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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci carlos Rocha Oliveira gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-LED EBL simulation

Smart Contract to Traceability of Food Social Selling

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Computers, Materials & Continua 2023年第3期74卷 4703-4728页

作者： Cristian Valencia-Payan JoséFernando Grass-Ramírez gustavo Ramirez-Gonzalez Juan carlos Corrales University of Cauca Calle 5#4-70190003Popayan-CaucaColombia

Traditionally,food sustainability has been considered solely in the stage of agricultural ***,globalization,the expansion of the food production industry,and the emergence of supermarket chains that control the retail food market require specific significant changes in supply chains in the food sector and,therefore,we need to address the economic,social,and environmental impacts of these *** the other hand,social selling has increased rapidly in recent years,with a further boom,following current events related to the coronavirus disease(COVID-19).This explosion of social sales,where there are usually no control and regulation entities,can bring problems associated with mishandling *** this paper,we expose how Blockchain technology supports the traceability of social sales by validating the data provided by the chain participants such as digital health passports,production and transport data in the sale process;the proposed solution generates recommendations on productmanagement considering the agreements previously made by the network *** evaluate the proposed smart contracts,we useHyperledger Caliper,obtaining an average throughput of 12.6 transactions per second and an average latency of 0.3 s for the asset update *** also use a study case to evaluate the proposed project platform’s selling-transport stage using Internet of Things(IoT)sensors.

关键词： Blockchain reliability smart contracts social selling traceability artisan sweets

A Bidimensional Finite Element Study of Crack Propagation in Austempered Ductile Iron

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Computers, Materials & Continua 2023年第11期77卷 1411-1424页

作者： gustavo von Zeska de França Roberto Luís de Assumpção Marco Antonio Luersen carlos Henrique da Silva Department of Mechanical Engineering Federal University of Technology–ParanáCuritiba81280-340Brazil

Austempered ductile iron(ADI)is composed of an ausferritic matrix with graphite nodules and has a wide range of applications because of its high mechanical strength,fatigue resistance,and wear resistance compared to other cast *** amount and size of the nodules can be controlled by the chemical composition and austenitizing *** the nodules have lower stiffness than the matrix and can act as stress concentrators,they influence crack ***,the crack propagation mechanism in ADI is not yet fully *** this study,we describe a numerical investigation of crack propagation in ADIs subjected to cyclic *** numerical model used to calculate the stress intensity factors in the material under the given conditions is built with the aid of Abaqus commercial finite element *** crack propagation routine,which is based on the Paris law,is implemented in *** results of the simulation show that the presence of a nodule generates a shear load on the crack ***,even under uniaxial tensile loading,the presence of the nodule yields a non-zero stress intensity factor in mode II,resulting in a deviation in the crack propagation *** is the primary factor responsible for changing the crack propagation direction towards the *** the parameters,for example,increasing the nodule size or decreasing the distance between the nodule and crack tip,can intensify this *** simulations comparing two different ADIs with the same graphite fraction area,the crack in the material with more nodules reaches another nodule in a shorter propagation time(or shorter number of cycles).This suggests that the high fatigue resistance observed in ADIs may be correlated with the number of nodules intercepted by a crack and the additional energy required to nucleate new *** summary,these findings contribute to a better understanding of crack propagation in ADIs,provide insights into the relationship between the presence

关键词： Austempered ductile iron(ADI) fatigue crack propagation graphite nodule

Chemical speciation of copper and manganese in solution of a copper-contaminated soil and young grapevine growth with amendment application

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Pedosphere 2023年第3期33卷 496-507页

作者： Daniela Basso FACCO Edicarla TRENTIN Gerson Laerson DRESCHER Rodrigo Knevitz HAMMERSCHMITT carlos Alberto CERETTA Leandro Souza DA SILVA gustavo BRUNETTO Paulo Ademar Avelar FERREIRA Department of Soil Science Federal University of Santa MariaSanta Maria 97105-900(Brazil) University of Arkansas System Division of Agriculture Arkansas 72704(USA) Federal University of Santa Maria Campus Cachoeira do SulCachoeira do Sul 96506-310(Brazil)

Copper(Cu)-based fungicide application to control foliar diseases in grapevine(Vitis vinifera L.)can increase soil Cu *** soils have high natural Cu and manganese(Mn)concentrations,increasing the potential for toxicity to grapevine *** of amendment substances can reduce the concentrations of toxic chemical species of Cu and Mn in soil solution,especially for the soils grown with young *** evaluated the chemical speciation of Cu and Mn in soil solution and young grapevine growth using a contaminated soil with amendment *** seedlings of Paulsen 1103rootstock were grown for 12 months on an old vineyard(>30 years of cultivation)soil without(control)and with vermicompost or limestone *** dry matter,root morphological characteristics,and plant tissue Cu and Mn concentrations were *** cation and anion concentrations,dissolved organic carbon,p H,and chemical speciation of Cu and Mn in soil solution from different soil layers were *** application did not reduce Cu and Mn phytotoxicity,and grapevine plants died after winter *** soluble Mn concentration in soil(5.56 mg L-1in 0–45 cm soil layer)and Mn concentration in plant tissue at pruning(380.8 mg kg-1)might be the primary cause of plant *** application reduced Cu2+and Mn2+chemical species in soil solution,thereby increasing plant *** Cu2+and Mn2+species were negatively correlated(P<0.05)with grapevine shoot production at pruning(r=-0.92 and-0.97,respectively)and at the end of the trial(r=-0.73 and-0.51,respectively).Limestone application increased grapevine shoot and root dry matter production by 36%and 41%,respectively,while also presenting the highest root length and volume in the 5–10 cm soil *** application is a viable and profitable alternative for reducing soil Cu and Mn availability and their phytotoxic effects.

关键词： bioavailability heavy metal limestone phytoxicity vermicompost vineyard Visual MINTEQ

Training birdsong recognition using virtual reality

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Virtual Reality & Intelligent Hardware 2021年第5期3卷 397-406页

作者： carlos ARCE-LOPERA María JoséARIAS gustavo CORRALES Department of Technology and Information Universidad IcesiCali 760046Colombia

Background In mega-biodiverse environments,where different species are more likely to be heard than seen,species monitoring is generally performed using bioacoustics ***,since bird vocalizations are reasonable estimators of biodiversity,their monitoring is of great importance in the formulation of conservation ***,birdsong recognition is an arduous task that requires dedicated training in order to achieve mastery,which is costly in terms of time and money due to the lack of accessibility of relevant information in field trips or even specialized *** technology based on virtual reality(VR)and spatial audio may improve species monitoring by enhancing information accessibility,interaction,and user *** This study used spatial audio,a Bluetooth controller,and a head-mounted display(HMD)to conduct an immersive training experience in *** moved inside a virtual world using a Bluetooth controller,while their task was to recognize targeted *** measured the accuracy of recognition and user engagement according to the User Engagement *** The experimental results revealed significantly higher engagement and accuracy for participants in the VR-based training system than in a traditional computer-based training *** four dimensions of the user engagement scale received high ratings from the participants,suggesting that VR-based training provides a motivating and attractive environment for learning demanding tasks through appropriate design,exploiting the sensory system,and virtual reality *** The accuracy and engagement of the VR-based training system were significantly high when tested against traditional *** research will focus on developing a variety of realistic ecosystems and their associated birds to increase the information on newer bird species within the training ***,the proposed VR-based training system must be tested with ad

关键词： Human computer interaction Virtual environment Birdsong Audio training User engagement

Interaction of piRNA-like sequences from the 3′-UTR of SARS-CoV-2 with mRNA regions

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Genes & Diseases 2023年第6期10卷 2282-2284页

作者： Laura Pérez-Campos Mayoral María Teresa Hernández-Huerta carlos Romero Díaz carlos Alberto Matias-Cervantes Eduardo Pérez-Campos Mayoral Margarito Martínez Cruz Juan de Dios Ruiz-Rosado Edgar gustavo Ramos Martínez Marco Antonio Sánchez Medina Eduardo Pérez-Campos Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico CONACyT Faculty of Medicine and Surgery.Autonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico National Technology of Mexico(TecNM)/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico The Research Institute at Nationwide Children's Hospital Columbus 43205USA Facultad de Química Universidad Nacional Autónoma de MéxicoCoyoacán 04510Mexico

Piwi-interacting RNAs(piRNAs of 26-32 nt in length)regulate gene expression,epigenetics,and transcriptional and post-transcriptional processes.1 In humans,piRNAs are expressed in germline and somatic tissues,and generally have a uracil at the 5'-end(position+1),an adenine at the+10 position,and are 2'-0 methylated at the 3'-end.2 Onice piRNAs form the RNA-induced silencing complex(RISC)with PIWl proteins,they serve as guides to find their complementary sequences of the target mRNA,thus initiating their *** Wuhan patient's genome is approximately 265 nucleotides(nts)in its 3'-UTR;piRNAs-like sequences have been reported in this region.3 Our objective was to search,through bioinformatics,for mRNA sequences that were homologous to the reverse complementary of the previously reported piRNA-like sequences from the 3'-UTR of SARS-Cov-2,3 and identify the possible interaction between them.

关键词： sequences complementary initiating

Fast preparation route to high-performances textured Sr-doped Ca_3Co_4O_9 thermoelectric materials through precursor powder modification

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Science China Materials 2019年第3期62卷 399-406页

作者： Miguel Angel Torres gustavo Garcia Idoia Urrutibeascoa Maria Antonieta Madre Juan carlos Diez Andres Sotelo ICMA (CSIC-Universidad de Zaragoza) Centro Stirling S. Coop. Mondragon Unibertsitatea

This work presents a short and very efficient method to produce high performance textured Ca_3Co_4O_9 thermoelectric materials through initial powders modification. Microstructure has shown good grain orientation, and low porosity while slightly lower grain sizes were obtained in samples prepared from attrition milled powders. All samples show the high density of around 96% of the theoretical *** similar characteristics are reflected in, approximately,the same electrical resistivity and Seebeck coefficient values for both types of samples. However, in spite of similar power factor(PF) at low temperatures, it is slightly higher at high temperature for the attrition milled samples. On the other hand, the processing time reduction(from 38 to 2 h) when using attrition milled precursors, leads to lower mechanical properties in these samples. All these data clearly point out to the similar characteristics of both kinds of samples, with a drastic processing time decrease when using attrition milled precursors, which is of the main economic importance when considering their industrial production.

关键词： ceramics oxides hot-pressing electrical properties power factor

Entanglement,Identical Particles and the Uncertainty Principle

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Communications in Theoretical Physics 2016年第8期65卷 201-206页

作者： gustavo Rigolin Departamento de Fisica Universidade Federal de Sao Carlos 13565-905 Sao Carlos SP Brazil

A new uncertainty relation(UR) is obtained for a system of N identical pure entangled particles if we use symmetrized observables when deriving the inequality. This new expression can be written in a form where we identify a term which explicitly shows the quantum correlations among the particles that constitute the system. For the particular cases of two and three particles, making use of the Schwarz inequality, we obtain new lower bounds for the UR that are different from the standard one.

关键词：粒子系统不确定性原理纠缠态 Schwarz不等式不确定关系量子关联下界