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Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： Elías martínez-López Aleix martínez-Pérez Sergio navarro-martínez Juan carlos Sebastián-Tomás nicola de'Angelis Eduardo García-Granero Department of Surgery University of ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGS)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGS in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGS are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGS in gastrointestinal oncologic *** put a special focus on the different applications of FGS,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： Surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak Lymph node

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Stability Analysis of a neurocontroller with Kalman Estimator for the Inverted Pendulum Case

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Applied Mathematics 2017年第11期8卷 1602-1618页

作者： julián Antonio Pucheta Cristian Rodríguez Rivero carlos Alberto Salas martín Herrera Sergio Oscar Laboret Departamentos de Electrotecnia y de Electrónica Laboratorio de Investigación Matemática Aplicada a Control (LIMAC) Facultad de Ciencias Exactas Físicas y Naturales-Universidad Nacional de Córdoba Córdoba Argentina Departamento de Ingeniería Electrónica Facultad de Tecnología y Ciencias Aplicadas Universidad Nacional de Catamarca Catamarca Argentina

In this paper, a practical analysis of stability by simulation for the effect of incorporating a Kalman estimator in the control loop of the inverted pendulum with a neurocontroller is presented. The neurocontroller is calculated by approximate optimal control, without considering the Kalman estimator in the loop following the Theorem of the separation. The results are compared with a time-varying linear controller, which in noiseless conditions in the state or in the measurement has an acceptable performance, but when it is under noise conditions its operation closes into a state space range more limited than the one proposed here.

关键词： Optimal Control neurocontroller Inverted Pendulum State Estimation Stability

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Depressive symptoms in neurodegenerative diseases

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World Journal of Clinical Cases 2015年第8期3卷 682-693页

作者： Miquel Baquero nuria martín Servei de neurologia Hospital Universitari i Politècnic La Fe

Depressive symptoms are very common in chronic conditions. This is true so for neurodegenerative diseases. A number of patients with cognitive decline and dementia due to Alzheimer's disease and related conditions like Parkinson's disease, Lewy body disease, vascular dementia, frontotemporal degeneration amongst other entities, experience depressive symptoms in greater or lesser grade at some point during the course of the illness. Depressive symptoms have aparticular significance in neurological disorders, specially in neurodegenerative diseases, because brain, mind, behavior and mood relationship. A number of patients may develop depressive symptoms in early stages of the neurologic disease, occurring without clear presence of cognitive decline with only mild cognitive deterioration. Classically, depression constitutes a reliable diagnostic challenge in this setting. However, actually we can recognize and evaluate depressive, cognitive or motor symptoms of neurodegenerative disease in order to establish their clinical significance and to plan some therapeutic strategies. Depressive symptoms can appear also lately, when the neurodegenerative disease is fully developed. The presence of depression and other neuropsychiatric symptoms have a negative impact on the quality-of-life of patients and caregivers. Besides, patients with depressive symptoms also tend to further decrease function and reduce cognitive abilities and also uses to present more affected clinical status, compared with patients without depression. Depressive symptoms are treatable. Early detection of depressive symptoms is very important in patients with neurodegenerative disorders, in order to initiate the most adequate treatment. We review in this paper the main neurodegenerative diseases, focusing in depressive symptoms of each other entities and current recommendations of management and treatment.

关键词： neurodegenerative diseases Alzheimer Depressive symptoms Frontotemporal degeneration Vascular dementia Lewy body disease Depression Dementia

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Changes in niche differentiation and environmental filtering over a hydric stress gradient

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Journal of Plant Ecology 2020年第2期13卷 185-194页

作者： Alejandra martínez-Blancas carlos martorell Departamento de Ecología y Recursos naturales Facultad de CienciasUniversidad Nacional Autónoma de MéxicoCoyoacán04510 Ciudad de MéxicoMexico Posgrado en Ciencias Biológicas Universidad Nacional Autónoma de MéxicoAv.Ciudad Universitaria 3000C.P.04510CoyoacánCiudad de MéxicoMexico

Aims Diversity in communities is determined by species’ability to coexist with each other and to overcome environmental stress that may act as an environmental *** differentiation(nD)results in stronger intra-than interspecific competition and promotes *** stress affects interactions,the strength of nD may change along stress gradients.A greater diversity of plant growth forms has been observed in stressful habitats,such as deserts and alpine regions,suggesting greater nD when stress is *** tested the hypothesis that niche differences and environmental filters become stronger with *** In a semiarid grassland in southern Mexico,we sowed six annual species in the field along a hydric stress *** were grown alone(without interactions),with conspecific neighbors(intraspecific interactions)or with heterospecific neighbors(interspecific interactions).We analyzed how the ratio of intra-to interspecific competition changed along the gradient to assess how water availability determines the strength of *** also determined if hydric stress represented an environmental *** Findings We observed stronger intra-than interspecific competition,especially where hydric stress was ***,we found nD in at least some portion of the gradient for all but one *** species were hindered by stress,but others were favored by it perhaps because it eliminates soil *** strong nD was slightly more frequent with stress,our species sample was small and there were exceptions to the general pattern,so further research is needed to establish if this is a widespread phenomenon in nature.

关键词： hydrological niche species interactions environmental constraints species coexistence stabilizing mechanisms equalizing mechanisms

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Architecture as device:Estrangement theory from literature to architecture

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Frontiers of Architectural Research 2022年第1期11卷 1-12页

作者： Qirui Wan Sergio martín Blas Department of Architectural Design ETSAMUniversidad Politécnica de MadridMadrid28040Spain

What is the estrangement of architecture?The concept has been incessantly mentioned by academics while there seems to be a lack of discussion systematically sorting out the significance,influence,and origins of estrangement asanarchitectural *** aims to discern the meaning of estrangement from the beginning and its process of entering the field of *** first part is expected to answer the following questions:what is estrangement’s original meaning in the field of literature and its variantions?The second part determines what estrangement is in architecture and in what form estrangement is represented according to these *** third part points out the difference during this translation fromliterature to architecture and demonstrates the reasonable inference thatmay actually compose the possibleway of applying the estranging technique in architecture.

关键词： Estrangement Architectural strategy Literature concept Decontextualization Anthropopathic architecture

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Light losses in hollow, prismatic light guides related to prism defects: a transmittance model

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Chinese Optics Letters 2015年第9期13卷 68-72页

作者： Berta García-Fernández Daniel Vázquez-Moliní Antonio álvarez Fernández-Balbuena Angel García-Botella Juan carlos martínez Antón Department of Optics Faculty of Optics and Optometry University Complutense of Madrid Department of Physics Applied to natural Resources School of Forestry EngineeringPolytechnic University of Madrid

Hollow, cylindrical, prismatic light guides （CPLGs） are optical components that, using total internal reflection （TIR）, are able to transmit high-diameter light beams in daylight and artificial lighting applications without relevant losses. It is necessary to study the prism defects of their surfaces to quantify the behavior of these optical components. In this Letter, we analyze a CPLG made of a transparent dielectric material. Scanning electron microscopy （SEM） and the topographic optical profilometry by absorption in fluids （TOPAF） imaging tech- nique are conducted to determine if there are defects in the corners of the prisms. A model for light guide trans- mittance that is dependent on prism defects is proposed. Finally, a simulation and an experimental study are carried out to check the validity of the proposed model.

关键词： Light losses in hollow a transmittance model prismatic light guides related to prism defects

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Alien plant species coexist over time with native ones in Chilean Mediterranean grasslands

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Journal of Plant Ecology 2016年第6期9卷 682-691页

作者： Irene martín-Forés Isabel Castro Belén Acosta-Gallo Alejandro del Pozo Laura Sánchez-Jardón JoséM.de Miguel carlos Ovalle Miguel A.Casado Department of Ecology Complutense University of MadridMadridSpain Department of Ecology Autónoma University of MadridMadridSpain Faculty of Agricultural Sciences University of TalcaTalcaChile Agricultural Research Institute InIA-La Cruz La CruzChile

Aims Alien species are commonly considered as harmful weeds capa-ble of decreasing native biodiversity and threatening *** this assumption,little is known about the long-term patterns of the native-alien relationships associated with human disturbed managed *** study aims to elucidate the commu-nity dynamics associated with a successional gradient in chilean Mediterranean grasslands,considering both native and alien *** Species richness(natives and aliens separately)and life-form(annu-als and perennials)were recorded in four chilean post-agricultural grazed grasslands each covering a broad successional gradient(from 1 to 40 years since crop abandonment).A detrended correspondence analysis(DcA),mixed model effects analyses and cor-relation tests were conducted to assess how this temporal gradient influenced natives and aliens through community *** Findings Our results show different life-form patterns between natives and aliens over *** were mainly represented by annuals(especially ruderals and weeds),which were established at the beginning of *** aliens also predominated at mid-successional stages,but in old grasslands native species were slightly more representative than alien ones within the *** the late successional states,positive or no correlations at all between alien and native species richness suggested the absence of competition between both species groups,as a result of differ-ent strategies in occupation of the *** dynamics over time constitute a net gain in biodiversity,increasing natives and maintaining a general alien pool,allowing the coexistence of *** interactions including facilitation and/or tolerance processes might be occurring in chilean post-agricultural grasslands,a fact that contradicts the accepted idea of the alien species as contenders.

关键词： community dynamics land abandonment gradient life-form livestock grazing successional gradient

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Cardiogenic shock due to left main related myocardial infarction:is revascularization enough?

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Journal of Geriatric Cardiology 2022年第2期19卷 152-157页

作者： Francisco Galván-Román Elena Puerto Roberto martín-Asenjo Albert Ariza-Solé Department of Cardiology Bellvitge University Hospital.Grup de Malalties Cardiovasculars.Institut d´InvestigacióBiomèdica de Bellvitge(IDIBELL).L’Hospitalet de LlobregatBarcelonaSpain Department of Cardiology Doce de Octubre University Hospital.Instituto de Investigación Sanitaria Hospital 12 de Octubre(imas12).MadridSpain*The authors contributed equally to this manuscript

The incidence of cardiogenic shock(CS)complicating acute myocardial infarction(AMI-CS)remains between 3%and 10%and in-hospital mortality is hardly less than 30%.[1-3]In addition,the economic cost of caring for these patients is high.[4]Revascularization in the acute phase is the only measure that has demonstrated to modify the prognosis of AMI-CS.

关键词： infarction acute mortality

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A review of the thermal stability of metastable austenite in steels:martensite formation

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Journal of Materials Science & Technology 2021年第32期91卷 200-214页

作者： Yong Li David San martín Jinliang Wang Chenchong Wang Wei Xu State key laboratory of rolling and automation Northeastern UniversityShenyang 110819China Materalia Research Group Centro Nacional de Investigaciones Metalúrgicas(CENIM-CSIC)Avda Gregorio del Amo 8Madrid E-28040Spain School of Mechanical and Power Engineering Guangdong Ocean UniversityZhanjiang 524088China

Metastable austenite plays a critical role in achieving improved combinations of high strength and high ductility/toughness in the design of advanced high-strength steels(AHSS). The thermal stability of metastable austenite determines the transformation characteristics of AHSS and thus primarily determines the microstructure evolution during complex processes, e.g., the quenching and partitioning process, to achieve the desirable microstructure. This study provides a review of the thermal stability of austenite and its influence on martensitic transformation from both experimental and theoretical modeling perspectives. From the experimental perspective, factors affecting the thermal stability are analyzed,the relative sensitivities are compared, and their corresponding mechanisms are discussed. From the theoretical modeling perspective, the most representative kinetic models that describe athermal and isothermal martensitic transformation are reviewed. The advantages, shortcomings, and applicability of each model are discussed. The systematic review of both experimental and theoretical aspects reveals critical factors in tailoring the stability of metastable austenite and, therefore, provides guidance for the design of advanced steels.

关键词： Austenite Thermal stability martensitic transformation Kinetic models

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Visual perception alterations in COVID-19:a preliminary study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： María Begoña Coco-martín Luis Leal-Vega Irene Alcoceba-Herrero Ainhoa Molina-martín Dolores de-Fez María JoséLuque carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara David PPiñero Group of Applied Clinical neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision

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