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Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence

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World Journal of Gastroenterology 2006年第27期12卷 4296-4303页

作者： Paula Jakszyn carlos Alberto gonzález Unit of Nutrition Environment and CancerDepartment of Epidemiology and Cancer Registry. Institut Català d' Oncologia(ICO-IDIBELL)L'Hospitalet de Llobregat (08907)BarcelonaSpain

AIM： To study the association between nitrite and nitrosamine intake and gastric cancer （GC）, between meat and processed meat intake, GC and oesophageal cancer （OC）, and between preserved fish, vegetable and smoked food intake and GC. METHODS： In this article we reviewed all the published cohort and case-control studies from 1985-2005, and analyzed the relationship between nitrosamine and nitrite intake and the most important related food intake （meat and processed meat, preserved vegetables and fish, smoked foods and beer drinking） and GC or OC risk. Sixty-one studies, 11 cohorts and 50 case-control studies were included. RESULTS： Evidence from case-control studies supported an association between nitrite and nitrosamine intake with GC but evidence was insufficient in relation to OC. A high proportion of case-control studies found a positive association with meat intake for both tumours （11 of 16 studies on GC and 11 of 18 studies on OC）. A relatively large number of case-control studies showed quite consistent results supporting a positive association between processed meat intake and GC and OC risk （10 of 14 studies on GC and 8 of 9 studies on OC）. Almost all the case-control studies found a positive and significant association between preserved fish, vegetable and smoked food intake and GC. The evidence regarding OC was more limited. Overall the evidence from cohort studies was insufficient or more inconsistent than that from case-control studies.CONCLUSION： The available evidence supports a positive association between nitrite and nitrosamine intake and GC, between meat and processed meat intake and GC and OC, and between preserved fish, vegetable and smoked food intake and GC, but is not conclusive.

关键词： Nitrites N-nitrosodimethylamine Nitrosocompounds Dietary intake Gastric cancer

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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： carlos gonzález-Fernández Pau gonzález Francisco Javier Rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Stem cells as an option for the treatment of COVID-19

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World Journal of Clinical Cases 2022年第18期10卷 6338-6340页

作者： Maria Veronica Cuevas-gonzález Juan carlos Cuevas-gonzález Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32310ChihuahuaMexico Institute of Biomedical Sciences Autonomous University of Ciudad JuárezCiudad Juarez 32310ChihuahuaMexico

The application of stem cells is among the many strategies currently available for the treatment of multiple *** cells are characterized as undifferentiated cells that have the ability to differentiate towards multiple lineages and selfrenewal,among other *** the first umbilical cord stem cell transplant for the treatment of Fanconi anemia,the use of stem cells for the treatment of multiple diseases,including coronavirus disease 2019,has increased,showing promising results that require evaluation through research studies that include a longer follow-up ***,the main objective of this Letter is to provide an update on the use of stem cells in the treatment of severe acute respiratory syndrome coronavirus 2,as well as identify the main challenges and limitations presented by this type of therapy.

关键词： COVID-19 Stem cells Multiple diseases Undifferentiated cells Appropriate treatment Cytokines granulocyte-macrophage colony-stimulating factor

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Deposition of carbon nanotubes onto glass fibers using ultrasound standing waves

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Frontiers of Materials Science 2021年第3期15卷 471-475页

作者： Julio Alejandro RODRÍGUEZ-gonzÁlez carlos RUBIO-gonzÁlez Alfonso PÉREZ-SÁNCHEZ Centro de Ingeniería y Desarrollo Industrial Departamento de EnergíaAv.Pie de la Cuesta#702Col.Desarrollo San PabloC.P.76125QuerétaroQroMexico

Carbon nanotubes(CNTs)are special types of carbon nanostructures with exceptional physical and mechanical properties such as high elastic modulus,high electrical and thermal conductivities,as well as high surface area and large aspect ratios[1].Given their tubular structure and size,CNTs are conceptualized as one-dimensional nanostructures with a crystalline structure of carbon sp2 hybridization formed by carbon–carbon covalent bonds[1].

关键词： carbon fibers exceptional

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Tumor invasion front in oral squamous cell carcinoma

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World Journal of Clinical Cases 2022年第28期10卷 10387-10390页

作者： Juan carlos Cuevas-gonzález Maria Veronica Cuevas-gonzález Leon Francisco Espinosa-Cristobal Alejandro Donohue Cornejo Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32320ChihuahuaMexico Faculty of Health Sciences Valle de las Palmas Universidad Autonoma de Baja CaliforniaTijuana 21480Baja CaliforniaMexico

Oral squamous cell carcinoma is a neoplasm that originates from the epithelial *** is usually more frequent between the fifth and sixth decades of life,and more than 90% of carcinomas of the oral cavity are squamous cell *** is an invasive neoplasia with a significant recurrence rate;40% of patients present with metastases in the cervical lymph nodes at the time of *** tumor invasion front is a characteristic of tumor growth,which can be infiltrative or *** histopathological parameters examined include the number of mitoses,depth of the tumor,invasion pattern,degree of keratinization,and nuclear *** the pathologist,these parameters are routinely evaluated but are not reported to the treating physician in all cases,which we consider to be useful information when determining the therapeutic route.

关键词： Oral squamous cell carcinoma Invasive neoplasia Therapeutic route Life Tumor growth Pleomorphism

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Biofilm and Helicobacter pylori:From environment to human host

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World Journal of Gastroenterology 2014年第19期20卷 5632-5638页

作者： Apolinaria García María José Salas-Jara Carolina Herrera carlos gonzález Laboratorio de Patogenicidad Bacteriana Departamento de MicrobiologíaFacultad de Ciencias BiológicasUniversidad de ConcepciónConcepción 4030000Chile

Helicobacter pylori(***)is a Gram negative pathogen that selectively colonizes the human gastric *** 50%of the world population is infected with *** reaching up to 90%of infected individuals in developing *** the increased impact upon public health care,its reservoir and the transmission pathway of the species has not been clearly established *** studies allowed the detection of *** in various aquatic environments,even forming biofilm in tap water distribution systems in several countries,suggesting a role of water as a possible reservoir of the *** persistence of human infection with *** and the resistance of clinical isolates to commonly used antibiotics in eradication therapy have been related to the genetic variability of the species and its ability to develop biofilm,demonstrated both in vivo and in vitro ***,during the last years,experimental work with this pathogen has been focused in the search for biofilm inhibitors and biofilm destabilizing ***,only two *** biofilm disrupting agents have been successfully used:Curcumin-a natural dye-and N-acetyl cysteine-a mucolytic agent used in respiratory *** main goal of this review was to discuss the evidences available in the literature supporting the ability of *** to form biofilm upon various surfaces in aquatic environments,both in vivo and in *** results published and our own observations suggest that the ability of *** to form biofilm may be important for surviving under stress conditions or in the spread of the infection among humans,mainly through natural water sources and water distribution systems.

关键词： Helicobacter pylori Biofilm,Water Infection

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Evolution of the Socio-cognitive Structure of Knowledge Management(1986–2015): An Author Co-citation Analysis

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Journal of Data and Information Science 2019年第2期4卷 36-55页

作者： carlos Luis gonzález-Valiente Magda León Santos Ricardo Arencibia-Jorge Biblioteca Nacional de Cuba "José Martí" ave.Independencia Facultad de Comunicación Universidad de la Habana San Pedro entre Ermita y Avenida Independencia Empresa de Tecnologías de la Información

Purpose: The evolution of the socio-cognitive structure of the field of knowledge management(KM) during the period 1986–2015 is described. Design/methodology/approach: Records retrieved from Web of Science were submitted to author co-citation analysis(ACA) following a longitudinal perspective as of the following time slices: 1986–1996, 1997–2006, and 2007–2015. The top 10% of most cited first authors by sub-periods were mapped in bibliometric networks in order to interpret the communities formed and their ***: KM is a homogeneous field as indicated by networks results. Nine classical authors are identified since they are highly co-cited in each sub-period, highlighting Ikujiro Nonaka as the most influential authors in the field. The most significant communities in KM are devoted to strategic management, KM foundations, organisational learning and behaviour, and organisational theories. Major trends in the evolution of the intellectual structure of KM evidence a technological influence in 1986–1996, a strategic influence in 1997–2006, and finally a sociological influence in 2007–*** limitations: Describing a field from a single database can offer biases in terms of output coverage. Likewise, the conference proceedings and books were not used and the analysis was only based on first authors. However, the results obtained can be very useful to understand the evolution of KM *** implications: These results might be useful for managers and academicians to understand the evolution of KM field and to(re)define research activities and organisational ***/value: The novelty of this paper lies in considering ACA as a bibliometric technique to study KM research. In addition, our investigation has a wider time coverage than earlier articles.

关键词： Knowledge management Bibliometrics Author co-citation analysis Knowledge domain visualization Social network analysis Intellectual structure

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Chilean University Students Digital Learning Technology Usage Patterns and Approachesto Learning

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ECNU Review of Education 2022年第1期5卷 37-64页

作者： carlos gonzález Dany Lópeza Lina Calle-Arangoa Helena Montenegro Paula Clasing Pontificia Universidad Catolica de Chile-Millennium Nucleus Universidad de Chile-Millennium Nucleus University of Michigan

Purpose:This study aims to explore Chilean students'digital technology usage patterns andapproaches to learningDesignlApproach/Methods:We conducted this study in two stages We worked with onesemester learning management systems(LMS),library,and students records data in the *** performed a k-means cluster analysis to identify groups with similar usage *** second stage,we invited students from emerging dusters to participate in group *** analysis was employed to analyze ***:Three groups were identified:ID digital library users/high performers,who adopteddeeper approaches to learning obtained higher marks,and used learning resources to integratematerials and expand understanding 2)LMS and physical library userslmid-performers,whoadopted mainly strategicapproaches obtained marks dlose to average,and used learning resources for studying in an organized manner toget good marks and 3)lower users of LMS andlibrarylmidlow performers,who adopted mainly a surface approach,obtained mid-to-lower-than-averagemarks,and used learning resources for minimum content understanding Originality/Value:We demonstrated the importance of combining learning analytics data withqualitative methods to make sense of digital technology usage patternss approaches to learningare associated with learning resources *** recommendations are presented.

关键词： Academic performance approaches to learning digital technology learning analytics

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Incidence, prevalence, and demographic characteristics of ocular cicatricial pemphigoid in Colombia: data from the National Health Registry 2009-2019

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1765-1770页

作者： carlos Cifuentes-gonzález Stefania Amaris-Martínez Juliana Reyes-Guanes Pilar Uribe-Reina Alejandra de-la-Torre Neuroscience Research Group Escuela de Medicina y Ciencias de la SaludUniversidad del RosarioBogota 111221Colombia Escuela Barraquer Research Group Escuela Superior de Oftalmología del Instituto Barraquer de AméricaBogota 110111Colombia

AIM:To provide an epidemiological characterization of ocular cicatricial pemphigoid(OCP)in ***:We conducted a cross-sectional study using *** applied the specific code of the International Classification of Diseases for Ocular Pemphigoid,from 2009-2019 to estimate prevalence,incidence,and the demographic status of the disease in ***:The estimated average prevalence was 0.22 per 1000000 inhabitants,and the estimated average incidence was 0.24 per 1000000 *** a female predominance of 62.5%,and a male/female ratio of 1:*** group of patients diagnosed with the disease after the age of 80 presented the highest *** departments with the highest prevalence were Antioquia,Bogotá,and ***:There are important differences between worldwide and Colombian prevalence and incidence data,which may be related to genetic and epigenetic factors,and the possible underdiagnosis of the *** to the results,OCP is an extremely rare disease in ***,it is important to encourage awareness of the disease due to its devastating consequences.

关键词： ocular cicatricial pemphigoid epidemiology incidenee ophthalmology Colombia autoimmune diseases

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The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： Juan Enrique Barranco-García Carolina Caicedo Enrique Javier Jiménez-Regalado carlos Espinoza-gonzález Graciela Morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

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