challenging aspects of such a strategy,however,is finding sources of donor cells for *** neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be *** possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long *** improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.

关键词： neural programming removed

Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV

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World Journal of Pediatrics 2019年第5期15卷 492-498页

作者： Isabel Cuéllar-Flores Talís Saínz carlos Velo María Isabel González-Tomé Cristina García-navarro Caroclina fernández-Mcphee Sara Guillén JoséTomás Ramos Pilar Miralles Rafae Rubio JoséIgnacio Bernardino Luis Prieto Pablo Rojo Santiago Jiménez de Ory Maria Luisa navarro CoRiSpe(FARO and NeuroCoRISpeS projects,RITIP-Traslational Research Network in Pediatric Infectious Diseases) Pediatric Department Hospital Clínico San CarlosMadridSpain Infectious Diseases Service Paed DepartmentHospital La PazMadridSpain La Paz Research Institute(IdiPAZ) MadridSpain Infectious Diseases Service Paed DepartmentHospital 12 de OctubreMadridSpain Infectious Diseases Service Paed DepartmentH.Gregorio MaranónMadridSpain Paed Department Hospital de GetafeMadridSpain Infectious Diseases Service H.Gregorio MaranónMadridSpain HIV Service Hospital 12 de OctubreMadridSpain Infectious Diseases Service Hospital La PazMadridSpain Instituto de Investigación Sanitaria Hospital Gregorio Maranón(IiSGM) MadridSpain Universidad Complutense de Madrid MadridSpain Translational Research Network in Pediatric Infectious Diseases(RITIP) MadridSpain 不详

Background Studies investigating health-related quality of life(HRQoL)in youth with perinatally acquired HIV(PHIV+)are *** study aimed to compare HRQoL of PHIV+to sociodemographic-matched youth not living with HIV(HIV-),Spanish general youth population,and to explore associations between sociodemographic variables,drug consumption,and *** PHIV+youth were randomly selected from CoRISpe database(Cohort of the Spanish Pediatric HIV Network).HRQoL was evaluated by *** Thirty-nine PHIV+youth(mean age:23.36 years,SD=3.83)and thirty-nine HIV-youth(mean age:22.97 years,SD=3.80)participated in this ***+obtained lower scores in SF-12 physical health subscale(PCS)than HIV-(P=0.001)and Spanish general youth population(P=0.006).PHIV+had lower scores on the mental health subscale(MCS)than the Spanish general youth population(P<0.001).PHIV+who were at school obtained better scores than those were not at ***+youth who had used cocaine and cannabis had lower scores in MCS(P=0.002).Conclusions There is a need for HRQoL management in the associated medical follow-up.

关键词： Drug consumption Health-related quality of life Mental health Perinatally acquired HIV youth

Abiotic and biotic drivers of struvite solubilization in contrasting soils

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Pedosphere 2023年第6期33卷 828-837页

作者： Antonio RUIZ-navarro Manuel DELGADO-BAQUERIZO Concha CANO-DíAZ carlos GARCíA Felipe BASTIDA Centro de Edafologia y Biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)Department of Soil and Water ConservationEspinardoMurcia E-30100Spain ICL Specialty Fertilizers Iberia TotanaMurcia E-30850Spain Laboratorio de Biodiversidad y Funcionamiento Ecosistemico Instituto de Recursos Naturales y Agrobiologia de Sevilla(IRNAS)CSICAv.Reina Mercedes 10Sevilla E-41012Spain IRNAS-CSIC Unidad Asociada Universidad Pablo de OlavideUniversidad Pablo de Olavide(UPO)Sevilla 41013Spain Centre for Research and Development in Agrifood Systems and Sustainability(CISAS) Instituto Politecnico de Viana do Castelo(IPVC)Rua Escola Industrial e Comercial Nun'Alvares 34Viana do Castelo 4900-347Portugal

Phosphorus(P) limitation in the coming decades calls for the utilization of alternative fertilizers in agriculture. Struvite is a promising P source, but its potential role as a fertilizer is dependent on different physical, chemical, and biological properties, which are very heterogeneous in soil, complicating the prediction of the best soil conditions for its application. Here, we evaluated the solubility of struvite in soil, its redistribution into P fractions, and its potential abiotic and biotic drivers in 62 globally distributed soils with contrasting properties through an incubation assay. We found that after 40 d, about 35% of struvite P was redistributed into soil fractions more accessible to plants and microbes. Phosphorus redistribution from struvite was driven by a complex suite of soil physical, chemical, and microbial properties as well as environmental factors that varied across soils. Soil texture played a critical role in determining the redistribution of P in struvite-amended soils in soluble(H2O extraction), labile(NaHCO3 extraction), and moderately labile(NaOH extraction) *** addition, the soil solution cation concentration was one of the most important drivers of available struvite-derived P fractions. The great importance of texture and cations in determining struvite-derived P fractions in soil was contrasted with the relatively minor role of pH. At the microbial level, the number of bacterial operational taxonomic units(OTUs) from the unfertilized soils that correlated with struvite-derived P fractions was higher than that of fungi. The number of OTUs that correlated with the struvite-derived soluble P fraction was dominated by fungi, whereas the number of OTUs that correlated with the struvite-derived labile P fraction was dominated by bacteria. Overall, this study provided a predictive framework for the potential use of struvite as a P fertilizer in contrasting soils.

关键词： bacteria fungi environmental factor operational taxonomic unit phosphorus fertilizer phosphorus fraction phosphorus solubilization soil fertility soil property

Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 1-8页

作者： Vidal Felix navarro Torres carlos Dinis da Gama Matilde Costa e Silva Paula Falcao Neves Qiang Xie Mining and Geo-resources Engineering Department of IST Technical University of Lisbon 1049-001 Portugal Faculty of Civil Engineering Chongqing University Chongqing 400045 China

The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been *** traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m×3.0 m pillars,while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high,to obtain a pillar section with an area of 3.0 m×3.0 *** stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor,more rock mass displacement,more extraction and selectivity ratios,and ore grade improvement,compared with the traditional *** results show that the selective technique is also more *** proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram,gold,*** as the famous La Rinconada gold mine in the Peruvian Andes.

关键词： mines and mining tungsten deposits productivity stability stoping

In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： Ana LMartínez-López carlos JGonzález-navarro Paula Aranaz JoséLVizmanos Juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition Research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health Research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROS)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROS

Gastrotomy closure with a new tissue anchoring device:A porcine survival study

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World Journal of Gastroenterology 2011年第13期17卷 1732-1738页

作者： carlos Guarner-Argente Henry Córdova Graciela Martínez-Pallí Ricard navarro-Ripoll Antonio Rodríguez-d’Jesús Cristina Rodríguez de Miguel Mireia Beltrán Gloria fernández-Esparrach Endoscopy Unit Hospital Clínic CIBERehd Barcelona 08026 Spain Anesthesiology Department Hospital Clínic CIBERehd Barcelona 08026 Spain

AIM: To evaluate the feasibility, reproducibility and efficacy of a new tissue anchoring device in a porcine survival model. METHODS: Gastrotomies were performed using a needle-knife and balloon dilator in 10 female Yorkshire pigs weighing 30-35 kg. Gastric closure was attempted using a new tissue anchoring device. The tightness of the closure was confirmed by means of air insufflation and the ability to maintain gastric distension with stability in peritoneal pressure measured with a Veress needle. All animals were monitored daily for signs of peritonitis and sepsis over 14 d. During necropsy, the peritoneal cavity and the gastric access site were ***: Transgastric access, closure and 14 d survival was achieved in all pigs. The mean closure time was 18.1 ± 19.2 min and a mean of 2.1 ± 1 devices were used. Supplementary clips were necessary in 2 cases. The closure time was progressively reduced (24.8 ± 13.9 min in the first 5 pigs vs 11.4 ± 5.9 min in the last 5, P = NS). At necropsy, the gastric access site was correctly closed in all cases with all brace-bars present. One device was misplaced in the mesocolon. Minimal adhesions were observed in 3 pigs and signs of mild peritonitis and adhesions in one. CONCLUSIONS: The use of this new tissue anchoring device in porcine stomachs is feasible, reproducible and effective and requires a short learning curve.

关键词： Gastrotomy Closure Suture Survival Porcine model Notes