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Inflammatory markers,oxidative stress,and mitochondrial dynamics:Repercussions on coronary artery disease in diabetes

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World Journal of Diabetes 2024年第9期15卷 1853-1857页

作者： Josécarlos Tatmatsu-rocha Luan Santos Mendes-Costa College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil Physical Therapy Federal University of CearáFortaleza 60000-000CearáBrazil

Inflammatory markers and mediators that affect the development of cardiovascular diseases have been the focus of recent scientific ***,the purpose of this editorial is to promote a critical debate about the article titled“Nε-carboxymethyl-lysine and inflammatory cytokines,markers,and mediators of coronary artery disease progression in diabetes”,published in the World Journal of Diabetes in *** work directs us to reflect on the role of advanced glycation end products,which are pro-inflammatory products arising from the metabolism of fatty acids and sugars whose main marker in tissues is Nε-carboxymethyllysine(NML).Recent studies have linked high levels of pro-inflammatory agents with the development of coronary artery disease(CAD),especially tumor necrosis factor alpha,interleukins,and C-reactive *** inflammatory agents increase the production of reactive oxygen species(ROS),of which people with diabetes are known to have an increased *** increase in ROS promotes lipid peroxidation,which causes damage to myocytes,promoting myocardial ***,oxidative stress induces the binding of NML to its receptor RAGE,which in turn activates the nuclear factor-kB,and consequently,inflammatory *** inflammatory cytokines induce endothelial dysfunction,with increased expression of adhesion molecules,changes in endothelial permeability and changes in the expression of nitric *** this sense,the therapeutic use of monoclonal antibodies(inflammatory reducers such as statins and sodium-glucose transport inhibitors)has demonstrated positive results in the regression of atherogenic plaques and consequently *** the other hand,many studies have demonstrated a relationship between mitochondrial dynamics,diabetes,and cardiovascular *** link occurs since ROS have their origin in the imbalance in glucose metabolism that occurs in the mitochondrial matrix,and this imbalance can have its origin in inadequate diet as well as

关键词： Mitochondrial dynamics Diabetes Oxidative stress Coronary artery disease Nε-carboxymethyl-lysine

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Diabetes mellitus and comorbidities in elderly people from the Lugu community:A critical-reflective analysis

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World Journal of Diabetes 2024年第11期15卷 2162-2166页

作者： Josécarlos Tatmatsu-rocha Josécarlos Gomes-Pinto College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of Ceará-UFCFortaleza 60810-786Brazil College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of CearáFortaleza 60000-000Brazil

Ageing has a close relationship with chronic non-communicable diseases,such as diabetes mellitus and high blood *** pathologies are often associated with changes in eating habits and promote crucial physiological changes which act silently in the long term in the elderly *** to the speed of urban development and technological advances,there has been an increase in the population's life ***,it is essential to know the socio-demographic profile and prevalent comorbidities of the elderly population,which can provide a reliable and broad database to enable the outline of strategies and the promotion of efficient health *** this sense,the purpose of this editorial is to contribute to the debate surrounding the article that analysed epidemiological data from the Lugu *** mellitus,hypertension and cardiovascular pathologies and their comorbidities were the most prevalent conditions in this *** data could contribute to develop public policies constructively and assertively,allowing investments in the prevention and treatment of these pathologies.

关键词： Diabetes mellitus Quality indicators Health care Hypertension Comorbidity Exercise

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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci carlos rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos carlos Eduardo rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

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Denitrification-nitrification process in permeable coastal sediments: An investigation on the effect of salinity and nitrate availability using flow-through reactors

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Acta Oceanologica Sinica 2021年第9期40卷 1-12页

作者： Shan Jiang Mark Kavanagh Juan Severino Pino Ibánhez carlos rocha State Key Laboratory of Estuarine and Coastal Research East China Normal University School of Natural Sciences Trinity College Dublin Trinity Centre for the Environment School of Natural Sciences Trinity College Dublin Instituto de Investigacións Mari?as Consejo Superior de Investigaciones Científicas

Permeable coastal sediments act as a reactive node in the littoral zone,transforming nutrients via a wide range of biogeochemical *** rates are controlled by abiotic factors,e.g.,salinity,temperature or solute ***,a series of incubation experiments,using flow-through reactors,were conducted to simulate the biogeochemical cycling of nitrate (NO3~?) and phosphorus (P) in permeable sediments under differentNO3~?availability conditions (factor I) along a salinity gradient (admixture of river and seawater,factor II).In an oligotrophic scenario,i.e.,unamendedNO3~?concentrations in both river and seawater,sediments acted as a permanent net source ofNO3~?to the water *** peak production rate occurred at an intermediate salinity(20).IncreasingNO3~?availability in river water significantly enhanced netNO3~?removal rates within the salinity range of 0 to 30,likely via the denitrification pathway based on the sediment microbiota *** this scenario,the most active removal was obtained at salinity of *** both river and seawater were spiked with NO3~?,the highest removal rate switched to the highest salinity (36).It suggests the salinity preference of theNO3~?removal pathway by local denitrifiers (e.g.,Bacillus and Paracoccus) and thatNO3~?removal in coastal sediments can be significantly constrained by the dilution relatedNO3~?*** with the obtained variation forNO3~?reactions,permeable sediments acted as a sink of soluble reactive P in all treatments,regardless of salinity andNO3~?input concentrations,indicating a possibility of P-deficiency for coastal water from the intensive cycling in permeable ***,the net production of dissolved organic carbon (DOC) in all treatments was positively correlated with the measuredNO3~?reaction rates,indicating that the DOC supply may not be the key factor forNO3~?removal rates due to the consumption by intensive aerobic *** the intensive pr

关键词： NO − 3 production and removal flow-through reactors salinity stable isotopes permeable sediments

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Sandy seepage faces as bioactive nitrate reactors:Biogeochemistry,microbial ecology and metagenomics

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Geoscience Frontiers 2023年第3期14卷 74-89页

作者： Shan Jiang Jie Jin Yongjun Wei Ying Wu Yixue Zhang carlos rocha Juan Severino Pino Ibánhez Guosen Zhang Jing Zhang State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China School of Pharmaceutical Sciences Key Laboratory of State Ministry of EducationKey Laboratory of Henan Province for Drug Quality Control and EvaluationCollaborative Innovation Center of New Drug Research and Safety EvaluationZhengzhou UniversityZhengzhou 450001HenanChina Biogeochemistry Research Group School of Natural SciencesTrinity College DublinDublin 2Ireland Instituto de Investigacións Mariñas Consejo Superior de Investigaciones Científicas(IIM-CSIC)Eduardo Cabello 636208 VigoSpain School of Oceanography Shanghai Jiao Tong UniversityShanghai 200040China

Subterranean estuaries are highly dynamic in processing dissolved inorganic nitrogen(DIN).Here we investigate DIN turnover in surface sediments(0–20 cm depth)at the higher,medium and lower intertidal of a seepage face,i.e.,the outer “mouth”of the subterranean estuary,during four consecutive seasons in Sanggou Bay,*** the studied period,ammonium(NH_(4)^(+))and nitrite(NO_(2)^(-))concentrations in the sampled porewaters did not vary significantly with depth or *** contrast,peaks in porewater nitrate(NO_(3)^(-))concentration and decreases in δ^(15)N-NO_(3)^(-) and δ^(18)O-NO_(3)^(-) were observed in the 15–20 cm depth(bottom)sediment,particularly during summer and *** with NO_(3)^(-) production,the sediment total nitrogen was also markedly peaking in the bottom layer of the studied seepage *** with abundant heterotrophic microbes in the sediment,this NO_(3)^(-) accumulation was linked to a reaction chain including organic matter decomposition,ammonification and *** winter,porewater enrichment in total nitrogen occurred closer to the surface of the seepage face but triggered also active NO_(3)^(-) *** pattern reinforced the importance of pelagic organic matter supply on NO_(3)^(-) *** the shallower depths of the seepage face(<12 cm),active net NO3removal occurred except in *** isotopic fractionation(δ^(15)N-NO_(3)^(-) and δ^(18)O-NO_(3)^(-) and metagenomic results revealed denitrification as the main pathway for NO_(3)^(-) *** assimilation from benthic primary producers may also consume a fraction of NO_(3)^(-) at the sediment water *** NO_(3)^(-) production and removal significantly varied in magnitude with season(13.6 to 6.2 nmol cm^(-3)h^(-1)).Substrate supply was the key driver for nitrate cycling,as evidenced by the high NO3production rate in spring by comparison to *** highest NO_(3)^(-) turnover rates were found in summer,suggesting the comb

关键词： Benthic microbiota Nitrate Stable isotopes Subterranean estuary Denitrification

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跨境水治理：基于葡萄牙与西班牙的合作案例研究

跨境水治理：基于葡萄牙与西班牙的合作案例研究

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作者： carlos MIGUEL rocha PEREIRA 浙江大学

学位级别：硕士

The right of access to water,as well as the right to its equitable and reasonable use are fundamental human ***,these are frequently conditioned by human activity(***)and natural phenomena(***,floods),which points to a necessity of developing proper models of transboundary water management and active cooperation that take into consideration not only socioeonomic and political aspects but that also address environmental *** situation is particularly worrying in Africa and Asia,where socieconomic vulnerability and risk of conflict tend to be the highest,but also very concerning for European countries,especially Portugal and Spain which are increasingly affected by *** thesis analyses the evolution of water cooperation between these two countries under the bilateral 1998 Albufeira *** is shown how important have international agreements been in the adoption and implementation of this Convention,particularly global conventions and EU water policy—namely the Water Framework *** is done always taking into account the unique conditions and factors of the national,regional and international *** terms of outcomes and impacts,it is argued that cooperation between both countries generated substantial benefits,such as more economic efficiency in the use of water,more preparedness and coordination in cases of floods and pollution accidents,and increased governance *** many ambitious environmental objectives were not fully met or have even deteriorated between different reporting *** results are followed by a discussion on several factors favouring cooperation,such as the dynamics of supranational and subnational regionalism,and several factors hindering cooperation,such as excessive centralization or excessive decentralization.

关键词： Spanish-Portuguese River Basin Cooperation Transboundary Water Governance Hydropolitics Water Diplomacy Impacts and Complementarities of National,Supranational and International Law

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Novel Brick Technology for Carbon Reduction Footprint in Steel Shop Linings

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China's Refractories 2024年第2期33卷 16-21页

作者： carlos PAGLIOSA Leandro rocha Marcelo BORGES Celio CAVALCANTE RHI MAGNESITA Contagem32210-000Brazil

Clean steel encompasses a multitude of concepts that are based on fulfilling customer requirements and can be produced in many ways depending on the existing equipment and detailed customer demands.A common feature of all clean steel production is tight process control along with continuous *** meet an increasing demand for cold-rolled(CR)steel sheets of improved mechanical properties,and to cope with the change of the annealing process from a batch-type to a continuous process,it is necessary to establish a technique for making ultralow carbon(ULC)steel with a C-concentration lower than 20 ppm for the steelmaking process associated with a major challenge to guarantee the competitiveness with observance of environmental *** ladle lining plays an important role on the energy consumption during the production and the refractory lining design contributes to minimize thermal bath loss,carbon pick up and shell temperature.A new generation of unfired zero carbon refractories was developed with two specific approaches:(1)replacement of firing bricks reducing CO_(2) footprint and(2)replacement of carbon containing with performance *** can be used in working and safety linings with a unique microstructure with better heat scattering and similar thermomechanical *** work presents customers’performance compared to traditional products highlighting energy savings.

关键词： steel ladle zero carbon energy saving

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Hair Growth Promoting Effect of Trichoxidil<up>TM</up>: A New Natural Compound for Hair Loss

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第4期10卷 176-190页

作者： Glaucia Labinas Fernando Amaral Valeria Maria de Souza Antunes Maira Jardim Leonardo Mendes Bella carlos rocha Oliveira Universidade Anhembi Morumbi S&#227 o Paulo Brazil

Background: Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of TrichoxidilTM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. Methods: The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of TrichoxidilTM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);TrichosolTM vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);TrichosolTM vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);TrichosolTM group with 2.5% TrichoxidilTM (n = 5) and Hydroalcoholic vehicle group with 2.5% TrichoxidilTM (n = 4) to dermoscopic and histologic. Results: Fibroblasts exhibited higher proliferation when treated with higher concentrations of TrichoxidilTM. TrichoxidilTM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that TrichoxidilTM associated with TrichosolTM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. Conclusion: TrichoxidilTM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.

关键词： TrichoxidilTM Hair Growth Anagen Telogen KGF IGF-1

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Quantification of Flavonoids in Brazilian Orange Peels and Industrial Orange Juice Processing Wastes

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Agricultural Sciences 2017年第7期8卷 631-644页

作者： Regina M.S.Pereira Begona Giménez-Cassina Lopez Susana N.Diniz Alyne Alexandrino Antunes Daniel Moreno Garcia carlos rocha Oliveira Maria Cristina Marcucci Post-Graduated School in Pharmacy and Biotechnology Anhanguera University of Sao Paulo—UNIAN-SPSao PauloBrazil Department of Plant Biology and Pharmacy Course Institute of BiologyUniversity of CampinasUNICAMPCampinasBrazil Centro Interdisciplinar de Investigacao Bioquimica Universidade de Mogi das Cruzes—UMCMogi das CruzesBrazil Departamento de Farmacologia Escola Paulista de MedicinaUniversidade Federal de Sao PauloSao PauloBrazil Escola de Ciencias da Saude Universidade Anhembi MorumbiSao PauloBrazil

The flavonoid content in orange peels of different Brazilian citrus varieties such as bahia, lima, lima-of-persian, morcote, pera, ponkan, seleta, cravo, kinkan and pomelo was assessed. Industry processing juice wastes such as bagasse, bagasse residues, animal feeding bagasse, pulp WEUE and CORE-wash were also analyzed. The HPLC analysis indicates that the most abundant flavonoids found in these Brazilian citrus peels are hesperidin and naringin. The solvents used are selective for flavonoid extraction, and depending on their polarity, glycoside or aglycone flavonoids are extracted. The use of multivariate analysis shows that DMSO is the best solvent to extract glycosides flavanones while hexane displays high selectivity in the extraction of polymethoxylated flavones. The flavonoids present in the orange wastes, obtained at different stages of the industrial processing, are qualitative and quantitatively different. The identification and quantification of the flavonoid composition in each Brazilian citrus variety were evaluated and allowed the selection of the best solvent for the extraction of each specific class of flavonoids. These compounds were found to be more abundant in the fruit peels than in their juices, revealing their great industrial potential. The residual portion of the processing juices is also rich in flavonoids, depending on the processing step.

关键词： Citrus Orange Peel Flavonoid Brazilian Orange Orange Juice Processing Wastes

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