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Journal of Arid Land 2017年第1期9卷 65-75页

作者： carlos ESCALANTE-SANDOVAL Pedro NUNEZ-GARCIA Faculty of Engineering National Autonomous University of Mexico Cd. Universitaria Coyoacan 04510 Mexico

Meteorological drought has been an inevitable natural disaster throughout Mexican history and the northern and northwestern parts of Mexico（i.e., the studied area）, where the mean annual precipitation（MAP） is less than 500 mm, have suffered even more from droughts in the past. The aim of this study was to conduct a meteorological drought analysis of the available MAP data（1950–2013） from 649 meteorological stations selected from the studied area and to predict the drought features under the different IPCC-prescribed climate change scenarios. To determine the long-term drought features, we collected 1×10~4 synthetic samples using the periodic autoregressive moving average（PARMA） model for each rainfall series. The simulations first consider the present prevailing precipitation conditions（i.e., the average from 1950 to 2013） and then the precipitation anomalies under IPCC-prescribed RCP 4.5 scenario and RCP 8.5 scenario. The results indicated that the climate changes under the prescribed scenarios would significantly increase the duration and intensity of droughts. The most severe impacts may occur in the central plateau and in the Baja California Peninsula. Thus, it will be necessary to establish adequate protective measures for the sustainable management of water resources in these regions.

关键词： meteorological drought synthetic simulation climate change water stress evapotranspiration

Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression

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Neural Regeneration Research 2020年第1期15卷 65-66页

作者： Fernando C.Ortiz carlos Puebla Mechanisms on Myelin Formation and Repair Laboratory Instituto de Ciencias BiomedicasFacultad de Ciencias de la SaludUniversidad Autonoma de ChileSantiagoChile Cellular Physiology Laboratory Instituto de Ciencias BiomedicasFacultad de Ciencias de la SaludUniversidad Autonoma de ChileSantiagoChile

Multiple sclerosis(MS):MS is a neurodegenerative disease affecting around 2.5 million people worldwide,representing the second cause of disabilities in the young adult *** is a demyelinating pathology which originates in the autoimmune attack of T and B lymphocytes against *** lack of myelin leads,in turn,to axonal degeneration,neuronal death and the consequent neurological disabilities(Franklin and Ffrench-Constant,2017).A main hallmark of MS is a preserved local neuroinflammatory *** is now acknowledged that this persistent inflammatory scenario is a central and common condition in almost all neurodegenerative pathologies(as in Parkinson’s and Alzheimer’s diseases,among others)controlling and modulating the regulatory responses of the system to the triggering *** the case of MS,this original insult corresponds to the loss of myelin(Chitnis and Weiner,2017;Franklin and Ffrench-Constant,2017).

关键词： Franklin representing degeneration

The effects of patch richness on con-specific interference in the parasitoid Ibalia leucospoides （Hymenoptera： Ibaliidae）

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Insect Science 2010年第4期17卷 379-385页

作者： Valeria Fernandez-Arhex Juan carlos Corley Lab. Ecologia de tnsectos INTA EEA-Bariloche Bariloche Rio Negro Argentina

We experimentally studied con-specific interference in Ibalia leucospoides, a parasitoid of the woodwasp Sirex noctilio, on pine logs containing variable numbers of woodwasp larvae. Competiton occurred when two different-sized female parasitoids foraged on a host patch, and consequently the small female always abandoned the patch. Regardless of host density, con-specific presence did not affect the attack rate, the number of hosts attacked, nor patch residence time by the winner, when compared to a control female that foraged alone. In contrast, con-specific presence reduced patch time and the number of hosts attacked by the loser. Finally patch time （by both） as well as number of hosts attacked （by the winner only） increased with host density per patch. Our results suggest that con-specific presence has different consequences for different-sized females during patch exploitation.

关键词： aggregation direct competition host-parasitoid interactions parasitoid com-petition patch quality Sirex noctilio

An unsupervised pattern recognition methodology based on factor analysis and a genetic-DBSCAN algorithm to infer operational conditions from strain measurements in structural applications

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Chinese Journal of Aeronautics 2021年第2期34卷 165-181页

作者： Juan carlos PERAFAN-LOPEZ Julian SIERRA-PEREZ Grupo de Investigacion en Ingenieria Aeroespacial Universidad Pontificia BolivarianaCircular 170-01Medellin 050031Colombia

Structural Health Monitoring(SHM) suggests the use of machine learning algorithms with the aim of understanding specific behaviors in a structural system. This work introduces a pattern recognition methodology for operational condition clustering in a structure sample using the well known Density Based Spatial Clustering of Applications with Noise(DBSCAN) *** methodology was validated using a data set from an experiment with 32 Fiber Bragg Gratings bonded to an aluminum beam placed in cantilever and submitted to cyclic bending loads under 13 different operational conditions(pitch angles). Further, the computational cost and precision of the machine learning pipeline called FA + GA-DBSCAN(which employs a combination of machine learning techniques including factor analysis for dimensionality reduction and a genetic algorithm for the automatic selection of initial parameters of DBSCAN) was measured. The obtained results have shown a good performance, detecting 12 of 13 operational conditions, with an overall precision over 90%.

关键词： Clustering DBSCAN Factor analysis FBGs Pattern recognition Strain field

An Unusual Organometallic Supramolecule Composed of Chiral Dirhodium Units and Sulfato Bridging Ligands

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Chinese Journal of Structural Chemistry 2011年第11期30卷 1569-1574页

作者：陈进余荣民 MURILLO carlos A State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Department of Chemistry Texas A&M University PO Box 30012 College Station

A chiral supramolecular compound （H3O）{[cis-Rh2（（C6H5）2P（C6H4））2（SO4）- （DMF）]2（μ- OC2H5）}·6C2H5OH （1） has been synthesized and characterized by X-ray single-crystal analysis. Compound 1 crystallizes in monoclinic, space group C2/c with a = 26.752（3）, b = 13.5868（16）, c = 26.611（3） A, β = 103.891（2）°, V= 9389.5（19）A^3, Z = 4, C92H114N2O18P4Rh4, Mr = 2135.49, Dc = 1.511 g/cm^3, F（000） = 4384 and μ（MoKa） = 0.870 mm^-1. The final R = 0.0441 and wR = 0.1186 for 8283 observed reflections with I 〉 2σ（I） and R = 0.0567 and wR = 0.1290 for all data. The structure of the compound is unique. It contains two inherent chiral {c/s-Rh2[（C6H5）2P（C6H4）]2}^2＋ units which are connected not only in the equatorial positions by two sulfato ligands, but also in two of their axial positions by a μ2 ethoxide anion. The remaining axial positions of Rh2^4＋ units in 1 are occupied by the DMF molecules. The sulfato ligands act as P4 tridentate bridges to connect the Rh2^4＋ units. The Rh-Rh metal-metal bond distances are comparable to those in analogous dirhodium compounds.

关键词： chiral dirhodium orthometalated crystal structure sulfato

Adapt or perish:SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1416-1417页

作者： Marta Ribes carlos Chaccour Gemma Moncunill ISGlobal Hospital Clínic-Universitat de BarcelonaBarcelonaSpain Ifakara Health Institute IfakaraUnited Republic of Tanzania Facultad de Medicina Universidad de NavarraPamplonaSpain

In a recent report in Science,McCarthy et *** observed a pattern of recurrent deletions in four discrete regions of the N-terminal Domain(NTD)of the Spike protein,which provide resistance to antibody neutralization,su... 详细信息

关键词： al. prompt Domain

Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis

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World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 389-395页

作者： carlos Robles-Medranda Maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel soria Gladys Bravo carlos Robles-Jara Hannah Pitanga Lukashok Gastroenterology and Endoscopy Division Instituto Ecuatoriano de Enfermedades DigestivasUniversity Hospital OMNIGuayaquil 090505Ecuador

To evaluate the clinical impact of confocal laser endomicroscopy (CLE) in the diagnosis and management of patients with an uncertain diagnosis. METHODSA retrospective chart review was performed. Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included. Baseline characteristics, indications, previous diagnostic studies, findings at the time of CLE, clinical management and histological results were analyzed. Interventions based on CLE findings were also analyzed. We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens. RESULTSA total of 144 patients were included. Of these, 51% (74/144) were female. The mean age was 51 years old. In all, 41/144 (28.4%) lesions were neoplastic (13 bile duct, 10 gastric, 8 esophageal, 6 colonic, 1 duodenal, 1 rectal, 1 ampulloma and 1 pancreatic). The sensitivity, specificity, positive predictive value, negative predictive value, and observed agreement when CLE was used to detect N-lesions were 85.37%, 87.38%, 72.92%, 93.75% and 86.81%, respectively. Cohen’s Kappa was 69.20%, thus indicating good agreement. Changes in management were observed in 54% of the cases. CONCLUSIONCLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis.

关键词： Confocal laser endomicroscopy In vivo microscopy Barret esophagus Gastrointestinal cancer Pancreatic cyst Biliary strictures

Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina

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World Journal of Gastroenterology 2006年第9期12卷 1426-1429页

作者： Luis Orlando Pérez Martin carlos Abba Fernando Noel Dulout carlos Daniel Golijow Centro de Investigaciones en Genética Básica y Aplicada Facultad de Ciencias Veterinarias Universidad Nacional de La PlataCalle 60 y 118 S/NB 1900 AVWLa PlataArgentina

AIM： To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development, and human papillornavirus （HPV） infection. METHODS： One-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed, p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively. RESULTS： The differences in the distribution ofp53 codon 72 polymorphisrn between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 （95% CI, 1.06-4.05; P〈0.05）. Lack of association was found between ,053 polymorphism and HPV infection in the set of adenocarcinomas. CONCLUSION： The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However, further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer.

关键词： p53 codon 72 polymorphism Human papillomavirus, Colorectal cancer

Association of CYP2C19 genotype with type 2 diabetes

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Health 2010年第10期2卷 1184-1190页

作者： carlos hoyo-Vadillo Jaime Garcia-Mena Adán Valladares Caterina R. Venturelli Niels Wacher-Rodarte Jesús Kumate Miguel Cruz 不详

Background: CYP2C19 is a major isoform of cytochrome P450 that metabolizes a number of commonly prescribed drugs such as omeprazole, diazepam, tolbutamide and propranolol. Its expression is regulated by the constitutive androstane receptor (CAR), involved in glucocorticoids synthesis. Since a number of crossliniks have been described for CYPs and some hormones, an association of CYP2C19 with type 2 diabetes is likely. Methods: Two groups were studied, 352 diagnosed with type 2 diabetes patients and 342 healthy volunteers form Mexico City. Both groups were tested for CYP2C19*2 and *3 alleles. We carried out an allelic discrimination using TaqMan assay for *2, and used FRET sensor and anchor probes for *3. Results: Ninety one percent of the subjects had the wild type allele, 9% have the *2 allele;no subject presented the *3 allele. The CYP2C19*2 allele is associated with type 2 diabetes (p = 0.012). Admixmap program was used to correct the admixture of this population and get the correlation. This was further confirmed in a linear model with a 67% power and by the method of Strom and Wienker for association on subjects within the mean range of Amerindian ancestry only (60%). Conclusion: Type 2 diabetes patients have significatly more *2 allele than healthy volunteers, more evident for the patients with the homocygous genotype.

关键词： Pharmacogenomics CYP2C19 Type 2 Diabetes Mexicans Allele Frequency

Study on textile waste generation in the undifferentiated municipal solid waste stream in Guimarães,Portugal

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Waste Disposal and Sustainable Energy 2023年第2期5卷 189-203页

作者： Alona Perebynos Dalila Sepúlveda carlos Ribeiro Landscape Laboratory Rua da Ponte RomanaCreixomil4835-095GuimarãesPortugal Environmental and Public Space Division Environmental and Sustainability DepartmentGuimarães City CouncilLargo Cónego JoséMaria Gomes4804-534GuimarãesPortugal

Guimarães is a middle sized city and municipality located in northern *** municipality has committed to reducing the annual amount of undifferentiated municipal solid waste(MSW)from 371 kg/capita in 2021 to 120 kg/capita by 2030 under the Zero Waste Cities Certification *** the municipality of Guimarães,one of the constant fractions of MSW composition is textile waste(TW),which the revised EU Waste Framework Directive requires separate collection by 1 January ***,two indicators of TW generation were analysed to identify waste collection routes with a high level of textile waste generation for the priority implementation of separate collection:TW composition in the undifferentiated MSW stream and TW generation per *** statistical analysis methods were used to process the source data of TW composition in the undifferentiated MSW *** analysis was applied to the data set on TW generation per capita,considering the area typology(urban,rural or mixed)of collection *** was considered that 39%of the industrial sector of Guimarães consists of textile and clothing production and represents small-and medium-sized enterprises,which can affect TW generation in the undifferentiated MSW ***-comparative research was used to define the correlation between TW generation per capita and the economic activity of the textile and clothing industry in the *** a result,applying a multi-disciplinary approach,a project of the Textile Waste Generation Map was presented.

关键词： Textile waste Municipal solid waste Waste generation indicators Waste management Circular economy