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Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1 vs University of Wisconsin appraisal

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World Journal of Gastroenterology 2017年第23期23卷 4211-4221页

作者： Mohamed Amine Zaouali Arnau Panisello-Roselló Alexandre Lopez carlos Castro benítez Emma Folch-Puy Agustín García-Gil Teresa Carbonell RenéAdam Joan Roselló-Catafau Experimental Hepatic Ischemia-Reperfusion Unit Institut d’Investigacions Biomèdiques de BarcelonaSpanish National Research Council Research Unit of Biology and molecular anthropology applied to development and Health(UR12ES11) Faculty of PharmacyUniversity of Monastir Tunisia and Institute of Biotechnology of Monastir University of Monastir Centre Hépatobiliaire AP-PHHopital Paul Brousse Hospital Clínico de Zaragoza Facultat Biologia Universitat de Barcelona

To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) *** liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to “ex vivo” normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system (UPS: measured as chymotryptic-like activity and 20S and 19S proteasome), the prevention of liver injury (transaminases), mitochondrial injury (confocal microscopy) and inflammation markers (TNF 1 alpha, high mobility group box-1 (HGMB-1) and PPAR gamma), and liver apoptosis (TUNEL assay, cytochrome c and caspase 3).RESULTSProfiles of free AA (alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW (P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity (measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury (AST/ALT) and mitochondrial damage (revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers (TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 *** comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a hig

关键词： Liver proteolysis Proteasome activation Fatty liver preservation Institut Georges Lopez-1 University of Wisconsin High mobility group box 1 Cold ischemia reperfusion injury

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Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury

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World Journal of Gastroenterology 2016年第28期22卷 6501-6508页

作者： Gianfranco Pasut Arnau Panisello Emma Folch-Puy Alexandre Lopez carlos Castro-benítez Maria Calvo Teresa Carbonell Agustín García-Gil RenéAdam Joan Roselló-Catafau Department of Pharmaceutical and Pharmacological University of Padova and Veneto Institute of Oncology IRCCS 35128 Padova Italy Experimental Pathology Department Institute of Biomedical Research of Barcelona 08036 Barcelona Spain Centre Hepatobiliaire AP-HP Hopital Paul Brousse Inserm U935 Universite Paris-Sud Villejuif 75008 Paris France Unitat de Microscopia Optic Avancada CCiTUB Centre Cientifics i Tecnologics Faculty of Medicine University of Barcelona 08036 Barcelona Spain Physiology Department Faculty of Biology Universitat de Barcelona 08036 Barcelona Spain Hospital Clinico de Zaragoza 50009 Zaragoza Spain

Liver ischemia-reperfusion injury(IRI) is an inherent feature of liver surgery and liver transplantation in which damage to a hypoxic organ(ischemia) is exacerbated following the return of oxygen delivery(reperfusion). IRI is a major cause of primary nonfunction after transplantation and may lead to graft rejection, regardless of immunological considerations. The immediate response involves the disruption of cellular mitochondrial oxidative phosphorylation and the accumulation of metabolic intermediates during the ischemic period, and oxidative stress during blood flow restoration. Moreover, a complex cascade of inflammatory mediators is generated during reperfusion, contributing to the extension of the damage and finally to organ failure. A variety of pharmacological interventions(antioxidants, anticytokines, etc.) have been proposed to alleviate graft injury but their usefulness is limited by the local and specific action of the drugs and by their potential undesirable toxic effects. Polyethylene glycols(PEGs), which are non-toxic water-soluble compounds approved by the FDA, have been widely used as a vehicle or a base in food, cosmetics and pharmaceuticals, and also as adjuvants for ameliorating drug pharmacokinetics. Some PEGs are also currently used as additives in organ preservation solutions prior to transplantation in order to limit the damage associated with cold ischemia reperfusion. More recently, the administration of PEGs of different molecular weights by intravenous injection has emerged as a new therapeutic tool to protect liver grafts from IRI. In this review, we summarize the current knowledge concerning the use of PEGs as a useful target for limiting liver IRI.

关键词： Ischemia reperfusion injury Polyethylene glycol Liver preconditioning Liver transplantation UW solution IGL-1 solution SCOT solution PEG rinse solution Machine perfusion

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Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus

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World Journal of Hepatology 2016年第25期8卷 1075-1086页

作者： Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese carlos benítez Departamento de Gastroenterología Escuela de Medicina Pontificia Universidad Católica de Chile Departamento de Medicina Interna and Programa de Salud Basada en la Evidencia Escuela de Medicina Pontificia Universidad Católica de Chile Sección de Gastroenterología Departamento de Medicina Hospital Clínico Universidad de Chile and Clínica Santa María Unidad de Gastroenterología Universidad del Desarrollo Clínica Alemana Servicio de Gastroentero-logía Unidad de Trasplante Hepático Hospital del Salvador Facultad de Medicina Universidad de Chile and Unidad de Gastroenterología Clínica Alemana de Santiago Clínica Indisa Clínica Las Condes y Servicio de Gastroenterología Hospital Fuerza Aérea de Chile Departamento de Nefrología Facultad de Medicina Pontificia Universidad Católica de Chile

AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal *** A group of eleven gastroenterologists and nephrologists performed a structured analysis of available *** expert was designated to review and answer a *** generated draft statements for evaluation by all the *** input was obtained from medical *** order to reach consensus,a modified three-round Delphi technique method was *** to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was *** Nine questions were *** available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its *** generated questions were answered by the expert panel with a high level of ***,a therapeutic algorithm was *** role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of *** the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was *** role of several other options was also evaluated and the available evidence was explored and *** transplantation is considered the definitive treatment for *** present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools *** Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1.

关键词： Hepatorenal syndrome Delphi Consensus Evidence-based medicine Treatment

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Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

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Harmonic Propagation from the Low Voltage Four-Wire Delta Systems

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Journal of Power and Energy Engineering 2016年第12期4卷 1-19页

作者： Jandecy Cabral Leite Manoel Socorro Santos Azevedo Ubiratan Holanda Bezerra Ignacio Pérez Abril carlos Alberto de León benítez Department of Electrical and Industrial Engineering Institute of Technology and Education Galileo of Amazonia (ITEGAM) Manaus Brazil Department of Electrical Engineering Federal University of Para Belém Brazil Department of Electrical Engineering Central University of Las Villas (UCLV) Santa Clara Cuba

The electric networks for the distribution to low voltage costumers can be configured in different layouts. Two main approaches are used: the European system composed by three-phase distribution transformers or the North American system composed by single-phase distribution transformers and three-phase transformer banks of single-phase transformers. With respect to harmonic analysis, much more attention has been focused on the three-phase balanced systems arrangements than on the unbalanced four-wire delta system extensively used to supply low voltage loads of 120/240 V. Different authors have shown the three-phase power systems modeling on a phase-coordinates frame. However, the presence of significant asymmetries in the network forces the need of adding a new phase-coordinates model to represent the three-phase transformers banks of two or three single-phase transformers in its various connections. Several papers treat the use of harmonic analysis programs based on a phase-coordinates frame to study the Wye or Delta connected three-phase systems. However, the commonly used four-wire delta connected systems are not fully treated in literature. This paper presents a phase-coordinates model for the representation of the commonly used three-phase transformer banks of three or two single-phase transformers, and single-phase distribution transformers for the harmonic analysis of the four-wire delta connected systems. The harmonic analysis method based on the presented model is used to examine the characteristics of this kind of distribution system with respect to the penetration of harmonics currents from loads to the primary system.

关键词： Harmonic Analysis Phase-Coordinates Four-Wire Delta Systems

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Hyperpycnal (over density) flows and deposits

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Journal of Palaeogeography 2020年第3期9卷 267-287页

作者： carlos Zavala Departamento de Geologia Universidad Nacional del SurSan Juan 6708000 Bahia BlancaArgentina GCS Argentina 5RL Molina Campos 1508000 Bahia BlancaArgentina

A hyperpycnal flow forms when a relatively dense land-derived gravity flow enters into a marine or lacustrine water reservoir. As a consequence of its excess of density, the incoming flow plunges in coastal areas, generating a highly dynamic and often long-lived dense underflow. Depending on the characteristics of the parent flow(flow duration and flow rheology) and basin salinity, the resulting deposits(hyperpycnites) can be very *** to flow duration, land-derived gravity flows can be classified into short-lived or long-lived flows. Shortlived gravity flows last for minutes or hours, and are mostly related to small mountainous river discharges, alluvial fans, collapse of natural dams, landslides, volcanic eruptions, j?kulhlaups, etc. Long-lived gravity flows last for days,weeks or even months, and are mostly associated with medium-to large-size river *** the rheology of the incoming flow, hyperpycnal flows can be initiated by non-Newtonian(cohesive debris flows), Newtonian supercritical(lahars, hyperconcentrated flows, and concentrated flows) or Newtonian subcritical flows(pebbly, sandy or muddy sediment-laden turbulent flows). Once plunged, non-Newtonian and Newtonian supercritical flows require steep slopes to accelerate, allow the incorporation of ambient water and develop flow transformations in order to evolve into a turbidity current and travel further basinward. Their resulting deposits are difficult to differentiate from those related to intrabasinal turbidites. On the contrary, long-lived Newtonian subcritical flows are capable of transferring huge volumes of sediment, freshwater and organic matter far from the coast even along gentle or flat slopes. In marine settings, the buoyant effect of interstitial freshwater in pebbly and sandy hyperpycnal flows can result in lofting due to flow density reversal. Since the excess of density in muddy hyperpycnal flows is provided by silt-clay sediments in turbulent suspension, lofting

关键词： Hyperpycnal flows Hyperpycnites Turbidites Sediment gravity flows

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MULTIGRID METHOD FOR A MODIFIED CURVATURE DRIVEN DIFFUSION MODEL FOR IMAGE INPAINTING

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Journal of Computational Mathematics 2008年第6期26卷 856-875页

作者： carlos Brito-Loeza Department of Mathematical Sciences University of Liverpool

Digital inpainting is a fundamental problem in image processing and many variational models for this problem have appeared recently in the literature. Among them are the very successfully Total Variation （TV） model [11] designed for local inpainting and its improved version for large scale inpainting： the Curvature-Driven Diffusion （CDD） model [10]. For the above two models, their associated Euler Lagrange equations are highly nonlinear partial differential equations. For the TV model there exists a relatively fast and easy to implement fixed point method, so adapting the multigrid method of [24] to here is immediate. For the CDD model however, so far only the well known but usually very slow explicit time marching method has been reported and we explain why the implementation of a fixed point method for the CDD model is not straightforward. Consequently the multigrid method as in [Savage and Chen, Int. J. Comput. Math., 82 （2005）, pp. 1001-1015] will not work here. This fact represents a strong limitation to the range of applications of this model since usually fast solutions are expected. In this paper, we introduce a modification designed to enable a fixed point method to work and to preserve the features of the original CDD model. As a result, a fast and efficient multigrid method is developed for the modified model. Numerical experiments are presented to show the very good performance of the fast algorithm.

关键词： Image inpainting Variational models Regularization Multilevel methods.

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QUANTUM FINANCIAL ECONOMICS——RISK AND RETURNS

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Journal of Systems Science & Complexity 2013年第2期26卷 187-200页

作者： GONCALVES carlos Pedro Instituto Superior de Ciencias Socials e Politicas-Technical University of Lisbon

Financial volatility risk and its relation to a business cycle-related intrinsic time is addressed through a multiple round evolutionary quantum game equilibrium leading to turbulence and multifractal signatures in the financial returns and in the risk *** model is simulated and the results are compared with actual financial volatility data.

关键词： Business cycle dynamics intrinsic time quantum chaotic volatility quantum financialeconomics.

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A Zonotopic-Based Watermarking Design to Detect Replay Attacks

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 1924-1938页

作者： carlos Trapiello Vicenc Puig the Supervision Safety and Automatic Control Research Center(CS2AC)of the Universitat Politécnica de Catalunya(UPC)Rambla Sant Nebridi2208222 TerrassaSpain the UMR 5218-IMS Laboratory France the Institut de Robòtica i Informàtica Industrial(CSIC-UPC) Carrer Llorens Artigas4-608028 BarcelonaSpain

This paper suggests the use of zonotopes for the design of watermark *** proposed approach exploits the recent analogy found between stochastic and zonotopic-based estimators to propose a deterministic counterpart to current approaches that study the replay attack in the context of stationary Gaussian *** this regard,the zonotopic analogous case where the control loop is closed based on the estimates of a zonotopic Kalman filter(ZKF)is *** formulation allows to propose a new performance metric that is related to the Frobenius norm of the prediction ***,the steadystate operation of the system can be related with the size of the minimal Robust Positive Invariant set of the estimation ***,analogous expressions concerning the impact that a zonotopic/Gaussian watermark signal has on the system operation are ***,a novel zonotopically bounded watermark signal that ensures the attack detection by causing the residual vector to exit the healthy residual set during the replay phase of the attack is *** proposed approach is illustrated in simulation using a quadruple-tank process.

关键词： Optimal control physical watermarking replay attack zonotopes

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The new knowledge is written on sedimentary rocks——a comment on Shanmugam’s paper “the hyperpycnite problem”

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Journal of Palaeogeography 2019年第3期8卷 306-313页

作者： carlos Zavala Departamento de Geología Universidad Nacional del Sur GCS Argentina SRL

In a recent contribution G. Shanmugam (2018) discusses and neglects the importance of hyperpycnal flows and hyperpycnites for the understanding of some sediment gravity flow deposits. For him, the hyperpycnal flow paradigm is strictly based on experimental and theoretical concepts, without the supporting empirical data from modern depositional systems. In this discussion I will demonstrate that G. Shanmugam overlooks growing evidences that support the importance of hyperpycnal flows in the accumulation of a huge volume of fossil clastic sediments. Sustained hyperpycnal flows also provide a rational explanation for the origin of well sorted fine-grained massive sandstones with floating clasts, a deposit often wrongly related to sandy debris flows.

关键词： Hyperpycnites Turbidites Sediment gravity flows

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