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Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats

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Neural Regeneration Research 2018年第11期13卷 1945-1952页

作者： Mayara Ferraz de Menezes Fabricio Nicola Ivy Reichert Vital da silva Adriana Vizuete Viviane Rostirola Eisner Leder Leal Xavier carlos alberto Saraiva Goncalves carlos Alexandre Netto Regis Gemerasca Mestriner Neurorehabilitation and Neural Repair Research Group Pontificia Universidade Catolica do Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Cellular and Molecular Biology Pontificia Universidade Catolica do Rio Grande do SUl Porto Alegre RS Brazil department of Biochemistry Basic Science Institute Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Biosciences and Rehabilitation. Centro Universitairio Metodista IPA Porto Alegre RS Brazil

Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury（SCI）. However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein（GFAP） and S100 calcium-binding protein B（S100B）（astrocytic reactivity classical markers） and global histone H4 acetylation levels. Sixty-one male Wistar rats（aged ~3 months） were divided into the following groups： sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases（first phase： no changes in the 6, 24 and 48 hours post-SCI groups; second phase： increased levels in the 72 hours post-SCI group; and a third phase： return to levels similar to control in the 7 days post-SCI group）. Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury.

关键词： histones spinal cord injury glial fibrillary acidic protein S100 calcium-binding protein B neuralplasticity astrocyte ELISA-immunoassay recovery neural repair rats

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Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: mathematical and modelling aspects of porous media

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 399-409,F0004页

作者： Fernando F.Rivera Berenice miranda-Alcantara German Orozco carlos Ponce de Leon Luis F.Arenas National Council of Science and Technology(CONACYT) Mexico City 03940Mexico Center of Research and Technological development in Electrochemistry(CIdeTEQ) Queretaro 76703Mexico Electrochemical Engineering Laboratory Energy Technology Research GroupFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries(RFBs)and other electrochemical *** order to determine their predictive capability,turbulent Reynolds-averaged Navier-Stokes(RANS)and free flow plus porous media(Brinkman)models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RFB for laboratory *** different platinized titanium electrodes were considered,a plate plus a turbulence promoter and an expanded metal *** pressure drop was validated against experimental data obtained with typical cerium *** was found that the pressure drop values were better described by the RANS approach,whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

关键词： CFD simulation porous media porous electrode pressure drop redox flow battery

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国际护理知识网络建设的调查研究

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International Journal of Nursing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： Margareth Santos Zanchetta Suzanne Fredericks Kateryna Metersky Geraldine Martorella Pammla Petrucka Laurie Clune Kelly Graziani Giacchero Vedana Cristina Rosa Soares Lavareda Baixinho Cristianne Maria Famer Rocha Sara Campagna Sally Zhang He Márcia Teles de Oliveira Gouveia Marcelo Medeiros denize Bouttelet Munari Daniel Gonzalo Eslava Albarracin carlos Aguilera-Serrano Walterlania silva Santos Toronto Metropolitan University TorontoCanada Florida State University TallahasseeUSA University of Saskatchewan ReginaCanada University of Regina ReginaCanada State of Sao Paulo University Ribeirao PretoBrazil Lisbon Superior School of Nursing LisbonPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil University of Turin TurinItaly Scarborough Health Network ScarboroughCanada Federal University of Piauí TeresinaBrazil Federal University of Goias GoianiaBrazil Fundacion Universitaria Cafam BogotaColombia University of Malaga MalagaSpain University of Brasília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

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Effect of rare-earth oxides on properties of silicon nitride obtained by normal sintering and sinter-HIP

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Journal of Rare Earths 2012年第11期30卷 1177-1183页

作者： Cecilia C.Guedes-silva Flávio Machado de Souza Carvalho José carlos Bressiani Nuclear and Energy Research Institute-IPEN/CNEN Geoscience Institute-IGC/USP

This paper presented the microstructure, mechanical properties and oxidation behavior of silicon nitride obtained by both conventional sintering and sintering followed by hot isostatic pressing （HIP）. Silicon nitride with additives such as 5 wt.% Al2O3 and 5 wt.% Ln203 （Ln= La, La concentrate, Gd or La＋Gd） were studied. The results revealed that Gd203 additions increased the formation of elongated grains of β-Si3N4, the fracture toughness and oxidation resistance. La2O3 additions led to higher densification and hardness values, while addition of La2O3 concentrate promoted the formation of materials with intermediate properties, compared to the other studied compositions. Hot isostatic pressing increased the hardness but decreased the fracture toughness of the material, mainly because it allowed residual pores to close and also reduced the average aspect ratio of β-Si3N4 grains.

关键词： rare earths silicon nitride properties normal sintering sinter-HIP

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Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 603-611页

作者： Diana Cholico-González NoemíOrtiz Lara Mario alberto Sánchez miranda Ricardo Morales Estrella Ramiro Escudero García carlos ALeón Patiño CONACYT-Metallurgy and Materials Research Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico Metallurgy and Materials Research Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico

The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert *** effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron *** with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass *** metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave *** results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing ***,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking.

关键词： magnetite concentrate agave bagasse biomass reduction metallization degree

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Time-dependent impact of a high-fat diet on the intestinal barrier of male mice

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World Journal of Methodology 2024年第1期14卷 114-123页

作者： Carolline Santos miranda Daiana Araujo Santana-Oliveira Isabela Lopes Vasques-Monteiro Nathan Soares Dantas-miranda Jade Sancha de Oliveira Glauser Flavia Maria silva-Veiga Vanessa Souza-Mello department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil

BACKGROUND Excessive saturated fat intake compromises the integrity of the intestinal mucosa,leading to low-grade inflammation,impaired mucosal integrity,and increased intestinal permeability,resulting in the migration of lipopolysaccharide(LPS)to other *** To evaluate the chronic effects(at 10 and 16 wk)of a high-fat diet(HFD)(with 50%energy as fat)on the phylogenetic gut microbiota distribution and intestinal barrier structure and protection in C57BL/6 *** Forty adult male mice were divided into four nutritional groups,where the letters refer to the type of diet(control and HFD or HF)and the numbers refer to the period(in weeks)of diet administration:Control diet for 10 wk,HFD for 10 wk,control diet for 16 wk,and HFD for 16 *** sacrifice,biochemical,molecular,and stereological analyses were *** The HF groups were overweight,had gut dysbiosis,had a progressive decrease in occludin immunostaining,and had increased LPS *** progression reduced the number of goblet cells per large intestine area and Mucin2 expression in the HF16 group,consistent with a completely disarranged intestinal ultrastructure after 16 wk of HFD *** Chronic HFD intake causes overweight,gut dysbiosis,and morphological and functional alterations of the intestinal barrier after 10 or 16 ***-dependent reductions in goblet cell numerical density and mucus production have emerged as targets for countering obesity-driven intestinal damage.

关键词： High-fat diet Intestine Ultrastructure Goblet cells Gut microbiota

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p-Cresol mineralization and bacterial population dynamics in a nitrifying sequential batch reactor

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Journal of Environmental Sciences 2014年第9期26卷 1885-1893页

作者： carlos David silva Lizeth Beristain-Montiel Flor de Maria Cuervo-López Anne-Claire Texier department of Biotechnology-CBS Universidad Autónoma Metropolitana-IztapalapaMexico City 09340Mexico department of Process and Technology-CNI Universidad Autónoma Metropolitana-CuajimalpaMexico City 05300Mexico

The ability of a nitrifying sludge to oxidize p-cresol was evaluated in a sequential batch reactor （SBR）. p-Cresol was first transformed to p-hydroxybenzaldehyde and p-hydroxybenzoate, which were later mineralized. The specific rates of p-cresol consumption increased throughout the cycles. The bacterial population dynamics were monitored by using denaturing gradient gel electrophoresis 0DGGE） and sequencing of DGGE fragments. The ability of the sludge to consume p-cresol and intermediates might be related to the presence of species such as Variouorax paradoxus and Thauera mechernichensis, p-Cresol （25 to 200 mg C/L） did not affect the nitrifying SBR performance （ammonium consumption efficiency and nitrate production yield were close to 100% and 1, respectively）. This may be related to the high stability observed in the nitrifying communities. It was shown that a nitrifying SBR may be a good alternative to eliminate simultaneously ammonium and p-cresol, maintaining stable the respiratory process as the bacterial community.

关键词： Nitrificationp-Cresol oxidationSequential batch reactorPopulation dynamicsEcological indices

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Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis

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World Journal of Gastroenterology 2017年第48期23卷 8439-8442页

作者： Aline silva miranda Ana Cristina Sim?es e silva In-terdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais Laboratory of Neurobiology Department of MorphologyInstitute of Biological SciencesFederal University of Minas Gerais department of Pediatrics Faculty of MedicineFederal University of Minas Gerais

The renin angiotensin system(RAS) is classically conceived as a circulating hormonal system involved in blood pressure control and hydroelectrolyte balance. The discovery that RAS components are locally expressed in a wide range of organs and tissues,including the liver,pointed to a role for this system in the pathogenesis of several conditions including hepatic fibrosis and cirrhosis. It has been widely reported that the classical RAS axis composed by the angiotensin converting enzyme(ACE)-angiotensin(Ang) Ⅱ-Ang type 1(AT1) receptor mediates pro-inflammatory,pro-thrombotic,and pro-fibrotic processes. On the other hand,the alternative axis comprising ACE2-Ang-(1-7)-Mas receptor seems to play a protective role by frequently opposing Ang Ⅱ action. Chronic hepatitis B(CHB) is one of the leading causes of liver fibrosis,accounting for the death of nearly one million people worldwide. Liver fibrosis is a key factor to determine therapeutic interventions for patients with CHB. However,the establishment of non-invasive and accurate methods to detect reversible stages of liver fibrosis is still a challenge. In an elegant study published in the 36 th issue of the World Journal of Gastroenterology,Noguchi et al showed the predictive value of serum ACE levels in detecting not only advanced stages of liver fibrosis but also initial and intermediate fibrotic stages. The serum levels of ACE might represent an accurate,non-invasive,widely available,and easy method to evaluate fibrosis related to CHB. Moreover,therapies involving the inhibition of the classical RAS axis components might be promising in the control of CHB-related liver fibrosis.

关键词： Renin angiotensin system Angiotensin converting enzyme Angiotensin Ⅱ Angiotensin-(1-7) Chronic hepatitis B hepatic cirrhosis Liver fibrosis

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A Bidimensional Finite Element Study of Crack Propagation in Austempered Ductile Iron

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Computers, Materials & Continua 2023年第11期77卷 1411-1424页

作者： Gustavo von Zeska de França Roberto Luís de Assumpção Marco Antonio Luersen carlos Henrique da silva department of Mechanical Engineering Federal University of Technology–ParanáCuritiba81280-340Brazil

Austempered ductile iron(ADI)is composed of an ausferritic matrix with graphite nodules and has a wide range of applications because of its high mechanical strength,fatigue resistance,and wear resistance compared to other cast *** amount and size of the nodules can be controlled by the chemical composition and austenitizing *** the nodules have lower stiffness than the matrix and can act as stress concentrators,they influence crack ***,the crack propagation mechanism in ADI is not yet fully *** this study,we describe a numerical investigation of crack propagation in ADIs subjected to cyclic *** numerical model used to calculate the stress intensity factors in the material under the given conditions is built with the aid of Abaqus commercial finite element *** crack propagation routine,which is based on the Paris law,is implemented in *** results of the simulation show that the presence of a nodule generates a shear load on the crack ***,even under uniaxial tensile loading,the presence of the nodule yields a non-zero stress intensity factor in mode II,resulting in a deviation in the crack propagation *** is the primary factor responsible for changing the crack propagation direction towards the *** the parameters,for example,increasing the nodule size or decreasing the distance between the nodule and crack tip,can intensify this *** simulations comparing two different ADIs with the same graphite fraction area,the crack in the material with more nodules reaches another nodule in a shorter propagation time(or shorter number of cycles).This suggests that the high fatigue resistance observed in ADIs may be correlated with the number of nodules intercepted by a crack and the additional energy required to nucleate new *** summary,these findings contribute to a better understanding of crack propagation in ADIs,provide insights into the relationship between the presence

关键词： Austempered ductile iron(ADI) fatigue crack propagation graphite nodule

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Ecophysiological acclimatization to cyclic water stress in Eucalyptus

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Journal of Forestry Research 2020年第3期31卷 797-806页

作者： Rogerio de Souza Noia Junior Genilda Canuto Amaral Jose Eduardo Macedo Pezzopane Mariana Duarte silva Fonseca Ana Paula Camara da silva Talita miranda Teixeira Xavier department of Biosystems Engineering ESALQ University of Sao PauloPiracicabaSao PauloBrazil department of Forestry Sciences NEDTEC Federal University of Espirito SantoJero nimo MonteiroEspirito SantoBrazil

Drought is considered the main environmental factor limiting productivity in eucalyptus plantations in Brazil. However, recent studies have reported that exposure to water deficit conditions enables plants to respond to subsequent stresses. Thus, this study investigates the ecophysiological acclimatization of eucalyptus clones submitted to recurrent water deficit cycles. Eucalyptus seedlings were submitted to three recurrent water deficit cycles and anatomical, morphological and physiological changes were analyzed. The results were:(1) Eucalyptus seedlings responded to water deficits by directing carbohydrates to root and stem growth;(2) Size and number of stomata were reduced;(3) Stomatal conductance decreased which allowed the plants to reduce water losses through transpiration,increasing instantaneous water use efficiency;(4) The relationship between gas exchanges and available water contents allowed the seedlings to uptake the retained soil water athigher tensions;and,(5) Physiological recovery from subsequent water deficits became faster. As a result of these changes, the eucalyptus seedlings recovered from the same degree of water stress more rapidly.

关键词： Carbon partition Drought Gas exchange Morpho-physiological changes Photosynthetic apparatus

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